Degradation Of Endogenous Opioids
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Degradation Of Endogenous Opioids
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Author : Seymour Ehrenpreis
language : en
Publisher: Raven Press (ID)
Release Date : 1983
Degradation Of Endogenous Opioids written by Seymour Ehrenpreis and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Endorphins categories.
Opioid Peptides
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Author : Rao S. Rapaka
language : en
Publisher:
Release Date : 1986
Opioid Peptides written by Rao S. Rapaka and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Endorphins categories.
"This monograph is based upon papers and discussion from the technical review on the medicinal chemistry and molecular pharmacology of opioid peptides and the opiates which took place on September 4-6, 1984, at Bethesda, Maryland. The meeting was sponsored by the Office of Science and the Division of Preclinical Research, National Institute on Drug Abuse. The papers on molecular pharmacology, biosynthesis, and analysis of opioid peptides are presented in this volume. Those on the medical chemistry of opioid peptides appear in NIDA Research Monograph 69" [entitled Opioid peptides : medicinal chemistry] -- page iv.
Advances In Endogenous And Exogenous Opioids
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Author : Hiroshi Takagi
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Advances In Endogenous And Exogenous Opioids written by Hiroshi Takagi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
Advances in Endogenous and Exogenous Opioids contains the proceedings of the International Narcotic Research Conference (Satellite Symposium of the 8th International Congress of Pharmacology) held in Kyoto, Japan on July 26-30, 1981. The conference provided a forum for discussing advances that have been made in the understanding of endogenous and exogenous opioids and tackled a wide array of topics ranging from novel opiate binding sites selective for benzomorphan drugs to the purification of opioid receptors and sequellae of receptor binding. Comprised of 156 chapters, this book begins with an analysis of the interaction of opioid peptides and alkaloid opiates with mu-, delta-, and kappa-binding sites. The reader is then systematically introduced to biochemical evidence for kappa and sigma opiate receptors; the action of morphine and oxymorphone as partial agonists on the field-stimulated rat vas deferens; mechanisms of supersensitivity in the enkephalinergic system; and properties of the solubilized opiate receptor from human placenta. Subsequent chapters explore the biosynthesis of opioid peptides as well as their localization, release, and degradation; physiological and pharmacological actions of opioids; and the use of analgesia in acupuncture. Results of behavioral and clinical studies of endogenous and exogenous opioids are also presented, and the structure-activity relationships of opioids are examined. This monograph will be of interest to students, practitioners, and researchers in the fields of psychiatry and pharmacology.
Cell Tissue Injury And Cytoprotection Organoprotection In The Gastrointestinal Tract
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Author : Ludmila P. Filaretova
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2012
Cell Tissue Injury And Cytoprotection Organoprotection In The Gastrointestinal Tract written by Ludmila P. Filaretova and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Up-to-date reviews on the mechanisms of gastrointestinal injury and protection In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage. This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection. This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.
Allosterism In Drug Discovery
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Author : Dario Doller
language : en
Publisher: Royal Society of Chemistry
Release Date : 2016-11-24
Allosterism In Drug Discovery written by Dario Doller and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-24 with Medical categories.
Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in studied in unprecedented detail has driven this trend. This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery. Bringing together research in a diverse range of scientific disciplines, Allosterism in Drug Discovery is a key reference for academics and industrialists interested in understanding allosteric interactions. The book provides an in-depth review of research using small molecules as chemical probes and drug candidates that interact allosterically with proteins of relevance to life sciences and human disease. Knowledge of these interactions can then be applied in the discovery of the novel therapeutics of the future. This book will be useful for people working in all disciplines associated with drug discovery in academia or industry, as well as postgraduate students who may be working in the design of allosteric modulators.
Frontiers In Pharmacology Of Neurotransmitters
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Author : Puneet Kumar
language : en
Publisher: Springer Nature
Release Date : 2020-10-29
Frontiers In Pharmacology Of Neurotransmitters written by Puneet Kumar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-29 with Medical categories.
Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.
Ectopeptidases
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Author : Jürgen Langner
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-02-28
Ectopeptidases written by Jürgen Langner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-02-28 with Medical categories.
The idea to compile recent results on the ectoenzymes aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 arose from the great interest given by readers world-wide to the two proceedings volumes edited by us in 1997 and 2000 (Ansorge and Langner, 1997; Langner and Ansorge, 2000). These volumes contained the presentations at two symposia held in Magdeburg (Germany) in 1996 and 1999 under the title "Cellular peptidases in immune functions and diseases", which was also the name of the Sonderforschungsbereich in Magdeburg, sponsored by the Deutsche Forschungsgemeinschaft between 1995 and 2001. Our groups in Magdeburg and Halle during the last two decades have provided results on these two enzymes in cells of the hematopoietic system that justify a review in an edited monograph like the present one (see the reviews by Kahne et at. , 1999; Lendeckel et at. ,1999; Riemann et at. , 1999). There are, however, many other groups in Europe, US and Japan which made important contributions to this field and particularly in topics improving the understanding of physiological and pathophysiological roles ofAPN/CD13 and DPIV/CD26. Therefore we decided to invite some of them to contribute reviews of their results to this book. Having worked for about 40 years in the field of proteolysis, for both of us to see the development of activities and knowledge from protein chemistry and enzymology to physiology and pathophysiology and even to therapy is very stimulating and fascinating. Of course, this development also reflects the dramatic improvement and refinement of methods.
Endogenous Opioids
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Author : Patrick L. Kerr
language : en
Publisher: Springer Nature
Release Date :
Endogenous Opioids written by Patrick L. Kerr and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
The Biological Basis For Mind Body Interactions
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Author : E.A. Mayer
language : en
Publisher: Elsevier
Release Date : 2000-02-03
The Biological Basis For Mind Body Interactions written by E.A. Mayer and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-02-03 with Medical categories.
The current volume focuses on several key aspects of mind/brain/body interactions in health and disease, including specific examples of interactions between body and brain, mechanisms underlying the response of the system to stressors, the role of early life events in permanently biasing the responsiveness of the system and practical implications of mind body interactions in human disease. The volume on Biological Basis for Mind Body Interactions is organized into 6 major sections, each dealing with a unique aspect of the general topic: After establishing the relationship between mind, brain and emotions, the first section deals with general neurobiological aspects mediating the effect of stress on various organ systems, including the immune and cardiovascular system. The second section covers the topic of how early life stressor can permanently alter responsiveness of the nervous system in animals and in man. The third section deals with influences of the internal environment, mediated by neuroendocrine and visceral afferent pathways on the CNS. The fourth section which deals with influences of body on the brain, focuses on mechanisms involved in perception and modulation of pain. The fifth section deals with influences of the mind/brain on the body, with an emphasis on central and peripheral mechanisms of autonomic control of body functions. The last section deals with a series of practical issues of mind body treatments, including acupuncture, breathing, body work and meditation. In addition, issues such as cost effectiveness and research aspects are discussed. Authors in this last section frequently refer to topics and mechanisms addressed in the early sections, making it a truly integrated volume. The unique aspect of the volume is the integration of state of the art research information on biological and practical aspects of mind/brain/body interactions. It is based on the beliefs of the editors and participants that the traditional separation of mind and body in research and in treatment of human disease is obsolete and needs to be replaced with a new unifying paradigm. Ironically, this evolving paradigm shares many similarities with ancient pre-Cartesian paradigms of health and disease.
Opioid Peptides And Blood Pressure Control
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Author : K.O. Stumpe
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Opioid Peptides And Blood Pressure Control written by K.O. Stumpe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book provides current knowledge on the influence of endogenous opioid peptides on blood pressure regulation. In view of the rapid increase in knowledge in the field, it is important that scientists in blood pressure research as well as specialist clinicians have access to such a comprehensive survey. The book is divided into sections on neuroanatomy, where both the central and peripheral nervous systems are considered; on physiology and pharmacology, whereby experiments with intact animals as well as with histologic preparations are described; and on clinical questions, where examinations of normotensive and hypertensive patients as well as experiments on the influence of various drugs are emphasized. The contributions are presented in the form of reviews and single articles which allow the reader to obtain a clear and detailed survey of a range of highly topical subjects.