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Drug Drug Interactions Scientific And Regulatory Perspectives

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Drug Drug Interactions Scientific And Regulatory Perspectives

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Author :
language : en
Publisher: Academic Press
Release Date : 1997-11-06

Drug Drug Interactions Scientific And Regulatory Perspectives written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-11-06 with Medical categories.

Drug Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug drug interactions, the prediction of drug drug interaction potential of new drugs, and the avoidance of clinically significant drug drug interaction in patients. Provides useful references on the science of drug-drug interactions Describes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpoint Contains original data from academic and industrial laboratories Presents an overview of regulatory agency positions

Drug Drug Interactions Scientific And Regulatory Perspectives

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Author :
language : en
Publisher: Academic Press
Release Date : 1997-10-02

Drug–Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug–drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug–drug interactions, the prediction of drug–drug interaction potential of new drugs, and the avoidance of clinically significant drug–drug interaction in patients.

Advances In Pharmacology

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Author : Albert P. Li
language : en
Publisher:
Release Date : 1997

Advances In Pharmacology written by Albert P. Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.

Herbal Supplements Drug Interactions

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Author : Y. W. Francis Lam
language : en
Publisher: CRC Press
Release Date : 2006-06-07

Herbal Supplements Drug Interactions written by Y. W. Francis Lam and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-07 with Medical categories.

The international popularity of herbal remedies has recently outpaced quality information on the utilization and dosing of these compounds. This book fills a void in the literature by offering an authoritative overview of the mechanisms of herbal remedies and their impact on standard medications. It offers a practical approach that focuses not only on specific drug interactions, but the mechanisms behind those interactions and their clinical significance. With contributions from leading experts on the subject, this text examines the overall use of herbs, includes sections on individual herbs, and considers pertinent regulatory issues and concerns in industry.

Drug Drug Interactions Scientific And Regulatory Perspectives

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Author :
language : en
Publisher: Academic Press
Release Date : 1997-10-02

Drug Drug Interactions

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Author : A. David Rodrigues
language : en
Publisher: CRC Press
Release Date : 2019-12

Drug Drug Interactions written by A. David Rodrigues and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12 with categories.

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives. Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on: key interplay between transporters and enzymes in drug metabolism and drug interactions the integral role of pharmacogenetics in metabolism-based drug-drug interactions in vivo - in vitro correlations (reversible, mechanism-based inhibition, induction) in silico approaches enabling structure-activity and structure-function studies high-throughput screening and GLP methods for evaluating drug interactions in vitro the use of transgenic animal models to evaluate drug interactions Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.

Enzyme And Transporter Based Drug Drug Interactions

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Author : K. Sandy Pang
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-17

Enzyme And Transporter Based Drug Drug Interactions written by K. Sandy Pang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-17 with Medical categories.

Germination of the thought of "Enzymatic- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges" Proceedings came about as part of the annual meeting of The American Association of Pharmaceutical Scientists (AAPS) that was held in San Diego in November of 2007. The attendance of workshop by more than 250 pharmaceutical scientists reflected the increased interest in the area of drug-drug interactions (DDIs), the greater focus of PhRMA, academia, and regulatory agencies, and the rapid pace of growth in knowledge. One of the aims of the workshop was to address the progress made in quantitatively predicting enzyme- and transporter-based DDIs as well as highlighted areas where such predictions are poor or areas that remain challenging for the future. Because of the serious clinical implications, initiatives have arisen from the FDA (http://www.fda.gov/cber/gdlns/interactstud.htm) to highlight the importance of enzyme- and transporter-based DDIs. During the past ten to fifteen years, we have come to realize that transporters, in addition to enzymes, play a vital role in drug elimination. Such insight has been possible because of the continued growth in PK-ADME (pharmacokinetics-absorption-distribution-metabolism-excretion) knowledge, fueled by further advances in molecular biology, greater availability of human tissues, and the development of additional and sophisticated model systems and sensitive assay methods for studying drug metabolism and transport in vitro and in vivo. This has sparked an in-depth probing into mechanisms surrounding DDIs, resulting from ligand-induced changes in nuclear receptors, as well as alterations in transporter and enzyme expression and function. Despite such advances, the in vitro and in vivo study of drug interactions and the integration of various data sets remain challenging. Therefore, it has become apparent that a proceeding that serves to encapsulate current strategies, approaches, methods and applications is necessary. As Editors, we have assembled a number of opinion leaders and asked them to contribute chapters surrounding these issues. Many of these are the original Workshop speakers whereas others had been selected specially to contribute on topics related to basic and applied information that had not been covered in other reference texts on DDI. The resulting tome, entitled Enzyme- and Transporter-Based Drug Interactions: Progress and Future Challenges, comprises of four sections. Twenty-eight chapters covering various topics and perspectives related to the subject of metabolic and transporter-based drug-drug interactions are presented.

Drug Drug Interactions

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Author : A. David Rodrigues
language : en
Publisher: CRC Press
Release Date : 2019-01-03

Pharmacogenomics

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Author : Yui-Wing Francis Lam
language : en
Publisher: Academic Press
Release Date : 2013-02-12

Pharmacogenomics written by Yui-Wing Francis Lam and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-12 with Science categories.

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference. Multi-contributed book and chapters are written by contributors who are experts in their field Provides perspectives from those involved in all aspects of pharmacogenomics—including academic, regulatory, economic, industry and medical—to illustrate how all of the pieces fit together and where the challenges may be Includes case studies of both successful and unsuccessful applications so readers can consider the potential and challenges in moving the science into drug development and direct therapeutic applications Chapters contain discussion questions and clinical pearls and enable readers to reflect on how to move pharmacogenomics forward and apply these observations and useful tips to their own work and research

Drug Drug Interactions In Pharmaceutical Development

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Author : Binghe Wang
language : en
Publisher: John Wiley & Sons
Release Date : 2008-03-05

Drug Drug Interactions In Pharmaceutical Development written by Binghe Wang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-05 with Medical categories.

Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the evaluation of potential drug-drug interactions, allowing researchers to address risk factors before a drug is put to market. The book covers both clinical and nonclinical aspects for understanding drug-drug interactions as well as in vitro and in vivo studies for use in studying interactions at the drug discovery stage.

Drug Drug Interactions Scientific And Regulatory Perspectives

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