Dopamine And Glutamate In Psychiatric Disorders
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Dopamine And Glutamate In Psychiatric Disorders
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Author : Werner Schmidt
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-04-21
Dopamine And Glutamate In Psychiatric Disorders written by Werner Schmidt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-21 with Medical categories.
An illuminating summary of our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and the therapeutic strategies and possibilities for future treatment. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, and on the origin and progression of Parkinson's disease. Additional chapters offer novel insights into a variety of psychiatric diseases, including ADHD, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques.
Dopamine Glutamate Interactions In The Basal Ganglia
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Author : Susan Jones
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Dopamine Glutamate Interactions In The Basal Ganglia written by Susan Jones and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
The basal ganglia are involved in complex brain functions, from voluntary movement control to learning and reward processing, and they are implicated in numerous neurological and psychiatric disorders. Information from the cerebral cortex and thalamus is conveyed to basal ganglia nuclei via glutamate release, while dopamine from the midbrain is rel
Glutamate Based Therapies For Psychiatric Disorders
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Author : Phil Skolnick
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-07
Glutamate Based Therapies For Psychiatric Disorders written by Phil Skolnick and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-07 with Medical categories.
Both metabotropic and ionotropic glutamate receptors present attractive “druggable” targets in treating disorders of the central nervous system. There has been a dramatic shift in the focus of glutamate-based therapies away from neurologic disorders such as stroke and traumatic brain injury to the treatment of psychiatric disorders. This “Milestones in Drug Therapy” volume offers a unique, contemporary overview of preclinical and clinical evidence that modulating glutamatergic tone is an effective means of treating psychiatric disorders ranging from depression and anxiety to schizophrenia and drug abuse. The ability to treat diseases such as depression and schizophrenia through multiple, glutamate-based mechanisms offers a unique therapeutic opportunity, as described in this book.
Studies On Psychiatric Disorders
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Author : Anna Dietrich-Muszalska
language : en
Publisher: Springer
Release Date : 2015-01-02
Studies On Psychiatric Disorders written by Anna Dietrich-Muszalska and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-02 with Science categories.
This authoritative volume reviews clinical, pathophysiological and therapeutic aspects of oxidative and nitrosative stress in different psychiatric disorders such as schizophrenia, bipolar disorder, autism, and attention deficit hyperactivity disorder (ADHD). Twenty-nine comprehensive chapters are divided into three distinct sections: clinical aspects, pathophysiological aspects, and therapeutic aspects. Together, these chapters present the environmental, genetic and neurodevelopmental factors in the generation of oxidative stress in psychiatric disorders, with particular emphasis on the biochemical changes associated with oxidative stress in dopaminergic and glutamate neurotransmission as well as mitochondrial dysfunction in the brain and peripheral cells. Through an investigation of glutamic acid decarboxylase (GAD) abnormalities in schizophrenia, the book provides a coherent framework to account for the impact of oxidative stress on pathological phenomena ranging from cellular to cognitive and clinical aspects. It describes biomarkers of oxidative damage, the role of oxidative stress in numerous abnormalities of biochemical pathways in the pathophysiology of schizophrenia, the development of new investigative techniques, specially neuroimaging, and studies of apoptotic pathways that seem to prove neurodegenerative and neurodevelopmental theories. Written by leading researchers in their fields, Studies on Psychiatric Disorders explores therapeutic approaches with aspects of various antioxidants, cryostimulation, and hyperbaric oxygen treatment in oxidative stress in neuropsychiatric diseases. The volume also discusses the role of antipsychotics in the treatment of schizophrenia on nitric oxide generation and biomarkers of oxidative stress together with the clinical symptomatology. Overall, it proposes that novel therapeutic strategies such as supplementation with antioxidants—in particular polyphenols, ω-3 fatty acids or combination of both—could be effective for long-term treatment of some neuropsychiatric disorders.
Genetic And Neurobiological Basis Of Schizophrenia
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Author : Patrick Kimuyu
language : en
Publisher: GRIN Verlag
Release Date : 2018-02-08
Genetic And Neurobiological Basis Of Schizophrenia written by Patrick Kimuyu and has been published by GRIN Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-08 with Medical categories.
Seminar paper from the year 2018 in the subject Medicine - Pathology, grade: 1, Egerton University, language: English, abstract: Schizophrenia has emerged as one of the most debilitating psychiatric disorders, and it impacts on an individual’s quality of life. Its prevalence is approximately 1.0%, whereas its incidence ranges from 0.16 to 0.42/1000 individuals. Evidence indicates that genetics have an integral role in the onset of schizophrenia. Some of genes involved in the development of schizophrenia include RELN gene, GRM3 gene, COMT gene, and NOS1AP gene. Similarly, neurological dysfunctions including dopamine and glutamate dysfunction have been identified as some of the main factors underlying the pathophysiology of the disorder. Overall, there is evidence that support the biological basis of schizophrenia.
Glutamate Based Therapies For Psychiatric Disorders
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Author : Phil Skolnick
language : en
Publisher: Birkhäuser
Release Date : 2010-11-06
Glutamate Based Therapies For Psychiatric Disorders written by Phil Skolnick and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-06 with Medical categories.
Both metabotropic and ionotropic glutamate receptors present attractive “druggable” targets in treating disorders of the central nervous system. There has been a dramatic shift in the focus of glutamate-based therapies away from neurologic disorders such as stroke and traumatic brain injury to the treatment of psychiatric disorders. This “Milestones in Drug Therapy” volume offers a unique, contemporary overview of preclinical and clinical evidence that modulating glutamatergic tone is an effective means of treating psychiatric disorders ranging from depression and anxiety to schizophrenia and drug abuse. The ability to treat diseases such as depression and schizophrenia through multiple, glutamate-based mechanisms offers a unique therapeutic opportunity, as described in this book.
Magnesium In The Central Nervous System
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Author : Robert Vink
language : en
Publisher: University of Adelaide Press
Release Date : 2011
Magnesium In The Central Nervous System written by Robert Vink and has been published by University of Adelaide Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Metabotropic Glutamate Receptors In Psychiatric And Neurological Disorders
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Author :
language : en
Publisher: Elsevier
Release Date : 2023-03
Metabotropic Glutamate Receptors In Psychiatric And Neurological Disorders written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03 with Medical categories.
Metabotropic Glutamate Receptors in Psychiatric and Neurological Disorders, Volume 168 in the International Review of Neurobiology series, highlights advances in the field, with this new volume presenting interesting chapters on topics such as mGlu receptors in Parkinson's disease, Metabotropic glutamate receptors in estradiol-mediated motivated behaviors in females, mGlu regulation of sleep, Implications for sleep disruptions in psychiatric disorders, Mechanisms of mGlu receptor trafficking; alterations by methamphetamine, Group I mGlu and cocaine seeking, The role of mGlu receptors in fear and anxiety, Regulation of Alcohol Consumption, Reward, Dependence, and Perception by Metabotropic Glutamate Receptor Signaling, and mGlu5 as a biomarker for psychiatric disorders.
Schizophrenia And Psychotic Spectrum Disorders
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Author : S. Charles Schulz
language : en
Publisher: Oxford University Press
Release Date : 2016-04-01
Schizophrenia And Psychotic Spectrum Disorders written by S. Charles Schulz and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-01 with Medical categories.
Schizophrenia and Psychotic Spectrum Disorders aims to engage young caregivers in psychiatry, psychology, nursing and social work so that they will be able to become well informed about this significant--and at times confusing--illness. Because schizophrenia is considered to be one of the most complicated and severe psychiatric disorders, this book has the goal of summarizing key issues of the illness, such as its presentation, frequency and age of onset, and diagnostic characteristics. It also contains informative chapters about the pathophysiology of schizophrenia, ranging from brain development issues, genetics, and likely abnormalities in neurotransmitters. This book will give young professionals and those joining the field an excellent and accessible background to treatment. In this area, Schizophrenia and Psychotic Spectrum Disorders provides a comprehensive approach to diagnosis, treatment initiation, strategies for non-response, approaches of therapy, and importantly, ways to provide family therapy and support.
Synaptic Stress And Pathogenesis Of Neuropsychiatric Disorders
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Author : Maurizio Popoli
language : en
Publisher: Springer
Release Date : 2014-07-28
Synaptic Stress And Pathogenesis Of Neuropsychiatric Disorders written by Maurizio Popoli and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-28 with Medical categories.
Recent studies show that changes in Glutamate/GABA synapses and related pathways may determine whether the synaptic plasticity that occurs as a response to stress is adaptive or maladaptive. Findings have shed new light on the mechanisms that determine the effects of stress on cognitive and affective function. Researchers have brought a wide range of techniques to bear on the study of this problem, including cutting-edge live imaging techniques, electrophysiology, glutamate release from isolated live synaptic terminals, development of transgenic and animal models and new behavioral methods. This book provides an overview of these recent findings and of the techniques used as well as a discussion of how the molecular, cellular, and functional effects of stress may trigger or precipitate neuropsychiatric disorders such as depression, schizophrenia, anxiety and PTSD.