Drug Delivery Systems In Cancer Therapy
DOWNLOAD
Download Drug Delivery Systems In Cancer Therapy PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Drug Delivery Systems In Cancer Therapy book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Drug Delivery Systems In Cancer Therapy
DOWNLOAD
Author : Dennis M. Brown
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-09-08
Drug Delivery Systems In Cancer Therapy written by Dennis M. Brown and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-08 with Medical categories.
Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.
Nanoparticle Drug Delivery Systems For Cancer Treatment
DOWNLOAD
Author : Hala Gali-Muhtasib
language : en
Publisher: CRC Press
Release Date : 2020-02-19
Nanoparticle Drug Delivery Systems For Cancer Treatment written by Hala Gali-Muhtasib and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-19 with Medical categories.
In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.
Advanced Drug Delivery Systems In The Management Of Cancer
DOWNLOAD
Author : Kamal Dua
language : en
Publisher: Elsevier
Release Date : 2021-06-24
Advanced Drug Delivery Systems In The Management Of Cancer written by Kamal Dua and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-24 with Business & Economics categories.
Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems
Cancer Drug Delivery Systems Based On The Tumor Microenvironment
DOWNLOAD
Author : Yasuhiro Matsumura
language : en
Publisher: Springer Nature
Release Date : 2020-01-07
Cancer Drug Delivery Systems Based On The Tumor Microenvironment written by Yasuhiro Matsumura and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-07 with Medical categories.
This book proposes the importance of new systems of drug design and delivery based on cancer pathophysiology in addition to cancer molecular and cellular biology. The current studies based on molecular and cellular biology while ignoring pathophysiology and pharmacology may be leading the development of antitumor drugs in the wrong direction and wasting a lot of money. Although there have been numerous reports of genetic and phenotypic changes in tumors, a large body of pathological and clinical evidence supports the conclusion that there are no pivotal changes in tumor cells that distinguish them consistently and reliably from normal dividing cells. Unlike using antibiotics against bacterial infection, therefore, anticancer agents (ACAs) need to be delivered selectively to tumor tissues and should be kept there long enough to reproduce the concentrations they reach in the Petri dish, which is a closed space where the cytocidal effects of any anticancer agents (ACAs) including molecular targeting agents are very strong. In the body, however, administered ACAs are cleared with the passage of time. Furthermore, most human cancers possess abundant stroma that hinders the penetration of drugs into the tumor microenvironment. Therefore, to overcome these difficulties, novel drug delivery systems have been designed, such as nanoparticles and ACA conjugated antibodies to stromal components and to cancer cell surface antigens. These advances are described in this book after the first section, which describes core features of the pathophysiology of the cancer microenvironment, on which these new developments are based.
Cancer Targeted Drug Delivery
DOWNLOAD
Author : You Han Bae
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-08-31
Cancer Targeted Drug Delivery written by You Han Bae and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-31 with Medical categories.
This book was conceived from a simple question as to why cancer is so difficult to treat. Ultimately we want to find ways to cure cancers, but that may be an elusive dream at least with the technologies we have now and expect to have in the near future. This leads the question of whether it is possible to improve current cancer treatment methods, especially from the perspective of enhancing targeted drug delivery to tumors. This volume is designed to provide information related to the difficulties in treating cancers through targeted drug delivery, our current understanding of cancer biology, and potential technologies that might be used to achieve enhanced drug delivery to tumors. An ideal drug delivery system for treating cancers would maximize the therapeutic efficacy with minimal side effects in clinical applications. The seemingly improved anticancer efficacy of the current nanoparticle-based formulations needs to be viewed from the context of very poor success rates for translation to human applications. The results of in vitro cell culture models and small animal in vivo experiments have not been extrapolated to clinical applications. Finding the reasons for the lack of successful translation is required if we are to discover approaches to substantially extend the survival time of cancer patients, and hopefully identify cures. Cancer Targeted Drug Delivery: Elusive Dream describes some answers of achieving the so far elusive dream of treating cancers like other chronic diseases with therapies that focus using improved drug delivery systems designed to better align with the unique biological and physiological properties of cancer.
Nano Drug Delivery Strategies For The Treatment Of Cancers
DOWNLOAD
Author : Awesh K. Yadav
language : en
Publisher: Academic Press
Release Date : 2020-09-03
Nano Drug Delivery Strategies For The Treatment Of Cancers written by Awesh K. Yadav and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-03 with Science categories.
Nano Drug Delivery Strategies for the Treatment of Cancers discusses several current and promising approaches for the diagnosis and treatment of cancer by using the most recent developments in nanomedical technologies. The book presents introductory information about the biology of different types of cancer in order to provide the reader with knowledge on their specificities. In addition, it discusses various novel drug delivery systems, detailing their functionalities, expected outcomes and future developments in the field, focusing on brain, mouth and throat, breast, lung, liver, pancreas, stomach, colon, bool, skin and prostate cancers. The book is a valuable source for cancer researchers, oncologists, pharmacologists and nanotechnologists who are interested in novel drug delivery systems and devices for treatment of various types of cancer that take advantage of recent advances in this exciting field. Discusses a wide range of promising approaches for the diagnosis and treatment of cancer using the latest advancement in cutting-edge nanomedical technologies Provides foundational information on different types of cancer and their biology to help the reader choose the best nano drug delivery system for patients Presents novel drug delivery systems based on nanoparticles, microparticles, liposomes, self-assembling Micelles and block copolymer micelles
Nanoparticulate Drug Delivery Systems For Cancer Therapy
DOWNLOAD
Author : NaikSachin S
language : en
Publisher: Independent Author
Release Date : 2023-03-31
Nanoparticulate Drug Delivery Systems For Cancer Therapy written by NaikSachin S and has been published by Independent Author this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-31 with Medical categories.
Molecular medicine has discovered many new therapeutic modalities by using state-of- the-art techniques in molecular biology. High through-put, in-vitro assays that screen for pharmacological actions on the desired cell type are frequently used to design new drugs. Although such agents are certainly justified by their, success in-vitro, they frequently perform much less effectively in-vivo where the agent must reach its target cells in a tissue in sufficient quantities to be potent while sparing bystander organs. Depending on the route of administration, the endothelium and/or epithelium form significant barriers that greatly limit the in-vivo accessibility of many drugs, antibodies, and gene vectors to their intended target sites of pharmacological action, namely, the cells inside the tissue (Jain, R. K. et al., 1998). Hence, the major challenge for formulation development scientist is to design drug delivery strategies that deliver the therapeutic agents to the desired intracellular targets based on ability to understand, utilize, modify and exploit membrane trafficking pathways (Miller, N. et al., 1995). Intracellular drug delivery refers to the delivery of therapeutic agents to specific compartments or organelles within the cell. The therapeutic agent could be a low molecular weight drug or a macromolecule like protein or DNA. Thus targeted intracellular drug delivery results in higher bioavailability of a therapeutic agent at its site of action (i.e. distinct intracellular compartments or microenvironments), potentiates the pharmacologic effect of the drug, and at the same time, reduces the side effects. (Jayanth Panyam et al, 2004). There are a number of pathways through which a therapeutic agent or a carrier can enter a cell. Such as Endocytosis, Caveolar endocytosis, Pinocytosis, Phagocytosis, In receptor-mediated endocytosis, Folate Receptor-Mediated Endocytosis, Transferrin Receptor-Mediated Endocytosis, Biotin Receptor-Mediated Endocytosis, Wheat Germ Agglutinin-Mediated Endocytosis, ICAM-1-Mediated Endocytosis, Antibody-Mediated Endocytosis, Physical or mechanical methods use force to traverse the cell membrane, e.g. Particle bombardment accelerates, Microinjection and Electroporation. The various Intracellular Targets are Endo-Lysosomal Targeting, Cytoplasmic Delivery, Nuclear Targeting, and Mitochondrial Targeting.
Antibody Mediated Drug Delivery Systems
DOWNLOAD
Author : Yashwant V. Pathak
language : en
Publisher: John Wiley & Sons
Release Date : 2012-05-15
Antibody Mediated Drug Delivery Systems written by Yashwant V. Pathak and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-15 with Science categories.
This book covers various aspects of antibody mediated drug delivery systems – theoretical aspects, processing, viral and non-viral vectors, and fields where these systems find and /or are being evaluated for applications as therapeutics and diagnostic treatment. Chapters discuss actual applications of techniques used for formulation and characterization. Applications areas include cancer, pulmonary, ocular diseases; brain drug delivery; and vaccine delivery. The contributing authors represent over 10 different countries, covering recent developments happening around the globe.
Nanomedicine For Cancer Diagnosis And Therapy
DOWNLOAD
Author : Arshi Malik
language : en
Publisher: Springer Nature
Release Date : 2021-08-01
Nanomedicine For Cancer Diagnosis And Therapy written by Arshi Malik and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-01 with Medical categories.
This book reviews the current applications and future prospects of nanomaterials in cancer diagnostics and therapy. Nanomaterials have recently emerged as a remarkable and promising tool for cancer therapy and diagnosis, due to their broad range of intrinsic molecular properties. To overcome the current limitations of nanoparticles in drug delivery systems, attempts have been made to synthesize nanoparticles from biological materials for targeted cancer therapy. This book provides concise evaluations of various potential bio-inspired platforms that mimic natural components of the body and offer effective and versatile drug delivery systems for cancer therapy. It also assesses the potential of nanoparticles to enhance the outcomes of cancer immunotherapy via immune cell activation and tumor microenvironment modulation. The book also summarizes in the applications of nanomaterials for the detection, prevention, and treatment of solid tumors and in the treatment of leukemia and lymphomas. In closing, it discusses ethical issues in nanomedicine, including risk assessment, risk management, and risk communication during clinical trials. The book offers offers a valuable source of information for students, academics, researchers, scientists, clinicians, and healthcare professionals working in nanotechnology and cancer research.
Nanotechnology Based Targeted Drug Delivery Systems For Lung Cancer
DOWNLOAD
Author : Prashant Kesharwani
language : en
Publisher: Academic Press
Release Date : 2019-01-26
Nanotechnology Based Targeted Drug Delivery Systems For Lung Cancer written by Prashant Kesharwani and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-26 with Business & Economics categories.
Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer is an indispensable resource that will help pharmaceutical scientists and clinical researchers design and develop novel drug delivery systems and devices for the treatment of lung cancer. As recent breakthroughs in nanomedicine are now making it possible to deliver drugs, genes and therapeutic agents to localized areas of disease to maximize clinical benefit, while also limiting unwanted side effects, this book explores promising approaches for the diagnosis and treatment of lung cancer using cutting-edge nanomedical technologies. Topics discussed include polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions. Provides an overview of an array of nanotechnology-based drug delivery systems Examines the design, synthesis and application of different nanocarriers in drug and gene delivery Provides an in-depth understanding of the design of targeted nanotherapeutics and technologies and its implication in various site-specific cancers