Dna Structure And Function
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Dna Structure And Function
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Author : Richard R. Sinden
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Dna Structure And Function written by Richard R. Sinden and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
DNA Structure and Function, a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations. Suitable for graduate courses on DNA structure and nucleic acids, the text is also excellent supplemental reading for courses in general biochemistry, molecular biology, and genetics. Explains basic DNA Structure and function clearly and simply Contains up-to-date coverage of cruciforms, Z-DNA, triplex DNA, and other DNA conformations Discusses DNA-protein interactions, chromosomal organization, and biological implications of structure Highlights key experiments and ideas within boxed sections Illustrated with 150 diagrams and figures that convey structural and experimental concepts
Mathematics Of Dna Structure Function And Interactions
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Author : Craig John Benham
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-04-29
Mathematics Of Dna Structure Function And Interactions written by Craig John Benham and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-29 with Medical categories.
Propelled by the success of the sequencing of the human and many related genomes, molecular and cellular biology has delivered significant scientific breakthroughs. Mathematics (broadly defined) continues to play a major role in this effort, helping to discover the secrets of life by working collaboratively with bench biologists, chemists and physicists. Because of its outstanding record of interdisciplinary research and training, the IMA was an ideal venue for the 2007-2008 IMA thematic year on Mathematics of Molecular and Cellular Biology. The kickoff event for this thematic year was a tutorial on Mathematics of Nucleic Acids, followed by the workshop Mathematics of Molecular and Cellular Biology, held September 15--21 at the IMA. This volume is dedicated to the memory of Nicholas R. Cozzarelli, a dynamic leader who fostered research and training at the interface between mathematics and molecular biology. It contains a personal remembrance of Nick Cozzarelli, plus 15 papers contributed by workshop speakers. The papers give an overview of state-of-the-art mathematical approaches to the understanding of DNA structure and function, and the interaction of DNA with proteins that mediate vital life processes.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Dna Structure And Function
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Author : The Open The Open Courses Library
language : en
Publisher:
Release Date : 2019-11-07
Dna Structure And Function written by The Open The Open Courses Library and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-07 with categories.
DNA Structure and Function Biology The three letters "DNA" have now become synonymous with crime solving and genetic testing. DNA can be retrieved from hair, blood, or saliva. Each person's DNA is unique, and it is possible to detect differences between individuals within a species on the basis of these unique features. DNA analysis has many practical applications beyond forensics. In humans, DNA testing is applied to numerous uses: determining paternity, tracing genealogy, identifying pathogens, archeological research, tracing disease outbreaks, and studying human migration patterns. In the medical field, DNA is used in diagnostics, new vaccine development, and cancer therapy. It is now possible to determine predisposition to diseases by looking at genes. Chapter Outline: Historical Basis of Modern Understanding DNA Structure and Sequencing Basics of DNA Replication DNA Replication in Prokaryotes DNA Replication in Eukaryotes DNA Repair The Open Courses Library introduces you to the best Open Source Courses.
A Dynamic Model Of Dna Structure And Function
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Author : Cheryl Lynn Sershen
language : en
Publisher:
Release Date : 2009
A Dynamic Model Of Dna Structure And Function written by Cheryl Lynn Sershen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Many existing models of the DNA molecule predict equilibrium properties of its molecular structure. But the biological environment within a cell is in dynamic flux. The DNA molecule is constantly disrupted through biological events such as protein binding, transcription, replication, recombination, and repair. Equilibrium-based models portray molecular properties in the thermodynamic limit and do not reflect the near-term dynamic effects of such events. Developing accurate non-equilibrium dynamic models is essential to understand these processes, and to predict the length of time it will take the DNA molecule to relax to its equilibrium state. Our research has focused on developing a dynamic statistical mechanical model for predicting the mechanical behavior of DNA in a dynamic biological environment. We extend to a non-equilibrium context the approach taken by Fye and Benham in their development of the equilibrium stress-induced duplex destabilization (SIDD) model. This incorporates an Ising-like framework to model the DNA molecule, and predicts the equilibrium destabilization free energy and probability of denaturation for each base pair in the molecule. The non-equilibrium properties of the traditional one-dimensional kinetic Ising model have been thoroughly studied, and we have leveraged these results in developing our approach. Our model is implemented as a time-dependent simulation using Glauber dynamics. The master equation developed here allows us to introduce complexities not seen in previous non-equilibrium statistical mechanical studies of the DNA molecule. The global coupling of the base pairing in the model induces physics that have not heretofore been employed in studying dynamic models of DNA. Among the measures calculated are the time-series probability distributions, time-dependent energies of opening and probabilities of opening for each base pair of the DNA molecule. Scenarios of transcription and protein binding are simulated using the model as a dynamic bioinformatics tool. An example of how to use the information in the superhelical stress profiles to identify features of the DNA molecule is presented. Our dynamic approach thus enables a more accurate modeling of DNA regulatory mechanisms in the cell and of the various functions of DNA in vivo.
Explorations In The Illustration Of Dna Structure And Function
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Author : Carol L. Wilde
language : en
Publisher:
Release Date : 1979
Explorations In The Illustration Of Dna Structure And Function written by Carol L. Wilde and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with DNA. categories.
Human Genome Structure Function And Clinical Considerations
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Author : Luciana Amaral Haddad
language : en
Publisher: Springer Nature
Release Date : 2021-06-07
Human Genome Structure Function And Clinical Considerations written by Luciana Amaral Haddad and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-07 with Medical categories.
This book provides a detailed evidence-based overview of the latest developments in how the structure of the human genome is relevant to the health professional. It features comprehensive reviews of genome science including human chromosomal and mitochondrial DNA structure, protein-coding and noncoding genes, and the diverse classes of repeat elements of the human genome. These concepts are then built upon to provide context as to how they functionally relate to differences in phenotypic traits that can be observed in human populations. Guidance is also provided on how this information can be applied by the medical practitioner in day-to-day clinical practice. Human Genome Structure, Function and Clinical Considerations collates the latest developments in genome science and current methods for genome analysis that are relevant for the clinician, researcher and scientist who utilises precision medicine techniques and is an essential resource for any such practitioner.
Abstracts Of Papers Presented At The Symposium On Dna Structure And Function
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Author :
language : en
Publisher:
Release Date :
Abstracts Of Papers Presented At The Symposium On Dna Structure And Function written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Dna Structure And Function
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Author : Jeffrey W. Pavlicek
language : en
Publisher:
Release Date : 2007
Dna Structure And Function written by Jeffrey W. Pavlicek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with DNA categories.
Development Of Selective Dna Interacting Ligands
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Author : Sefan Asamitsu
language : en
Publisher: Springer Nature
Release Date : 2020-09-16
Development Of Selective Dna Interacting Ligands written by Sefan Asamitsu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-16 with Science categories.
This book addresses the development of both DNA-sequence-selective and DNA-form-selective ligands, with the aim of creating potential molecular probes and therapeutic agents for non-canonical DNA structure-caused human diseases. Over the past two decades, the structural diversity of DNA forms has been proven to have profound implications in various biological, neurological, and pharmacological events. In response, researchers have since made tremendous efforts to obtain highly active drugs interacting with disease-related non-canonical DNA structures. These drugs, however, have not yet been approved for clinical use. One obstacle impeding their clinical application has to do with selectivity. This book focuses on secondary DNA structures formed by trinucleotide repeat sequences (“hairpin form”) or guanine-rich sequences (“G-quadruplex form”), both of which are pathological molecules for neurodegenerative diseases and/or cancer. Most importantly, it contends that a particular secondary structure of DNA in the context of the human genome can be targeted with a minimal affinity to other DNA structures by means ofcareful and rational ligand design. This approach opens an avenue to the development of highly selective drugs or diagnostic chemical tools for human diseases. Readers who want to know how synthetic ligands can be designed to selectively target a certain DNA molecule will find this book highly informative.
