Metronomic Chemotherapy
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Metronomic Chemotherapy
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Author : Guido Bocci
language : en
Publisher: Springer
Release Date : 2014-09-04
Metronomic Chemotherapy written by Guido Bocci and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-04 with Medical categories.
This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.
Novel Approaches In Metronomic Chemotherapy For Breast Cancer Treatment
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Author : Manzoor Ahmad Mir
language : en
Publisher: CRC Press
Release Date : 2024-05-28
Novel Approaches In Metronomic Chemotherapy For Breast Cancer Treatment written by Manzoor Ahmad Mir and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-28 with Medical categories.
This book provides the latest research and developments in the field of metronomic chemotherapy for breast cancer. It presents the principles and mechanisms of metronomic chemotherapy, preclinical and clinical studies, and the latest developments in drug delivery systems and nanoformulations. The clinical pharmacology of metronomic chemotherapy, including pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions, are also examined. Key Features: Introduces metronomics therapy in the neoadjuvant and adjuvant treatment of breast cancer Explores the potential of metronomics in terms of personalized chemotherapy Present pharmacological bases of metronomic chemotherapy Covers the latest developments in drug delivery systems, nanotechnology, and nanoformulations Discusses antiangiogenic effects and the impact of metronomics on immunity This book is useful for students, researchers, oncologists, pharmacologists, and healthcare experts interested in understanding the clinical potential of metronomic chemotherapy in breast cancer.
Clinical Applications Of Metronomic Chemotherapy
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Author : Guido Bocci
language : en
Publisher: Mdpi AG
Release Date : 2023-12-15
Clinical Applications Of Metronomic Chemotherapy written by Guido Bocci and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-15 with Medical categories.
Metronomic chemotherapy is now, finally, in clinical use. After 20 years of preclinical development and clinical trials, the emerging data will be of paramount importance in allowing us to assess the impact of metronomic chemotherapy on different tumor types. Indeed, it is likely that the next decade will see a major reassessment of the possible applications of metronomic chemotherapy, both alone and in combination with new therapeutic approaches such as immunotherapies, for the management of cancer. Moreover, the results of clinical trials will likely profoundly affect the direction of the laboratory efforts that are going on in parallel and aiming to improve the personalization of this therapeutic strategy. This Special Issue is our attempt to cover the past and present clinical results that have brought us to this pivotal moment and will form the basis of future clinical developments. Scientists and clinicians caring for cancer patients are well aware of the challenges in dealing with this particular therapeutic approach; one such challenge is obtaining improvements in patient survival without significant toxicity. This edition includes clinical research on chemotherapy and ongoing controversies related to metronomic chemotherapy.
Combination Trastuzumab Metronomic Low Dose Chemotherapy For The Treatment Of Erbb2 Overexpressing Breast Cancer Microform
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Author : Jeanne Michelle Du Manoir
language : en
Publisher: Library and Archives Canada = Bibliothèque et Archives Canada
Release Date : 2004
Combination Trastuzumab Metronomic Low Dose Chemotherapy For The Treatment Of Erbb2 Overexpressing Breast Cancer Microform written by Jeanne Michelle Du Manoir and has been published by Library and Archives Canada = Bibliothèque et Archives Canada this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
The purpose of these studies was to evaluate the preclinical anti-tumor and antiangiogenic effects of long-term metronomic chemotherapy in combination with trastuzumab relative to standard MTD regimens. Using an orthotopic mammary tumor model with an erbB2 overexpressing variant of MDA-MB-231, SCID mice treated with metronomic or MTD cyclophosphamide (CTX) in combination with trastuzumab showed long-term tumor growth delay compared to single agent therapy. The superior benefit of metronomic dosing was indicated by an absence of severe toxicity. Tumor perfusion and Matrigel assays indicated an additive antiangiogenic effect of metronomic CTX and trastuzumab. Acquired resistance observed after prolonged treatment with trastuzumab alone or combined with CTX was observed and led to studies of possible mechanisms of resistance. Of interest was the upregulation of VEGF and the detection of stable in vivo/in vitro acquired resistance to trastuzumab. Resistant tumors responded to subsequent treatment with bevacizumab, cetuximab, A12 and in some circumstances, pertuzumab.
Tumor Dormancy And Recurrence
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Author : Yuzhuo Wang
language : en
Publisher: Humana Press
Release Date : 2017-08-31
Tumor Dormancy And Recurrence written by Yuzhuo Wang and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-31 with Medical categories.
This volume will be the first to provide a comprehensive description of tumor dormancy. It will define the clinical and biological aspects of this phenomenon, as well as the cellular and molecular mechanisms associated with tumor dormancy. Chapters will be authored by world-renewed experts who are conducting cutting-edge research in the field. A unique feature will be a conclusive paragraph detailing future development and foreseeable clinical applications at the end of each chapter. The volume will serve as a fundamental instrument for every researcher and clinician interested in the field of tumor dormancy as well as a means of disseminating stimulating concepts and prompting the development of innovative technological solutions.
Rx For Hope
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Author : Nick Chen
language : en
Publisher: Rowman & Littlefield
Release Date : 2018-10-16
Rx For Hope written by Nick Chen and has been published by Rowman & Littlefield this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-16 with Health & Fitness categories.
In our current era of rapidly developing cancer drugs and therapies, we also see improvement of cancer treatment outcomes stagnating when it comes to determining quality of life or long-term survival. This is because while new treatments are making small incremental progress in outcomes, most cancer patients still depend on conventional methods that are both toxic and ineffective. While new cancer drugs are becoming more precise or targeted, less attention is being paid to the overall health and wellbeing of the patient, which we propose is essential for long-term cancer control and improving a patient’s quality of life. Rx for Hope, backed by rigorous science and real-life patient cases, calls for an urgent reevaluation of the current conventional approach to cancer treatments and encourages a progressive treatment model combining metronomic low-dose chemotherapy with complementary integrative medicine. Along with new, breakthrough immunotherapy drugs, these treatments can potentially create a response powerful enough to not only eradicate the presence of cancer but also to prevent it from returning. Because every 23 seconds someone in America is diagnosed with cancer, the number of people affected is growing rapidly. The American Cancer Society estimates that nearly two million new patients will need treatment in the coming year. Judging by current trends and methods of treatment, far too many of these people will be treated without the benefits of low-dose chemotherapy, and even less will enjoy the positive impact of immune-supportive complementary integrative medicine. Rx for Hope offers insight into a powerful way of treating cancer that patients and doctors can implement immediately for optimal results.
Antiangiogenic Agents In Cancer Therapy
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Author : Beverly A. Teicher
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-08
Antiangiogenic Agents In Cancer Therapy written by Beverly A. Teicher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-08 with Medical categories.
This volume represents a compendium of scientific findings and approaches to the study of angiogenesis in cancer. The second edition of Antiangiogenic Agents in Cancer Therapy is intended to give a current perspective on the state-of-the-art of angiogenensis and therapy directed at this process. Antiangiogenesis is a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge.
Sensitization Of Cancer Cells For Chemo Immuno Radio Therapy
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Author : Benjamin Bonavida
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-07-31
Sensitization Of Cancer Cells For Chemo Immuno Radio Therapy written by Benjamin Bonavida and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-31 with Medical categories.
This book reviews novel approaches developed to reverse tumor cell resistance to chemo/immuno/radio-therapy and the use of various sensitizing agents in combination with various cytotoxics. It also introduces several current approaches developed by established investigators that are aimed at overcoming resistance. This is the first volume to compile studies on tumor cell sensitization. It will prove useful for students, scientists, clinicians and pharmaceutical companies.
Angiogenesis Inhibition
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Author : Rüdiger Liersch
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-24
Angiogenesis Inhibition written by Rüdiger Liersch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-24 with Medical categories.
Angiogenesis is attracting increased scientific and clinical interest. The identification of novel mediators and targeting molecules has led to significant progress in our understanding of tumor angiogenesis and tumor vessel targeting. Important advances in cancer treatment have already emerged, and in the future, blood vessel targeting will play a significant role within individualized therapeutic strategies. This volume provides a general overview of the latest developments in angiogenesis inhibition in cancer. All aspects from the bench to the bedside are considered, with detailed attention both to basic research and to its translation into clinical practice. Individual chapters are devoted to the roles of angiopoietins, HIF-1a, chemokines, PDGF and VEGF, and vascular integrins. The latest results of clinical trials are presented, and various advanced targeting strategies are discussed. This book will be invaluable to all who wish to learn of the most recent advances in this exciting field.
Antiangiogenic Cancer Therapy
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Author : Darren W. Davis
language : en
Publisher: CRC Press
Release Date : 2007-07-25
Antiangiogenic Cancer Therapy written by Darren W. Davis and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-25 with Science categories.
Top Investigators Explore the Complexities of Angiogenesis Cancer Research The targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies. However, as of yet, no antiangiogenic agent used as a monotherapy has demonstrated a survival benefit in a randomized Phase III trial. The combination of bevacizumab, the first FDA approved angiogenesis inhibitor, with cytotoxic regimens has led to survival benefits in cancer patients. This has raised important questions about the complexities inherent in the clinical application of angiogenesis inhibitors. Compiles the results of four decades of progress Integrating fundamental concepts with therapeutic strategies, Anti-Angiogenic Cancer Therapy promotes the idea that an understanding of the molecular and cellular regulation of angiogenesis leads to optimal therapeutic strategies and positive clinical results. It brings together contributions from leading researchers to provide the most authoritative and encyclopedic volume available on this subject. Examines the role of angiogenesis in cancer, including strategies to prolong the nonangiogenic dormant state of human tumors, molecular mechanisms and cellular regulation of angiogenesis in solid tumors and hematologic malignancies, and the regulation of angiogenesis by the tumor microenvironment. Covers specific molecular targets for inhibiting angiogenesis in cancer therapy. Discusses clinical trial design and translational research approaches essential for identifying and developing effective angiogenesis inhibitors. Outlines current understanding of the molecular biology of each cancer type followed by discussions that examine strategies for targeting angiogenesis in specific cancers. This volume celebrates progress made in four decades, and more importantly, it provides a clear indication of the complex biology that needs further investigation to realize the possibilities envisioned for this beneficial therapeutic modality.