Drug Discovery And Design Using Natural Products
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Drug Discovery And Design Using Natural Products
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Author : Jorddy Neves Cruz
language : en
Publisher: Springer Nature
Release Date : 2023-08-28
Drug Discovery And Design Using Natural Products written by Jorddy Neves Cruz and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-28 with Medical categories.
Historically, natural products have great relevance for the development of new drugs. Natural molecules, in addition to directly providing new compounds with different therapeutic functions have provided scaffolds and a great diversity of structures that serve as inspiration for the design and discovery of new drugs. The great structural complexity and the significant number of natural compounds that can be obtained and their advantages also present some historical problems that need to be overcome. Issues such as difficulty in isolation, difficulty in synthesizing compounds found in nature in the laboratory, screening to evaluate the biological properties of these compounds, and structural optimization to enhance the pharmacological properties of biomolecules; are some of the main difficulties encountered in research with natural products and in the design/discovery of new medicines. Therefore, this book addresses the great scientific advances that provide practical solutions to using natural products to develop new drugs. We address topics related to the genesis of research projects that use natural products to design new drugs. We address the discovery of new species, initial processes for identification and extraction of compounds, isolation and identification of these structures, techniques, and advances in vitro and in vivo methods that support the discovery of new natural drugs, synthesis of new compounds from natural molecules, in silico optimization processes of potentially promising compounds.
Natural Products And Drug Discovery
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Author : Subhash C. Mandal
language : en
Publisher: Elsevier
Release Date : 2018-02-16
Natural Products And Drug Discovery written by Subhash C. Mandal and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-16 with Science categories.
Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout
Natural Products In Clinical Trials
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Author : Atta-ur- Rahman
language : en
Publisher: Bentham Science Publishers
Release Date : 2018-03-03
Natural Products In Clinical Trials written by Atta-ur- Rahman and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-03 with Medical categories.
Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This book series focuses on reviews of exciting new bioactive natural products that have huge potential as drugs. It highlights the everlasting importance of natural products in our lives. Each volume brings reviews contributed by eminent scientists in the field. The first volume covers the following topics: - bioactive compounds from marine invertebrates - natural product derived drugs for immunological and inflammatory diseases - clinical trials of curcumin, camptothecin, astaxanthin, and biochanin - antibacterial and antifungal drugs from natural sources - natural products as anti-HIV medicines.
Drug Discovery And Development
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Author : Ramarao Poduri
language : en
Publisher: Springer Nature
Release Date : 2021-02-15
Drug Discovery And Development written by Ramarao Poduri and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-15 with Medical categories.
This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.
Natural Products And Drug Discovery
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Author : Pinarosa Avato
language : en
Publisher: MDPI
Release Date : 2020-04-22
Natural Products And Drug Discovery written by Pinarosa Avato and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-22 with Medical categories.
Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.
Textbook Of Drug Design And Discovery Third Edition
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Author : Tommy Liljefors
language : en
Publisher: CRC Press
Release Date : 2002-07-25
Textbook Of Drug Design And Discovery Third Edition written by Tommy Liljefors and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-07-25 with Medical categories.
Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.
The Role Of Natural Products In Drug Discovery
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Author : J. Mulzer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
The Role Of Natural Products In Drug Discovery written by J. Mulzer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.
Natural Products
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Author : Anne Osbourn
language : en
Publisher: John Wiley & Sons
Release Date : 2014-04-02
Natural Products written by Anne Osbourn and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-02 with Science categories.
Natural Products: Discourse, Diversity andDesign provides an informative and accessible overview ofdiscoveries in the area of natural products in the genomic era,bringing together advances across the kingdoms. As genomicsdata makes it increasingly clear that the genomes of microbes andplants contain far more genes for natural product synthesis thanhad been predicted from the numbers of previously identifiedmetabolites, the potential of these organisms to synthesize diversenatural products is likely to be far greater than previouslyenvisaged. Natural Products addresses notonly the philosophical questions of the natural role of thesemetabolites, but also the evolution of single and multiplepathways, and how these pathways and products may be harnessed toaid discovery of new bioactives and modes of action. Edited by recognized leaders in the fields of plant andmicrobial biology, bioorganic chemistry and natural productschemistry, and with contributions from researchers at top labsaround the world, Natural Products isunprecedented in its combination of disciplines and the breadth ofits coverage. Natural Produces: Discourse, Diversity andDesign will appeal to advanced students andexperienced researchers, from academia to industry, in diverseareas including ecology, industrial biotechnology, drug discovery,medicinal chemistry, agronomy, crop improvement, and naturalproduct chemistry.
A Guide To The Chemical Basis Of Drug Design
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Author : Alfred Burger
language : en
Publisher:
Release Date : 1983-09-23
A Guide To The Chemical Basis Of Drug Design written by Alfred Burger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983-09-23 with Medical categories.
This book by a leading author in the field of medicinal chemistry deals with the chemical structure of biologically active compounds. Presents a unique historical overview of drug discovery and design using the historical facts of the pharmacology to reveal the serendipity of discovery and to point toward new structures that may be developed based on what has gone before.
Textbook Of Drug Design And Discovery Fifth Edition
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Author : Kristian Stromgaard
language : en
Publisher: CRC Press
Release Date : 2016-08-19
Textbook Of Drug Design And Discovery Fifth Edition written by Kristian Stromgaard and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-19 with Medical categories.
Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects. Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery. The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding). The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.