Development And Applications In Solubility
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Development And Applications In Solubility
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Author : Trevor M. Letcher
language : en
Publisher: Royal Society of Chemistry
Release Date : 2007
Development And Applications In Solubility written by Trevor M. Letcher and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Science categories.
Solubility is fundamental to most areas of chemistry and is one of the most basic of thermodynamic properties. It underlies most industrial processes. Bringing together the latest developments and ideas, Developments and Applications in Solubility covers many varied and disparate topics. The book is a collection of work from leading experts in their fields and covers the theory of solubility, modelling and simulation, industrial applications and new data and recent developments relating to solubility. Of particular interest are sections on: experimental, calculated and predicted solubilities; solubility phenomena in 'green' quaternary mixtures involving ionic liquids; molecular simulation approaches to solubility; solubility impurities in cryogenic liquids and carbon dioxide in chemical processes. The book is a definitive and comprehensive reference to what is new in solubility and is ideal for researcher scientists, industrialists and academics
Advances In The Development And Application Of Deep Eutectic Solvents
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Author : Maria Luisa Di Gioia
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-09
Advances In The Development And Application Of Deep Eutectic Solvents written by Maria Luisa Di Gioia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-09 with Science categories.
The continuous effort to perform a more sustainable chemistry has led to the development of new materials that accomplish the principles of green chemistry. In this context, deep eutectic solvents (DESs) have arisen as a new generation of solvents that respond well to most of the characteristics that an ideal green solvent must possess: they are easy and cheap to prepare, stable, easy to handle (they show chemical stability, non-flammability and conductivity), separable from the reaction products, biodegradable and safe for both humans and the environment. At the same time, they show chemical-physical properties similar to ionic liquids, such as low volatility, conductivity and high solvent power. These characteristics mean that DESs are today classified as 2-st century solvents. DESs have been raising a lot of attention and a sharp increase of their applications in numerous sectors of chemistry: they are mainly used as alternative solvents and/or catalysts for various organic transformations including metal-catalyzed reactions, biotransformations, polymerization, in sample preparation and analytical techniques as well as in the design of pharmaceutical formulations and drug delivery systems.
Applications Of Computational Tools In Drug Design And Development
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Author : S.N. Koteswara Rao G.
language : en
Publisher: Springer Nature
Release Date : 2025-05-20
Applications Of Computational Tools In Drug Design And Development written by S.N. Koteswara Rao G. and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-20 with Medical categories.
This book provides a comprehensive overview of the role of computers and computational tools at different stages of drug discovery and development. Designed to meet the needs of a beginner to advanced learner, the book provides the information on the tools, how they work, with the latest reports on applications in drug design, drug delivery and building network pharmacology models. Part I explores the pharmacological aspects, covering computational simulation of drug delivery at the molecular level, modeling for formulation design, and the revolutionary use of computational fluid dynamics in pharmaceutical processes. Specific applications such as pharmaceutical die filling processes, inhalation aerosol-based targeted drug delivery, and the development of inhalation compounds using in silico modeling tools are discussed. The use of computational tools in cheminformatics and their application in preformulation perspectives for drug delivery are also included. Part II expands the scope to include solubility prediction, absorption prediction, protein binding prediction, bio-permeability prediction, toxicity prediction, and metabolism prediction. It covers the identification of potential sites of metabolism in lead molecules and computer-assisted simulation studies to understand drug-polymer interactions. Recent advances in drug likeness screening using software and online tools are also reviewed. Part III focuses on specific therapeutic areas. The chapters examine the mechanistic understanding of anti-Alzheimer's agents, the design of novel antidiabetic agents, and the exploration of drug design for atherosclerosis. It also covers modern computational intelligence-based drug repurposing for cancer therapeutics, computational analyses of the mechanism of action of antiepileptic agents, and rational approaches for designing antihypertensive agents. The final chapters explore drug discovery and computational strategies in the context of multi-drug-resistant tuberculosis and the network pharmacology approach to uncover the pharmacological mechanisms of natural products. The book will be a useful reference for researchers, students and professionals in the field of life sciences, chemistry, pharmaceutics and bioinformatics.
Multifaceted Development And Application Of Biopolymers For Biology Biomedicine And Nanotechnology
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Author : P.K. Dutta
language : en
Publisher: Springer
Release Date : 2013-09-18
Multifaceted Development And Application Of Biopolymers For Biology Biomedicine And Nanotechnology written by P.K. Dutta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-18 with Technology & Engineering categories.
Nanoparticles for Gene Delivery into Stem Cells and Embryos, by Pallavi Pushp, Rajdeep Kaur, Hoon Taek Lee, Mukesh Kumar Gupta. Engineering of Polysaccharides via Nanotechnology, by Joydeep Dutta. Hydroxyapatite-Packed Chitosan-PMMA Nanocomposite: A Promising Material for Construction of Synthetic Bone, by Arundhati Bhowmick, Subhash Banerjee, Ratnesh Kumar, Patit Paban Kundu. Biodegradable Polymers for Potential Delivery Systems for Therapeutics, by Sanjeev K. Pandey, Chandana Haldar, Dinesh K. Patel, Pralay Maiti. Phytomedicine-Loaded Polymeric Nanomedicines: Potential Cancer Therapeutics, by S. Maya, M. Sabitha, Shantikumar V. Nair, R. Jayakumar. Proteins and Carbohydrates as Polymeric Nanodrug Delivery Systems: Formulation, Properties and Toxicological Evaluation, by Dhanya Narayanan, J. Gopikrishna, Shantikumar V. Nair, Deepthy Menon. Biopolymeric Micro and Nanoparticles: Preparation, Characterization and Industrial Applications, by Anil Kumar Anal, Alisha Tuladhar. Applications of Glyconanoparticles as “Sweet” Glycobiological Therapeutics and Diagnostics, by Naresh Kottari, Yoann M. Chabre, Rishi Sharma, René Roy.
Chemical Engineering In The Pharmaceutical Industry
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Author : Mary T. am Ende
language : en
Publisher: John Wiley & Sons
Release Date : 2019-04-08
Chemical Engineering In The Pharmaceutical Industry written by Mary T. am Ende and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-08 with Technology & Engineering categories.
A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.
Recent Developments In The Synthesis And Applications Of Pyridines
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Author : Parvesh Singh
language : en
Publisher: Elsevier
Release Date : 2022-09-17
Recent Developments In The Synthesis And Applications Of Pyridines written by Parvesh Singh and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-17 with Science categories.
Recent Developments in the Synthesis and Applications of Pyridines is a comprehensive handbook for organic chemists working on innovative approaches to the synthesis of pyridines. Written by scientists in both academia and industry and designed to be a standalone reference, the book features reviews, research results and case studies on synthetic methods and applications of pyridine-based chemotypes. The book will bridge the gap between industry and academia by presenting recent innovative approaches to the synthesis of pyridines, diverse application of pyridines in drug development, heterogeneous catalysis and material science, as well as benchtop to shelf narratives of pyridine-based compounds in the industry. The role of computational chemistry in the development of pyridine-based bioactive molecules is also included. This reference is essential for researchers in organic chemistry both in academic and industrial settings, postgraduates in chemistry and medicinal chemistry. - Includes a detailed review of recent research on the reactivity, synthesis and applications of pyridines - Features concise accounts of the reactivity, synthetic and optimized protocols - Discusses the medicinal, inorganic and polymer chemistry applications of pyridines
Solubility In Pharmaceutical Chemistry
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Author : Christoph Saal
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2020-01-20
Solubility In Pharmaceutical Chemistry written by Christoph Saal and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-20 with Medical categories.
This book describes the physicochemical fundamentals and biomedical principles of drug solubility. Methods to study and predict solubility in silico and in vitro are described and the role of solubility in a medicinal chemistry and pharmaceutical industry context are discussed. Approaches to modify and control solubility of a drug during the manufacturing process and of the pharmaceutical product are essential practical aspects of this book.
Applications Of Pharmacokinetic Principles In Drug Development
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Author : Rajesh Krishna
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Applications Of Pharmacokinetic Principles In Drug Development written by Rajesh Krishna and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume is an important advancement in the application ofpharmacokinetic (PK) and pharmacodynamic (PO) principles to . drug development. The series of topics presented deal with the application of these tools to everyday decisions that a pharmaceutical scientist encounters. The ability to integrate these topics using PK and PO methods has optimized drug development pathways in the clinic. New technologies in the areas of in vitro assays that are more predictive of human absorption and metabolism and advancement in bioanalytical assays are leading the way to minimize drug failures in later, more expensive clinical development programs. of Pharmacokinetics and pharmacodynamics have become an important component understanding the drug action on the body and is becoming increasingly important in drug labeling due to it's potential for predicting drug behavior in populations that may be difficult to study in adequate numbers during drug development. The ability to correlate drug exposure to effect and model it during the drug development value chain provides valuable insight into optimizing the next steps to derive maximum information from each study. These principles and modeling techniques have resulted in an expanded and integrated view of PK and PO and have led to the expectations that we may be able to optimally design clinical trials and eventually lead us to identifying the optimal therapy for the patient, while minimizing cost and speeding up drug development. There is wide utility for the book both as a text and as a reference.
Hansen Solubility Parameters
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Author : Charles M. Hansen
language : en
Publisher: CRC Press
Release Date : 2002-01-01
Hansen Solubility Parameters written by Charles M. Hansen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-01-01 with Science categories.
Charles Hansen began his work with solvents in 1962, and almost immediately began producing new and groundbreaking results. Since then, his Hansen Solubility Parameters have been extensively used and proven valuable to a variety of industries, including coatings, adhesives, plastics, protective clothing, and environmental protection. They allow correlations and systematic comparisons previously not possible, such as polymer solubility, swelling and permeation, surface wetting and dewetting, the solubility of organic salts, and many biological applications. Until now, however, their seemingly universal ability to predict molecular affinities has been generally taken as semiempirical. Moving beyond the Hildebrand and Flory theories, Hansen found that his approach not only quantitatively describes hydrogen bonding and polar bonding in many types of systems, but in fact agrees with and extends the very general Prigogine theory. This explains why the correlations all seem to fit with an apparently "universal" 4: it results from the validity of applying the geometric mean rule to describe dispersion, permanent dipole-permanent dipole, and hydrogen bonding interaction in mixtures of unlike molecules. Hansen Solubility Parameters provides new tables of previously unpublished correlations and parameters. The author illuminates his text with practical examples related to coatings, biological systems, pigments, and fibers, and takes a general approach that makes this reference ideal for predicting compatibility, adsorption on surfaces, orientation toward materials of similar affinities (self-assembly), and other phenomena associated with solubility and affinity. Chemists, chemical engineers, and biochemists will find this book-the collected work and experience of the father of its concept-intriguing for its theory and invaluable for its data.
Proceedings Of The International Field Exploration And Development Conference 2023
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Author : Jia'en Lin
language : en
Publisher: Springer Nature
Release Date : 2024-03-12
Proceedings Of The International Field Exploration And Development Conference 2023 written by Jia'en Lin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-12 with Science categories.
This book focuses on reservoir surveillance and management, reservoir evaluation and dynamic description, reservoir production stimulation and EOR, ultra-tight reservoir, unconventional oil and gas resources technology, oil and gas well production testing, and geomechanics. This book is a compilation of selected papers from the 13th International Field Exploration and Development Conference (IFEDC 2023). The conference not only provides a platform to exchanges experience, but also promotes the development of scientific research in oil and gas exploration and production. The main audience for the work includes reservoir engineer, geological engineer, enterprise managers, senior engineers as well as students.