Development Of Soft Sensors For Monitoring And Control Of Bioprocesses
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Development Of Soft Sensors For Monitoring And Control Of Bioprocesses
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Author : Robert Gustavsson
language : en
Publisher: Linköping University Electronic Press
Release Date : 2018-10-31
Development Of Soft Sensors For Monitoring And Control Of Bioprocesses written by Robert Gustavsson and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-31 with categories.
In the manufacture of bio-therapeutics the importance of a well-known process is key for a high product titer and low batch to batch variations. Soft sensors are based on the concept that online sensor signals can be used as inputs to mathematical models to derive new valuable process information. This information could then be used for better monitoring and control of the bioprocess. The aim of the present thesis has been to develop soft sensor solutions for upstream bioprocessing and demonstrate their usefulness in improving robustness and increase the batch-to-batch reproducibility in bioprocesses. The thesis reviews the potential and possibilities with soft sensors for use in production of bio-therapeutics to realize FDA´s process analytical technology (PAT) initiative. Modelling and hardware sensor alternatives which could be used in a soft sensor setup are described and critically analyzed. Different soft sensor approaches to control glucose feeding in fed-batch cultures of Escherichia coli are described. Measurements of metabolic fluxes and specific carbon dioxide production was used as control parameters to increase product yield and decrease the variability of produced recombinant proteins. Metabolic heat signals were used in uninduced cultures to estimate and control the specific growth rate at a desired level and thereby also estimate the biomass concentration online. The introduction of sequential filtering of the signal enabled this method to be used in a down-scaled system. The risk and high impact of contaminations in cell cultures are also described. An in situ microscope (ISM) was used as an online tool to estimate cell concentration and also to determine cell diameter size which enabled the detection of contaminant cells at an early stage. The work presented in this thesis supports the idea that soft sensors can be a useful tool in the strive towards robust and reliable bioprocesses, to ensure high product quality and increased economic profit.
Bioprocess Monitoring And Control
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Author : Bernd Hitzmann
language : en
Publisher:
Release Date : 2020
Bioprocess Monitoring And Control written by Bernd Hitzmann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Process monitoring and control are fundamental to all processes; this holds especially for bioprocesses, due to their complex nature. Usually, bioprocesses deal with living cells, which have their own regulatory systems. It helps to adjust the cell to its environmental condition. This must not be the optimal condition that the cell needs to produce whatever is desired. Therefore, a close monitoring of the cell and its environment is essential to provide optimal conditions for production. Without measurement, no information of the current process state is obtained. In this book, methods and techniques are provided for the monitoring and control of bioprocesses. From new developments for sensors, the application of spectroscopy and modelling approaches, the estimation and observer implementation for ethanol production and the development and scale-up of various bioprocesses and their closed loop control information are presented. The processes discussed here are very diverse. The major applications are cultivation processes, where microorganisms were grown, but also an incubation process of bird's eggs, as well as an indoor climate control for humans, will be discussed. Altogether, in 12 chapters, nine original research papers and three reviews are presented.
Computational Intelligence Techniques For Bioprocess Modelling Supervision And Control
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Author : Maria Carmo Nicoletti
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-29
Computational Intelligence Techniques For Bioprocess Modelling Supervision And Control written by Maria Carmo Nicoletti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-29 with Mathematics categories.
Computational Intelligence (CI) and Bioprocess are well-established research areas which have much to offer each other. Under the perspective of the CI area, Biop- cess can be considered a vast application area with a growing number of complex and challenging tasks to be dealt with, whose solutions can contribute to boosting the development of new intelligent techniques as well as to help the refinement and s- cialization of many of the already existing techniques. Under the perspective of the Bioprocess area, CI can be considered a useful repertoire of theories, methods and techniques that can contribute and offer interesting alternative approaches for solving many of its problems, particularly those hard to solve using conventional techniques. Although throughout the past years CI and Bioprocess areas have accumulated substantial specific knowledge and progress has been quick and with a high degree of success, we believe there is still a long way to go in order to use the potentialities of the available CI techniques and knowledge at their full extent, as tools for supporting problem solving in bioprocesses. One of the reasons is the fact that both areas have progressed steadily and have been continuously accumulating and refining specific knowledge; another reason is the high level of technical expertise demanded by each of them. The acquisition of technical skills, experience and good insights in either of the two areas is very demanding and a hard task to be accomplished by any professional.
Bioprocessing Technology For Production Of Biopharmaceuticals And Bioproducts
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Author : Claire Komives
language : en
Publisher: John Wiley & Sons
Release Date : 2018-12-27
Bioprocessing Technology For Production Of Biopharmaceuticals And Bioproducts written by Claire Komives and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-27 with Science categories.
Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: • Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries • Includes illustrative case studies that review six milestone bio-products • Discuses a wide selection of host strain types and disruptive bioprocess technologies
Soft Sensors For Monitoring And Control Of Industrial Processes
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Author : Luigi Fortuna
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-31
Soft Sensors For Monitoring And Control Of Industrial Processes written by Luigi Fortuna and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-31 with Technology & Engineering categories.
This book reviews current design paths for soft sensors, and guides readers in evaluating different choices. The book presents case studies resulting from collaborations between the authors and industrial partners. The solutions presented, some of which are implemented on-line in industrial plants, are designed to cope with a wide range of applications from measuring system backup and what-if analysis through real-time prediction for plant control to sensor diagnosis and validation.
Current Developments In Biotechnology And Bioengineering
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Author : Ashok Pandey
language : en
Publisher: Elsevier
Release Date : 2022-08-18
Current Developments In Biotechnology And Bioengineering written by Ashok Pandey and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-18 with Technology & Engineering categories.
Advances in Bioprocess Engineering, the latest release in the Current Developments in Biotechnology and Bioengineering series, provides a comprehensive overview of bioprocess systems, kinetics, bioreactor design, batch and continuous reactors and introduces key principles that enable bioprocess engineers to engage in analysis, optimization and design with consistent control over biological and chemical transformations. The bioprocessing sector is also updating its technologies with state-of-the art techniques to keep up with the rising demand of the industry and R&D. This book covers these aspects, taking readers through a step-by-step journey of bioprocessing while also guiding them towards a new era and future. - Covers state-of-the-art, technological advancements in the field of bioprocessing - Includes design and scale-up of bioreactors, monitoring and control systems, advances in upstream and downstream processing - Includes design and development of fermentation processes such as the suitability of experimental design, full factorial, central composite design, Box-Behnken, Plackett-Burman, and more
Handbook Of Manufacturing Systems And Design
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Author : Uzair Khaleeq uz Zaman
language : en
Publisher: CRC Press
Release Date : 2023-08-24
Handbook Of Manufacturing Systems And Design written by Uzair Khaleeq uz Zaman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-24 with Technology & Engineering categories.
This book provides a comprehensive overview of manufacturing systems, their role in product/process design, and their interconnection with an Industry 4.0 perspective, especially related to design, manufacturing, and operations. Handbook of Manufacturing Systems and Design: An Industry 4.0 Perspective provides the knowledge related to the theories and concepts of Industry 4.0. It focuses on the different types of manufacturing systems in Industry 4.0 along with associated design, and control strategies. It concentrates on the operations in Industry 4.0 with a particular focus on supply chain, logistics, risk management, and reverse engineering perspectives. Offering basic concepts and applications through to advanced topics, the handbook feeds into the goal of being a source of knowledge as well as a vehicle to explore the future possibilities of design, techniques, methods, and operations associated with Industry 4.0. Concepts with practical applications in the form of case studies are added to each chapter to round out the many attributes this handbook offers. This handbook targets students, engineers, managers, designers, and manufacturers, and will assist in their understanding of the core concepts of manufacturing systems in connection with Industry 4.0 and optimize alignment between supply and demand in real time for effective implementation of the design concepts.
Measurement Monitoring Modelling And Control Of Bioprocesses
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Author : Carl-Fredrik Mandenius
language : en
Publisher: Springer
Release Date : 2014-07-08
Measurement Monitoring Modelling And Control Of Bioprocesses written by Carl-Fredrik Mandenius and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Science categories.
Automated Measurement and Monitoring of Bioprocesses: Key Elements of the M3C Strategy, by Bernhard Sonnleitner Automatic Control of Bioprocesses, by Marc Stanke, Bernd Hitzmann An Advanced Monitoring Platform for Rational Design of Recombinant Processes, by G. Striedner, K. Bayer Modelling Approaches for Bio-Manufacturing Operations, by Sunil Chhatre Extreme Scale-Down Approaches for Rapid Chromatography Column Design and Scale-Up During Bioprocess Development, by Sunil Chhatre Applying Mechanistic Models in Bioprocess Development, by Rita Lencastre Fernandes, Vijaya Krishna Bodla, Magnus Carlquist, Anna-Lena Heins, Anna Eliasson Lantz, Gürkan Sin and Krist V. Gernaey Multivariate Data Analysis for Advancing the Interpretation of Bioprocess Measurement and Monitoring Data, by Jarka Glassey Design of Pathway-Level Bioprocess Monitoring and Control Strategies Supported by Metabolic Networks, by Inês A. Isidro, Ana R. Ferreira, João J. Clemente, António E. Cunha, João M. L. Dias, Rui Oliveira Knowledge Management and Process Monitoring of Pharmaceutical Processes in the Quality by Design Paradigm, by Anurag S Rathore, Anshuman Bansal, Jaspinder Hans The Choice of Suitable Online Analytical Techniques and Data Processing for Monitoring of Bioprocesses, by Ian Marison, Siobhán Hennessy, Róisín Foley, Moira Schuler, Senthilkumar Sivaprakasam, Brian Freeland
Bioreactors
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Author : Carl-Fredrik Mandenius
language : en
Publisher: John Wiley & Sons
Release Date : 2016-05-16
Bioreactors written by Carl-Fredrik Mandenius and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-16 with Science categories.
In this expert handbook both the topics and contributors are selected so as to provide an authoritative view of possible applications for this new technology. The result is an up-to-date survey of current challenges and opportunities in the design and operation of bioreactors for high-value products in the biomedical and chemical industries. Combining theory and practice, the authors explain such leading-edge technologies as single-use bioreactors, bioreactor simulators, and soft sensor monitoring, and discuss novel applications, such as stem cell production, process development, and multi-product reactors, using case studies from academia as well as from industry. A final section addresses the latest trends, including culture media design and systems biotechnology, which are expected to have an increasing impact on bioreactor design. With its focus on cutting-edge technologies and discussions of future developments, this handbook will remain an invaluable reference for many years to come.
Control In Bioprocessing
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Author : Pablo A. López Pérez
language : en
Publisher: John Wiley & Sons
Release Date : 2020-06-08
Control In Bioprocessing written by Pablo A. López Pérez and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-08 with Technology & Engineering categories.
Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation and the Use of Sensors is divided into three sections. Part I, Mathematical preliminaries and overview of the control and monitoring of bioprocess, provides a general overview of the control and monitoring of bioprocesses, and introduces the mathematical framework necessary for the analysis and characterization of bioprocess dynamics. Part II, Observability and control concepts, presents the observability concepts which form the basis of design online estimation algorithms (software sensor) for bioprocesses, and reviews controllability of these concepts, including automatic feedback control systems. Part III, Software sensors and observer-based control schemes for bioprocesses, features six application cases including dynamic behavior of 3-dimensional continuous bioreactors; observability analysis applied to 2D and 3D bioreactors with inhibitory and non-inhibitory models; and regulation of a continuously stirred bioreactor via modeling error compensation. Applicable across all areas of bioprocess engineering, including food and beverages, biofuels and renewable energy, pharmaceuticals and nutraceuticals, fermentation systems, product separation technologies, wastewater and solid-waste treatment technology, and bioremediation Provides a clear explanation of the mass-balance–based mathematical modelling of bioprocesses and the main tools for its dynamic analysis Offers industry-based applications on: myco-diesel for implementing "quality" of observability; developing a virtual sensor based on the Just-In-Time Model to monitor biological control systems; and virtual sensor design for state estimation in a photocatalytic bioreactor for hydrogen production Control in Bioengineering and Bioprocessing is intended as a foundational text for graduate level students in bioengineering, as well as a reference text for researchers, engineers, and other practitioners interested in the field of estimation and control of bioprocesses.