Targets And Emerging Therapies For Schizophrenia
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Targets And Emerging Therapies For Schizophrenia
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Author : Jeffrey S. Albert
language : en
Publisher: John Wiley & Sons
Release Date : 2012-06-06
Targets And Emerging Therapies For Schizophrenia written by Jeffrey S. Albert and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-06 with Medical categories.
New and emerging directions in pharmaceutical research to better treat schizophrenia Although the dopamine hypothesis has been the cornerstone of schizophrenia therapeutics, it is clear that dopamine-based approaches do not treat all aspects of the disease. Moreover, many schizophrenia patients fail to respond to current antipsychotics. Integrating chemistry, biology, and pharmacology, this book explores emerging directions in pharmaceutical research for drug targeting and discovery in order to find more effective treatments for schizophrenia, one of the most serious and widespread psychiatric diseases. Targets and Emerging Therapies for Schizophrenia presents the basics of schizophrenia, drug targets for the disease, and potential new drugs and therapeutics. It begins with a discussion of prevalence and etiology. Then, it describes therapies such as dopamine agonists and phosphodiesterase (PDE) inhibitors as well as growing research aimed at addressing untreated symptoms. Next, the authors discuss receptor modulators, inhibitors, and targeting strategies for drug discovery. Both the neurobiological and chemical aspects of all major pharmacological targets are examined. With contributions from an international team of pioneering pharmaceutical researchers, this book compiles the current knowledge in the field, setting the stage for new breakthroughs in the treatment of schizophrenia. Targets and Emerging Therapies for Schizophrenia: Provides a comprehensive resource for neuro-drug discovery and the development of molecular targets for schizophrenia treatment Draws from chemistry, biology, and pharmacology for more effective drug targeting and discovery Explores a wide range of receptors and molecular targets, including dopamine, PDEs, and neuropeptides With Targets and Emerging Therapies for Schizophrenia as their guide, drug discovery and development scientists have the information they need to advance their own research so that new, more effective treatments for schizophrenia will soon be a reality.
Novel Antipsychotic Drugs
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Author : Herbert Y. Meltzer
language : en
Publisher: Raven Press (ID)
Release Date : 1992
Novel Antipsychotic Drugs written by Herbert Y. Meltzer and has been published by Raven Press (ID) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
Contains highlights of an American College of Neuropsychopharmacology conference on new directions in the development of atypical and other novel antipsychotic drugs. Presents new theories and preclinical and clinical data on various drugs and classes of drugs including amperozide and other drugs.
Current Antipsychotics
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Author : Gerhard Gross
language : en
Publisher: Springer
Release Date : 2014-12-14
Current Antipsychotics written by Gerhard Gross and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-14 with Medical categories.
Six decades after the serendipitous discovery of chlorpromazine as an antipsychotic and four decades after the launch of clozapine, the first atypical or second generation antipsychotic, psychopharmacology has arrived at an important crossroad. It is clear that pharmacological research and pharmaceutical development must now focus on complementary or even alternative mechanisms of action to address unmet medical needs, i.e. poorly treated domains of schizophrenia, improved acceptance by patients, better adherence to medication, safety in psychoses in demented patients, and avoiding cardiac and metabolic adverse effects. The first completely novel mechanisms evolving from our insights into the pathophysiology of psychotic disorders, especially the role of glutamatergic mechanisms in schizophrenia, are now under development, and further principles are on the horizon. This situation, in many respects similar to that when the initial second-generation antipsychotics became available, can be rewarding for all. Preclinical and clinical researchers now have the opportunity to confirm their hypotheses and the pharmaceutical industry may be able to develop really novel classes of therapeutics. When we were approached by the publishers of the Handbook of Experimental Pharmacology to prepare a new volume on antipsychotics, our intention was to capture both, the accumulated preclinical and clinical knowledge about current antipsychotics as well as prospects for new and potentially more specific antischizophrenia principles. These efforts should be based on the pathophysiology of the diseases and the affected neurotransmitter systems. Since preclinical research on antipsychotic compounds is only reliable when intimately linked through translational aspects to clinical results, we decided to include clinical science as well. It turned out that that this endeavor could not be covered by a single volume. We thank the editorial board and the publishers for supporting our decision to prepare two volumes: Current Antipsychotics and Novel Antischizophrenia Treatments. These topics cannot really be separated from one another and should be seen as a composite entity despite the somewhat arbitrary separation of contributions into two volumes. The continuing challenges of developing improved and safer antipsychotic medications remain of concern and are discussed in the first volume. The new opportunities for the field to develop and license adjunctive treatments for the negative symptoms and cognitive deficits that are treated inadequately by existing compounds have been incentivized recently and provide the focus for the second volume. We hope these collective contributions will facilitate the development of improved treatments for the full range of symptomatology seen in the group of schizophrenias and other major psychotic disorders. Gerhard Gross, Ludwigshafen, Germany Mark A. Geyer, La Jolla, CA This volume will try to put current therapy - achievements, shortcomings, remaining medical needs - and emerging new targets into the context of increasing knowledge regarding the genetic and neurodevelopmental contributions to the pathophysiology of schizophrenia. Some of the chapters will also deal with respective experimental and clinical methodology, biomarkers, and translational aspects of drug development. Non-schizophrenia indications will be covered to some extent, but not exhaustively.
Neuropsychiatric And Cognitive Changes In Parkinson S Disease And Related Movement Disorders
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Author : Dag Aarsland
language : en
Publisher: Cambridge University Press
Release Date : 2013-08-29
Neuropsychiatric And Cognitive Changes In Parkinson S Disease And Related Movement Disorders written by Dag Aarsland and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-29 with Medical categories.
A broad and in-depth discussion of the important, but still uninformed, field of behavioral disturbances associated with Parkinson's disease.
The Neurobiology Of Schizophrenia
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Author : Ted Abel
language : en
Publisher: Academic Press
Release Date : 2016-07-08
The Neurobiology Of Schizophrenia written by Ted Abel and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-08 with Science categories.
The Neurobiology of Schizophrenia begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance. Provides a comprehensive overview of neurobiological aspects of schizophrenia Discusses schizophrenia at behavioral, cognitive, clinical, electrophysiological, molecular, and genetic levels Edited by a translational researcher and a psychiatrist to promote synthesis between basic neuroscience and clinical relevance Elucidates connections between the various systems depicted, when possible
Personalized Psychiatry
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Author : Bernhard Baune
language : en
Publisher: Academic Press
Release Date : 2019-10-16
Personalized Psychiatry written by Bernhard Baune and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-16 with Medical categories.
Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective
Ending Discrimination Against People With Mental And Substance Use Disorders
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2016-09-03
Ending Discrimination Against People With Mental And Substance Use Disorders written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-03 with Social Science categories.
Estimates indicate that as many as 1 in 4 Americans will experience a mental health problem or will misuse alcohol or drugs in their lifetimes. These disorders are among the most highly stigmatized health conditions in the United States, and they remain barriers to full participation in society in areas as basic as education, housing, and employment. Improving the lives of people with mental health and substance abuse disorders has been a priority in the United States for more than 50 years. The Community Mental Health Act of 1963 is considered a major turning point in America's efforts to improve behavioral healthcare. It ushered in an era of optimism and hope and laid the groundwork for the consumer movement and new models of recovery. The consumer movement gave voice to people with mental and substance use disorders and brought their perspectives and experience into national discussions about mental health. However over the same 50-year period, positive change in American public attitudes and beliefs about mental and substance use disorders has lagged behind these advances. Stigma is a complex social phenomenon based on a relationship between an attribute and a stereotype that assigns undesirable labels, qualities, and behaviors to a person with that attribute. Labeled individuals are then socially devalued, which leads to inequality and discrimination. This report contributes to national efforts to understand and change attitudes, beliefs and behaviors that can lead to stigma and discrimination. Changing stigma in a lasting way will require coordinated efforts, which are based on the best possible evidence, supported at the national level with multiyear funding, and planned and implemented by an effective coalition of representative stakeholders. Ending Discrimination Against People with Mental and Substance Use Disorders: The Evidence for Stigma Change explores stigma and discrimination faced by individuals with mental or substance use disorders and recommends effective strategies for reducing stigma and encouraging people to seek treatment and other supportive services. It offers a set of conclusions and recommendations about successful stigma change strategies and the research needed to inform and evaluate these efforts in the United States.
Essential Psychiatry
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Author : Robin M. Murray
language : en
Publisher: Cambridge University Press
Release Date : 2008-09-18
Essential Psychiatry written by Robin M. Murray and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-18 with Medical categories.
This is a major international textbook for psychiatrists and other professionals working in the field of mental healthcare. With contributions from opinion-leaders from around the globe, this book will appeal to those in training as well as to those further along the career path seeking a comprehensive and up-to-date overview of effective clinical practice backed by research evidence. The book is divided into cohesive sections moving from coverage of the tools and skills of the trade, through descriptions of the major psychiatric disorders and on to consider special topics and issues surrounding service organization. The final important section provides a comprehensive review of treatments covering all of the major modalities. Previously established as the Essentials of Postgraduate Psychiatry, this new and completely revised edition is the only book to provide this depth and breadth of coverage in an accessible, yet authoritative manner.
Madness And Subjectivity
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Author : Ayurdhi Dhar
language : en
Publisher: Routledge
Release Date : 2019-08-13
Madness And Subjectivity written by Ayurdhi Dhar and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-13 with Psychology categories.
This crucial new work draws on empirical findings from rural North India in relation to madness and subjectivity, revealing the different structures of subjectivity underlying the narratives of schizophrenia, spirits, ghosts, and deities. Unravelling the loose ends of madness, the author explores the cultural differences in understanding and experiencing madness to examine how modern insanity is treated as a clinical disorder, but historically it represents how we form knowledge and understand self-knowledge. The author begins by theoretically investigating how the schizophrenic personifies the fractures in modern Western thought to explain why, despite decades of intense contention, the category of schizophrenia is still alive. She then examines the narratives of people in the Himalayan Mountains of rural India to reveal the discursive conditions that animate their stories around what psychology calls psychosis, critiquing the monoculturalism in trauma theory and challenging the ongoing march of the Global Mental Health Movement in the Global South. Examining what a study of madness reveals about two different cultures, and their ways of thinking and being, this is fascinating reading for students interested in mental health, critical psychology, and Indian culture.
Small Molecule Therapeutics For Schizophrenia
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Author : Sylvain Celanire
language : en
Publisher: Springer
Release Date : 2014-10-13
Small Molecule Therapeutics For Schizophrenia written by Sylvain Celanire and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-13 with Science categories.
The topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drug ability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine.