Danger Signals Scholar S Choice Edition
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Danger Signals Scholar S Choice Edition
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Author : John a Hill
language : en
Publisher: Scholar's Choice
Release Date : 2015-02-17
Danger Signals Scholar S Choice Edition written by John a Hill and has been published by Scholar's Choice this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-17 with categories.
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Danger Signals Triggering Immune Response And Inflammation
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Author : Abdulraouf Ramadan
language : en
Publisher: Frontiers Media SA
Release Date : 2017-09-18
Danger Signals Triggering Immune Response And Inflammation written by Abdulraouf Ramadan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-18 with Diseases categories.
The immune system detects "danger" through a series of what we call pathogen-associated molecular patterns (PAMPs) or damage-associated molecular pattern molecules (DAMPs), working in concert with both positive and negative signals derived from other tissues. PAMPs are molecules associated with groups of pathogens that are small molecular motifs conserved within a class of microbes. They are recognized by Toll-like receptors (TLRs) and other pattern recognition receptors. A vast array of different types of molecules can serve as PAMPs, including glycans and glycoconjugates. Bacterial lipopolysaccharides (LPSs), endotoxins found on the cell membranes of Gram-negative bacteria, are considered to be the prototypical class of PAMPs. LPSs are specifically recognized by TLR4, a recognition receptor of the innate immune system. Other PAMPs include bacterial flagellin (recognized by TLR5), lipoteichoic acid from Gram-positive bacteria, peptidoglycan, and nucleic acid variants normally associated with viruses, such as double-stranded RNA, recognized by TLR3 or unmethylated CpG motifs, recognized by TLR9. DAMPs, also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the immune and inflammatory response. DAMPs vary greatly depending on the type of cell (epithelial, mesenchymal, etc.) and injured tissue. Some endogenous danger signals include heat-shock proteins, HMGB1 (high-mobility group box 1), reactive oxygen intermediates, extracellular matrix breakdown products such as hyaluronan fragments, neuromediators, and cytokines like the interferons (IFNs). Non-protein DAMPs include ATP, uric acid, heparin sulfate, and DNA. Furthermore, accumulating evidence supports correlation between alarmins and changes in the microbiome. Increased serum or plasma levels of these DAMPs have been associated with many inflammatory diseases, including gastric and intestinal inflammatory diseases, graft-versus-host disease (GVHD), sepsis and multiple organ failure, allergies particularly in the lungs, atherosclerosis, age-associated insulin resistance, arthritis, lupus, neuro-inflammation/degeneration and more recently in tumors, which is particularly interesting with the emergence of immunotherapies. Therapeutic strategies are being developed to modulate the expression of these DAMPs for the treatment of these diseases. A vast number of reviews have already been published in this area; thus, in an effort to not duplicate what has already been written, we will focus on recent discoveries particularly in disease models that are epidemic in Western society: intestinal chronic inflammatory diseases including GVHD and its relationship with the microbiome, chronic infectious diseases, allergies, autoimmune diseases, neuroinflammation and cancers. We will also focus on the basic cellular roles of macrophages, T cells and B cells. This research topic brings together sixteen articles that provide novel insights into the mechanisms of action of DAMPS/alarmins and their regulation and subsequent immunologically driven responses.
Danger Signal
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Author : Solomon O. Lichter
language : en
Publisher:
Release Date :
Danger Signal written by Solomon O. Lichter and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Danger Signals
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Author : Francis E. (Francis Edward) 1851 Clark
language : en
Publisher:
Release Date : 2016-08-25
Danger Signals written by Francis E. (Francis Edward) 1851 Clark and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-25 with History categories.
A Manual Of Signals
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Author : Albert J Myer
language : en
Publisher: Scholar's Choice
Release Date : 2015-02-20
A Manual Of Signals written by Albert J Myer and has been published by Scholar's Choice this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-20 with categories.
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Emergency Signaling Scholar S Choice Edition
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Author : New Y. Gamewell Fire Alarm Telegraph Co
language : en
Publisher:
Release Date : 2015-02-13
Emergency Signaling Scholar S Choice Edition written by New Y. Gamewell Fire Alarm Telegraph Co and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-13 with categories.
This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
The Classical Review
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Author :
language : en
Publisher:
Release Date : 1910
The Classical Review written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1910 with Classical philology categories.
Negative Affect As A Danger Signal
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Author : Mikayla Hughes
language : en
Publisher:
Release Date : 2006
Negative Affect As A Danger Signal written by Mikayla Hughes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Affect (Psychology) categories.
Crisis Consciousness And The Novel
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Author : Eugene Hollahan
language : en
Publisher: University of Delaware Press
Release Date : 1992
Crisis Consciousness And The Novel written by Eugene Hollahan and has been published by University of Delaware Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Language Arts & Disciplines categories.
"This book examines the emergence of modern consciousness as consciousness develops historically in one cultural form: prose fiction narrative. The book represents a critical history of crisis, arguably the most characterizing single word in the modern world and a major figuration or trope. Eugene Hollahan has studied the history of this important word within the development of the English-language novel, from Samuel Richardson to Saul Bellow. After establishing a heuristic model for such a critical history, Hollahan tracks the word (characterized by George Eliot in Felix Holt, the Radical as a "great noun") through two-and-a-half centuries of narratives by major novelists, with contextualizing excursions into discourses in related fields such as autobiography, philosophy, theology, and social science." "Hollahan contextualizes his study of English-language narrative fiction by examining the writings of crisis-rhetoricians in the eighteenth century (Thomas Paine), nineteenth century (Thomas Carlyle, J. S. Mill, and J. H. Newman), and twentieth century (Karl Barth, Edmund Husserl, T. S. Kuhn, and Richard M. Nixon). Such varied and powerful crisis-rhetorics establish a matrix of language and ideas for the crisis-centered novels Hollahan surveys. These novels include major works by Samuel Richardson, Walter Scott, Jane Austen, George Eliot, George Meredith, George Gissing, George Moore, D. H. Lawrence, E. M. Forster, James Joyce, Lawrence Durrell, Robert Coover, and Saul Bellow." "Hollahan's description of the crisis-trope interfaces with various critical issues such as canonical inclusion, reader response, and deconstruction. On the whole, his book acknowledges current critical issues but endeavors to remain basically a critical history. It attempts to demonstrate that the crisis-riddled modern world and the crisis-conscious novel are analogous and coeval." "Crisis begins as Aristotle's term for logical plot structuring, becomes Longinus's term for emotional exacerbation, and eventually enters into a variety of critical and narrative formulations: Matthew Arnold's cultural centrality, Henry James's existential aestheticism, Lawrence's self-defining sexuality, Marshall Brown's revolutionary turning point, Paul de Man's error-ridden criticism, Floyd Merrell's cut into the primordial flux, Durrell's reborn self, and Bellow's analysis of hysterical escapism. Broadly speaking, Hollahan argues that any crisis-trope will enable or even necessitate a unique confluence of writerly and readerly skills." "In Louis Lambert, Balzac urged: "What a wonderful book one would write by narrating the life and adventures of a word." The story Hollahan narrates fulfills Balzac's expectations as it depicts writer after writer working out influential representations of human life in terms of crisis-consciousness centering upon George Eliot's "great noun" crisis. Historically, Hollahan demonstrates, such consciousness comes to define modern humanity."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
The Oxford Handbook Of Positive Organizational Scholarship
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Author : Kim S. Cameron
language : en
Publisher: Oxford University Press
Release Date : 2013-05-02
The Oxford Handbook Of Positive Organizational Scholarship written by Kim S. Cameron and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-02 with Business & Economics categories.
An ideal resource for organizational scholars, students, practitioners, and human resource managers, this handbook covers the full spectrum of organizational theories and outcomes that define, explain, and predict the occurrence, causes, and consequences of positivity.