Danger Signals Triggering Immune Response And Inflammation
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Danger Signals Triggering Immune Response And Inflammation
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Author : Abdulraouf Ramadan
language : en
Publisher: Frontiers Media SA
Release Date : 2017-09-18
Danger Signals Triggering Immune Response And Inflammation written by Abdulraouf Ramadan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-18 with Diseases categories.
The immune system detects "danger" through a series of what we call pathogen-associated molecular patterns (PAMPs) or damage-associated molecular pattern molecules (DAMPs), working in concert with both positive and negative signals derived from other tissues. PAMPs are molecules associated with groups of pathogens that are small molecular motifs conserved within a class of microbes. They are recognized by Toll-like receptors (TLRs) and other pattern recognition receptors. A vast array of different types of molecules can serve as PAMPs, including glycans and glycoconjugates. Bacterial lipopolysaccharides (LPSs), endotoxins found on the cell membranes of Gram-negative bacteria, are considered to be the prototypical class of PAMPs. LPSs are specifically recognized by TLR4, a recognition receptor of the innate immune system. Other PAMPs include bacterial flagellin (recognized by TLR5), lipoteichoic acid from Gram-positive bacteria, peptidoglycan, and nucleic acid variants normally associated with viruses, such as double-stranded RNA, recognized by TLR3 or unmethylated CpG motifs, recognized by TLR9. DAMPs, also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the immune and inflammatory response. DAMPs vary greatly depending on the type of cell (epithelial, mesenchymal, etc.) and injured tissue. Some endogenous danger signals include heat-shock proteins, HMGB1 (high-mobility group box 1), reactive oxygen intermediates, extracellular matrix breakdown products such as hyaluronan fragments, neuromediators, and cytokines like the interferons (IFNs). Non-protein DAMPs include ATP, uric acid, heparin sulfate, and DNA. Furthermore, accumulating evidence supports correlation between alarmins and changes in the microbiome. Increased serum or plasma levels of these DAMPs have been associated with many inflammatory diseases, including gastric and intestinal inflammatory diseases, graft-versus-host disease (GVHD), sepsis and multiple organ failure, allergies particularly in the lungs, atherosclerosis, age-associated insulin resistance, arthritis, lupus, neuro-inflammation/degeneration and more recently in tumors, which is particularly interesting with the emergence of immunotherapies. Therapeutic strategies are being developed to modulate the expression of these DAMPs for the treatment of these diseases. A vast number of reviews have already been published in this area; thus, in an effort to not duplicate what has already been written, we will focus on recent discoveries particularly in disease models that are epidemic in Western society: intestinal chronic inflammatory diseases including GVHD and its relationship with the microbiome, chronic infectious diseases, allergies, autoimmune diseases, neuroinflammation and cancers. We will also focus on the basic cellular roles of macrophages, T cells and B cells. This research topic brings together sixteen articles that provide novel insights into the mechanisms of action of DAMPS/alarmins and their regulation and subsequent immunologically driven responses.
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2004
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.
Inflammatory Diseases Of Blood Vessels
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Author : Gary S. Hoffman
language : en
Publisher: John Wiley & Sons
Release Date : 2012-04-10
Inflammatory Diseases Of Blood Vessels written by Gary S. Hoffman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-10 with Medical categories.
Inflammatory Diseases of Blood Vessels“/b> Inflammatory Diseases of Blood Vessels Second Edition Inflammatory Diseases of Blood Vessels provides a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease. In recent years, considerable progress has been made in understanding different forms of vasculitis. Investigation of pathogenesis of vascular inflammation has led to improved treatments and outcomes. Surgical and transplant procedures have improved in parallel with medical therapies. These areas are extensively examined in this new edition. Inflammatory Diseases of Blood Vessels is an excellent resource for a broad readership, including clinicians, investigators and their support teams in numerous specialties e.g. rheumatology, immunology, cardiology, cardiovascular surgery, pulmonary medicine, nephrology, pathology, vascular biology, embryology and imaging.
Emerging Insights In Controlling Autoimmunity
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Author : Zahava Vadasz
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-19
Emerging Insights In Controlling Autoimmunity written by Zahava Vadasz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-19 with Medical categories.
Innovative Perspective In Surgery
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Author : Sibel AKYOL
language : en
Publisher: Livre de Lyon
Release Date : 2023-02-15
Innovative Perspective In Surgery written by Sibel AKYOL and has been published by Livre de Lyon this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-15 with Medical categories.
Innovative Perspective in Surgery
Vaccine Peer Review
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Author : Jeff Prager
language : en
Publisher: Hospitallers Order of the Good News
Release Date : 2024-12-01
Vaccine Peer Review written by Jeff Prager and has been published by Hospitallers Order of the Good News this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-01 with Health & Fitness categories.
VACCINE Peer Review The History Of The Global Vaccination Program In 1000 Peer Reviewed Reports And Studies 1915-2015 A Jeff Prager Publication
Cell Based Immunotherapies For Cancer
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Author : Alok K. Mishra
language : en
Publisher: Springer Nature
Release Date : 2025-06-24
Cell Based Immunotherapies For Cancer written by Alok K. Mishra and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-24 with Medical categories.
This book explores the rapidly evolving field of cancer immunotherapy, which focuses on harnessing the immune system's power to combat cancer. As traditional treatments like chemotherapy and radiation therapy often have significant side effects and may not be effective for all cancer types, immunotherapy offers a promising alternative. Among the most notable advancements in this field are cell-based therapies, which involve modifying a patient’s own immune cells or engineering specialized cells to enhance their ability to target cancer. Key approaches include chimeric antigen receptor (CAR) T-cell therapy, tumor-infiltrating lymphocyte (TIL) therapy, and dendritic cell (DC)-based therapy. Providing a comprehensive overview of these therapies, this book explores their scientific foundations, recent developments, clinical applications, and associated challenges. It also discusses emerging immunotherapeutic strategies, the commercial landscape, and future research directions. A valuable resource for researchers, clinicians, and industry professionals involved in cancer treatment, this book also serves as an informative reference for students and academics in biology, biotechnology, immunology, and related disciplines seeking a deeper understanding of cancer immunotherapy.
Metabolism Meets Function Untangling The Cross Talk Between Signalling And Metabolism
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Author : Alessandra Castegna
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-18
Metabolism Meets Function Untangling The Cross Talk Between Signalling And Metabolism written by Alessandra Castegna and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-18 with Medical categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Chronic Obstructive Pulmonary Disease
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Author : Kian Chung Ong
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-03-02
Chronic Obstructive Pulmonary Disease written by Kian Chung Ong and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-02 with Medical categories.
A decade or so ago, many clinicians were described as having an unnecessarily 'nihilistic' view of COPD. This has certainly changed over the years... This open access book on COPD provides a platform for scientists and clinicians from around the world to present their knowledge of the disease and up-to-date scientific findings, and avails the reader to a multitude of topics: from recent discoveries in the basic sciences to state-of-the-art interventions on COPD. Management of patients with COPD challenges the whole gamut of Respiratory Medicine - necessarily pushing frontiers in pulmonary function (and exercise) testing, radiologic imaging, pharmaceuticals, chest physiotherapy, intensive care with respiratory therapy, bronchology and thoracic surgery. In addition, multi-disciplinary inputs from other specialty fields such as cardiology, neuro-psychiatry, geriatric medicine and palliative care are often necessary for the comprehensive management of COPD. The recent progress and a multi-disciplinary approach in dealing with COPD certainly bode well for the future. Nonetheless, the final goal and ultimate outcome is in improving the health status and survival of patients with COPD.
Inflammation And Cancer
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Author : Bharat B. Aggarwal
language : en
Publisher: Springer
Release Date : 2014-05-12
Inflammation And Cancer written by Bharat B. Aggarwal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-12 with Medical categories.
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.