Drug Discovery For Psychiatric Disorders
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Drug Discovery For Psychiatric Disorders
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Author : Zoran Rankovic
language : en
Publisher: Royal Society of Chemistry
Release Date : 2012
Drug Discovery For Psychiatric Disorders written by Zoran Rankovic and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
This is a wide scope and in-depth coverage of the state of the art and future directions in drug discovery for major psychiatric disorders.
Drug Discovery For Schizophrenia
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Author : Tatiana V. Lipina
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015-05-13
Drug Discovery For Schizophrenia written by Tatiana V. Lipina and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-13 with Medical categories.
Since the pioneering pharmacotherapy for treatment of schizophrenia in the 1950s by antipsychotics, only a few major innovations have been made, pointing to a general stagnation in the field of pharmacology of schizophrenia. Drug Discovery for Schizophrenia covers new insights in the field of schizophrenia with an aim to advance the understanding of scientists and clinicians in this area and to fuel drug discovery. The book outlines a change in the way schizophrenia is treated by moving away from focusing only on treating symptoms in patients. Innovative drugs emerge from deeper comprehension of the pathological processes that emerge earlier in life, hence, providing strategies for preventative therapy to alter the course of this mental disorder. Amongst other current topics, the book covers new findings in genetics and epigenetics, progress in animal models for schizophrenia and the usage of induced pluripotent stem cells. The combination of these important areas benefit psychiatric neuroscience, filling the gaps in the knowledge of neurobiology of schizophrenia and providing novel perspectives for future drug development.
Drug Development In Psychiatry
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Author : Matthew Macaluso
language : en
Publisher: Springer Nature
Release Date : 2023-03-16
Drug Development In Psychiatry written by Matthew Macaluso and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-16 with Medical categories.
The book reviews clinical trial methodology as it pertains to drug development in psychiatry. The reader will understand the process of drug development in psychiatry from discovery through marketing with the help of clinically relevant examples. The reader will appreciate the history of drug development in psychiatry dating back to the era of serendipitous discovery and culminating in an era of new and highly focused targets. Readers will understand how drug development in psychiatry has changed and adapted with the discovery of novel mechanism of action drugs. Novel drugs and disease targets have changed the way developers and regulatory agencies think about clinical trial methodology. The book elucidates how biomarkers, genetics and advances in neuroscience and neuroimaging have influenced drug development approaches, which will ultimately change the practice of psychiatry. The book will be broken down into the following sections: a. Prior to the 1960s - Drug discovery by chance observation b. The last 50 years – refined targeting of CNS drugs without the discovery of mechanistically new drugs c. The future – the discovery and development of mechanistically new drugs. The examination of new targets, genetics and biomarkers.
Animal And Translational Models For Cns Drug Discovery Psychiatric Disorders
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Author : Robert A. McArthur
language : en
Publisher: Academic Press
Release Date : 2008-11-17
Animal And Translational Models For Cns Drug Discovery Psychiatric Disorders written by Robert A. McArthur and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-17 with Psychology categories.
Psychiatric Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. Psychiatric Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the first volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, and is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Psychiatric Disorders is available for purchase individually.
Therapeutic Discovery In Psychiatry
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Author : Mark Tricklebank
language : en
Publisher: Academic Press
Release Date : 2025-02-01
Therapeutic Discovery In Psychiatry written by Mark Tricklebank and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-01 with Psychology categories.
According to the National Alliance on Mental Illness 1 in 5 adults (46.6 million) experiences mental illness in a given year. With that number steadily increasing every year it is vital that we invest into new drug discoveries as treatment options. At present the number of drugs available to treat individual with psychiatric disorders varies widely, and it is crucially important to identify new therapeutic targets in order to develop new, effective drugs. Therapeutic Discovery in Psychiatry aims to provide researchers with a complete guide to new technologies and techniques that can effectively manage risk and deliver of new drugs for psychiatric disorders. This book not only addresses issues of reproducibility, but addresses other topics including, drug profiling in vitro, examining drug targets, brain circuits and behavior, medicinal chemistry, drug formulation and pharmacokinetics, and much more. Therapeutic Discovery in Psychiatry is a prime resource for researchers who are trying to understand the field of psychopharmacology.
Animal And Translational Models For Cns Drug Discovery Psychiatric Disorders
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Author : Robert A. McArthur
language : en
Publisher: Academic Press
Release Date : 2008-10-20
Animal And Translational Models For Cns Drug Discovery Psychiatric Disorders written by Robert A. McArthur and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-20 with Medical categories.
Psychiatric Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. Psychiatric Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the first volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, and is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Psychiatric Disorders is available for purchase individually.
Animal And Translational Models For Cns Drug Discovery Reward Deficit Disorders
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Author : Robert A. McArthur
language : en
Publisher: Academic Press
Release Date : 2009-02-24
Animal And Translational Models For Cns Drug Discovery Reward Deficit Disorders written by Robert A. McArthur and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-24 with Medical categories.
Reward Deficit Disorders is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. Reward Deficit Disorders has introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. Reward Deficit Disorders also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on Animal and Translational Models for CNS Drug Discovery is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery. This is the third volume in the three volume-set, Animal and Translational Models for CNS Drug Discovery 978-0-12-373861-5, which is also available for purchase individually. Provides clinical, academic, government and industry perspectives fostering integrated communication between principle participants at all stages of the drug discovery process Critical evaluation of animal and translational models improving transition from drug discovery and clinical development Emphasizes what results mean to the overall drug discovery process Explores issues in clinical trial design and conductance in each therapeutic area Neurological Disorders is available for purchase individually.
Neurological And Psychiatric Disorders Neurogenomics
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Author : Stan M. Goldin
language : en
Publisher: International Business Communications
Release Date : 1997-01-01
Neurological And Psychiatric Disorders Neurogenomics written by Stan M. Goldin and has been published by International Business Communications this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-01-01 with Antipsychotic drugs industry categories.
Drug Repositioning
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Author : Joel Dudley
language : en
Publisher: CRC Press
Release Date : 2017-07-14
Drug Repositioning written by Joel Dudley and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-14 with Medical categories.
Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet. In the last decades, traditional R&D has failed in identifying new effective therapies in many medical areas and drug repositioning has recently emerged as a promising alternative strategy to de novo drug discovery to improve and accelerate therapeutic development. For the first time, Drug Repositioning: Approaches and Applications for Neurotherapeutics reviews history and advances in drug repositioning, with a special focus on therapeutics for nervous system diseases. International experts from Academia, Industry and Non-profit organisations will provide different views on drug repositioning advantages, challenges and specific applications, which will be covered for nervous system diseases including Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, ischemic stroke, and psychiatric disorders. This book provides a balanced overview and synthesis of drug repositioning concept, methods and applications for neurotherapeutics. It represents a valuable resource for students, scientists and clinicians working in academic settings, industry and government agencies within the fields of neuroscience, pharmacology, neurology, pharmaceutical sciences, drug discovery and development.
Targets And Emerging Therapies For Schizophrenia
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Author : Jeffrey S. Albert
language : en
Publisher: John Wiley & Sons
Release Date : 2012-06-06
Targets And Emerging Therapies For Schizophrenia written by Jeffrey S. Albert and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-06 with Medical categories.
New and emerging directions in pharmaceutical research to better treat schizophrenia Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of the disease. Moreover, many schizophrenia patients fail to respond to current antipsychotics. Integrating chemistry, biology, and pharmacology, this book explores emerging directions in pharmaceutical research for drug targeting and discovery in order to find more effective treatments for schizophrenia, one of the most serious and widespread psychiatric diseases. Targets and Emerging Therapies for Schizophrenia presents the basics of schizophrenia, drug targets for the disease, and potential new drugs and therapeutics. It begins with a discussion of prevalence and etiology. Then, it describes therapies such as dopamine agonists and phosphodiesterase (PDE) inhibitors as well as growing research aimed at addressing untreated symptoms. Next, the authors discuss receptor modulators, inhibitors, and targeting strategies for drug discovery. Both the neurobiological and chemical aspects of all major pharmacological targets are examined. With contributions from an international team of pioneering pharmaceutical researchers, this book compiles the current knowledge in the field, setting the stage for new breakthroughs in the treatment of schizophrenia. Targets and Emerging Therapies for Schizophrenia: Provides a comprehensive resource for neuro-drug discovery and the development of molecular targets for schizophrenia treatment Draws from chemistry, biology, and pharmacology for more effective drug targeting and discovery Explores a wide range of receptors and molecular targets, including dopamine, PDEs, and neuropeptides With Targets and Emerging Therapies for Schizophrenia as their guide, drug discovery and development scientists have the information they need to advance their own research so that new, more effective treatments for schizophrenia will soon be a reality.