Diabetes Insulin And Alzheimer S Disease
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Diabetes Insulin And Alzheimer S Disease
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Author : Suzanne Craft
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-10
Diabetes Insulin And Alzheimer S Disease written by Suzanne Craft and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-10 with Medical categories.
This text provides a broad survey of the role of insulin in the brain. And it discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease.
Diabetes Mellitus
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Author : Yusaku Nakabeppu
language : en
Publisher: Springer
Release Date : 2019-05-06
Diabetes Mellitus written by Yusaku Nakabeppu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-06 with Medical categories.
This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.
Diabetes Insulin And Alzheimer S Disease
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Author : Suzanne Craft
language : en
Publisher:
Release Date : 2010
Diabetes Insulin And Alzheimer S Disease written by Suzanne Craft and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Neurons share more similarities with insulin-producing pancreatic islet cells than with any other cell type. The root of this similarity may lie in the islet's evolution from an ancestral insulin-producing neuron. The islet-neuron connection becomes less surprising as we learn more about insulin's involvement in functions far from its traditional role in mediating glucose uptake in muscle. The importance of insulin in the regulation of corporal aging has been established by the dramatic increases in longevity experienced by animals in which the adipose insulin receptor has been genetically eliminated, or in which the insulin-related daf genes have been mutated. New research suggests that, analogous to its influence on corporal aging, insulin also makes important contributions to brain aging and the expression of late-life neurodegenerative disease. Insulin plays a key role in cognition and other aspects of normal brain function. Insulin resistance induces chronic peripheral insulin elevations and is associated with reduced insulin activity both in periphery and brain. The insulin resistance syndrome underlies conditions such as Type 2 diabetes mellitus and hypertension, which are associated with age-related cognitive impairment and Alzheimer's disease. This book discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease. Given the recent pandemic of conditions associated with insulin resistance, it is imperative that we achieve a comprehensive knowledge of the mechanisms through which insulin resistance affects brain function in order to develop therapeutic strategies to address these effects.
The Diabetic Brain In Alzheimer S Disease How Insulin Resistance In Type 2 Diabetes And Type 3 Diabetes Triggers Your Risk For Alzheimer S And How
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Author : Ralph Sanchez Mtcm
language : en
Publisher: Braindefend LLC
Release Date : 2019-08-21
The Diabetic Brain In Alzheimer S Disease How Insulin Resistance In Type 2 Diabetes And Type 3 Diabetes Triggers Your Risk For Alzheimer S And How written by Ralph Sanchez Mtcm and has been published by Braindefend LLC this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-21 with Medical categories.
The thought of living out one's life with dementia conjures up a helpless and foreboding feeling. What if it happens to me?Can I do anything to prevent it?One in ten people age 65 and older has Alzheimer's, and the prevalence of the disease jumps to three in ten after the age of 85. One in three seniors will die from Alzheimer's or another form of dementia according to the Alzheimer's Association. The financial burden for top level care can be staggering, and the difficult challenges imposed by attending to care and finances can be extremely stressful and exhausting for family as well as caretakers.Is there an answer for you and the Alzheimer's pandemic that is projected to almost triple by the year 2050? To date, drug trials are struggling to provide any meaningful interventions, and it is unlikely that a pharmaceutical centered approach will provide anything resembling a cure or a reversal of the disease process anytime soon. There is hope! The solution is based on early detection and intervention. Scientific research as well as many enlightened physicians and clinics are now demonstrating that prevention is possible, and the key lies in a comprehensive evaluation of your risk for Alzheimer's long before the onset of dementia. This is vital as we now know that the Alzheimer's disease process starts decades before you might notice you are in trouble.Don't wait to be diagnosed! The Diabetic Brain in Alzheimer's Disease reveals the most critical and common risk factors for Alzheimer's disease as you age, and how you can take control of your risk. The in-depth science-based information in this book will illuminate your path to protecting your brain and drastically reducing your odds of developing Alzheimer's as you age. Read this book and discover the actionable steps that you can begin taking now to save your brain from dementia.
The New Threat Of Type 3 Diabetes
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Author : Alan D. Raguso
language : en
Publisher: iUniverse
Release Date : 2018-11-08
The New Threat Of Type 3 Diabetes written by Alan D. Raguso and has been published by iUniverse this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-08 with Medical categories.
The American diet is typically high in sugar consumption and extremely acidic. This lifestyle leads to insulin resistance, inflammation, diabetes, high blood pressure, risk for heart attack or stroke, and possibly dementia and Alzheimer’s disease. In The New Threat of Type 3 Diabetes, authors Alan D. Raguso and Maria Lizotte offer an understanding of diabetes, discussing why people’s health declines and why they get sick. Based on their personal and professional experiences with diabetes, they discuss concepts of body chemistry, look at inflammation as a health risk, and share how it’s a result of improper food intake, heredity, and environmental conditions, along with economics, poor pH balance, lack of moderate exercise, and the modern technological world. Raguso and Lizotte tell how type 3 diabetes is a newly accepted category, connecting a lifetime of damage caused by excessive blood sugar levels. With illustrations and graphics included, The New Threat of Type 3 Diabetes reviews the basic definitions of medical terms, the possible connections to prediabetes, type 2 and type 3 diabetes, and the steps that can be taken to prevent or reverse these diseases. Raguso and Lizotte suggest ways to make simple changes to live more healthily, better, and longer.
The Interaction Of Type 2 Diabetes Type 3 Diabetes Alzheimer S Disease And The Gut Microbiota
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Author : Hyder Mirghani
language : en
Publisher: GRIN Verlag
Release Date : 2017-12-19
The Interaction Of Type 2 Diabetes Type 3 Diabetes Alzheimer S Disease And The Gut Microbiota written by Hyder Mirghani and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-19 with Medical categories.
Literature Review from the year 2017 in the subject Medicine - Internal Medicine, grade: C, , language: English, abstract: Dementia is a multifaceted syndrome with a significant public health, social, and economic burden; there are forty-four million people affected by the disease worldwide according to the most recent estimate.The number is projected to double by the year 2030 and to triple by 2050. Alzheimer's disease (AD, or type-3 diabetes mellitus) and vascular dementia are the most common forms of dementia. Lifestyle risk factors including obesity and type 2 diabetes increase the risk for the development of both vascular and nonvascular dementia in later life. Previous literature reported that people with diabetes mellitus had 70% greater risk for dementia development.Traditionally, type-2 diabetes and AD (type-3 diabetes) have been thought as independent disorders; recent literature suggests possible links that could lead to common effective modalities of treatment. Furthermore, the highly innervated pancreas shares many features with the brain at molecular levels. Metformin is recommended as the first line for the treatment of patients with type 2 diabetes mellitus due to its effectiveness, favorable effects on lipids and cardiovascular risks, and safety profile.The previous restriction of the use of metformin in patients with the moderate renal disease is loosened by the Food and Drug Organization(5,6). Thus the use of this valuable and affordable drug is expected to increase. The American Diabetes Association recommended the periodic measurement of vitamin B12 and supplementation as needed to reflect the recent evidence showing the association of long-term use of metformin and B12 deficiency.Although the role of vitamin B12 deficiency in the development of dementia is well-established, the role of metformin in B12 deficiency and dementia remain to be elucidated. Insulin resistance is considered as a primary factor for the association of diabetes mellitus and dementia. However, the role of insulin sensitizer in the prevention of dementia remains unclear.Furthermore, there is an increasing concern about the role of metformin in cognitive disorders.Thus we conducted this narrative review, in this study we reviewed the literature to assess the interaction of Alzheimer's disease, the gut, and its microbiome, and to assess the role of metformin and other drugs used for type 1&2 diabetes mellitus as possible therapies for the AD. The role of microbiota and fecal transplantation on cognitive disorders was also discussed.
Diabetes And The Brain
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Author : Geert Jan Biessels
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-09-18
Diabetes And The Brain written by Geert Jan Biessels and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-18 with Medical categories.
Diabetes, particularly type 2, has become increasingly more common around the world. Consequently, the effect of diabetes on the brain has achieved enormous public health importance. A surge in pre-clinical and clinical research on topics ranging from management of hyperglycemia in acute stroke to disturbances in insulin signaling in Alzheimer’s disease has led to substantial progress in the field. Written by a panel of international experts, Diabetes and the Brain provides in depth reviews on the cerebral complications of diabetes, and offers introductory chapters on current insights on the pathophysiology and clinical management of diabetes, as well as neuropsychological assessment and dementia. This relevant and easily accessible book explains the cerebral complications of diabetes, with an update on diabetes for neurologists, psychiatrists, and mental health providers and researchers in general,and on stroke and dementia for those involved in research and clinical practice in diabetes.
Freedom From Disease
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Author : Peter M. Kash
language : en
Publisher: Diversion Books
Release Date : 2017-03-12
Freedom From Disease written by Peter M. Kash and has been published by Diversion Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-12 with Health & Fitness categories.
With the latest scientific research, this simple guide shows how insulin and inflammation affect your health and what you can to take control. Insulin: It's a scary word for anyone. Levels too high or too low can have grave medical consequences, and the rigorous testing and change in diet it takes to manage it can be daunting. Inflammation: Is this the cause of damage within the body? Worse still, insulin and inflammation have increasingly been found to affect much more than diabetes. Heart disease, cancer, Alzheimer's disease, and strokes have all been found to possibly link back to insulin resistance. The good news? You’ve got armor. While managing your insulin and inflammation levels can seem like impossible work, Dr. Peter Kash, Dr. Linda Friedland, and Dr. Jay Lombard have created an easy to follow guide that not only breaks down how insulin and inflammation affect your health, but also provides the information you need to keep it in check. “Drs. Kash, Friedland and Lombard finally put together the real story of the underlying cause of our epidemic of chronic illness from ADD to Alzheimer's, from depression to heart attacks, from cancer to obesity—it is the insulin flooding through our bodies triggering a deathly cascade. Read this book—it will save your life.”—Mark Hyman, MD, author of the New York Times bestseller, UltraMetabolism
Neurodegeneration And Alzheimer S Disease
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Author : Ralph N. Martins
language : en
Publisher: John Wiley & Sons
Release Date : 2019-05-01
Neurodegeneration And Alzheimer S Disease written by Ralph N. Martins and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-01 with Technology & Engineering categories.
Understanding the impact of diet, exercise, genetics, and hormones on the risk and development of Alzheimer’s and other neurogenerative diseases Diet is widely known to impact on neurological function. Nevertheless, academic texts discussing this relationship are relatively few in number. This book therefore fills an important gap in the current literature. Opening with an overview of neurodegenerative diseases, particularly Alzheimer’s disease, the text then focuses on explaining the means by which glycemic control and lipid metabolism – and associated nutritional and lifestyle variables – may factor into such disorders’ prevention and treatment. An international group of experts in the fields of food science and neurodegeneration have contributed chapters that examine Alzheimer’s disease within a broad range of contexts. Offering dietary, genetic, and hormonal perspectives, the authors explore topics ranging from sugar consumption to digestive fermentation, and Alzheimer’s disease animal models to the cognition-enhancing effects of physical exercise. Also included are overviews of the latest research into current and developing methods of treatment and diagnosis, as well as differential diagnostics. This groundbreaking book: Explores how glucose metabolism, insulin resistance, lipid metabolism, and high intake of refined carbohydrates are linked to Alzheimer's disease Discusses how genetic makeup can impact risk of Alzheimer’s and Parkinson’s disease Examines cognitive changes in neurodegeneration, lists current tests for determining cognitive impairment, and provides information concerning differential diagnosis Discusses potential advantages of increasing antioxidant and micronutrient intake Reviews hormonal influences on neurodegeneration Examines the links between protein intake and Alzheimer’s disease. Neurodegeneration and Alzheimer's Disease is an essential resource for researchers, medical practitioners, dietitians, and students with an interest in neurological diseases and their diagnosis and risk factors, as well as diet-related conditions such as diabetes and obesity. Lifestyle and diet influence neurodegeneration risk, and a better understanding of this evidence amongst health professionals will hopefully lead to greater public awareness of how to reduce the likelihood of these widespread conditions.
The Interaction Of Type 2 Diabetes Type 3 Diabetes Alzheimer S Disease And Thegut Microbiota
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Author : Hyder Mirghani
language : en
Publisher: Grin Publishing
Release Date : 2018-01-12
The Interaction Of Type 2 Diabetes Type 3 Diabetes Alzheimer S Disease And Thegut Microbiota written by Hyder Mirghani and has been published by Grin Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-12 with categories.
Literature Review from the year 2017 in the subject Medicine - Internal Medicine, grade: C, language: English, abstract: Dementia is a multifaceted syndrome with a significant public health, social, and economic burden; there are forty-four million people affected by the disease worldwide according to the most recent estimate.The number is projected to double by the year 2030 and to triple by 2050. Alzheimer's disease (AD, or type-3 diabetes mellitus) and vascular dementia are the most common forms of dementia. Lifestyle risk factors including obesity and type 2 diabetes increase the risk for the development of both vascular and nonvascular dementia in later life. Previous literature reported that people with diabetes mellitus had 70% greater risk for dementia development.Traditionally, type-2 diabetes and AD (type-3 diabetes) have been thought as independent disorders; recent literature suggests possible links that could lead to common effective modalities of treatment. Furthermore, the highly innervated pancreas shares many features with the brain at molecular levels. Metformin is recommended as the first line for the treatment of patients with type 2 diabetes mellitus due to its effectiveness, favorable effects on lipids and cardiovascular risks, and safety profile.The previous restriction of the use of metformin in patients with the moderate renal disease is loosened by the Food and Drug Organization(5,6). Thus the use of this valuable and affordable drug is expected to increase. The American Diabetes Association recommended the periodic measurement of vitamin B12 and supplementation as needed to reflect the recent evidence showing the association of long-term use of metformin and B12 deficiency.Although the role of vitamin B12 deficiency in the development of dementia is well-established, the role of metformin in B12 deficiency and dementia remain to be elucidated. Insulin resistance is considered as a primary factor for the association of diabetes melli