Data Sharing And Secondary Use Of Scientific Data

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Data Sharing And Secondary Use Of Scientific Data

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Author : Ann S. Zimmerman
language : en
Publisher:
Release Date : 2003

Data Sharing And Secondary Use Of Scientific Data written by Ann S. Zimmerman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Ecology categories.

Sharing Clinical Trial Data

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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2015-04-20

Sharing Clinical Trial Data written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-20 with Medical categories.

Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.

Secondary Analysis Of Electronic Health Records

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Author : MIT Critical Data
language : en
Publisher: Springer
Release Date : 2016-09-09

Secondary Analysis Of Electronic Health Records written by MIT Critical Data and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-09 with Medical categories.

This book trains the next generation of scientists representing different disciplines to leverage the data generated during routine patient care. It formulates a more complete lexicon of evidence-based recommendations and support shared, ethical decision making by doctors with their patients. Diagnostic and therapeutic technologies continue to evolve rapidly, and both individual practitioners and clinical teams face increasingly complex ethical decisions. Unfortunately, the current state of medical knowledge does not provide the guidance to make the majority of clinical decisions on the basis of evidence. The present research infrastructure is inefficient and frequently produces unreliable results that cannot be replicated. Even randomized controlled trials (RCTs), the traditional gold standards of the research reliability hierarchy, are not without limitations. They can be costly, labor intensive, and slow, and can return results that are seldom generalizable to every patient population. Furthermore, many pertinent but unresolved clinical and medical systems issues do not seem to have attracted the interest of the research enterprise, which has come to focus instead on cellular and molecular investigations and single-agent (e.g., a drug or device) effects. For clinicians, the end result is a bit of a “data desert” when it comes to making decisions. The new research infrastructure proposed in this book will help the medical profession to make ethically sound and well informed decisions for their patients.

Open Scientific Data

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Author : Vera J. Lipton
language : en
Publisher:
Release Date : 2020

Open Scientific Data written by Vera J. Lipton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Big data categories.

Public science is critical to the economy and to society. However, much of the beneficial impact of scientific research only occurs when scientific knowledge is disseminated broadly and is used by others. This book examines the emerging policy, law and practice of facilitating open access to scientific research data. One particular focus is to examine the open data policies recently introduced by research funders and publishers, and the potential in these for driving the practice of open scientific data into the future. This study identifies five major stumbling blocks to sustainable open scientific data. Firstly, it is the prevailing mindset that facilitating open access to data is analogous to facilitating open access to publications and, therefore, research data can easily be shared, with research funders and librarians effectively leading the process. Secondly, it is the unclear meaning of the term data which causes confusion among stakeholders. Thirdly, it is the misunderstood incentives for data sharing and the additional inputs required from researchers. Fourthly, data privacy—an issue that only applies to selected research datasets, and yet appears to dominate the discussion about open research data. Finally, there is a copyright law, which poses challenges at different stages of data release and reuse. In this book, it is argued that the above problems can be addressed using a staged model for open scientific data. I draw specifically on the practice with open scientific data at CERN (the European Organization for Nuclear Research) and the practice of sharing clinical trial data to argue that open data can be shared at various stages of processing and diversification. This model is supplemented by recommendations proposing changes to existing open data mandates and the introduction of a text and data mining exemption into Australian copyright law.

Discussion Framework For Clinical Trial Data Sharing

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Author : Committee on Strategies for Responsible Sharing of Clinical Trial Data
language : en
Publisher:
Release Date : 2014

Discussion Framework For Clinical Trial Data Sharing written by Committee on Strategies for Responsible Sharing of Clinical Trial Data and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Clinical trials categories.

Sharing data generated through the conduct of clinical trials offers the promise of placing evidence about the safety and efficacy of therapies and clinical interventions on a firmer basis and enhancing the benefits of clinical trials. Ultimately, such data sharing - if carried out appropriately - could lead to improved clinical care and greater public trust in clinical research and health care. Discussion Framework for Clinical Trial Data Sharing: Guiding Principles, Elements, and Activities is part of a study of how data from clinical trials might best be shared. This document is designed as a framework for discussion and public comment. This framework is being released to stimulate reactions and comments from stakeholders and the public. The framework summarizes the committee's initial thoughts on guiding principles that underpin responsible sharing of clinical trial data, defines key elements of clinical trial data and data sharing, and describes a selected set of clinical trial data sharing activities.

Principles And Practice Of Clinical Trials

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Author : Steven Piantadosi
language : en
Publisher: Springer Nature
Release Date : 2022-07-19

Principles And Practice Of Clinical Trials written by Steven Piantadosi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-19 with Medical categories.

This is a comprehensive major reference work for our SpringerReference program covering clinical trials. Although the core of the Work will focus on the design, analysis, and interpretation of scientific data from clinical trials, a broad spectrum of clinical trial application areas will be covered in detail. This is an important time to develop such a Work, as drug safety and efficacy emphasizes the Clinical Trials process. Because of an immense and growing international disease burden, pharmaceutical and biotechnology companies continue to develop new drugs. Clinical trials have also become extremely globalized in the past 15 years, with over 225,000 international trials ongoing at this point in time. Principles in Practice of Clinical Trials is truly an interdisciplinary that will be divided into the following areas: 1) Clinical Trials Basic Perspectives 2) Regulation and Oversight 3) Basic Trial Designs 4) Advanced Trial Designs 5) Analysis 6) Trial Publication 7) Topics Related Specific Populations and Legal Aspects of Clinical Trials The Work is designed to be comprised of 175 chapters and approximately 2500 pages. The Work will be oriented like many of our SpringerReference Handbooks, presenting detailed and comprehensive expository chapters on broad subjects. The Editors are major figures in the field of clinical trials, and both have written textbooks on the topic. There will also be a slate of 7-8 renowned associate editors that will edit individual sections of the Reference.

Implementing Reproducible Research

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Author : Victoria Stodden
language : en
Publisher: CRC Press
Release Date : 2014-04-14

Implementing Reproducible Research written by Victoria Stodden and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-14 with Mathematics categories.

In computational science, reproducibility requires that researchers make code and data available to others so that the data can be analyzed in a similar manner as in the original publication. Code must be available to be distributed, data must be accessible in a readable format, and a platform must be available for widely distributing the data and code. In addition, both data and code need to be licensed permissively enough so that others can reproduce the work without a substantial legal burden. Implementing Reproducible Research covers many of the elements necessary for conducting and distributing reproducible research. It explains how to accurately reproduce a scientific result. Divided into three parts, the book discusses the tools, practices, and dissemination platforms for ensuring reproducibility in computational science. It describes: Computational tools, such as Sweave, knitr, VisTrails, Sumatra, CDE, and the Declaratron system Open source practices, good programming practices, trends in open science, and the role of cloud computing in reproducible research Software and methodological platforms, including open source software packages, RunMyCode platform, and open access journals Each part presents contributions from leaders who have developed software and other products that have advanced the field. Supplementary material is available at www.ImplementingRR.org.

Public Health Research Methods

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Author : Greg Guest
language : en
Publisher: SAGE
Release Date : 2015

Public Health Research Methods written by Greg Guest and has been published by SAGE this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Medical categories.

Providing a comprehensive foundation for planning, executing, and monitoring public health research of all types, this book goes beyond traditional epidemiologic research designs to cover technology-based approaches emerging in the new public health landscape.

How To Write A Successful Research Grant Application

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Author : Willo Pequegnat
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-11-02

How To Write A Successful Research Grant Application written by Willo Pequegnat and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-02 with Medical categories.

Over the last fifty years behavioral and medical research has been generously supported by the federal government, private foundations, and other philanthropic organizations contributing to the development of a vibrant public health system both in the United States and worldwide. However, these funds are dwindling and to stay competitive, investigators must understand the funding environment and know how to translate their hypotheses into research grant applications that reviewers evaluate as having scientific merit. The Second Edition of ‘How to Write a Successful Research Grant Application’ is the only book of its kind written by federal research investigators which provides technical assistance for researchers applying for biobehavioral and psychosocial research funding and can give them an edge in this competitive environment. The book provides invaluable tips on all aspects of the art of grantsmanship, including: how to determine research opportunities and priorities, how to develop the different elements of an application, how to negotiate the electronic submission and review processes, and how to disseminate the findings. Charts, visual aids, Web links, an extensive real-world example of a research proposal with budget, and a "So You Were Awarded Your Grant—Now What?" chapter show prospective applicants how to: - Formulate a testworthy—and interesting—hypothesis. - Select the appropriate research mechanism. - Avoid common pitfalls in proposal writing. - Develop an adequate control group. - Conduct a rigorous qualitative inquiry. - Develop a budget justification of costs. - Develop a human subjects of animal welfare plan. - Write a data analytic plan. - Design a quality control/assurance program. - Read between the lines of a summary of the review of your application. Although its focus is on Public Health Service funding, ‘How to Write a Successful Research Grant’ is equally useful for all research proposals, including graduate students preparing a thesis or dissertation proposal. Service providers in community-based organizations and public health agencies will also find this a useful resource in preparing a proposal to compete for grant funds from state and community resources, non-government organizations, and foundations.

Privacy Big Data And The Public Good

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Author : Julia Lane
language : en
Publisher: Cambridge University Press
Release Date : 2014-06-09

Privacy Big Data And The Public Good written by Julia Lane and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-09 with Computers categories.

Data access is essential for serving the public good. This book provides new frameworks to address the resultant privacy issues.