Disease Pathways
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Disease Pathways
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Author : Anastasia P. Nesterova
language : en
Publisher: Elsevier
Release Date : 2019-10-18
Disease Pathways written by Anastasia P. Nesterova and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-18 with Science categories.
Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. - Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. - Disease pathways are based on computational models from Elsevier's Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. - Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.
Gut Microbiota And Their Impact On Disease Pathways And Interventions
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Author : Sandipan Dasgupta, Moitreyee Chattopadhyay
language : en
Publisher: Bentham Science Publishers
Release Date : 2025-04-29
Gut Microbiota And Their Impact On Disease Pathways And Interventions written by Sandipan Dasgupta, Moitreyee Chattopadhyay and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-29 with Medical categories.
Gut Microbiota and their Impact on Disease Pathways and Interventions discusses the intricate world of gut microbiota and its profound influence on human health and disease. This comprehensive volume explores the microbiome's pivotal role in conditions ranging from obesity and cardiovascular disease to inflammatory bowel disease, diabetes, ocular diseases, and neurological disorders. It offers cutting-edge insights into therapeutic strategies such as probiotics, prebiotics, and fecal microbiota transplantation, alongside emerging approaches like gut microbial metabolites as diagnostic biomarkers. It serves as a vital resource for understanding and harnessing the role of gut health in disease prevention and management. Key Features: - Multidisciplinary approach integrating microbiology, medicine, and biotechnology. - Innovative treatment modalities including personalized medicine based on microbiome analysis. - Exploration of gut-brain, gut-heart, and gut-immune system interactions.
Advancing Genomics For Rare Disease Diagnosis And Therapy Development
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Author : Zhichao Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-08
Advancing Genomics For Rare Disease Diagnosis And Therapy Development written by Zhichao Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-08 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Rare Immune Mediated Diseases Novel Insights Into Underlying Mechanisms And Therapeutic Approaches
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Author : Yuval Tal
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-07
Rare Immune Mediated Diseases Novel Insights Into Underlying Mechanisms And Therapeutic Approaches written by Yuval Tal and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-07 with Medical categories.
Systems Genetics Of Human Complex Diseases Volume Ii
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Author : Guiyou Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-19
Systems Genetics Of Human Complex Diseases Volume Ii written by Guiyou Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-19 with Science categories.
Integrative Multi Omics For Diagnosis Treatments And Drug Discovery Of Aging Related Neuronal Diseases
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Author : Min Tang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-23
Integrative Multi Omics For Diagnosis Treatments And Drug Discovery Of Aging Related Neuronal Diseases written by Min Tang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-23 with Science categories.
As the cost of high-throughput sequencing goes down, huge volumes of biological and medical data have been produced from various sequencing platforms at multiple molecular levels including genome, transcriptome, proteome, epigenome, metabolome, and so on. For a long time, data analysis on single molecular levels has paved the way to answer many important research questions. However, many Aging-Related Neuronal Diseases (ARNDs) and Central Nervous System (CNS) aging involve interactions of molecules from multiple molecular levels, in which conclusions based on single molecular levels are usually incomplete and sometimes misleading. In these scenarios, multi-omics data analysis has unprecedentedly helped capture much more useful information for the diagnosis, treatment, prognosis, and drug discovery of ARNDs. The first step towards a multi-omics analysis is to establish reliable and robust multi-omics datasets. In the past years, a few important ARNDs-associated multi-omics databases like Allen Brain have been constructed, which raised immediate needs like data curation, normalization, interpretation, and visualization for integrative multi-omics explorations. Though there have been several well-established multi-omics databases for ARNDs like Alzheimer’s disease, similar databases for other ARNDs are still in urgent need. After the databases establish, many computational tools and experiential strategies should be developed specifically for them. First, the multi-omics data are usually extremely noisy, complex, heterogeneous and in high dimension, which presents the need for appropriate denoising and dimension reduction methods. Second, since the multi-omics and non-omics data like pathological and clinical data are usually in different data spaces, a useful algorithm to mapping them into the same data space and integrate them is nontrivial. In the multi-omics era, there are numerous data-centric tools for the integration of multi-omics datasets, which could be generally divided into three categories: unsupervised, supervised, and semi-supervised methods. Commonly used algorithms include but not limited to Bayesian-based methods, Network-based methods, multi-step analysis methods, and multiple kernel learning methods. Third, methods are needed in studying and verifying the association between two or more levels of multi-omics data and non-omics data. For example, expression quantitative trait loci (eQTL) analysis is widely used to infer the association between a single nucleotide polymorphism (SNP) and the expression of a gene. Recently, the association between omics data and more complex data like pathological and clinical imaging data has been a hot research topic. The outcomes may reveal the underlying molecular mechanism and promote de novo drug design as well as drug repurposing for ARNDs. Here, we welcome investigators to share their Original Research, Review, Mini Review, Hypothesis and Theory, Perspective, Conceptual Analysis, Data Report, Brief Research Report, Code related to multi-omics studies of ARNDs, which can be applied for better diagnosis, treatment, prognosis and drug discovery of human diseases in the future era of precision medicine. Potential contents include but are not limited to the following: ▪ Methods for integrating, interpreting, or visualizing two or more omics data. ▪ Methods for identifying interactions between different data modalities. ▪ Methods for disease subtyping, biomarker prediction. ▪ Machine learning or deep learning methods on dimensional reduction and feature selection for big noisy data. ▪ Methods for studying the association among different omics data or between omics and non-omics data like clinical, pathological, and imaging data. ▪ Review of multi-omics resource about ARNDs and/or CNS aging. ▪ Experimental validation of biomarkers identified from multi-omics data analysis. ▪ Disease diagnosis and prognosis prediction from imaging and non-imaging data analysis, or both. ▪ Clinical applications or validations of findings from multi-omics data analysis.
Biochips As Pathways To Drug Discovery
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Author : Gary Hardiman
language : en
Publisher: CRC Press
Release Date : 2006-10-19
Biochips As Pathways To Drug Discovery written by Gary Hardiman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-19 with Medical categories.
In the fiercely competitive pharmaceutical marketplace, your organization cannot afford to spend excess dollars developing drugs that will fail to get FDA approval or have profoundly poor characteristics. Biochips as Pathways to Drug Discovery takes a comprehensive look at how the industry faces these challenges, using new technologies such as bioc
Role Of Inflammation In Neurodegenerative Diseases
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Author : Maya Koronyo-Hamaoui
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-13
Role Of Inflammation In Neurodegenerative Diseases written by Maya Koronyo-Hamaoui and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-13 with Medical categories.
Precision Medicine And The Reinvention Of Human Disease
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Author : Jules J. Berman
language : en
Publisher: Academic Press
Release Date : 2018-01-15
Precision Medicine And The Reinvention Of Human Disease written by Jules J. Berman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-15 with Medical categories.
Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. - Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine - Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine - Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter - Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way - Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field
Creativity Innovation And Entrepreneurship In Healthcare And Service Systems
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Author : Fu-Sheng Tsai
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-30
Creativity Innovation And Entrepreneurship In Healthcare And Service Systems written by Fu-Sheng Tsai and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-30 with Medical categories.