The Interaction Of Type 2 Diabetes Type 3 Diabetes Alzheimer S Disease And The Gut Microbiota
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The Interaction Of Type 2 Diabetes Type 3 Diabetes Alzheimer S Disease And The Gut Microbiota
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Author : Hyder Mirghani
language : en
Publisher: GRIN Verlag
Release Date : 2017-12-19
The Interaction Of Type 2 Diabetes Type 3 Diabetes Alzheimer S Disease And The Gut Microbiota written by Hyder Mirghani and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-19 with Medical categories.
Literature Review from the year 2017 in the subject Medicine - Internal Medicine, grade: C, , language: English, abstract: Dementia is a multifaceted syndrome with a significant public health, social, and economic burden; there are forty-four million people affected by the disease worldwide according to the most recent estimate.The number is projected to double by the year 2030 and to triple by 2050. Alzheimer's disease (AD, or type-3 diabetes mellitus) and vascular dementia are the most common forms of dementia. Lifestyle risk factors including obesity and type 2 diabetes increase the risk for the development of both vascular and nonvascular dementia in later life. Previous literature reported that people with diabetes mellitus had 70% greater risk for dementia development.Traditionally, type-2 diabetes and AD (type-3 diabetes) have been thought as independent disorders; recent literature suggests possible links that could lead to common effective modalities of treatment. Furthermore, the highly innervated pancreas shares many features with the brain at molecular levels. Metformin is recommended as the first line for the treatment of patients with type 2 diabetes mellitus due to its effectiveness, favorable effects on lipids and cardiovascular risks, and safety profile.The previous restriction of the use of metformin in patients with the moderate renal disease is loosened by the Food and Drug Organization(5,6). Thus the use of this valuable and affordable drug is expected to increase. The American Diabetes Association recommended the periodic measurement of vitamin B12 and supplementation as needed to reflect the recent evidence showing the association of long-term use of metformin and B12 deficiency.Although the role of vitamin B12 deficiency in the development of dementia is well-established, the role of metformin in B12 deficiency and dementia remain to be elucidated. Insulin resistance is considered as a primary factor for the association of diabetes mellitus and dementia. However, the role of insulin sensitizer in the prevention of dementia remains unclear.Furthermore, there is an increasing concern about the role of metformin in cognitive disorders.Thus we conducted this narrative review, in this study we reviewed the literature to assess the interaction of Alzheimer's disease, the gut, and its microbiome, and to assess the role of metformin and other drugs used for type 1&2 diabetes mellitus as possible therapies for the AD. The role of microbiota and fecal transplantation on cognitive disorders was also discussed.
The Interaction Of Type 2 Diabetes Type 3 Diabetes Alzheimer S Disease And Thegut Microbiota
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Author : Hyder Mirghani
language : en
Publisher: Grin Publishing
Release Date : 2018-01-12
The Interaction Of Type 2 Diabetes Type 3 Diabetes Alzheimer S Disease And Thegut Microbiota written by Hyder Mirghani and has been published by Grin Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-12 with categories.
Literature Review from the year 2017 in the subject Medicine - Internal Medicine, grade: C, language: English, abstract: Dementia is a multifaceted syndrome with a significant public health, social, and economic burden; there are forty-four million people affected by the disease worldwide according to the most recent estimate.The number is projected to double by the year 2030 and to triple by 2050. Alzheimer's disease (AD, or type-3 diabetes mellitus) and vascular dementia are the most common forms of dementia. Lifestyle risk factors including obesity and type 2 diabetes increase the risk for the development of both vascular and nonvascular dementia in later life. Previous literature reported that people with diabetes mellitus had 70% greater risk for dementia development.Traditionally, type-2 diabetes and AD (type-3 diabetes) have been thought as independent disorders; recent literature suggests possible links that could lead to common effective modalities of treatment. Furthermore, the highly innervated pancreas shares many features with the brain at molecular levels. Metformin is recommended as the first line for the treatment of patients with type 2 diabetes mellitus due to its effectiveness, favorable effects on lipids and cardiovascular risks, and safety profile.The previous restriction of the use of metformin in patients with the moderate renal disease is loosened by the Food and Drug Organization(5,6). Thus the use of this valuable and affordable drug is expected to increase. The American Diabetes Association recommended the periodic measurement of vitamin B12 and supplementation as needed to reflect the recent evidence showing the association of long-term use of metformin and B12 deficiency.Although the role of vitamin B12 deficiency in the development of dementia is well-established, the role of metformin in B12 deficiency and dementia remain to be elucidated. Insulin resistance is considered as a primary factor for the association of diabetes melli
Neurodegenerative Diseases
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Author : Nagehan Ersoy Tunalı
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-01-20
Neurodegenerative Diseases written by Nagehan Ersoy Tunalı and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-20 with Science categories.
Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.
The New Threat Of Type 3 Diabetes
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Author : Alan D. Raguso
language : en
Publisher: iUniverse
Release Date : 2018-11-08
The New Threat Of Type 3 Diabetes written by Alan D. Raguso and has been published by iUniverse this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-08 with Medical categories.
The American diet is typically high in sugar consumption and extremely acidic. This lifestyle leads to insulin resistance, inflammation, diabetes, high blood pressure, risk for heart attack or stroke, and possibly dementia and Alzheimer’s disease. In The New Threat of Type 3 Diabetes, authors Alan D. Raguso and Maria Lizotte offer an understanding of diabetes, discussing why people’s health declines and why they get sick. Based on their personal and professional experiences with diabetes, they discuss concepts of body chemistry, look at inflammation as a health risk, and share how it’s a result of improper food intake, heredity, and environmental conditions, along with economics, poor pH balance, lack of moderate exercise, and the modern technological world. Raguso and Lizotte tell how type 3 diabetes is a newly accepted category, connecting a lifetime of damage caused by excessive blood sugar levels. With illustrations and graphics included, The New Threat of Type 3 Diabetes reviews the basic definitions of medical terms, the possible connections to prediabetes, type 2 and type 3 diabetes, and the steps that can be taken to prevent or reverse these diseases. Raguso and Lizotte suggest ways to make simple changes to live more healthily, better, and longer.
Diabetes Mellitus
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Author : Yusaku Nakabeppu
language : en
Publisher: Springer
Release Date : 2019-05-06
Diabetes Mellitus written by Yusaku Nakabeppu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-06 with Medical categories.
This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.
The Gut Microbiota A Driver Of Type 2 Diabetes
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Author :
language : en
Publisher:
Release Date : 2023
The Gut Microbiota A Driver Of Type 2 Diabetes written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
The studies described in this thesis investigated how changes in the gut microbiota relate to alterations in the immune system and the development of beta-cell dysfunction. Moreover, we addressed the interrelation between intestinal immunoglobulins and gut microbiota in individuals with metabolic diseases. Chapter 1 provides a general introduction to the gut microbiota, the pathogenesis of T2D, and the function of IgA. Chapter 2 summarizes the current literature on gut microbiota, obesity, and T2D. A western diet leads to changes in gut microbial composition and intestinal physiology. Altered intestinal microbial composition promotes obesity by increasing energy harvest and gut permeability that may facilitate the translocation of bacteria or bacterial components into the circulation. Thereby, the gut microbiota can impact the function of metabolic organs. Interventions aiming to restore gut microbial homeostasis, such as ingestion of fibers or therapeutic microbes, are novel strategies to reduce metabolic abnormalities. Inflammation in the pancreas can lead to beta-cell dysfunction with the driving inflammatory triggers yet to be identified. The gut microbiota provides a plausible source of pro-inflammatory molecules. Chapter 3 shows that a high-fat diet significantly altered the gut and pancreatic bacterial signature in mice. Importantly, our findings could not be traced back to contamination, a well-known factor disturbing microbial signal identification in low-abundance samples. Our data point out that the pancreas comprises bacterial DNA. This underscores similar speculations and observations in the field implying that gut microbial components translocate and act on distal organs and tissue. Chapter 4 summarizes the current literature on gut microbiota and metabolic inflammation. T2D is characterized by a chronic state of low-grade inflammation, which has been linked to the development of insulin resistance. Intestinal microbiota drive the development of insuli
Gut Microbiota In Neurologic And Visceral Diseases
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Author : Tahira Farooqui
language : en
Publisher: Academic Press
Release Date : 2021-03-11
Gut Microbiota In Neurologic And Visceral Diseases written by Tahira Farooqui and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-11 with Medical categories.
Gut Microbiota in Neurologic and Visceral Diseases presents readers with comprehensive information on the involvement of microbiota in the pathogenesis of neurological disorders. Chapters cover the effect of microbiota on the development of visceral (obesity, type 2 diabetes, heart disease) and neurological disorders (Alzheimer’s disease, Parkinson’s, depression, anxiety, and autism). Sections focus on the molecular mechanisms and signal transduction processes associated with the links among microbiota-related visceral and neurological disorders. It is hoped that this discussion will not only integrate and consolidate knowledge in this field but will also jumpstart more studies on the involvement of microbiota in the pathogenesis of neurological disorders. Reviews the relationship between gut microbiome, diseases and disorders Discusses the relationship between diet, microbiota and inflammation Includes neurodegenerative, neuropsychiatric and cardiovascular disorders Covers diabetes, obesity and metabolic disorders Identifies molecular mechanisms and signal transduction processes Encompasses dietary fiber, fat, prebiotics and probiotics
Geriatric Gastroenterology
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Author : C. S. Pitchumoni
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-26
Geriatric Gastroenterology written by C. S. Pitchumoni and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-26 with Medical categories.
As aging trends in the United States and Europe in particular are strongly suggestive of increasingly older society, it would be prudent for health care providers to better prepare for such changes. By including physiology, disease, nutrition, pharmacology, pathology, radiology and other relevant associated topics, Geriatric Gastroenterology fills the void in the literature for a volume devoted specifically to gastrointestinal illness in the elderly. This unique volume includes provision of training for current and future generations of physicians to deal with the health problems of older adults. It will also serve as a comprehensive guide to practicing physicians for ease of reference. Relevant to the geriatric age group, the volume covers epidemiology, physiology of aging, gastrointestinal physiology, pharmacology, radiology, pathology, motility disorders, luminal disorders, hepato-biliary disease, systemic manifestations, neoplastic disorders, gastrointestinal bleeding, cancer and medication related interactions and adverse events, all extremely common in older adults; these are often hard to evaluate and judge, especially considering the complex aging physiology. All have become important components of modern medicine. Special emphasis is be given to nutrition and related disorders. Capsule endoscopy and its utility in the geriatric population is also covered. Presented in simple, easy to read style, the volume includes numerous tables, figures and key points enabling ease of understanding. Chapters on imaging and pathology are profusely illustrated. All chapters are written by specialists and include up to date scientific information. Geriatric Gastroenterology is of great utility to residents in internal medicine, fellows in gastroenterology and geriatric medicine as well as gastroenterologists, geriatricians and practicing physicians including primary care physicians caring for older adults.
Diabetes Insulin And Alzheimer S Disease
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Author : Suzanne Craft
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-10
Diabetes Insulin And Alzheimer S Disease written by Suzanne Craft and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-10 with Medical categories.
This text provides a broad survey of the role of insulin in the brain. And it discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease.
Comorbidity Of Mental And Physical Disorders
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Author : N. Sartorius
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2014-11-26
Comorbidity Of Mental And Physical Disorders written by N. Sartorius and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-26 with Medical categories.
This publication presents evidence about the magnitude and severe consequences of comorbidity of mental and physical illnesses from a personal and societal perspective. Leading experts address the huge burden of co-morbidity to the affected individual as well as the public health aspects, the costs to society and interaction with factors stemming from the context of socioeconomic developments. The authors discuss the clinical challenge of managing cardiovascular illnesses, cancer, infectious diseases and other physical illness when they occur with a range of mental and behavioral disorders, including substance abuse, eating disorders and anxiety. Also covered are the organization of health services, the training of different categories of health personnel and the multidisciplinary engagement necessary to prevent and manage comorbidity effectively. The book is essential reading for general practitioners, internists, public health specialists, psychiatrists, cardiologists, oncologists, medical educationalists and other health care professionals.