Cytotoxic Cells Recognition Effector Function Generation And Methods
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Cytotoxic Cells Recognition Effector Function Generation And Methods
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Author : SITKOVSKY
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cytotoxic Cells Recognition Effector Function Generation And Methods written by SITKOVSKY and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Our motivation for putting together this book was the need for a single source reference that could be used as an introduction to cell-mediated cytotoxicity for newcomers to this field, such as students and fellows beginning work in our laboratories. At present no such book is available, and we felt that it would be useful as a teaching tool and as a way of conveying our enthusiasm about recent progress in the cytotoxicity field to our colleagues in allied areas. It was with some hesitation that we approached our colleagues with the proposal for this book, and we were pleased to find them very supportive of the idea and willing to participate. We thought it important to broaden the scope of the book to include historical, molecular, cell biological, and clinical aspects of cell-mediated cytotoxicity. To our knowledge this is the first book on cell-mediated cytotoxicity with such a broad scope. Historically, studies on cellular cytotoxicity were part of cellular immunology from its origin. One development of tremendous import was the advent of the 51 Cr assay, which allowed this arm of the immune response to be measured easily and quantitatively. Thus, a readout of this effector pathway is available within a few hours; other immune effector functions can take days or even longer to assay, and the assays are often less quantitative.
Advanced Methods In Cellular Immunology
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Author : Rafael Fernandez-Botran
language : en
Publisher: CRC Press
Release Date : 2000-05-26
Advanced Methods In Cellular Immunology written by Rafael Fernandez-Botran and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-05-26 with Medical categories.
Immunologists as well investigators in other disciplines may often use protocols involving the isolation, cultures and characterization of different types of leukocytes. Advanced Methods in Cellular Immunology is a collection of techniques in an easy-to-use format. Each chapter provides readers with related program information, a step-by-step de
The Enzyme Reference
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Author : Daniel L. Purich
language : en
Publisher: Elsevier
Release Date : 2003-01-04
The Enzyme Reference written by Daniel L. Purich and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-04 with Science categories.
The aim of this work is to provide a fuller spectrum of information in a single source on enzyme-catalyzed reactions than is currently available in any published reference work or as part of any Internet database. The Enzyme Reference: A Comprehensive Guidebook to Enzyme Nomenclature, Reactions, and Methods includes 20,000 review articles and seminal research papers. Additionally, it provides a novel treatment of so-called ATPase and GTPase reactions to account for the noncovalent substratelike and productlike states of molecular motors, elongation factors, transporters, DNA helicases, G-reulatory proteins, and other energases. - Includes a compendium of over 6,000 enzyme reactions (including enzyme commission numbers, alternative names, substrates, products, alternative substrates, and properties) - Covers over 900 chemical structures of key metabolites and cofactors - Index directs readers to the exact pages for over 9,500 enzyme names
Comprehensive Toxicology
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Author :
language : en
Publisher: Elsevier
Release Date : 2010-06-01
Comprehensive Toxicology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-01 with Science categories.
An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version
The Major Histocompatibility Complex Mhc Hla In Medicine
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Author : Federico Garrido
language : en
Publisher: Springer Nature
Release Date : 2024-07-11
The Major Histocompatibility Complex Mhc Hla In Medicine written by Federico Garrido and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-11 with Medical categories.
This book takes the reader on a journey through past and current research on the Major Histocompatibility Complex (MHC/HLA). It describes how it was discovered, what its biological function is and its application in medicine. The reader will learn about the molecular structure of the encoded molecules and different aspects of their role in medicine, including organ transplantation, their link to autoimmune diseases, cancer immunity, resistance to infectious diseases, and other related scientific areas, such as population genetics. In particular, the book focusses on the impact of MHC/HLA altered expression in tumours and their relevance in cancer immune escape and immunotherapy. It contains a large number of original figures and photographs of pioneers in the field, who made seminal contributions. Each chapter is supported by relevant key publications and enriched with a personal account of the early research that has contributed to our current understanding of the role of the major histocompatibility complex. This book is an excellent resource for all scientists in the biomedical life sciences who wish to gain insight into the discovery of the MHC/HLA and the role of this important genetic complex in health and disease.
Antibodies In Diagnosis And Therapy
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Author : Matzku
language : en
Publisher: Routledge
Release Date : 2019-06-14
Antibodies In Diagnosis And Therapy written by Matzku and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-14 with Medical categories.
Monoclonal antibodies have had their impact on biomedical research for more than a decade. Beside their exuberant use as reagents, quite a number of diagnostic and therapeutic approaches have been followed and an impressive number of technological improvements, e.g., humanization, recombinant miniantibodies, have been elaborated to strengthen the principle. With respect to clinical applications, the first generation of antibody 'drugs' is yielding promising results while second and third generation antibody constructs are already underway. The book reviews the status of technological development and brings this into the perspective of clinical results. A rapidly growing amount of clinical data is collected in an expanding number of indications. Hence, the review of clinical study results has been grouped according to the fields of oncology and of chronic and acute inflammation. This book will be of interest to scientists working in the fields of oncology, immunology, internal medicine and clinical chemistry.
Oxidative Stress Cell Activation And Viral Infection
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Author : C. Pasquier
language : en
Publisher: Birkhäuser
Release Date : 2013-03-08
Oxidative Stress Cell Activation And Viral Infection written by C. Pasquier and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Science categories.
Since the appearance of photosynthesis on our planet, all living organisms have been facing a new abundant, extremely reactive element, oxygen. This element is used for the synthesis of highly energetic compounds, but can also generate molecules capable of damaging constituents of living structures, including proteins, nucleic acids and lipids. It is therefore no surprise that all biological organisms have evolved multiple and sophisticated ways to reduce the detrimental effects of oxygen. For cells and tissues of highly organized animals, particularly cells of the immune system, superoxidation products play an important role, via oxidative stress, in activation, inflammation and viral and bacterial infections. We must be grateful to Drs. C. Pasquier, C. Auclair, L. Packer and R. Olivier for having brought together many specialists in an international meeting held in Paris in March 1993, at the Ministry of Research. This book comprises an impressive amount of recent knowledge, a real mine for the reader in this fast developing field of research. Furthermore, we should not forget that this basic research may lead in the future to new therapeutic approaches to the most important pathologies of the latter part of this century, including AIDS.
National Library Of Medicine Current Catalog
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Author : National Library of Medicine (U.S.)
language : en
Publisher:
Release Date : 1993
National Library Of Medicine Current Catalog written by National Library of Medicine (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medicine categories.
Toward A Molecular Basis Of Alcohol Use And Abuse
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Author : B. Jansson
language : en
Publisher: Birkhäuser
Release Date : 2013-03-13
Toward A Molecular Basis Of Alcohol Use And Abuse written by B. Jansson and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Science categories.
The 39 chapters in this volume consider subjects ranging from genetics, markers, and molecular biology of alcoholism, to clinical observations and treatment. The aim is to integrate pertinent information from the fields of molecular and cell biology with view to establishing a molecular basis of alcohol use and abuse. An initial preview summarizes historical aspects of alcohol use, and subsequent chapters concern novel drugs, pharmacological aspects, gene structures, cloning, and enzymatic properties. Also contributions by "non-traditional" alcohol scientists have been included in this collection, in order to highlight possible interaction and parallels between different fields. Novel results of particular interest include up-dated summaries on receptors, enzymes, and other proteins, as well as corresponding gene structures and regulation, setting the basis for distinguishing markers and pinpointing further possible pharmacological treatments.
Graft Vs Host Disease
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Author : James Ferrara
language : en
Publisher: CRC Press
Release Date : 1996-09-13
Graft Vs Host Disease written by James Ferrara and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-09-13 with Medical categories.
With detailed contributions from more than 40 leading authorities on the topic, this Third Edition comprehensively explores the immunobiology, pathophysiology, and clinical manifestations of graft-versus-host disease (GVHD)-offering sections revealing the most up-to-date research on immune activation and dysregulation, the pathophysiology of target organ damage, and GVHD prevention and treatment.