Direct Methods For Solving Macromolecular Structures
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Direct Methods For Solving Macromolecular Structures
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Author : S. Fortier
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Direct Methods For Solving Macromolecular Structures written by S. Fortier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
This book of the proceedings of the 1997 NATO Advanced Study Institute (ASI) on Direct Methods for Solving Macromolecular Structures was assembled from the lecturers' contributions and represents a comprehensive and in-depth overview of crystallographic structure determination methods for macromolecules. While having a focus based on the direct methods, the Institute adopted an inclusive and broad perspective. Thus, both direct and experimental phasing techniques are presented in this book, highlighting their complementarities and synergies. As weil, methodologies spanning the full crystallographic image reconstruction process - from low resolution envelope definition to high resolution atomic refinement- are discussed. The first part of the book introduces the array of tools currently used in structure determination, whether originating from a mathematical, computational or experimental framework. This section of the book displays the variety and ingenuity of old and new phasing approaches developed to solve increasingly complex structures. Some of the contributions focus on recent developments and/or implementations that have given older approaches a new life. A case in point is the re-implementation of Buerger's superposition approach, which is now solving protein structures. Another beautiful example is found in the introduction to the traditional multiple isomorphous replacement approach where new techniques, such as site-directed mutagenesis and the use of inert gases in the preparation of heavy atom derivatives, are described. Equally impressive are the presentations of newer approaches, which take advantage of advances on the experimental front (e. g.
Methods In Macromolecular Crystallography
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Author : North Atlantic Treaty Organization. Scientific Affairs Division
language : en
Publisher: IOS Press
Release Date : 2001
Methods In Macromolecular Crystallography written by North Atlantic Treaty Organization. Scientific Affairs Division and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Science categories.
This volume contains 20 papers from two courses ("Methods for Macromolecular Crystallography" and "Chemical Prospective in Crystallography of Molecular Biology") held during the late spring of 2000 in Reice, Italy. The papers discuss crystals, synchrotrons, detector development, data processing, ab initio phasing and high and low resolution, molecular placement, experimental phase measurement, density modification methods, map improvements, interpretation of electron density maps, automatic structure determination, and the dissection of ultra-high resolution structures. c. Book News Inc.
Understanding Single Crystal X Ray Crystallography
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Author : Dennis W. Bennett
language : en
Publisher: John Wiley & Sons
Release Date : 2010-03-08
Understanding Single Crystal X Ray Crystallography written by Dennis W. Bennett and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-08 with Science categories.
The first textbook for teaching this method to users with little mathematical background logically presents the theory and fundamentals in an easily comprehensible, self-contained way. The result is a must-have for advanced undergraduate students, as well as masters and graduate students and other users of single-crystal X-ray crystallography from many various disciplines.
Structure Determination From Powder Diffraction Data
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Author : W. I. F. David
language : en
Publisher: OUP Oxford
Release Date : 2006-08-03
Structure Determination From Powder Diffraction Data written by W. I. F. David and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-03 with Science categories.
The art of solving a structure from powder diffraction data has developed rapidly over the last ten years to the point where numerous crystal structures, both organic and inorganic, have been solved directly from powder data. However, it is still an art and, in contrast to its single crystal equivalent, is far from routine. The art lies not only in the correct application of a specific experimental technique or computer program, but also in the selection of the optimal path for the problem at hand. Written and edited by experts active in the field, and covering both the fundamental and applied aspects of structure solution from powder diffraction data, this book guides both novices and experienced practitioners alike through the maze of possibilities.
Advancing Methods For Biomolecular Crystallography
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Author : Randy Read
language : en
Publisher: Springer
Release Date : 2013-04-03
Advancing Methods For Biomolecular Crystallography written by Randy Read and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-03 with Science categories.
This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web. Methods driving the latest automated structure determination pipelines are explained, as well as how to deal with problems such as crystal pathologies that still demand expert analysis. These methods are illustrated through their application to problems of great biological interest, such as the molecular machinery underlying the complement pathway, the mechanism of action of monoamine oxidase inhibitors, and the structure of the eukaryotic ribosome. Complementary approaches, such as neutron diffraction, small angle X-ray scattering, coherent diffraction and computational modelling, are also explored.
Advances In Imaging And Electron Physics
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Author : Peter W. Hawkes
language : en
Publisher: Elsevier
Release Date : 2005-06-15
Advances In Imaging And Electron Physics written by Peter W. Hawkes and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-15 with Technology & Engineering categories.
Advances in Imaging and Electron Physics merges two long-running serials-Advances in Electronics and Electron Physics and Advances in Optical and Electron Microscopy. This series features extended articles on the physics of electron devices (especially semiconductor devices), particle optics at high and low energies, microlithography, image science and digital image processing, electromagnetic wave propagation, electron microscopy, and the computing methods used in all these domains.
Modern Protein Chemistry
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Author : Gary C. Howard
language : en
Publisher: CRC Press
Release Date : 2001-09-12
Modern Protein Chemistry written by Gary C. Howard and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-09-12 with Medical categories.
In recent years, interest in proteins has surged. This resurgence has been driven by the expansion of the post-genomic era when structural genomics and proteomics require new techniques in protein chemistry and new applications of older techniques. Protein chemistry methods are used by nearly every discipline of biomedical research. Many techniques
Stereodynamics Of Molecular Systems
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Author : Ramaswamy H. Sarma
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Stereodynamics Of Molecular Systems written by Ramaswamy H. Sarma and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.
Stereodynamics of Molecular Systems covers the proceedings of a symposium held at the State University of New York at Albany, on 23-24 April 1979. The book focuses on the stereodynamics of molecules and ions and nucleic acid structure. The contributions tackle spectroscopy, crystallography, perturbations, and electron-transfer reactions. The selection first offers information on nuclear magnetic resonance spectroscopy chemical shifts, coupling constants, and molecular geometry, including chemical shifts, bond coupling constants, and constitutional features of nucleic acids. The book then takes a look at nuclear magnetic resonance spectroscopy stereodynamics of small molecules; nuclear magnetic resonance spectroscopy solution dynamics of polymer chains; and single crystal crystallography. The publication evaluates the steric effects on electron-transfer reactions of sulfonamides; effects of isotopic perturbation on NMR spectra; and conformational mobility of the backbone of cyclic tripeptides. The book also discusses accessible surface areas of nucleic acids and their relation to folding, conformational transition, and protein recognition. Topics include polarity of exposed atoms, surface of DNA double helices, transfer RNA, and calculation of “static“ accessible surface area. The selection is a dependable reference for readers interested in the stereodynamics of molecules and ions and nucleic acid structure.
X Ray And Neutron Dynamical Diffraction
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Author : André Authier
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
X Ray And Neutron Dynamical Diffraction written by André Authier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This volume collects the proceedings of the 23rd International Course of Crystallography, entitled "X-ray and Neutron Dynamical Diffraction, Theory and Applications," which took place in the fascinating setting of Erice in Sicily, Italy. It was run as a NATO Advanced Studies Institute with A. Authier (France) and S. Lagomarsino (Italy) as codirectors, and L. Riva di Sanseverino and P. Spadon (Italy) as local organizers, R. Colella (USA) and B. K. Tanner (UK) being the two other members of the organizing committee. It was attended by about one hundred participants from twenty four different countries. Two basic theories may be used to describe the diffraction of radiation by crystalline matter. The first one, the so-called geometrical, or kinematical theory, is approximate and is applicable to small, highly imperfect crystals. It is used for the determination of crystal structures and describes the diffraction of powders and polycrystalline materials. The other one, the so-called dynamical theory, is applicable to perfect or nearly perfect crystals. For that reason, dynamical diffraction of X-rays and neutrons constitutes the theoretical basis of a great variety of applications such as: • the techniques used for the characterization of nearly perfect high technology materials, semiconductors, piezoelectric, electrooptic, ferroelectric, magnetic crystals, • the X-ray optical devices used in all modem applications of Synchrotron Radiation (EXAFS, High Resolution X-ray Diffractometry, magnetic and nuclear resonant scattering, topography, etc. ), and • X-ray and neutron interferometry.
X Ray Free Electron Lasers
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Author : Sébastien Boutet
language : en
Publisher: Springer
Release Date : 2018-12-27
X Ray Free Electron Lasers written by Sébastien Boutet and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-27 with Technology & Engineering categories.
The timely volume describes recent discoveries and method developments that have revolutionized Structural Biology with the advent of X-ray Free Electron Lasers. It provides, for the first time, a comprehensive examination of this cutting-edge technology. It discusses of-the-moment topics such as growth and detection of nanocrystals, Sample Delivery Techniques for serial femtosecond crystallography, data collection methods at XFELs, and more. This book aims to provide the readers with an overview of the new methods that have been recently developed as well as a prospective on new methods under development. It highlights the most important and novel Structural Discoveries made recently with XFELS, contextualized with a big-picture discussion of future developments.