Diagnostic And Therapeutic Challenges In Rare And Complex Autoimmune Diseases
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Diagnostic And Therapeutic Challenges In Rare And Complex Autoimmune Diseases
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Author : Savino Sciascia
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-05
Diagnostic And Therapeutic Challenges In Rare And Complex Autoimmune Diseases written by Savino Sciascia and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-05 with Medical categories.
Rare Diseases
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Author : Mani T. Valarmathi
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-09-22
Rare Diseases written by Mani T. Valarmathi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-22 with Medical categories.
A rare disease is any disease or condition that affects a small percentage of the population. Many rare conditions are life-threatening or chronically debilitating, and unfortunately do not have appropriate treatments, rendering them incurable. In recent years, there has been substantial development in the area of rare disease research and its clinical applications, for instance, rare disease biology and genomics, epidemiology and preventions, early detection and screening, and diagnosis and treatment. In this context, this book consolidates the recent advances in rare disease biology and therapeutics, covering a wide spectrum of interrelated topics, and disseminates this essential knowledge in a comprehensible way to a greater scientific and clinical audience as well as patients, caregivers, and drug and device manufacturers, especially to support rare disease product development. Chapters cover such diseases as Felty’s syndrome, Löfgren’s syndrome, mesothelioma, epidermolysis bullosa, and more. This book is a valuable resource not only for medical and allied health students but also for researchers, clinical and nurse geneticists, genetic counselors, and physician assistants.
Diagnostic Criteria In Autoimmune Diseases
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Author : Yehuda Shoenfeld
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-06-08
Diagnostic Criteria In Autoimmune Diseases written by Yehuda Shoenfeld and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-08 with Medical categories.
According to the Autoimmune Diseases Coordinating Committee (ADCC), between 14.7 and 23.5 million people in the USA – up to eight percent of the population are affected by autoimmune disease. Autoimmune diseases are a family of more than 100 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Handbook of Autoimmune Disease, the editors have gathered in a comprehensive handbook a critical review, by renowned experts, of more than 100 autoimmune diseases, divided into two main groups, namely systemic and organ-specific autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. Each chapter contains the essential information required by attending physicians as well as bench scientists to understand the definition of a specific autoimmune disease, the diagnostic criteria, and the treatment.
Pathogenesis Of Systemic Lupus Erythematosus
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Author : Alberta Hoi
language : en
Publisher: Springer Nature
Release Date : 2021-11-15
Pathogenesis Of Systemic Lupus Erythematosus written by Alberta Hoi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-15 with Medical categories.
The scope of this contributed volume is to provide an overview of the latest translational research in the field of lupus pathogenesis, with particular emphasis on how these discoveries progress in parallel with therapeutic drug development. Systemic lupus erythematosus (SLE) is a multifaceted disease with a number of well-defined immune pathways that are dysregulated, resulting in an immune-mediated chronic inflammatory injury at target organs. As knowledge of these pathways evolves to provide opportunities for targeted drug therapy and lays the foundation for personalized medicine, clinicians and researchers need to keep up with the ever-expanding medical literature. This book will critically appraise the current understanding of important immunological pathways that contribute to the pathogenesis of lupus. We will review the role of interferons as part of the innate immune defects that perpetuate the loss of self-tolerance in SLE. B cell hyperactivity, as a defining hallmark of SLE, and different strategies of B cell targeted therapy will be discussed. The role of co-stimulation or immune checkpoint molecules in activating B and T cells will be reviewed, as well as other cytokines that serve in the amplification loop promoting a more proinflammatory Th1 or Th17 responses. Intracellular targets, such as signaling molecules in the JAK/STAT pathway, or a variety of kinases and proteasomes, can cause a cascading downstream effect of transcriptional responses that are important in SLE. Immune homeostasis can also be restored by bolstering the naturally occurring anti-inflammatory mechanisms. Glucocorticoid, as a potent natural anti-inflammatory hormone, can mediate its effects by recruiting histone deacetylase that serve to repress gene transcription. Glucocorticoid-induced leucine zipper is a gene upregulated by glucocorticoid that can be a potential target for development of anti-inflammatory strategy. Finally, T regulatory cells can be utilized to help restore to immune tolerance and are amongst the latest focus of therapeutic development in SLE.
Autoimmune Diseases
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Author : Munther A Khamashta
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-05-26
Autoimmune Diseases written by Munther A Khamashta and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-26 with Medical categories.
Autoimmune Diseases: Acute and Complex Situations provides a detailed overview of conditions associated with autoimmune diseases that are considered either life-threatening or requiring complex management. These include abdominal pain, arthritis, cutaneous ulcers, gastrointestinal hemorrhage, epilepsy, pancreatitis, stroke and white-matter CNS lesions. Autoimmune Diseases: Acute and Complex Situations addresses the latest clinical and immunological prognostic factors that may help to identify patients at higher risk of developing potentially life-threatening involvement. This book comprehensively helps the reader to diagnose these patients, in whom an early therapeutic approach is essential. Autoimmune Diseases: Acute and Complex Situations is a valuable reference tool for rheumatologists, internists, immunologists, and all the specialists involved in the multidisciplinary care of patient with rheumatic and systemic autoimmune diseases.
Complex Scenarios Of Drug Resistant Epilepsies Diagnostic Challenges And Novel Therapeutic Options
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Author : Giuseppe Didato
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-25
Complex Scenarios Of Drug Resistant Epilepsies Diagnostic Challenges And Novel Therapeutic Options written by Giuseppe Didato and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-25 with Medical categories.
Registries For Evaluating Patient Outcomes
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Author : Agency for Healthcare Research and Quality/AHRQ
language : en
Publisher: Government Printing Office
Release Date : 2014-04-01
Registries For Evaluating Patient Outcomes written by Agency for Healthcare Research and Quality/AHRQ and has been published by Government Printing Office this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-01 with Medical categories.
This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.
Polymyositis And Dermatomyositis
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Author : Marinos C Dalakas
language : en
Publisher: Butterworth-Heinemann
Release Date : 2013-10-22
Polymyositis And Dermatomyositis written by Marinos C Dalakas and has been published by Butterworth-Heinemann this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Health & Fitness categories.
Polymyositis and Dermatomyositis provides extensive information regarding Polymyositis and Dermatomyositis (PM/DM), which is described as a heterogeneous disease complex. This book is divided into four sections: Part I (Clinical Features) covers the classification of PM/DM, details of the clinical presentation, and the disease's association with the other connective tissue disorders and malignancies. Part II (Etiology and Mechanisms) covers advances in the immunopathology and viral etiology of PM/DM along with a frequently recognized entity: inclusion body myositis. Part III (Diagnosis and Treatment) covers the histologic, muscle enzyme histochemical, electron microscopic, and resin histology features of PM/DM along with those electromyographic features that could help make a more accurate diagnosis. Part IV (Overview) summarizes the issues that may not have been clear and highlights differing and unsettled views or present available data. This text is directed to clinicians in private practice or in academic institutions concerned with PM/DM patients, including neurologists, rheumatologists, pediatricians, dermatologists, physiatrists, and neuromuscular investigators. This book is intended as well for neuromuscular pathologists who interpret muscle biopsy specimens and electromyographers who perform EMG studies to help determine the clinical diagnosis. Researchers in immunology and immunopathology of neuromuscular diseases will find discussions in this book invaluable.
Adrenal Gland Q A
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Author : Ahmed Bayouda
language : en
Publisher: Ahmed Bayouda
Release Date : 2024-06-14
Adrenal Gland Q A written by Ahmed Bayouda and has been published by Ahmed Bayouda this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-14 with Health & Fitness categories.
Discover the secrets of your body's stress handlers with "Adrenal Gland Q&A" by Ahmed Bayouda. This comprehensive guide delves into the fascinating world of the adrenal glands, offering a wealth of knowledge in a reader-friendly question-and-answer format. Whether you're a medical student, healthcare professional, or simply someone interested in the marvels of human biology, this ebook is your go-to resource for understanding the adrenal glands and their crucial role in maintaining overall health. In "Adrenal Gland Q&A" you'll find clear, concise explanations of complex medical concepts, making it accessible for readers at all levels. From the anatomy and function of the adrenal glands to the hormones they produce and the conditions that can affect them, this ebook covers it all. Learn about Addison's disease, Cushing's syndrome, adrenal tumors, and more, with in-depth discussions on their causes, symptoms, and treatments. Why choose "Adrenal Gland Q&A"? Comprehensive Coverage: Explore every aspect of adrenal gland function and health in detail. Easy Navigation: The Q&A format allows you to quickly find answers to your specific questions. Clear and Concise: Complex medical concepts are explained in straightforward language. Valuable Resource: Ideal for students, professionals, and health enthusiasts alike. Join the countless readers who have already benefited from this insightful and educational guide. Enhance your knowledge, support your studies, or simply satisfy your curiosity with "Adrenal Gland Q&A" by Ahmed Bayouda. Available now, Don't miss out—get your copy today and embark on a journey to better understand the vital role of the adrenal glands in your health and well-being.
Primary Immunodeficiency Diseases
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Author : Hans D. Ochs,
language : en
Publisher: Oxford University Press
Release Date : 2013-09
Primary Immunodeficiency Diseases written by Hans D. Ochs, and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09 with Health & Fitness categories.
This third edition of Primary Immunodeficiency Diseases provides readers with the historic and scientific background, clinical presentations, immunologic characteristics, and the molecular/genetic underpinnings of this rapidly enlarging class of diseases.