Discovering Molecular Genetics
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Discovering Molecular Genetics
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Author : Jeffrey H. Miller
language : en
Publisher: CSHL Press
Release Date : 1996
Discovering Molecular Genetics written by Jeffrey H. Miller and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Molecular genetics categories.
Landmark Experiments In Molecular Biology
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Author : Michael Fry
language : en
Publisher: Academic Press
Release Date : 2016-06-10
Landmark Experiments In Molecular Biology written by Michael Fry and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-10 with Science categories.
Landmark Experiments in Molecular Biology critically considers breakthrough experiments that have constituted major turning points in the birth and evolution of molecular biology. These experiments laid the foundations to molecular biology by uncovering the major players in the machinery of inheritance and biological information handling such as DNA, RNA, ribosomes, and proteins. Landmark Experiments in Molecular Biology combines an historical survey of the development of ideas, theories, and profiles of leading scientists with detailed scientific and technical analysis. - Includes detailed analysis of classically designed and executed experiments - Incorporates technical and scientific analysis along with historical background for a robust understanding of molecular biology discoveries - Provides critical analysis of the history of molecular biology to inform the future of scientific discovery - Examines the machinery of inheritance and biological information handling
Molecular Genetic And Statistical Techniques For Behavioral And Neural Research
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Author : Robert T. Gerlai
language : en
Publisher: Academic Press
Release Date : 2018-04-24
Molecular Genetic And Statistical Techniques For Behavioral And Neural Research written by Robert T. Gerlai and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-24 with Science categories.
Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. - Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials - Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior - Written and edited by leading international experts
Models Of Discovery And Creativity
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Author : Joke Meheus
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-08
Models Of Discovery And Creativity written by Joke Meheus and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-08 with Science categories.
Since the origin of the modern sciences, our views on discovery and creativity had a remarkable history. Originally, discovery was seen as an integral part of methodology and the logic of discovery as algorithmic or nearly algorithmic. During the nineteenth century, conceptions in line with romanticism led to the famous opposition between the context of discovery and the context of justification, culminating in a view that banned discovery from methodology. The revival of the methodological investigation of discovery, which started some thirty years ago, derived its major impetus from historical and sociological studies of the sciences and from developments within cognitive psychology and artificial intelligence. Today, a large majority of philosophers of science agrees that the classical conception as well as the romantic conception are mistaken. Against the classical conception, it is generally accepted that truly novel discoveries are not the result of simply applying some standardized procedure. Against the romantic conception, it is rejected that discoveries are produced by unstructured flashes of insight. An especially important result of the contemporary study concerns the availability of (descriptive and normative) models for explaining discoveries and creative processes. Descriptive models mainly aim at explaining the origin of novel products; normative models moreover address the question how rational researchers should proceed when confronted with problems for which a standard procedure is missing. The present book provides an overview of these models and of the important changes they induced within methodology. As appears from several papers, the methodological study of discovery and creativity led to profound changes in our conceptions of justification and acceptance, of rationality, of scientific change, and of conceptual change. The book contains contributions from both historians and philosophers of science. All of them, however, are methodological in the contemporary sense of the term. The central values of this methodology are empirical accurateness, clarity and precision, and rationality. The different contributions realize these values by their interdisciplinary nature. Some philosophically oriented papers rely on historical case studies and results from the cognitive sciences, others on recent results from the computer sciences and/or non-standard logics. The historically oriented papers address central philosophical questions and hypotheses.
Biotherapeutics
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Author : Lyn H. Jones
language : en
Publisher: Royal Society of Chemistry
Release Date : 2013
Biotherapeutics written by Lyn H. Jones and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
Biotherapeutics are often considered to be beyond the reach of the medicinal chemist, but this book demonstrates that chemistry has an essential role in the future success of this area.
Discovery And Explanation In Biology And Medicine
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Author : Kenneth F. Schaffner
language : en
Publisher: University of Chicago Press
Release Date : 1993
Discovery And Explanation In Biology And Medicine written by Kenneth F. Schaffner and has been published by University of Chicago Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
Kenneth F. Schaffner compares the practice of biological and medical research and shows how traditional topics in philosophy of science—such as the nature of theories and of explanation—can illuminate the life sciences. While Schaffner pays some attention to the conceptual questions of evolutionary biology, his chief focus is on the examples that immunology, human genetics, neuroscience, and internal medicine provide for examinations of the way scientists develop, examine, test, and apply theories. Although traditional philosophy of science has regarded scientific discovery—the questions of creativity in science—as a subject for psychological rather than philosophical study, Schaffner argues that recent work in cognitive science and artificial intelligence enables researchers to rationally analyze the nature of discovery. As a philosopher of science who holds an M.D., he has examined biomedical work from the inside and uses detailed examples from the entire range of the life sciences to support the semantic approach to scientific theories, addressing whether there are "laws" in the life sciences as there are in the physical sciences. Schaffner's novel use of philosophical tools to deal with scientific research in all of its complexity provides a distinctive angle on basic questions of scientific evaluation and explanation.
The Blueprint Of Life Exploring Dna And Genetic Innovations
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Author : Dr. Ruchita Tripath
language : en
Publisher: Chyren Publication
Release Date : 2025-01-17
The Blueprint Of Life Exploring Dna And Genetic Innovations written by Dr. Ruchita Tripath and has been published by Chyren Publication this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-17 with Antiques & Collectibles categories.
Molecular Pharmacology
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Author : John Dickenson
language : en
Publisher: John Wiley & Sons
Release Date : 2012-11-30
Molecular Pharmacology written by John Dickenson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-30 with Medical categories.
This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.
Chemoinformatics
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Author : Jürgen Bajorath
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Chemoinformatics written by Jürgen Bajorath and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Medical categories.
In the literature, several terms are used synonymously to name the topic of this book: chem-, chemi-, or chemo-informatics. A widely recognized de- nition of this discipline is the one by Frank Brown from 1998 (1) who defined chemoinformatics as the combination of “all the information resources that a scientist needs to optimize the properties of a ligand to become a drug. ” In Brown’s definition, two aspects play a fundamentally important role: de- sion support by computational means and drug discovery, which distinguishes it from the term “chemical informatics” that was introduced at least ten years earlier and described as the application of information technology to ch- istry (not with a specific focus on drug discovery). In addition, there is of course “chemometrics,” which is generally understood as the application of statistical methods to chemical data and the derivation of relevant statistical models and descriptors (2). The pharmaceutical focus of many developments and efforts in this area—and the current popularity of gene-to-drug or si- lar paradigms—is further reflected by the recent introduction of such terms as “discovery informatics” (3), which takes into account that gaining kno- edge from chemical data alone is not sufficient to be ultimately successful in drug discovery. Such insights are well in accord with other views that the boundaries between bio- and chemoinformatics are fluid and that these d- ciplines should be closely combined or merged to significantly impact b- technology or pharmaceutical research (4).
Computational Drug Discovery
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Author : Pooja A. Chawla
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2024-10-07
Computational Drug Discovery written by Pooja A. Chawla and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-07 with Science categories.
Computational methods and understanding computational models are important in modern drug discovery. The book focuses on computational approaches that can improve the development of in silico methodologies. It includes lead hit methods, docking algorithms, computational chiral compounds, structure-based drug design, GROMACS and NAMD, structural genomics, toxicity prediction, enzyme inhibitors and peptidomimetic therapeutics