Design Synthesis And Bio Relevant Applications Of Zwitterionic Amphiphilic Macromolecular Assemblies
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Design Synthesis And Bio Relevant Applications Of Zwitterionic Amphiphilic Macromolecular Assemblies
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Author : Rajasekhar Reddy Rami Reddy
language : en
Publisher:
Release Date : 2015
Design Synthesis And Bio Relevant Applications Of Zwitterionic Amphiphilic Macromolecular Assemblies written by Rajasekhar Reddy Rami Reddy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Supramolecular nanoassemblies capable of reducing non-specific interactions with biological macromolecules, such as proteins, are of great importance for various biological applications especially for targeted drug delivery therapeutics. Recently, zwitterionic materials have been shown to reduce non-specific interactions with biomolecules, owing both to their charge neutrality and their ability to form strong hydration layer around zwitterions via electrostatic interactions. This dissertation focuses on design, synthesis, thorough characterization, and applications of zwitterionic amphiphilic dendrimers and polymeric materials. Firstly, A new triazole-based zwitterionic moiety was conceived and incorporated as the hydrophilic functionality in facially amphiphilic dendrons. Self-assembly characteristics and the structural and functional characteristics of the zwitterionic dendrons were then evaluated by spectroscopic techniques and by comparison with the corresponding charge-neutral PEG and anionic carboxylate-based dendrons respectively. Surface charge measurements, temperature sensitivity and evaluation of interactions of these assemblies with proteins form the bases for these comparisons. Because of the charge neutral characteristics of zwitterionic moieties exposed to outer aqueous phase, these dendritic assemblies evade non-specific interactions with biological milieu while enhancing the responsiveness towards specific biological triggers, such as proteins. We further simplified this molecular design by developing synthetically accessible zwitterionic carboxybetaine based amphiphilic polymers. Zwitterionic amphiphilic polymers are synthesized in a simple one-pot reaction by treating reactive acrylate polymer with secondary amine and 2-bromoaceticacid. This zwitterionic polymer possesses hydrophilic glycinebetaine and hydrophobic decyl chains placed orthogonally and forms environment dependent self-assembled aggregates owing to its amphiphilicity. The zwitterionic assemblies stably encapsulate guest molecules and undergo pH-dependent zeta potential and size variations owing to the pH sensitivity of zwitterionic component. In a related project, we've developed degradable polycarbonate based amphiphilic polymers possessing hydrophilic peg and hydrophobic decyl components. This degradable polymers form self-assembled aggregates encapsulate hydrophobic guest molecules, undergo degradation upon changes in pH or in presence of enzymes (PLE, an esterase). Work is underway towards the design and synthesis of zwitterionic amphiphilic degradable polymers and their characterization. Over all the work presented in this thesis have implications in design and development of polymeric excipients for targeted drug delivery, controlled release of drugs, and stimuli-sensitive therapeutics.
Macromolecular Self Assembly
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Author : Laurent Billon
language : en
Publisher: John Wiley & Sons
Release Date : 2016-09-06
Macromolecular Self Assembly written by Laurent Billon and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-06 with Technology & Engineering categories.
This book describes techniques of synthesis and self-assembly of macromolecules for developing new materials and improving functionality of existing ones. Because self-assembly emulates how nature creates complex systems, they likely have the best chance at succeeding in real-world biomedical applications. • Employs synthetic chemistry, physical chemistry, and materials science principles and techniques • Emphasizes self-assembly in solutions (particularly, aqueous solutions) and at solid-liquid interfaces • Describes polymer assembly driven by multitude interactions, including solvophobic, electrostatic, and obligatory co-assembly • Illustrates assembly of bio-hybrid macromolecules and applications in biomedical engineering
Design Synthesis And Utility Of Fuctionalized Nanoscale Amphiphilic Macromolecules For Biomedical Applications
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Author : Sarah Marie Sparks
language : en
Publisher:
Release Date : 2011
Design Synthesis And Utility Of Fuctionalized Nanoscale Amphiphilic Macromolecules For Biomedical Applications written by Sarah Marie Sparks and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Biomedical materials categories.
Polymeric micelles are spherical assemblies of amphiphilic polymers widely studied for many biomedical applications. Nanoscale amphiphilic macromolecules (AMs) are novel amphiphilic polymers composed of an alkylated sugar backbone covalently linked to poly(ethylene glycol) (PEG). In aqueous solution, AMs self-assemble to form 10-20 nm micelles with critical micelle concentrations as low as 100 nM, making them more stable than other common micelles. In addition, the basic structure of AMs has multiple points of modification such that the polymer can be modified and evaluated for virtually any application. This work highlights the promise of functionalized AMs as a novel, versatile biomaterial. Carboxy-terminated AMs were previously shown to inhibit highly oxidized low- density lipoprotein (hoxLDL) uptake in macrophage cells. To gain a mechanistic understanding of this inhibition, a series of AMs were designed and synthesized by modifying the basic polymer structure to evaluate several characteristics including: amphiphilicity, PEG chain length, anionic charge location, type of anionic charge, number of anionic charges, rotational motion of the anionic group, and PEG architecture. The optimal AM for inhibiting hoxLDL uptake was determined to be one with a rigid, rotationally-restricted carboxylic acid within the hydrophobic portion of the polymer. Building upon previous work that showed AMs deliver cargo intracellulary, a series of cationic polymers were designed and synthesized for nucleic acid delivery. The cationic moiety was added within the hydrophobic component of the AMs such that when the cationic portion complexed with anionic nucleic acids, the nucleic acids would be localized in the micellar interior. Three cationic AMs were evaluated with varying surface charges. The polymer with the highest surface charge was the most effective at complexing with and delivering small interfering RNA to U87 glioma cells. Finally, without modification, AMs are capable of water-solubilizing hydrophobic drugs. This property can be applied to hydrophobic fluorescent nanocrystals, which are useful for biological imaging. In the last chapter, AMs were utilized to water-solubilize white light-emitting nanocrystals without altering the emission properties of the nanocrystals. By modifying the polymer structure to incorporate functionalities that can coordinate to the surface of the nanocrystals, smaller, water-soluble assemblies that maintain white light-emission were obtained.
Single Chain Polymer Nanoparticles
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Author : José A. Pomposo
language : en
Publisher: John Wiley & Sons
Release Date : 2017-08-18
Single Chain Polymer Nanoparticles written by José A. Pomposo and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-18 with Technology & Engineering categories.
This first book on this important and emerging topic presents an overview of the very latest results obtained in single-chain polymer nanoparticles obtained by folding synthetic single polymer chains, painting a complete picture from synthesis via characterization to everyday applications. The initial chapters describe the synthetics methods as well as the molecular simulation of these nanoparticles, while subsequent chapters discuss the analytical techniques that are applied to characterize them, including size and structural characterization as well as scattering techniques. The final chapters are then devoted to the practical applications in nanomedicine, sensing, catalysis and several other uses, concluding with a look at the future for such nanoparticles. Essential reading for polymer and materials scientists, materials engineers, biochemists as well as environmental chemists.
Polyfluorenes
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Author : Ullrich Scherf
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-07-29
Polyfluorenes written by Ullrich Scherf and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-29 with Technology & Engineering categories.
With this collection of short review papers we would like to present a broad overview of research on poly?uorenes and related heteroanalogues over the last two decades. The collection begins with papers on the synthesis of po- ?uorenesandrelatedpolyheteroarenes, thenreportsphotophysicalproperties of this class of conjugated polymers both at the ensemble and the single chain level, continues with a discussion of the rich solid state structures of poly?uorenes, and ?nally switches to device applications (e.g. in OLEDs). In addition, two chapters are devoted to de?ned oligo?uorenesas lowmolecular weight model systems forpoly?uorenes and also to degradation studies. We feel that this up-to-date collection will be very helpful to all polymer chemists and physicists, and will also aid graduate students interested in this fascinating and still growing area of research, since such a compact overview is only now available. All articles are presented by leading scientists in their ?elds, insuring state-of-the-art coverage of all relevant aspects. Together with the body of references this volume is meant to assist researchers in the daily lab routine. Moreover, Advances in Polymer Science, as an established series of high quality review papers, represents a very appropriate platform for our project.Wehopethatthisshortcollectionwillbeofgreatvaluebothforbeg- ners and established researchscientists inthe?eldofpoly?uorene research.
Polymer Capsules
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Author : Ye Liu
language : en
Publisher: CRC Press
Release Date : 2019-05-10
Polymer Capsules written by Ye Liu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-10 with Science categories.
Polymers are one of the most versatile and important materials used for capsule preparation despite various others available. Suitably formulated capsules can securely protect ingredients, deliver them to targeted sites, and release them expeditiously, improving functions and minimizing adverse effects. New polymers are constantly being explored to develop more efficient capsules as they are routinely used in pharmaceuticals, consumer healthcare products, nutrients, and food. This book focuses on the current state of the art of polymer-based capsules and delivery systems. It describes the formulation processes of capsules developed from redox-responsive polymers and polymer-functionalized carbon nanotubes, in addition to shedding light on coacervation of polymers for encapsulation. It reviews different active ingredients that can be used with polymer capsules in various products, encapsulation of essential oils using such capsules, and development of polymer capsules of cells and bacteriophages.
Biomimetic And Bioinspired Membranes For New Frontiers In Sustainable Water Treatment Technology
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Author : Amira Abdelrasoul
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-12-06
Biomimetic And Bioinspired Membranes For New Frontiers In Sustainable Water Treatment Technology written by Amira Abdelrasoul and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-06 with Science categories.
Biomimetic and bioinspired membranes are the most promising type of membrane for multiple usage scenarios, including commercial separation applications as well as water and wastewater treatment technologies. In recent years, aquaporin biomimetic membranes (ABMs) for water purification have raised considerable interest. These membranes display uniquely favorable properties and outstanding performances, such as diverse interactions, varied selective transport mechanisms, superior stability, high resistance to membrane fouling, and distinct adaptability. Biomimetic membranes would make a significant contribution to alleviate water stress, environmental threats, and energy consumption.
Cationic Polymers In Regenerative Medicine
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Author : Sangram Keshari Samal
language : en
Publisher: Royal Society of Chemistry
Release Date : 2014-11-14
Cationic Polymers In Regenerative Medicine written by Sangram Keshari Samal and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-14 with Technology & Engineering categories.
The unique physico-chemical properties of cationic polymers and their ability to be easily modified make them attractive for many biological applications. As a result there is a vast amount of research focussed on designing novel natural or synthetic cationic polymers with specific biological functionality. Cationic Polymers in Regenerative Medicine brings together the expertise of leading experts in the field to provide a comprehensive overview of the recent advances in cationic polymer synthesis, modification and the design of biomaterials with different structures for therapeutic applications. Chapters cover recent developments in novel cationic polymer based systems including poly(L-lysine), Poly(N,N-dimethylaminoethyl methacrylate) and cationic triazine dendrimers as well as cationic polymer-coated micro- and nanoparticles and cationic cellulose and chitin nanocrystals. Applications discussed in the book include drug and gene delivery, therapeutics in thrombosis and inflammation as well as gene therapy. Suitable both for an educational perspective for those new to the field and those already active in the field, the book appeals to postgraduates and researchers. The broad aspects of the topics covered are suitable for polymer chemists interested in the fundamentals of the materials systems as well as pharmaceutical chemists, bioengineering and medical professionals interested in their applications.
Handbook Of Raft Polymerization
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Author : Christopher Barner-Kowollik
language : en
Publisher: John Wiley & Sons
Release Date : 2008-09-08
Handbook Of Raft Polymerization written by Christopher Barner-Kowollik and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-08 with Technology & Engineering categories.
Spanning the entire field from fundamentals to applications in material science, this one-stop source is the first comprehensive reference for polymer, physical and surface chemists, materials scientists, chemical engineers, and those chemists working in industry. From the contents: * Introduction: Living Free Radical Polymerization and the RAFT Process * Fundamental Structure-Reactivity Correlations Governing the RAFT Process * Mechanism and Kinetics * The RAFT Process as a Kinetic Tool * Theory and Practice in Technical Applications * RAFT Polymerization in Bulk and Organic Solvents, as well as Homogeneous Aqueous Systems * Emulsion and Mini-Emulsion Polymerization * Complex Architecture Design * Macromolecular Design via the Interchange of Xanthates * Surface Modification * Stability and Physical Properties of RAFT Polymers * Novel Materials: From Drug Delivery to Opto-Electronics * Outlook and Future Developments
Peptide Based Materials
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Author : Timothy Deming
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-13
Peptide Based Materials written by Timothy Deming and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-13 with Technology & Engineering categories.
Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides, by Jianjun Cheng and Timothy J. Deming.- Peptide Synthesis and Self-Assembly, by S. Maude, L. R. Tai, R. P. W. Davies, B. Liu, S. A. Harris, P. J. Kocienski and A. Aggeli.- Elastomeric Polypeptides, by Mark B. van Eldijk, Christopher L. McGann, Kristi L. Kiick andJan C. M. van Hest.- Self-Assembled Polypeptide and Polypeptide Hybrid Vesicles: From Synthesis to Application, by Uh-Joo Choe, Victor Z. Sun, James-Kevin Y. Tan and Daniel T. Kamei.- Peptide-Based and Polypeptide-Based Hydrogels for Drug Delivery and Tissue Engineering, by Aysegul Altunbas and Darrin J. Pochan.-