Dna Damage And Repair In Human Tissues
DOWNLOAD
Download Dna Damage And Repair In Human Tissues PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Dna Damage And Repair In Human Tissues book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Dna Damage And Repair In Human Tissues
DOWNLOAD
Author : Betsy M. Sutherland
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Dna Damage And Repair In Human Tissues written by Betsy M. Sutherland and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Physical and chemical agents in the environment damage the DNA of humans, and pose a major threat to human health today, and to the genetic integrity of human populations. Although studies on isolated DNA in vitro, on prokaryotes, on mammalian cells in culture, and on laboratory animals have provided essential background information, it is now possible to study DNA damage and repair in human tissues directly. New techniques of high sensitivity, especially those not requiring radioactive labeling have made possible quantitation of DNA damage and repair, as well as detection of residual, unrepaired DNA lesions . In recent years, several investigators have taken up the challenge of studying damage and repair responses in humans, and we have chosen that work as the special focus of this Symposium. Major advances in under standing damage and responses in human skin, in blood cells and in human internal organs indicate three major themes. First, DNA damage levels in human tissues depend not only on the initial exposures, but also on the capapacity of that tissue for repair of the specific lesion type. Second, repair in human tissues may differ quantitatively and qualitatively from that in human cells in culture.
Dna Damage And Repair
DOWNLOAD
Author : Jac A. Nickoloff
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-08-12
Dna Damage And Repair written by Jac A. Nickoloff and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-12 with Science categories.
Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.
Mechanisms Of Dna Damage And Repair
DOWNLOAD
Author : Michael G. Simic
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21
Mechanisms Of Dna Damage And Repair written by Michael G. Simic and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Science categories.
This book is based on the papers presented at the conference on "Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.
Dna Damage And Repair
DOWNLOAD
Author : Jac A. Nickoloff
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-01-21
Dna Damage And Repair written by Jac A. Nickoloff and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-01-21 with Science categories.
Continuing the tradition of presenting information on DNA damage and repair, this 3rd volume provides the latest reviews by leading researchers. They illuminate key aspects of DNA repair in mammalian systems and its relationship to human disease.
Aging Sex And Dna Repair
DOWNLOAD
Author : Bozzano G Luisa
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Aging Sex And Dna Repair written by Bozzano G Luisa and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Why organisms age and why sexual reproduction exists are major unsolved problems in biology. This book provides an integrated explanation of aging and sex based on current knowledge of DNA damage and repair. Discusses the universality of the problem of DNA damage Describes aging as a consequence of accumulated DNA damage Considers meiosis as an adaptation for DNA repair Discusses mating in eukaryotes as an adaptation for masking mutation
Dna Damage Dna Repair And Disease Volume 1
DOWNLOAD
Author : R. Stephen Lloyd
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-11-19
Dna Damage Dna Repair And Disease Volume 1 written by R. Stephen Lloyd and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-19 with Science categories.
The overall aim of this book is to give scientists in academia and industry a comprehensive overview of the field of DNA damage and DNA repair and related human diseases.
The Role Of Dna Damage And Repair In Cell Aging
DOWNLOAD
Author : B.A. Gilchrest
language : en
Publisher: Elsevier
Release Date : 2001-03-09
The Role Of Dna Damage And Repair In Cell Aging written by B.A. Gilchrest and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-03-09 with Science categories.
Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear", with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging. As part of a series entitled "Advances in Cell Aging and Gerontology," this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters. This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas.
Dna Damage And Repair
DOWNLOAD
Author : Jac A. Nickoloff
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-03-13
Dna Damage And Repair written by Jac A. Nickoloff and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-03-13 with Science categories.
Jac A. Nickoloff and Merl F. Hoekstra update and expand their two earlier acclaimed volumes (Vol. I: DNA Repair in Prokaryotes and Lower Eukaryotes and Vol. II: DNA Repair in Higher Eurkaryotes) with cutting-edge reviews by leading authorities of primary experimental findings about DNA repair processes in cancer biology. The reviews cover a wide range of topics from viruses and prokaryotes to higher eukaryotes, and include several new topics, among them the role of recombination in replication of damaged DNA, X-ray crystallographic analysis of DNA repair protein structures, DNA repair proteins and teleomere function, and the roles of BRCA1 and BRCA2 in DNA repair. Authoritative and up-to-date, DNA Damage and Repair, Vol. III: Advances from Phage to Humans surveys the rapidly moving research in DNA damage and repair, and explains the important functional relationships among different DNA repair pathways and the relationship between DNA repair pathways, cancer etiology, and cancer therapies.
The Dna Damage Response Implications On Cancer Formation And Treatment
DOWNLOAD
Author : Kum Kum Khanna
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-09-18
The Dna Damage Response Implications On Cancer Formation And Treatment written by Kum Kum Khanna and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-18 with Medical categories.
The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.
Dna
DOWNLOAD
Author : Payam Behzadi
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-05-19
Dna written by Payam Behzadi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-19 with Medical categories.
DNA is the most important biomolecule ever discovered. Indeed, this molecule bears genetic information from one generation to another. In this regard, DNA bases have a key role in transferring genetic information and data safely. However, there are cellular, genetic, and environmental factors that may damage the different parts of DNA molecules. These damages may result in mutations and cell death. As such, several DNA repair mechanisms have evolved. Over three sections, this book examines many of these mechanisms.