Dna And Rna Cleavers And Chemotherapy Of Cancer And Viral Diseases
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Dna And Rna Cleavers And Chemotherapy Of Cancer And Viral Diseases
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Author : B. Meunier
language : en
Publisher: Springer
Release Date : 1996-03-31
Dna And Rna Cleavers And Chemotherapy Of Cancer And Viral Diseases written by B. Meunier and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-03-31 with Science categories.
The past decade has witnessed a burst of activity and interest in the discovery and design of drugs that cleave DNA and RNA with sequence specificity. This interest stems from the potential of this class of compounds to be useful as therapeutics agents, in particular in the field of the treatment of cancer and viral diseases. Further, a side benefit of such studies is the discovery of novel mechanisms and uses of such agents as tools in the study of structure and function of nucleic acids. Up to now, no international meeting has been organized to recognize the immense progress that has been made in this field. The field of DNA and RNA cleavage by natural and chemical drugs now includes researchers working with rather dissimilar agents but with common underlying mechanisms of DNA damage. Until recently, these scientists were working in separate, apparently unrelated areas, such as the enediyne antibiotics and their synthetic analogues, bleomycin-metal complexes, metal-drug complexes, ribozymes and ribozyme mimics, and antisense and antigene oligonucleotides, etc. It is now clear that these research areas have in common strategies and targets. Researchers representing these areas worked together at this workshop where these common interests were discussed and scientific ideas modified and criticized. Such a workshop should lead to new research approaches and collaborative interactions, and is expected to significantly enhance the progress in the field of DNA and RNA cleavage.
Nucleic Acids In Chemistry And Biology
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Author : G Michael Blackburn
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015-11-09
Nucleic Acids In Chemistry And Biology written by G Michael Blackburn and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-09 with Science categories.
The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.
Progress In Nucleic Acid Research And Molecular Biology
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Author :
language : en
Publisher: Academic Press
Release Date : 1997-06-12
Progress In Nucleic Acid Research And Molecular Biology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-06-12 with Science categories.
Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology Contributions from leaders in their fields Abundant references
Small Molecule Dna And Rna Binders
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Author : Martine Demeunynck
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Small Molecule Dna And Rna Binders written by Martine Demeunynck and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
The development of molecules that selectively bind to nucleic acids has provided many details about DNA and RNA recognition. The range of such substances, such as metal complexes, peptides, oligonucleotides and a wide array of synthetic organic compounds, is as manifold as the functions of nucleic acids. Nucleic acid recognition sequences are often found in the major or minor groove of a double strand, while other typical interactions include intercalation between base pairs or the formation of triple or quadruple helices. One example of a binding mode that has recently been proposed is end stacking on such complex structures as the telomere tetraplex. In this comprehensive book, internationally recognized experts describe in detail the important aspects of nucleic acid binding, and in so doing present impressive approaches to drug design. Since typical substances may be created naturally or synthetically, emphasis is placed on natural products, chemical synthesis, the use of combinatorial libraries, and structural characterization. The whole is rounded off by contributions on molecular modeling, as well as investigations into the way in which any given drug interacts with its nucleic acid recognition site.
Bio Targets And Drug Delivery Approaches
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Author : Sabyasachi Maiti
language : en
Publisher: CRC Press
Release Date : 2016-11-03
Bio Targets And Drug Delivery Approaches written by Sabyasachi Maiti and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-03 with Medical categories.
The advances in drug delivery systems over recent years have resulted in a large number of novel delivery systems with the potential to revolutionize the treatment and prevention of diseases. Bio-Targets and Drug Delivery Approaches is an easy-to-read book for students, researchers and pharmaceutical scientists providing a comprehensive introduction to the principles of advanced drug delivery and targeting their current applications and potential future developments.
Triple Helix Forming Oligonucleotides
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Author : Claude Malvy
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Triple Helix Forming Oligonucleotides written by Claude Malvy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.
Hyper Structured Molecules Iii
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Author : Hiroyuki Sasabe
language : en
Publisher: CRC Press
Release Date : 2010-12-12
Hyper Structured Molecules Iii written by Hiroyuki Sasabe and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-12 with Science categories.
Hyper-Structured Molecules are topologically well-defined molecules in two or three dimensions, expected to show novel quantum effects in the molecular sequences. This book covers molecular designs of dendrimers, oligomers, hyperbranched polymers and/or high spin systems, molecular organizations and nanostructures, mesoscopic pattern formation, and
Drug Nucleic Acid Interactions
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Author :
language : en
Publisher: Elsevier
Release Date : 2001-07-31
Drug Nucleic Acid Interactions written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-31 with Medical categories.
This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.
Expanded Contracted Isomeric Porphyrins
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Author : J.L. Sessler
language : en
Publisher: Elsevier
Release Date : 1997-08-21
Expanded Contracted Isomeric Porphyrins written by J.L. Sessler and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-08-21 with Science categories.
The porphyrins are a class of naturally-occurring macrocycles and are ubiquitous in our world. As such, they have been called the Pigments of Life. This auspicious designation reflects their importance in numerous biological functions. Indeed, life as we understand it relies on the full range of biological processes that are either performed by or catalyzed by porphyrin-containing proteins. Chlorophyll-containing photosynthetic reaction centers in plants, for instance, convert light energy into chemical energy while producing oxygen along the way. It is this oxygen, evolved from photosynthesis, that is transported, stored, and reduced by heme-containing proteins in many organisms, including mammals. Not surprisingly, therefore, these molecules remain of fundamental interest to chemists and biochemists. Indeed, they continue to be intensely investigated by researchers world-wide. Inspired by the importance of the porphyrins, a new research direction has emerged in recent years that is devoted to the preparation and study of non-porphyrin polypyrrole macrocycles. Here, the principal objectives have been to generate completely synthetic systems that bear some structural resemblance to naturally-occurring porphyrin derivatives while being quite different in their specific chemical makeup. Within this context, three different research directions have evolved, namely those involving the syntheses of contracted, isomeric, and expanded porphyrins, respectively. It is the chemistry of these systems that is the subject of this book. Because of the newness of the field, the emphasis of this book will be on synthesis and characterization (all work on porphyrin isomers and much of that associated with expanded porphyrins has only appeared in the last 10 years). One chapter on applications has, however, been included. Also, in the context of the preparative portions of the text, some efforts have been made to explain why various porphyrin analogue targets are of interest.
Advances In Inorganic Chemistry
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Author : Rudi van Eldik
language : en
Publisher: Elsevier
Release Date : 2006-01-18
Advances In Inorganic Chemistry written by Rudi van Eldik and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-18 with Science categories.
Advances in Inorganic Chemistry Volume 58 focuses on homogeneous biomimetic oxidation catalysis. Contributions by leading experts in the field cover important advances in inorganic and bioinorganic chemistry. Contributions include diversity-based approaches to selective biomimetic oxidation catalysis; the selective conversion of hydrocarbons with H2O2 using biomimetic non-heme iron and manganese oxidation catalysis; DNA oxidation by copper and manganese complexes; influences of the ligand in copper-dioxygen complex-formation and substrate oxidations; biomimetic oxidations by dinuclear and trinuclear copper complexes. In the final contribution the authors focus on green oxidation of alcohols using biomimetic copper complexes and enzymes as catalysts. Volume 58 provides another welcomed addition to the widely acclaimed series, Advances in Inorganic Chemistry. * Includes new information on the important advances in inorganic and bioinorganic chemistry * Each chapter is fully referenced * Contains comprehensive reviews written by leading experts in the field