Discriminative Pattern Discovery On Biological Networks
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Discriminative Pattern Discovery On Biological Networks
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Author : Fabio Fassetti
language : en
Publisher: Springer
Release Date : 2017-09-01
Discriminative Pattern Discovery On Biological Networks written by Fabio Fassetti and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-01 with Computers categories.
This work provides a review of biological networks as a model for analysis, presenting and discussing a number of illuminating analyses. Biological networks are an effective model for providing insights about biological mechanisms. Networks with different characteristics are employed for representing different scenarios. This powerful model allows analysts to perform many kinds of analyses which can be mined to provide interesting information about underlying biological behaviors. The text also covers techniques for discovering exceptional patterns, such as a pattern accounting for local similarities and also collaborative effects involving interactions between multiple actors (for example genes). Among these exceptional patterns, of particular interest are discriminative patterns, namely those which are able to discriminate between two input populations (for example healthy/unhealthy samples). In addition, the work includes a discussion on the most recent proposal on discovering discriminative patterns, in which there is a labeled network for each sample, resulting in a database of networks representing a sample set. This enables the analyst to achieve a much finer analysis than with traditional techniques, which are only able to consider an aggregated network of each population.
Exploiting The Power Of Group Differences
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Author : Guozhu Dong
language : en
Publisher: Springer Nature
Release Date : 2022-05-31
Exploiting The Power Of Group Differences written by Guozhu Dong and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-31 with Computers categories.
This book presents pattern-based problem-solving methods for a variety of machine learning and data analysis problems. The methods are all based on techniques that exploit the power of group differences. They make use of group differences represented using emerging patterns (aka contrast patterns), which are patterns that match significantly different numbers of instances in different data groups. A large number of applications outside of the computing discipline are also included. Emerging patterns (EPs) are useful in many ways. EPs can be used as features, as simple classifiers, as subpopulation signatures/characterizations, and as triggering conditions for alerts. EPs can be used in gene ranking for complex diseases since they capture multi-factor interactions. The length of EPs can be used to detect anomalies, outliers, and novelties. Emerging/contrast pattern based methods for clustering analysis and outlier detection do not need distance metrics, avoiding pitfalls of the latter in exploratory analysis of high dimensional data. EP-based classifiers can achieve good accuracy even when the training datasets are tiny, making them useful for exploratory compound selection in drug design. EPs can serve as opportunities in opportunity-focused boosting and are useful for constructing powerful conditional ensembles. EP-based methods often produce interpretable models and results. In general, EPs are useful for classification, clustering, outlier detection, gene ranking for complex diseases, prediction model analysis and improvement, and so on. EPs are useful for many tasks because they represent group differences, which have extraordinary power. Moreover, EPs represent multi-factor interactions, whose effective handling is of vital importance and is a major challenge in many disciplines. Based on the results presented in this book, one can clearly say that patterns are useful, especially when they are linked to issues of interest. We believe that many effective ways to exploit group differences' power still remain to be discovered. Hopefully this book will inspire readers to discover such new ways, besides showing them existing ways, to solve various challenging problems.
Biological Pattern Discovery With R Machine Learning Approaches
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Author : Zheng Rong Yang
language : en
Publisher: World Scientific
Release Date : 2021-09-17
Biological Pattern Discovery With R Machine Learning Approaches written by Zheng Rong Yang and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-17 with Science categories.
This book provides the research directions for new or junior researchers who are going to use machine learning approaches for biological pattern discovery. The book was written based on the research experience of the author's several research projects in collaboration with biologists worldwide. The chapters are organised to address individual biological pattern discovery problems. For each subject, the research methodologies and the machine learning algorithms which can be employed are introduced and compared. Importantly, each chapter was written with the aim to help the readers to transfer their knowledge in theory to practical implementation smoothly. Therefore, the R programming environment was used for each subject in the chapters. The author hopes that this book can inspire new or junior researchers' interest in biological pattern discovery using machine learning algorithms.
Computational Knowledge Discovery For Bioinformatics Research
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Author : Li, Xiao-Li
language : en
Publisher: IGI Global
Release Date : 2012-06-30
Computational Knowledge Discovery For Bioinformatics Research written by Li, Xiao-Li and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-30 with Medical categories.
"This book discusses the most significant research and latest practices in computational knowledge discovery approaches to bioinformatics in a cross-disciplinary manner that is useful for researchers, practitioners, academicians, mathematicians, statisticians, and computer scientists involved in the many facets of bioinformatics"--
Proteomics For Biological Discovery
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Author : Timothy D. Veenstra
language : en
Publisher: John Wiley & Sons
Release Date : 2006-06-12
Proteomics For Biological Discovery written by Timothy D. Veenstra and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-12 with Science categories.
Written by recognized experts in the study of proteins, Proteomics for Biological Discovery begins by discussing the emergence of proteomics from genome sequencing projects and a summary of potential answers to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are then dealt with in terms of underlying concepts, limitations and future directions. An invaluable source of information, this title also provides a thorough overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, microfabrication, applied proteomics, and bioinformatics relevant to proteomics. Presents a comprehensive and coherent review of the major issues faced in terms of technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Accessible to the novice while providing experienced investigators essential information Proteomics for Biological Discovery is an essential resource for students, postdoctoral fellows, and researchers across all fields of biomedical research, including biochemistry, protein chemistry, molecular genetics, cell/developmental biology, and bioinformatics.
Pattern Recognition In Computational Molecular Biology
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Author : Mourad Elloumi
language : en
Publisher: John Wiley & Sons
Release Date : 2015-11-30
Pattern Recognition In Computational Molecular Biology written by Mourad Elloumi and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-30 with Technology & Engineering categories.
A comprehensive overview of high-performance pattern recognition techniques and approaches to Computational Molecular Biology This book surveys the developments of techniques and approaches on pattern recognition related to Computational Molecular Biology. Providing a broad coverage of the field, the authors cover fundamental and technical information on these techniques and approaches, as well as discussing their related problems. The text consists of twenty nine chapters, organized into seven parts: Pattern Recognition in Sequences, Pattern Recognition in Secondary Structures, Pattern Recognition in Tertiary Structures, Pattern Recognition in Quaternary Structures, Pattern Recognition in Microarrays, Pattern Recognition in Phylogenetic Trees, and Pattern Recognition in Biological Networks. Surveys the development of techniques and approaches on pattern recognition in biomolecular data Discusses pattern recognition in primary, secondary, tertiary and quaternary structures, as well as microarrays, phylogenetic trees and biological networks Includes case studies and examples to further illustrate the concepts discussed in the book Pattern Recognition in Computational Molecular Biology: Techniques and Approaches is a reference for practitioners and professional researches in Computer Science, Life Science, and Mathematics. This book also serves as a supplementary reading for graduate students and young researches interested in Computational Molecular Biology.
Applications Of Synthetic Biology In Health Energy And Environment
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Author : Arshad, Muhammad
language : en
Publisher: IGI Global
Release Date : 2023-10-02
Applications Of Synthetic Biology In Health Energy And Environment written by Arshad, Muhammad and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-02 with Science categories.
The application of genetic engineering techniques by redesigning and repurposing biological systems for novel biotechnical applications has paved the way for the field of synthetic biology. This field boosted the evolution and discovery of various novel technologies essential to the conquest of biological problems related to health, disease, the environment, and energy. The field of synthetic biology is growing rapidly, and further research is required. Applications of Synthetic Biology in Health, Energy, and Environment deliberates on principles and the advancement of synthetic biology and their translation in the fields of health, disease, energy, and the environment. Covering topics such as climate change, bioremediation, and smart drugs, this premier reference source is an excellent resource for students and educators of higher education, industrialists, medical professionals, hospital administrators, policymakers, environmental scientists, pharmacists, librarians, researchers, and academicians.
New Frontiers Of Network Analysis In Systems Biology
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Author : Avi Ma'ayan
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-25
New Frontiers Of Network Analysis In Systems Biology written by Avi Ma'ayan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-25 with Medical categories.
The rapidly developing field of systems biology is influencing many aspects of biological research and is expected to transform biomedicine. Some emerging offshoots and specialized branches in systems biology are receiving particular attention and are becoming highly active areas of research. This collection of invited reviews describes some of the latest cutting-edge experimental and computational advances in these emerging sub-fields of systems biology. In particular, this collection focuses on the study of mammalian embryonic stem cells; new technologies involving mass-spectrometry proteomics; single cell measurements; methods for modeling complex stochastic systems; network-based classification algorithms; and the revolutionary emerging field of systems pharmacology.
Association Analysis Techniques And Applications In Bioinformatics
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Author : Qingfeng Chen
language : en
Publisher: Springer Nature
Release Date : 2024-04-25
Association Analysis Techniques And Applications In Bioinformatics written by Qingfeng Chen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-25 with Computers categories.
Advances in experimental technologies have given rise to tremendous amounts of biology data. This not only offers valuable sources of data to help understand biological evolution and functional mechanisms, but also poses challenges for accurate and effective data analysis. This book offers an essential introduction to the theoretical and practical aspects of association analysis, including data pre-processing, data mining methods/algorithms, and tools that are widely applied for computational biology. It covers significant recent advances in the field, both foundational and application-oriented, helping readers understand the basic principles and emerging techniques used to discover interesting association patterns in diverse and heterogeneous biology data, such as structure-function correlations, and complex networks with gene/protein regulation. The main results and approaches are described in an easy-to-follow way and accompanied by sufficientreferences and suggestions for future research. This carefully edited monograph is intended to provide investigators in the fields of data mining, machine learning, artificial intelligence, and bioinformatics with a profound guide to the role of association analysis in computational biology. It is also very useful as a general source of information on association analysis, and as an overall accompanying course book and self-study material for graduate students and researchers in both computer science and bioinformatics.
Networks In Cell Biology
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Author : Mark Buchanan
language : en
Publisher: Cambridge University Press
Release Date : 2010-05-13
Networks In Cell Biology written by Mark Buchanan and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-13 with Science categories.
Key introductory text for graduate students and researchers in physics, biology and biochemistry.