Design And Fabrication Of Biomedical Platform Technologies For Improved Diagnostic Performance
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Design And Fabrication Of Biomedical Platform Technologies For Improved Diagnostic Performance
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Author : Brian O'Reilly
language : en
Publisher:
Release Date : 2016
Design And Fabrication Of Biomedical Platform Technologies For Improved Diagnostic Performance written by Brian O'Reilly and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Point-of-care diagnostics and therapeutics have the potential to radically change and improve the way disease and illness are detected and managed. This can be achieved by empowering the patient with rapid, real time information. Point of care testing also has the potential to alleviate some of the burden on crippled health care systems worldwide. Furthermore, personalised point-of-care testing can give more tailored and specific feedback to the end user. In this body of work, a novel single cell analysis system for antibody discovery and an integrated personalised point-ofcare platform is presented. In the first instance key challenges in the development of a novel single cell analysis antibody selection platform were addressed. This Direct Clone Analysis and Selection (DiCAST) Technology incorporates a highly ordered array of glass microcapillaries of 20 μm diameter. The first key challenge was to identify a single target micro-capillary of interest, containing the single antibody secreting cell of interest, among ≈ 1,000,000 other identical capillaries and cells. To achieve this, the ability to map assay patterns from the micro-capillary array to the master array containing the target cell was critical. Similar to where X marks the spot on a treasure map, micro-capillaries in a predefined pattern and orientation were blocked permanently using photolithography providing a reference stamp for alignment. These blocked capillaries provided a reference point upon the array, giving both spatial reference and orientation, allowing the cell recovery hardware to locate the micro-capillaries required to be evacuated. Following the successful mapping of the array of micro capillaries the recovery of the contents of the micro-capillaries proved elusive. Here a system for the recovery of single cells from a micro-capillary was developed. Initially investigated was a method whereby a micro-jet of air, passed through a nozzle equal in diameter to the micro-capillary, for the removal of its contents. With limited success it was demonstrated that, while single micro-capillaries could be interrogated and the contents removed, the successful and controlled recovery of the contents was inconclusive. Subsequently, a liquid recovery system was investigated. By coupling both ends of the micro-capillary with a glass capillary of similar internal diameter, and by flowing a buffer solution through the capillary, recovery of the contents of a single micro-capillary was demonstrated. In a second body of work, a method for cellular fraction extraction using an active trapping (CLEAR) approach was developed. CLEAR separates plasma from a whole blood sample in
Cmos Integrated Lab On A Chip System For Personalized Biomedical Diagnosis
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Author : Hao Yu
language : en
Publisher: John Wiley & Sons
Release Date : 2018-04-04
Cmos Integrated Lab On A Chip System For Personalized Biomedical Diagnosis written by Hao Yu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-04 with Technology & Engineering categories.
A thorough examination of lab-on-a-chip circuit-level operations to improve system performance A rapidly aging population demands rapid, cost-effective, flexible, personalized diagnostics. Existing systems tend to fall short in one or more capacities, making the development of alternatives a priority. CMOS Integrated Lab-on-a-Chip System for Personalized Biomedical Diagnosis provides insight toward the solution, with a comprehensive, multidisciplinary reference to the next wave of personalized medicine technology. A standard complementary metal oxide semiconductor (CMOS) fabrication technology allows mass-production of large-array, miniaturized CMOS-integrated sensors from multi-modal domains with smart on-chip processing capability. This book provides an in-depth examination of the design and mechanics considerations that make this technology a promising platform for microfluidics, micro-electro-mechanical systems, electronics, and electromagnetics. From CMOS fundamentals to end-user applications, all aspects of CMOS sensors are covered, with frequent diagrams and illustrations that clarify complex structures and processes. Detailed yet concise, and designed to help students and engineers develop smaller, cheaper, smarter lab-on-a-chip systems, this invaluable reference: Provides clarity and insight on the design of lab-on-a-chip personalized biomedical sensors and systems Features concise analyses of the integration of microfluidics and micro-electro-mechanical systems Highlights the use of compressive sensing, super-resolution, and machine learning through the use of smart SoC processing Discusses recent advances in complementary metal oxide semiconductor-integrated lab-on-a-chip systems Includes guidance on DNA sequencing and cell counting applications using dual-mode chemical/optical and energy harvesting sensors The conventional reliance on the microscope, flow cytometry, and DNA sequencing leaves diagnosticians tied to bulky, expensive equipment with a central problem of scale. Lab-on-a-chip technology eliminates these constraints while improving accuracy and flexibility, ushering in a new era of medicine. This book is an essential reference for students, researchers, and engineers working in diagnostic circuitry and microsystems.
Microsystems For Enhanced Control Of Cell Behavior
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Author : Andrés Díaz Lantada
language : en
Publisher: Springer
Release Date : 2016-03-23
Microsystems For Enhanced Control Of Cell Behavior written by Andrés Díaz Lantada and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-23 with Technology & Engineering categories.
This handbook focuses on the entire development process of biomedical microsystems that promote special interactions with cells. Fundamentals of cell biology and mechanobiology are described as necessary preparatory input for design tasks. Advanced design, simulation, and micro/nanomanufacturing resources, whose combined use enables the development of biomedical microsystems capable of interacting at a cellular level, are covered in depth. A detailed series of chapters is then devoted to applications based on microsystems that offer enhanced cellular control, including microfluidic devices for diagnosis and therapy, cell-based sensors and actuators (smart biodevices), microstructured prostheses for improvement of biocompatibility, microstructured and microtextured cell culture matrices for promotion of cell growth and differentiation, electrophoretic microsystems for study of cell mechanics, microstructured and microtextured biodevices for study of cell adhesion and dynamics, and biomimetic microsystems (including organs-on-chips), among others. Challenges relating to the development of reliable in vitro biomimetic microsystems, the design and manufacture of complex geometries, and biofabrication are also discussed.
Diagnostic Devices With Microfluidics
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Author : Francesco Piraino
language : en
Publisher: CRC Press
Release Date : 2017-06-26
Diagnostic Devices With Microfluidics written by Francesco Piraino and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-26 with Technology & Engineering categories.
This book provides a current view of the research and commercial landscape of diagnostics devices, particularly those that utilize microscale technologies, intended for both patient and laboratory use. Common diagnostic devices that are based on microfluidic principles include glucose sensors for diabetic patients and over-the-counter pregnancy tests. Other diagnostic devices are being developed to quickly test a patient for bacterial and viral infections, and other diseases. The chapters, written by experts from around the world, discuss how to fabricate, apply, and market microfluidic diagnostic chips – for lab and at-home use. Most importantly, the book also contains a discussion of topics relevant to the private sector, including patient-focused, market-oriented development of diagnostics devices. Chapter 9 of this book is freely available as a downloadable Open Access PDF under a CC-BY 3.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781498772938_oachapter9.pdf
Molecular Sensors And Nanodevices
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Author : John X. J. Zhang
language : en
Publisher: Academic Press
Release Date : 2018-11-19
Molecular Sensors And Nanodevices written by John X. J. Zhang and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-19 with Technology & Engineering categories.
Molecular Sensors and Nanodevices: Principles, Designs and Applications in Biomedical Engineering, Second Edition is designed to be used as a foundational text, aimed at graduates, advanced undergraduates, early-career engineers and clinicians. The book presents the essential principles of molecular sensors, including theories, fabrication techniques and reviews. In addition, important devices and recently, highly-cited research outcomes are also cited. This differentiates the book from other titles on the market whose primary focus is more research-oriented and aimed at more of a niche market. Covers the fundamental principles of device engineering and molecular sensing, sensor theories and applications in biomedical science and engineering Introduces nano/micro fabrication techniques, including MEMS, bioMEMS, microTAS and nanomaterials science that are essential in the miniaturization of versatile molecular sensors Explores applications of nanomaterials and biomaterials, including proteins, DNAs, nanoparticles, quantum dots, nanotubes/wires and graphene in biomedicine
Digital Design And Manufacturing Of Medical Devices And Systems
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Author : Rajkumar Velu
language : en
Publisher: Springer Nature
Release Date :
Digital Design And Manufacturing Of Medical Devices And Systems written by Rajkumar Velu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Integrated Smart Micro Systems Towards Personalized Healthcare
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Author : Yu Song
language : en
Publisher: John Wiley & Sons
Release Date : 2021-12-13
Integrated Smart Micro Systems Towards Personalized Healthcare written by Yu Song and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-13 with Technology & Engineering categories.
Integrated Smart Micro-Systems Towards Personalized Healthcare Presents a thorough summary of recent advances in microelectronic systems and their applications for personalized healthcare Integrated Smart Micro-Systems Towards Personalized Healthcare provides up-to-date coverage of developments in smart microelectronics and their applications in health-related areas such as sports safety, remote diagnosis, and closed-loop health management. Using a comprehensive approach to the rapidly growing field, this one-stop resource examines different methods, designs, materials, and applications of systems such as multi-modal sensing biomedical platforms and non-invasive health monitoring sensors. The book’s five parts detail the core units of micro-systems, self-charging power units, self-driven monitor patches, self-powered sensing platforms, and integrated health monitoring systems. Succinct chapters address topics including multi-functional material optimization, multi-dimensional electrode preparation, multi-scene application display, and the use of multi-modal signal sensing to monitor physical and chemical indicators during exercise. Throughout the text, the authors offer key insights on device performance improvement, reliable fabrication processing, and compatible integration designs. Provides an overview self-powered, wearable micro-systems with emphasis on personalized healthcare Covers the working mechanisms and structural design of different energy-harvesting units, energy storage units, and functional units Introduces an integrated self-charging power unit consisting of triboelectric nanogenerators with supercapacitor Describes a general solution-evaporation method for developing porous CNT-PDMS conductive elastomers Examines a fully-integrated self-powered sweat sensing platform built on a wearable freestanding-mode triboelectric nanogenerator Integrated Smart Micro-Systems Towards Personalized Healthcare is an essential text for researchers, electronic engineers, entrepreneurs, and industry professionals working in material science, electronics, mechanical engineering, bioengineering, and sensor development.
The 4th International Workshop On Structural Control
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Author : Andrew Smyth
language : en
Publisher: DEStech Publications, Inc
Release Date : 2005
The 4th International Workshop On Structural Control written by Andrew Smyth and has been published by DEStech Publications, Inc this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Technology & Engineering categories.
Presents the research and applications on sensing technologies to monitor and control the structure and health of buildings, bridges, installations, and other constructed facilities.
Electrochemical Sensors
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Author : Giuseppe Maruccio
language : en
Publisher: Woodhead Publishing
Release Date : 2022-02-01
Electrochemical Sensors written by Giuseppe Maruccio and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-01 with Technology & Engineering categories.
Electrochemical Sensors: From Working Electrodes to Functionalization and Miniaturized Devices provides an overview of the materials, preparation and fabrication methods for biosensor applications. The book introduces the field of electrochemistry and its fundamentals, also providing a practical overview of working electrodes as key components for the implementation of sensors and assays. Features covered include the prompt transfer of electrons, favorable redox behavior, biocompatibility, and inertness in terms of electrode fouling. Special attention is dedicated to analyzing the various working materials systems for electrodes used in electrochemical cells such as gold, carbon, copper, platinum and metal oxides. This book is suitable for academics and practitioners working in the disciplines of materials science and engineering, analytical chemistry and biomedical engineering. Introduces key concepts for electrochemistry and biosensors Reviews the most common and emerging materials-based electrodes for sensor applications, including gold, carbon, platinum and metal oxides Discusses both macro and miniaturized electrodes, including their cleaning, engineering, fabrication, examples of working biosensors, and advantages and disadvantages
Smart Medical Data Sensing And Iot Systems Design In Healthcare
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Author : Chakraborty, Chinmay
language : en
Publisher: IGI Global
Release Date : 2019-09-20
Smart Medical Data Sensing And Iot Systems Design In Healthcare written by Chakraborty, Chinmay and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-20 with Medical categories.
Smart healthcare technology improves the diagnosis and treatment of patients, provides easy access to medical facilities and emergency care services, and minimizes the gaps between patients and healthcare providers. While clinical data protection remains a major challenge, innovations such as the internet of medical things and smart healthcare systems increase the efficiency and quality of patient care. Healthcare technology can only become faster, more profitable, and more flexible as additional research on its advancements is conducted and collected. Smart Medical Data Sensing and IoT Systems Design in Healthcare is an essential reference source that focuses on robust and easy solutions for the delivery of medical information from patients to doctors and explores low-cost, high-performance, highly efficient, deployable IoT system options in healthcare systems. Featuring research on topics such as hospital management systems, electronic health records, and bio-signals, this book is ideally designed for technologists, engineers, scientists, clinicians, biomedical engineers, hospital directors, doctors, nurses, healthcare practitioners, telemedical agents, students, and academicians seeking coverage on the latest technological developments in medical data analysis and connectivity.