Direct Methods For Solving Macromolecular Structures
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Direct Methods For Solving Macromolecular Structures
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Author : S. Fortier
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Direct Methods For Solving Macromolecular Structures written by S. Fortier and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
This book of the proceedings of the 1997 NATO Advanced Study Institute (ASI) on Direct Methods for Solving Macromolecular Structures was assembled from the lecturers' contributions and represents a comprehensive and in-depth overview of crystallographic structure determination methods for macromolecules. While having a focus based on the direct methods, the Institute adopted an inclusive and broad perspective. Thus, both direct and experimental phasing techniques are presented in this book, highlighting their complementarities and synergies. As weil, methodologies spanning the full crystallographic image reconstruction process - from low resolution envelope definition to high resolution atomic refinement- are discussed. The first part of the book introduces the array of tools currently used in structure determination, whether originating from a mathematical, computational or experimental framework. This section of the book displays the variety and ingenuity of old and new phasing approaches developed to solve increasingly complex structures. Some of the contributions focus on recent developments and/or implementations that have given older approaches a new life. A case in point is the re-implementation of Buerger's superposition approach, which is now solving protein structures. Another beautiful example is found in the introduction to the traditional multiple isomorphous replacement approach where new techniques, such as site-directed mutagenesis and the use of inert gases in the preparation of heavy atom derivatives, are described. Equally impressive are the presentations of newer approaches, which take advantage of advances on the experimental front (e. g.
Methods In Macromolecular Crystallography
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Author : North Atlantic Treaty Organization. Scientific Affairs Division
language : en
Publisher: IOS Press
Release Date : 2001
Methods In Macromolecular Crystallography written by North Atlantic Treaty Organization. Scientific Affairs Division and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Science categories.
This volume contains 20 papers from two courses ("Methods for Macromolecular Crystallography" and "Chemical Prospective in Crystallography of Molecular Biology") held during the late spring of 2000 in Reice, Italy. The papers discuss crystals, synchrotrons, detector development, data processing, ab initio phasing and high and low resolution, molecular placement, experimental phase measurement, density modification methods, map improvements, interpretation of electron density maps, automatic structure determination, and the dissection of ultra-high resolution structures. c. Book News Inc.
Macromolecular Crystallography
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Author : Charles W. Carter
language : en
Publisher: Gulf Professional Publishing
Release Date : 1997
Macromolecular Crystallography written by Charles W. Carter and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Computer simulation categories.
Annotation Accurate molecular structures is vital for rational drug design and for structure based functional studies directed toward the development of effective therapeutic agents and drugs. Crystallography can reliably predict structure, both in terms of folding and atomic details of bonding. * Phases * Map interpretation and refinement * Analysis and software.
International Tables For Crystallography Volume B
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Author : Uri Shmueli
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-08-27
International Tables For Crystallography Volume B written by Uri Shmueli and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-27 with Science categories.
International Tables for Crystallography are no longer available for purchase from Springer. For further information please contact Wiley Inc. (follow the link on the right hand side of this page). Volume B presents accounts of the numerous aspects of reciprocal space in crystallographic research. After an introductory chapter, Part 1 presents the reader with an account of structure-factor formalisms, an extensive treatment of the theory, algorithms and crystallographic applications of Fourier methods, and fundamental as well as advanced treatments of symmetry in reciprocal space. In Part 2, these general accounts are followed by detailed expositions of crystallographic statistics, the theory of direct methods, Patterson techniques, isomorphous replacement and anomalous scattering, and treatments of the role of electron microscopy and diffraction in crystal structure determination, including applications of direct methods to electron crystallography. Part 3 deals with applications of reciprocal space to molecular geometry and `best'-plane calculations, and contains a treatment of the principles of molecular graphics and modelling and their applications. A convergence-acceleration method of importance in the computation of approximate lattice sums is presented and the part concludes with a discussion of the Ewald method. Part 4 contains treatments of various diffuse-scattering phenomena arising from crystal dynamics, disorder and low dimensionality (liquid crystals), and an exposition of the underlying theories and/or experimental evidence. Polymer crystallography and reciprocal-space images of aperiodic crystals are also treated. Part 5 of the volume contains introductory treatments of the theory of the interaction of radiation with matter (dynamical theory) as applied to X-ray, electron and neutron diffraction techniques. The simplified trigonometric expressions for the structure factors in the 230 three-dimensional space groups, which appeared in Volume I of International Tables for X-ray Crystallography, are now given in Appendix 1.4.3 to Chapter 1.4 of this volume. Volume B is a vital addition to the library of scientists engaged in crystal structure determination, crystallographic computing, crystal physics and other fields of crystallographic research. Graduate students specializing in crystallography will find much material suitable for self-study and a rich source of references to the relevant literature.
Direct Methods Of Solving Crystal Structures
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Author : Henk Schenk
language : en
Publisher: Springer
Release Date : 1991
Direct Methods Of Solving Crystal Structures written by Henk Schenk and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Science categories.
Proceedings of the 18th course of the International School of Crystallography, held April 1990, in Erice, Italy. Annotation copyrighted by Book News, Inc., Portland, OR
Macromolecular Crystallography
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Author : Mark R. Sanderson
language : en
Publisher: OUP Oxford
Release Date : 2007-08-23
Macromolecular Crystallography written by Mark R. Sanderson and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-23 with Science categories.
Macromolecular Crystallography is the study of macromolecules (proteins and nucleic acids) using X-ray crystallographic techniques in order to determine their molecular structure. The knowledge of accurate molecular structures is a pre-requisite for rational drug design, and for structure-based function studies to aid the development of effective therapeutic agents and drugs. The successful determination of the complete genome (genetic sequence) of several species (including humans) has recently directed scientific attention towards identifying the structure and function of the complete complement of proteins that make up that species; a new and rapidly growing field of study called 'structural genomics'. There are now several important and well-funded global initiatives in operation to identify all of the proteins of key model species. One of the main requirements for these initiatives is a high-throughput crystallization facility to speed-up the protein identification process. The extent to which these technologies have advanced, calls for an updated review of current crystallographic theory and practice. This practical reference book features the latest conventional and high-throughput methods, and includes contributions from a team of internationally recognized leaders and experts. It will be of relevance and use to graduate students, research scientists and professionals currently working in the field of conventional and high-throughput macromolecular crystallography.
Fundamentals Of Molecular Structural Biology
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Author : Subrata Pal
language : en
Publisher: Academic Press
Release Date : 2019-08-13
Fundamentals Of Molecular Structural Biology written by Subrata Pal and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-13 with Science categories.
Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology. Based on these fundamental concepts, it then describes molecular structure and explains basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them up-to-speed on the foundations of a particular field. This book fills that niche. Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advances Addresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biology Presents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease
Advancing Methods For Biomolecular Crystallography
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Author : Randy Read
language : en
Publisher: Springer
Release Date : 2013-04-03
Advancing Methods For Biomolecular Crystallography written by Randy Read and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-03 with Science categories.
This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web. Methods driving the latest automated structure determination pipelines are explained, as well as how to deal with problems such as crystal pathologies that still demand expert analysis. These methods are illustrated through their application to problems of great biological interest, such as the molecular machinery underlying the complement pathway, the mechanism of action of monoamine oxidase inhibitors, and the structure of the eukaryotic ribosome. Complementary approaches, such as neutron diffraction, small angle X-ray scattering, coherent diffraction and computational modelling, are also explored.
Modern Protein Chemistry
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Author : Gary C. Howard
language : en
Publisher: CRC Press
Release Date : 2001-09-12
Modern Protein Chemistry written by Gary C. Howard and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-09-12 with Medical categories.
In recent years, interest in proteins has surged. This resurgence has been driven by the expansion of the post-genomic era when structural genomics and proteomics require new techniques in protein chemistry and new applications of older techniques. Protein chemistry methods are used by nearly every discipline of biomedical research. Many techniques
Comprehensive Natural Products Iii
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Author :
language : en
Publisher: Elsevier
Release Date : 2020-07-22
Comprehensive Natural Products Iii written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-22 with Science categories.
Comprehensive Natural Products III, Third Edition, Seven Volume Set updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community. Provides readers with an in-depth review of current natural products research and a critical insight into the future direction of the field Bridges the gap in knowledge by covering developments in the field since the second edition published in 2010 Split into 7 sections on key topics to allow students, researchers and professionals to find relevant information quickly and easily Ensures that the knowledge within is easily understood by and applicable to a large audience