Gene Therapy For Hiv Infection
DOWNLOAD
AUDIOBOOK
Download Gene Therapy For Hiv Infection PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Gene Therapy For Hiv Infection book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Gene Therapy For Hiv Infection
DOWNLOAD
AUDIOBOOK
Author : Clay Smith
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Gene Therapy For Hiv Infection written by Clay Smith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
ince the early 1980s, the HIV epidemic has been raging within the S 1 United States and around the world. Drug therapy for HIV infection has not been curative, prompting the search for alternative strategies to control HIV infection within infected persons. One potential alterna tive to drug therapy is a developing medical technology termed gene therapy. 2 Gene therapy involves introducing genetic elements into popu lations of cells in order to correct or prevent a pathologic process. A large number of gene therapy strategies have been developed in an at tempt to inhibit HIV expression and spread. These strategies fall into two general categories, genetic modification of cells in order to elicit an immune response against HIV and genetic modification of the target cells of HIV infection in order to block HIV expression and reproduction. In the first strategy, termed genetic immunotherapy by some, genetic material encoding HIV proteins is introduced into patient's cells in order to stimulate a cellular immune response above and beyond 3 5 that stimulated by the viral infection itself. - Two general genetic im munotherapy strategies have been developed. Genes encoding HIV pro teins have been directly injected into the dermis or muscle tissue of patients. These genes have been encoded in plasmids or viral DNA and have been injected either in the form of naked DNA or complexed with lipids.
Gene Therapy For Hiv
DOWNLOAD
AUDIOBOOK
Author : Gerhard Bauer
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-02-07
Gene Therapy For Hiv written by Gerhard Bauer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-07 with Medical categories.
This Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV. Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, HIV-resistant hematopoietic stem cells for the first patients that received stem cell gene therapy for HIV, including the first child in the world and the first fully marrow-ablated HIV infected patient. Joseph Anderson developed the most recent and most potent combination anti-HIV lentiviral vectors and pluripotent stem cell applications for HIV gene therapy and tested these in the appropriate in vitro and vivo models, paving the way for novel HIV gene therapy approaches to possibly cure patients. In Gene Therapy for HIV, Bauer and Anderson discuss the unique aspects of this therapy, including its limitations and proper safety precautions and outline a path for a possible functional cure for HIV using stem cell gene therapy based on a cure already achieved with a bone marrow stem cell transplantation performed in Germany using donor stem cells with a naturally arising CCR5 mutation. In addition, the Brief provides a thorough and methodical explanation of the basics of gene therapy, gene therapy vector development, in vitro and in vivo models for HIV gene therapy and clinical applications of HIV gene therapy, including Good Manufacturing Practices.
Gene Therapy For Hiv Infection
DOWNLOAD
AUDIOBOOK
Author : Clay Smith
language : en
Publisher: Springer
Release Date : 2014-01-15
Gene Therapy For Hiv Infection written by Clay Smith and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-01-15 with categories.
This book focuses primarily on the development of effective gene therapy approaches for HIV infection, including the improvement of gene transfer vectors, procedures for the ex-vivo manipulation and transduction of T-lymphocytes and hematopoietic stem cells, and preclinical testing of HIV inhibition strategies. It provides a balanced perspective of the many accomplishments in this field as well as the problems which need to be solved in order to develop safe and effective therapies which benefit persons with HIV infection.
Gene Therapy For Hiv And Chronic Infections
DOWNLOAD
AUDIOBOOK
Author : Ben Berkhout
language : en
Publisher: Springer
Release Date : 2015-03-10
Gene Therapy For Hiv And Chronic Infections written by Ben Berkhout and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-10 with Medical categories.
This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). Ample anti-HIV drugs are currently available in the clinic and the development of an effective combination therapy has dramatically improved the lifespan and quality of life of infected individuals. A similar trend can already be recognized for HBV and HCV: the development of multiple (directly acting) antiviral drugs and plans to control or even cure the infection. However, approaches that help prevent infection, or which provide long-lasting treatment (such as a cure) remain important goals. Immunization through gene transfer vehicles encoding immunogenic viral proteins shows promise in preventing infections with complex, highly variable, viruses such as HIV-1 or HCV. Gene therapy applications for virus infections have been discussed since the early 1990’s. Whereas a true cure seems difficult to achieve for HIV-1 due to its intrinsic property to deposit its genome into that of the host, such attempts may be within reach for HCV where spontaneous viral clearance occurs in a small percentage of the infected individuals. The prospect of original gene therapy approaches may provide alternative ways to reach the same endpoint by, for example, silencing of CCR5 expression post-transcriptionally. Many alternative antiviral strategies have been developed based on a variety of novel molecular methods: e.g. ribozymes. Some studies have progressed towards pre-clinical animal models and a few antiviral gene therapies have progressed towards clinical trials. This book provides an overview of this rapidly progressing field, while focusing on the interface of gene therapy and immunology/vaccinology.
Immunotreatment And Gene Therapy Of Hiv Infection
DOWNLOAD
AUDIOBOOK
Author : Ulrich R Hengge
language : en
Publisher:
Release Date :
Immunotreatment And Gene Therapy Of Hiv Infection written by Ulrich R Hengge and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Immunotreatment And Gene Therapy Of Hiv Infection
DOWNLOAD
AUDIOBOOK
Author : Ulrich R. Hengge
language : en
Publisher:
Release Date : 2004
Immunotreatment And Gene Therapy Of Hiv Infection written by Ulrich R. Hengge and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Tremendous progress in the understanding of the immune pathogenesis of HIV disease has been made in the last two decades like in no other field of science ever before. Besides the inhibition of viral replication with highly active antiretroviral therapy (HAART) immunoreconstitution remains an important mainstay to be achieved in the battle against HIV. Intensive research has led to worldwide phase-III studies of immunotreatment of HIV infection such as the SILCAAT and ESPRIT trials to boost existing immune responses and to restore the immune system leading to the control of viral replication. The science and practical management of immunotherapy of HIV patients is described by famous experts from immunology, virology, gene therapy, dermatology, and clinical medicine.
Recent Translational Research In Hiv Aids
DOWNLOAD
AUDIOBOOK
Author : Yi-Wei Tang
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-11-02
Recent Translational Research In Hiv Aids written by Yi-Wei Tang and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-02 with Medical categories.
The collective efforts of HIV/AIDS research scientists from over 16 countries in the world are included in the book. This 27-chapter Open Access book well covers HIV/AIDS translational researches on pathogenesis, diagnosis, treatment, prevention, and also those beyond conventional fields. These are by no means inclusive, but they do offer a good foundation for the development of clinical patient care. The translational model forms the basis for progressing HIV/AIDS clinical research. When linked to the care of the patients, translational researches should result in a direct benefit for HIV/AIDS patients.
Advances In Hiv Treatment
DOWNLOAD
AUDIOBOOK
Author : Gene D. Morse
language : en
Publisher: Bentham Science Publishers
Release Date : 2016-12-04
Advances In Hiv Treatment written by Gene D. Morse and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-04 with Medical categories.
Advances in HIV Treatment: HIV Enzyme Inhibitors and Antiretroviral Therapy presents comprehensive and updated information on drug therapies used to treat and manage HIV infection in human patients. The volume is organized in to chapters detailing respective classes of HIV Drugs including HIV entry inhibitors, reverse transcriptase inhibitors (RTIs), integrase strand inhibitors (INSTIs), and protease inhibitors (PIs). Each chapter compiles background information, pharmacology and clinical aspects such as side effects on the specific classes of drugs represented. Available data for ongoing research for new targets, including vaccines is also presented. Readers will also find a useful introduction to HIV virology and pathogenesis as well as a comparison of the availability and activity of these agents in different populations, opening a discussion on the influence of genetics and resources in curbing the HIV epidemic. Advances in HIV Treatment: HIV Enzyme Inhibitors and Antiretroviral Therapy is, therefore, a holistic resource for researchers, healthcare professionals and clinicians interested in understanding antiretroviral drugs and the management of HIV infection/AIDS. The volume is also of interest to undergraduate and graduate students undertaking specialized courses in pharmacology and HIV/AIDS management.
Trends In Basic And Therapeutic Options In Hiv Infection
DOWNLOAD
AUDIOBOOK
Author : Bartholomew Ibeh
language : en
Publisher: BoD – Books on Demand
Release Date : 2015-09-02
Trends In Basic And Therapeutic Options In Hiv Infection written by Bartholomew Ibeh and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-02 with Medical categories.
The past decade has seen several changes in HIV prevention, transmission and therapeutic interventions to end the scourge. This book is a collection of expert assays on various aspects of HIV prevention, bioresource deployment, microbicides, host antiviral proteins, antiviral drug responses and novel treatment strategies for which there is evident need for scientific focus and review of the current trend. A visible objective of the book is to provide a wider readership of scientist, clinicians, social workers/HIV caregivers, immunologist, postgraduate students, trainers and vaccine developers an informative and multidisciplinary approach to HIV treatment and intervention strategy by presenting current trends in the development of therapeutic options and its attendant challenges. Practical and informative, the book provides state-of-the-art information on dynamics of HIV distribution, transmission, therapeutic measures and functional cure.
Development And Applications Of Vaccines And Gene Therapy In Aids
DOWNLOAD
AUDIOBOOK
Author : Gaetano Giraldo
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1996-01-01
Development And Applications Of Vaccines And Gene Therapy In Aids written by Gaetano Giraldo and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-01 with Medical categories.
This publication is an overview of the exciting discoveries in the field of AIDS which were discussed at the workshop 'Development and Applications of Vaccines and Gene Therapy in AIDS' (Naples, June 1995). Various articles present the latest advances in the development of vaccines, focusing on the analysis of immunogenetic epitopes and models of expression and/or administration. Some contributions describe the results of recent vaccine trials with animal models while others concentrate on human clinical trials. Furthermore, articles on new approaches in the field of gene therapy are included. The data compiled in this outstanding volume is essential not only for biomedical scientists but also for all researchers interested in the latest developments in the field of HIV/AIDS.