Dna Helicases And Dna Motor Proteins
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Dna Helicases And Dna Motor Proteins
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Author : Maria Spies
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-19
Dna Helicases And Dna Motor Proteins written by Maria Spies and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-19 with Medical categories.
In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines. The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.
Fluorescent Methods For Molecular Motors
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Author : Christopher P. Toseland
language : en
Publisher: Springer
Release Date : 2014-08-05
Fluorescent Methods For Molecular Motors written by Christopher P. Toseland and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-05 with Science categories.
This book focuses on the application of fluorescence to study motor proteins (myosins, kinesins, DNA helicases and RNA polymerases). It is intended for a large community of biochemists, biophysicists and cell biologists who study a diverse collection of motor proteins. It can be used by researchers to gain an insight into their first experiments, or by experienced researchers who are looking to expand their research to new areas. Each chapter provides valuable advice for executing the experiments, along with detailed background knowledge in order to develop own experiments.
The Mechanisms Of Dna Replication
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Author : David Stuart
language : en
Publisher: IntechOpen
Release Date : 2013-02-20
The Mechanisms Of Dna Replication written by David Stuart and has been published by IntechOpen this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-20 with Medical categories.
DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer. The reader will be provided with new insights into the initiation, regulation, and progression of DNA replication as well as a collection of thought provoking questions and summaries to direct future investigations.
Nanopore Sequencing An Introduction
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Author : Branton Daniel
language : en
Publisher: World Scientific
Release Date : 2019-04-09
Nanopore Sequencing An Introduction written by Branton Daniel and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-09 with Science categories.
This is an introductory text and laboratory manual to be used primarily in undergraduate courses. It is also useful for graduate students and research scientists who require an introduction to the theory and methods of nanopore sequencing. The book has clear explanations of the principles of this emerging technology, together with instructional material written by experts that describes how to use a MinION nanopore instrument for sequencing in research or the classroom.At Harvard University the book serves as a textbook and lab manual for a university laboratory course designed to intensify the intellectual experience of incoming undergraduates while exploring biology as a field of concentration. Nanopore sequencing is an ideal topic as a path to encourage students about the range of courses they will take in Biology by pre-emptively addressing the complaint about having to take a course in Physics or Maths while majoring in Biology. The book addresses this complaint by concretely demonstrating the range of topics — from electricity to biochemistry, protein structure, molecular engineering, and informatics — that a student will have to master in subsequent courses if he or she is to become a scientist who truly understands what his or her biology instrument is measuring when investigating biological phenomena.
Fluorescent Methods For Molecular Motors
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Author : Christopher P. Toseland
language : en
Publisher:
Release Date : 2014-08-31
Fluorescent Methods For Molecular Motors written by Christopher P. Toseland and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-31 with categories.
Helicases From All Domains Of Life
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Author : Renu Tuteja
language : en
Publisher: Academic Press
Release Date : 2018-10-15
Helicases From All Domains Of Life written by Renu Tuteja and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-15 with Science categories.
Helicases are ubiquitous enzymes found throughout evolution. Research in the helicase field has been going on for a long time now but in recent past with the completion of so many genomes, these enzymes have been discovered in a number of organisms. But the available literature is scattered. The huge number of identified DNA and RNA helicases, along with the structural and functional differences among them, make difficult for the interested scholar to grasp a comprehensive view of the field. Helicases from all Domains of Life is the first book to compile information about helicases from many different organisms in one place. Knowledge of the functions and features of helicases across the different kingdoms of life are a valuable source of novel ideas and information The book begins with a chapter on the evolutionary history of helicases followed by three "overview" chapters: one for bacteria/archaea (which are not mentioned), one for plants/algae and one for human helicases The overview chapters are followed by specific chapters on selected helicases of great importance from a biological/applicative point of view
Single Molecule Force Spectroscopy Of Single Stranded Dna Binding Protein And Rep Helicase
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Author :
language : en
Publisher:
Release Date : 2012
Single Molecule Force Spectroscopy Of Single Stranded Dna Binding Protein And Rep Helicase written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Energy Coupling And Molecular Motors
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Author : Fuyuhiko Tamanoi
language : en
Publisher: Elsevier
Release Date : 2003-12-18
Energy Coupling And Molecular Motors written by Fuyuhiko Tamanoi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-12-18 with Science categories.
This volume examines a number of different molecular motors that utilize ATP. The molecular machines to be discussed include ATP synthase, myosin, kinesin, DNA helicases, DNA topoisomerases, chaperones and bacterial rotory motors. The discussion of these various molecular motors is rarely undertaken in one volume and will serve as a great resource for scientists studying structure and function of multiprotein complexes as well as those working on energy coupling mechanisms. The areas of research presented in this volume do not normally overlap, and yet they share common mechanisms. This volume examines a number of different molecular motors that utilize ATP. The molecular machines to be discussed include ATP synthase, myosin, kinesin, DNA helicases, DNA topoisomerases, chaperones and bacterial rotory motors. The discussion of these various molecular motors is rarely undertaken in one volume and will serve as a great resource for scientists studying structure and function of multiprotein complexes as well as those working on energy coupling mechanisms. The areas of research presented in this volume do not normally overlap, and yet they share common mechanisms.
Helicases From All Domains Of Life
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Author : Renu Tuteja
language : en
Publisher: Academic Press
Release Date : 2018-09-21
Helicases From All Domains Of Life written by Renu Tuteja and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-21 with Science categories.
Helicases from All Domains of Life is the first book to compile information about helicases from many different organisms in a single volume. Research in the helicase field has been going on for a long time now, but the completion of so many genomes of these ubiquitous enzymes has made it difficult to keep up with new discoveries. As the huge number of identified DNA and RNA helicases, along with the structural and functional differences among them, make it difficult for the interested scholar to grasp a comprehensive view of the field, this book helps fill in the gaps. Presents updates on the functions and features of helicases across the different kingdoms Begins with a chapter on the evolutionary history of helicases Contains specific chapters on selected helicases of great importance from a biological/applicative point-of-view
Dna Repair Protocols
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Author : Daryl S. Henderson
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Dna Repair Protocols written by Daryl S. Henderson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Science categories.
The first edition of this book, published in 1999 and called DNA Repair Protocols: Eukaryotic Systems, brought together laboratory-based methods for studying DNA damage and repair in diverse eukaryotes: namely, two kinds of yeast, a nematode, a fruit fly, a toad, three different plants, and human and murine cells. This second edition of DNA Repair Protocols covers mammalian cells only and hence its new subtitle, Mammalian Systems. There are two reasons for this fresh emphasis, both of them pragmatic: to cater to the interests of what is now a largely mammalocentric DNA repair field, and to expedite editing and prod- tion of this volume. Although DNA Repair Protocols: Mammalian Systems is a smaller book than its predecessor, it actually contains a greater variety of methods. Fourteen of the book’s thirty-two chapters are entirely new and areas of redundancy present in the first edition have been eliminated here (for example, now just two chapters describe assays for nucleotide excision repair [NER], rather than seven). All eighteen returning chapters have been revised, many of them ext- sively. In order to maintain a coherent arrangement of topics, the four-part p- titioning seen in the first edition was dispensed with and chapters concerned with ionizing radiation damage and DNA strand breakage and repair were re- cated to near the front of the book. Finally, an abstract now heads each chapter.