Development And Applications Of Vaccines And Gene Therapy In Aids
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Development And Applications Of Vaccines And Gene Therapy In Aids
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Author : Gaetano Giraldo
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1996-01-01
Development And Applications Of Vaccines And Gene Therapy In Aids written by Gaetano Giraldo and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-01 with Medical categories.
This publication is an overview of the exciting discoveries in the field of AIDS which were discussed at the workshop 'Development and Applications of Vaccines and Gene Therapy in AIDS' (Naples, June 1995). Various articles present the latest advances in the development of vaccines, focusing on the analysis of immunogenetic epitopes and models of expression and/or administration. Some contributions describe the results of recent vaccine trials with animal models while others concentrate on human clinical trials. Furthermore, articles on new approaches in the field of gene therapy are included. The data compiled in this outstanding volume is essential not only for biomedical scientists but also for all researchers interested in the latest developments in the field of HIV/AIDS.
Developments And Applications Of Vaccines And Gene Therapy In Aids International Workshop Naples June 15 16 1995
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Author : G. Giraldo
language : en
Publisher:
Release Date : 1996
Developments And Applications Of Vaccines And Gene Therapy In Aids International Workshop Naples June 15 16 1995 written by G. Giraldo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Gene Therapy For Hiv
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Author : Gerhard Bauer
language : en
Publisher: Springer
Release Date : 2014-02-08
Gene Therapy For Hiv written by Gerhard Bauer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-08 with Medical categories.
This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV. Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, HIV-resistant hematopoietic stem cells for the first patients that received stem cell gene therapy for HIV, including the first child in the world and the first fully marrow-ablated HIV infected patient. Joseph Anderson developed the most recent and most potent combination anti-HIV lentiviral vectors and pluripotent stem cell applications for HIV gene therapy and tested these in the appropriate in vitro and vivo models, paving the way for novel HIV gene therapy approaches to possibly cure patients. In Gene Therapy for HIV, Bauer and Anderson discuss the unique aspects of this therapy, including its limitations and proper safety precautions and outline a path for a possible functional cure for HIV using stem cell gene therapy based on a cure already achieved with a bone marrow stem cell transplantation performed in Germany using donor stem cells with a naturally arising CCR5 mutation. In addition, the Brief provides a thorough and methodical explanation of the basics of gene therapy, gene therapy vector development, in vitro and in vivo models for HIV gene therapy and clinical applications of HIV gene therapy, including Good Manufacturing Practices.
Gene Therapy For Hiv And Chronic Infections
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Author : Ben Berkhout
language : en
Publisher: Springer
Release Date : 2015-03-10
Gene Therapy For Hiv And Chronic Infections written by Ben Berkhout and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-10 with Medical categories.
This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). Ample anti-HIV drugs are currently available in the clinic and the development of an effective combination therapy has dramatically improved the lifespan and quality of life of infected individuals. A similar trend can already be recognized for HBV and HCV: the development of multiple (directly acting) antiviral drugs and plans to control or even cure the infection. However, approaches that help prevent infection, or which provide long-lasting treatment (such as a cure) remain important goals. Immunization through gene transfer vehicles encoding immunogenic viral proteins shows promise in preventing infections with complex, highly variable, viruses such as HIV-1 or HCV. Gene therapy applications for virus infections have been discussed since the early 1990’s. Whereas a true cure seems difficult to achieve for HIV-1 due to its intrinsic property to deposit its genome into that of the host, such attempts may be within reach for HCV where spontaneous viral clearance occurs in a small percentage of the infected individuals. The prospect of original gene therapy approaches may provide alternative ways to reach the same endpoint by, for example, silencing of CCR5 expression post-transcriptionally. Many alternative antiviral strategies have been developed based on a variety of novel molecular methods: e.g. ribozymes. Some studies have progressed towards pre-clinical animal models and a few antiviral gene therapies have progressed towards clinical trials. This book provides an overview of this rapidly progressing field, while focusing on the interface of gene therapy and immunology/vaccinology.
Gene Therapy For Hiv Infection
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Author : Clay Smith
language : en
Publisher: Springer
Release Date : 2013-01-06
Gene Therapy For Hiv Infection written by Clay Smith and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-06 with Medical categories.
ince the early 1980s, the HIV epidemic has been raging within the S 1 United States and around the world. Drug therapy for HIV infection has not been curative, prompting the search for alternative strategies to control HIV infection within infected persons. One potential alterna tive to drug therapy is a developing medical technology termed gene therapy. 2 Gene therapy involves introducing genetic elements into popu lations of cells in order to correct or prevent a pathologic process. A large number of gene therapy strategies have been developed in an at tempt to inhibit HIV expression and spread. These strategies fall into two general categories, genetic modification of cells in order to elicit an immune response against HIV and genetic modification of the target cells of HIV infection in order to block HIV expression and reproduction. In the first strategy, termed genetic immunotherapy by some, genetic material encoding HIV proteins is introduced into patient's cells in order to stimulate a cellular immune response above and beyond 3 5 that stimulated by the viral infection itself. - Two general genetic im munotherapy strategies have been developed. Genes encoding HIV pro teins have been directly injected into the dermis or muscle tissue of patients. These genes have been encoded in plasmids or viral DNA and have been injected either in the form of naked DNA or complexed with lipids.
Novel Technologies For Vaccine Development
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Author : Igor S Lukashevich
language : en
Publisher: Springer
Release Date : 2014-11-13
Novel Technologies For Vaccine Development written by Igor S Lukashevich and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-13 with Medical categories.
This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.
Pharmaceutical Biotechnology
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Author : Daan J. A. Crommelin
language : en
Publisher: CRC Press
Release Date : 2002-11-14
Pharmaceutical Biotechnology written by Daan J. A. Crommelin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-11-14 with Medical categories.
The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.
Immunopharmacology
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Author : Manzoor M. Khan
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-19
Immunopharmacology written by Manzoor M. Khan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-19 with Medical categories.
During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
Cancer Gene Therapy
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Author : David T. Curiel
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-03
Cancer Gene Therapy written by David T. Curiel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-03 with Medical categories.
A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.
Opportunities In Biotechnology For Future Army Applications
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2001-07-11
Opportunities In Biotechnology For Future Army Applications written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-11 with Science categories.
This report surveys opportunities for future Army applications in biotechnology, including sensors, electronics and computers, materials, logistics, and medical therapeutics, by matching commercial trends and developments with enduring Army requirements. Several biotechnology areas are identified as important for the Army to exploit, either by direct funding of research or by indirect influence of commercial sources, to achieve significant gains in combat effectiveness before 2025.