Design Of Selective Ligands For Conjugate Drug Targeting To Human Serum Albumin Hsa Through Cysteine 34 And Beta D Galactopyranoside Inhibitors Towards Galectins
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Design Of Selective Ligands For Conjugate Drug Targeting To Human Serum Albumin Hsa Through Cysteine 34 And Beta D Galactopyranoside Inhibitors Towards Galectins
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Author : Subhash Rao Rauthu
language : en
Publisher:
Release Date : 2011
Design Of Selective Ligands For Conjugate Drug Targeting To Human Serum Albumin Hsa Through Cysteine 34 And Beta D Galactopyranoside Inhibitors Towards Galectins written by Subhash Rao Rauthu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Hyaluronan In Cancer Biology
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Author : Robert Stern
language : en
Publisher: Academic Press
Release Date : 2009-03-07
Hyaluronan In Cancer Biology written by Robert Stern and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-07 with Medical categories.
Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance
Metronomic Chemotherapy
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Author : Guido Bocci
language : en
Publisher: Springer
Release Date : 2014-09-04
Metronomic Chemotherapy written by Guido Bocci and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-04 with Medical categories.
This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.
Bioinformatics For Glycobiology And Glycomics
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Author : Claus-Wilhelm von der Lieth
language : en
Publisher: John Wiley & Sons
Release Date : 2009-10-01
Bioinformatics For Glycobiology And Glycomics written by Claus-Wilhelm von der Lieth and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-01 with Medical categories.
This book is the first to be dedicated to the bioinformatics of carbohydrates and glycoproteins. It provides an introduction to this emerging field of science both for the experimentalist working in glycobiology and glycomics, and also for the computer scientist looking for background information for the development of highly sophisticated algorithmic approaches. The book provides an overview of the state-of-the-art in the field, with reviews on databases, and the tools in use for analysis, interpretation, and prediction of the structures of complex carbohydrates, and demonstrates the value of bioinformatics for glycobiology. The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of experimental data relating to the structure of carbohydrates, will be a prerequisite for the success of the large-scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans. Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs. For a complete understanding of the molecular processes in which carbohydrates are involved, such as protein–carbohydrate interactions and the impact of glycosylation on protein function, knowledge of the 3D structure of the carbohydrate, the protein–carbohydrate complex, or the glycoprotein is often indispensable. This book provides a thorough introduction into methods used for conformational analysis of carbohydrates. Key features: Describes bioinformatic approaches to handle carbohydrate-active enzymes and glycosylation. Provides an overview on bioinformatics tools that facilitate analysis of carbohydrate structures. Gives introduction into molecular modelling of carbohydrate 3D structure and carbohydrates contained in the Protein Databank. Assumes only a basic knowledge of biology and bioinformatics.
Nanobiomedicine
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Author : Shailendra K. Saxena
language : en
Publisher: Springer Nature
Release Date : 2020-02-03
Nanobiomedicine written by Shailendra K. Saxena and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-03 with Medical categories.
This book provides a comprehensive overview of the recent trends in various Nanotechnology-based therapeutics and challenges associated with its development. Nanobiotechnology is an interdisciplinary research that has wide applications in the various fields of biomedical research. The book discusses the various facets of the application of Nanotechnology in drug delivery, clinical diagnostics, Nanomedicine and treatment of infectious and chronic diseases. The book also highlights the recent advancements on important devices and applications that are based on Nanotechnology in medicine and brief the regulatory and ethical issues related to nanomedical devices. It also reviews the toxicological profile of various nanomaterials and emphasizes the need for safe nanomaterials for clinical use. Finally, the book discusses the recent developments of potential commercial applications of Nanotechnology.
Pediatric Allergy Asthma And Immunology
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Author : Arnaldo Cantani
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-23
Pediatric Allergy Asthma And Immunology written by Arnaldo Cantani and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-23 with Medical categories.
Easy to understand and easy to use, this essential book reflects the rapid progress in one of the most intriguing fields of medicine. It offers state-of-the-art information on basic immunology, fetal-neonatal immunology, and many more fascinating areas.
Optimizing The Drug Like Properties Of Leads In Drug Discovery
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Author : Ronald Borchardt
language : en
Publisher: Springer
Release Date : 2006-09-25
Optimizing The Drug Like Properties Of Leads In Drug Discovery written by Ronald Borchardt and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-25 with Medical categories.
This book arises from a workshop organized by the American Association of Pharmaceutical Scientists entitled "Optimizing the Drug-Like Properties of Leads in Drug Discovery," which took place in Parsippany, NJ in September 2004. The workshop focused on the optimization of the drug-like properties of leads in drug discovery. The volume outlines strategies and methodologies designed to guide pharmaceutical and biotechnology companies through the drug discovery and development process.
Lipid Domains
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Author :
language : en
Publisher: Academic Press
Release Date : 2015-06-08
Lipid Domains written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-08 with Science categories.
Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains. Written by leading experts Contains original material, both textual and illustrative, that should become a very relevant reference material The material is presented in a very comprehensive manner Both researchers in the field and general readers should find relevant and up-to-date information
Pulmonary Manifestations Of Pediatric Diseases
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Author : Nelson L. Turcios
language : en
Publisher: Elsevier Health Sciences
Release Date : 2009
Pulmonary Manifestations Of Pediatric Diseases written by Nelson L. Turcios and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
A practical approach to treating the respiratory aspects of pediatric conditions.
The Biology And Pathology Of Innate Immunity Mechanisms
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Author : Yona Keisari
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-07-06
The Biology And Pathology Of Innate Immunity Mechanisms written by Yona Keisari and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-06 with Medical categories.
In recent years increased scientific attention has been given to immediate defense mechanisms based on non-clonal recognition of microbial components. These mechanisms constitute the innate immunity arm of the body s defense. Identification of pathogens by these mechanisms involves primarily receptors recognizing sugar moieties of various microorganisms. Innate immunity based mechanisms are essential for the existence of multicellular organisms. They are evolutionarily conserved and designed to provide immediate protection against microbial pathogens to eradicate infection. Activation of innate immunity is crucial for transition to specific immunity and for its orientation, and to assist the specific immune response in the recognition of pathogens and their destruction. Innate immunity is regularly involved in the arrest of bacterial, mycotic, viral and parasitic infections, giving the specific immune response time to become effective. It becomes critically essential in immunocompromised patients who fail to mount specific immune responses due to congenital or acquired immunodeficiencies as a result of chemotherapy, dialysis, immunosuppressive drugs, or HIV infection. The Innate Immunity arsenal constitutes polymorphonuclear and mononuclear phagocytes, mast cells, the complement system, Natural Killer cells, antimicrobial peptides, and presumably a subset of T lymphocytes with TCRl receptors.