Distinct Cell Guidance Pathways Control The Extension Of The Excretory Canals In C Elegans
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Distinct Cell Guidance Pathways Control The Extension Of The Excretory Canals In C Elegans
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Author : Nancy Marcus
language : en
Publisher:
Release Date : 2012
Distinct Cell Guidance Pathways Control The Extension Of The Excretory Canals In C Elegans written by Nancy Marcus and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Actin categories.
The excretory cell is the functional equivalent to the kidney in the nematode Caenorhabditis elegans, and provides an excellent in vivo model to study directional cell migration and extension. The leading edges of the growing canals resemble neuronal growth cones in that they must be able to sense and integrate directional cues in both the dorsoventral and anteroposterior axes. The cytoskeleton regulator UNC-53/NAV2 is required for both the anterior and posterior outgrowth of several neurons, as well as the excretory cell. UNC-53 and the Abelson kinase interactor (ABI-1) appear to function cell autonomously in the excretory canals to promote outgrowth, have overlapping expression patterns, and display similar cell migration phenotypes in the canals and mechanosensory neurons. Moreover, proteins known to function with abi-1 in actin dynamics, including members of the ARP2/3 complex exhibit similar excretory cell and neuronal outgrowth defects by RNAi, suggesting that UNC-53 may act as a scaffold that links ABI-1 to the ARP2/3 complex to regulate actin cytoskeleton remodelling. Genetic analysis of putative interactors of UNC-53 suggests that UNC-53 appears to function together with UNC-71/ADAM, while the kinesin-like motor VAB-8 appears to act in a separate pathway to control the posteriorly directed excretory canal outgrowth. Analysis of putative interactors of VAB-8 suggests that VAB-8, SAX-3/ROBO, SLT-1/Slit and EVA-1 are functioning together in the outgrowth of the excretory canals. The known VAB-8 interactor, the Rac/Rho GEF UNC-73/TRIO operates in both pathways, as isoform specific alleles exhibit enhancement of the phenotype in double mutant combination with either unc-53 or vab-8. Rescue experiments suggest that a cell autonomous pathway is mediated by the Rho specific GEF domain of the UNC-73E isoform in conjunction with UNC-53, UNC-71, and ABI-1, and a cell non-autonomous pathway is mediated by the Rac specific GEF domain of the UNC-73B isoform, through partnering with VAB-8 and the receptors SAX-3 and EVA-1. Taken together, my studies indicate that the migration of the excretory canals requires two or more signaling pathways, and the guidance cues involved are also essential migration molecules functioning to guide neuronal cells and axon growth cones.
Advances In Rhabditidae Research And Application 2012 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-26
Advances In Rhabditidae Research And Application 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-26 with Science categories.
Advances in Rhabditidae Research and Application / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Rhabditidae in a concise format. The editors have built Advances in Rhabditidae Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Rhabditidae in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Rhabditidae Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Caenorhabditis Elegans
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Author : Henry F. Epstein
language : en
Publisher: Academic Press
Release Date : 1995
Caenorhabditis Elegans written by Henry F. Epstein and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Caenorhabditis elegans categories.
The first of its kind, this laboratory handbook emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. Four primary sections--Genetic and Culture Methods, Neurobiology, Cell and Molecular Biology, and Genomics and Informatics--reflect the cross-disciplinary nature of C. elegans research. Because C. elegans is a simple and malleable organism with a small genome and few cell types, it provides an elegant demonstr.
C Elegans Ii
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Author : Donald L. Riddle
language : en
Publisher: Firefly Books
Release Date : 1997
C Elegans Ii written by Donald L. Riddle and has been published by Firefly Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR
Germline Development
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Author : Joan Marsh
language : en
Publisher: John Wiley & Sons
Release Date : 1994-08-16
Germline Development written by Joan Marsh and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-08-16 with Medical categories.
Connects classical cellular descriptive studies with more recent work on the molecular and genetic aspects regarding germline development. Prominent scientists discuss research on a range of organisms including insects, worms, birds, fish, amphibia, mammals and green algae. Specification of germ cells, their migration to the gonads and subsequent interactions with the soma and evolutionary factors of their segregation are among the topics covered.
Cellular And Molecular Aspects Of Plant Nematode Interactions
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Author : Carmen Fenoll
language : en
Publisher: Springer Science & Business Media
Release Date : 1997
Cellular And Molecular Aspects Of Plant Nematode Interactions written by Carmen Fenoll and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Science categories.
In 1992 a Concerted Action Programme (CAP) was initiated by Peter Sijmons with the purpose of intensifying collaborations between 16 European laboratories working on plant-parasitic nematodes. The four-year programme entitled Resistance Mechanisms Against Plant-Parasitic Nematodes focused on molecular aspects of the interaction between sedentary nematodes and plants on the model system Arabidopsis and on novel resistance strategies. Funding was provided mainly for exchange visits between collaborating laboratories and for the organization of annual meetings. During the last annual meeting which was held in May 1996 in Toledo, Spain, Carmen Fenoll initiated the production of this volume.
The Biology Of Reproduction
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Author : Giuseppe Fusco
language : en
Publisher: Cambridge University Press
Release Date : 2019-10-10
The Biology Of Reproduction written by Giuseppe Fusco and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-10 with Medical categories.
A look into the phenomena of sex and reproduction in all organisms, taking an innovative, unified and comprehensive approach.
The Conservation Biology Of Tortoises
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Author : IUCN/SSC Tortoise and Freshwater Turtle Specialist Group
language : en
Publisher: IUCN
Release Date : 1989
The Conservation Biology Of Tortoises written by IUCN/SSC Tortoise and Freshwater Turtle Specialist Group and has been published by IUCN this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Nature conservation categories.
Micrornas
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Author : Krishnarao Appasani
language : en
Publisher: Cambridge University Press
Release Date : 2009-08-20
Micrornas written by Krishnarao Appasani and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-20 with Science categories.
MicroRNAs (miRNAs) are RNA molecules, conserved by evolution, that regulate gene expressions and their recent discovery is revolutionising both basic biomedical research and drug discovery. Expression levels of MiRNAs have been found to vary between tissues and with developmental stages and hence evaluation of the global expression of miRNAs potentially provides opportunities to identify regulatory points for many different biological processes. This wide-ranging reference work, written by leading experts from both academia and industry, will be an invaluable resource for all those wishing to use miRNA techniques in their own research, from graduate students, post-docs and researchers in academia to those working in R&D in biotechnology and pharmaceutical companies who need to understand this emerging technology. From the discovery of miRNAs and their functions to their detection and role in disease biology, this volume uniquely integrates the basic science with industry application towards drug validation, diagnostic and therapeutic development. Forewords by: Sidney Altman, Yale University, Winner of the Nobel Prize in Chemistry, 1989 and Victor R. Ambros, Dartmouth Medical School, Co-discoverer of MicroRNAs
Pediatric Nephrology
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Author : Ellis D. Avner
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-08-20
Pediatric Nephrology written by Ellis D. Avner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-20 with Medical categories.
Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.