Drug Prototypes And Their Exploitation
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Drug Prototypes And Their Exploitation
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Author : Walter Sneader
language : en
Publisher:
Release Date : 1996
Drug Prototypes And Their Exploitation written by Walter Sneader and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Bioavailability categories.
This critical analysis of 150 different pharmaceuticals reveals the key prototype drugs from which all medicinal compounds in current use are derived. The volume charts the history and development of the various therapeutic drug classes.
Drug Discovery
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Author : Walter Sneader
language : en
Publisher: John Wiley & Sons
Release Date : 2005-06-23
Drug Discovery written by Walter Sneader and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-23 with Medical categories.
This edition provides expanded coverage of pre-20th century drugs, including emphasis on setting chapters in a wide historical and social context.
Drug Design
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Author : Gerhard Klebe
language : en
Publisher: Springer Nature
Release Date : 2025-02-04
Drug Design written by Gerhard Klebe and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-04 with Medical categories.
This English-language textbook, based on the successful German edition 'Wirkstoffdesign', brings the subject of drug design back to the cutting edge of research. The reader learns about new methods in genetic engineering and the expanded range of structural biological methods. Especially in the last 10 years, many complex target structures such as G-protein coupled receptors or ion channels have been elucidated by using these methods. The reader learns how these long-sought complex structures with classical drugs look like and how the therapeutic effect is achieved. This textbook is aimed at students of pharmacy, chemistry and the life sciences, but also at career changers and medicinal chemists in research and development departments of the pharmaceutical industry. Conceptually, it is very different from classical textbooks on pharmaceutical chemistry. It focuses on the path to a new drug substance. The selection of case studies is based on didactic aspects and attempts to give a broad overview of methods and strategies without forgetting to look back at the beginnings of this field of work. Thus, the arc spans from the history of drug research, the mechanisms of action of drugs and the methods for lead structure search and optimisation to structure determination methods, modelling, molecular dynamics and QSAR methods to structure- and computer-aided design. This textbook also discusses new methods and concepts such as epigenetics, the PROTAC approach, CRISPR-Cas9 gene scissors, structural predictions from sequence, the use of artificial intelligence and new screening technologies from biophysics. It presents successes in disrupting or enhancing protein-protein interactions as a concept for drug therapy and discusses optimising drugs considering their thermodynamic as well as kinetic binding profiles . Videos via app: simply download the SN More Media app free of charge, scan a link with the play button and immediately play the video on your smartphone or tablet.
Fragment Based Approaches In Drug Discovery
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Author : Wolfgang Jahnke
language : en
Publisher: John Wiley & Sons
Release Date : 2006-12-13
Fragment Based Approaches In Drug Discovery written by Wolfgang Jahnke and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-13 with Science categories.
This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.
The Rise And Fall Of Modern Medicine
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Author : James Le Fanu
language : en
Publisher: Hachette UK
Release Date : 2011-11-03
The Rise And Fall Of Modern Medicine written by James Le Fanu and has been published by Hachette UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-03 with History categories.
The medical achievements of the post-war years rank as one of the supreme epochs of human endeavour. Advances in surgical technique, new ideas about the nature of disease and huge innovations in drug manufacture vanquished most common causes of early death, But, since the mid-1970s the rate of development has slowed, and the future of medicine is uncertain. How has this happened? James Le Fanu's hugely acclaimed survey of the 'twelve definitive moments' of modern medicine and the intellectual vacuum which followed them has been fully revised and updated for this edition. The Rise and Fall of Modern Medicine is both riveting drama and a clarion call for change.
Metabolism Pharmacokinetics And Toxicity Of Functional Groups
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Author : Dennis A Smith
language : en
Publisher: Royal Society of Chemistry
Release Date : 2010-04-09
Metabolism Pharmacokinetics And Toxicity Of Functional Groups written by Dennis A Smith and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-09 with Medical categories.
Until now, the area of drug metabolism and pharmacokinetics has been lacking in texts written for the Medicinal Chemist. This outstanding book, aimed at postgraduate medicinal chemists and those working in industry, fills this gap in the literature. Written by medicinal chemists and ADMET scientists with a combined experience of around 300 years, this aid to discovering drugs addresses the absorption, distribution, metabolism, excretion and toxicity (ADMET) issues associated with drugs. The book starts by describing drug targets and their structural motifs before moving on to explain ADMET for the medicinal chemist. It is the functional groups which most profoundly influence the drug molecules of which they form a part. They characterise the pharmacology, are essential to the activity, and alter the ADMET characteristics of each drug. Their effects follow a pattern, thus allowing medicinal chemists to predict and overcome potential challenges. For this reason, the Editors have taken the unique approach of dividing the remainder of the book into chapters which each focus on a different functional group. They describe drugs containing the functional group under consideration, explain why the group is there, and outline its physicochemical properties before going on to detail the ADMET issues. Where possible, prodrugs and bioisosteres, which may give alternative ADMET outcomes, are described. The chapters cross refer where similar matters are covered but individual chapters can be used in a stand alone manner. The book ends with a discussion of future targets and chemistry needs.
Pharmaceutical Achievers
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Author : Mary Ellen Bowden
language : en
Publisher: Chemical Heritage Foundation
Release Date : 2003
Pharmaceutical Achievers written by Mary Ellen Bowden and has been published by Chemical Heritage Foundation this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Biography & Autobiography categories.
This biographical collection highlights individuals who made outstanding achievements in the arenas of pharmaceuticals and biotechnology. Pharmaceutical Achievers presents chronologically the major directions of pharmaceutical research and, in their historical context, the breakthroughs in treating various diseases. It concludes with a look at tomorrow's medicines. This work is particularly useful in the classroom, where its accounts of challenges and triumphs may inspire students to consider careers that support pharmaceutical research and development.
Biographies Of Remedies
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Author :
language : en
Publisher: BRILL
Release Date : 2016-08-29
Biographies Of Remedies written by and has been published by BRILL this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-29 with Medical categories.
At a time when genetics and informatics are seen to transform therapeutic thinking once again, it is pertinent to look back to earlier therapeutic regimes. The long twentieth century has witnessed a tremendous upsurge in new drugs, remedies and therapeutic strategies. The cultural environments in which they emerged, the social circumstances from which they sprang, and the social effects that remedies engendered are treated in depth in this collection of essays. They address the historical variety of remedies as economic, social, and cultural objects and discuss their particular forms of production and distribution. Drawing predominantly on British and Dutch cases, the curious ‘biographies’ of modern drugs like streptomycin, taxol and interferon are reviewed, the shifting boundaries between medicines and toxic substances are explored, and remedial strategies such as contraceptives are scrutinised. This book, which emerged out of an Anglo-Dutch conference held in 1998, explores cultures of remedies from a comparative perspective.
The Practice Of Medicinal Chemistry
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Author : Camille Georges Wermuth
language : en
Publisher: Academic Press
Release Date : 2011-05-02
The Practice Of Medicinal Chemistry written by Camille Georges Wermuth and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-02 with Medical categories.
The Practice of Medicinal Chemistry fills a gap in the list of available medicinal chemistry literature. It is a single-volume source on the practical aspects of medicinal chemistry. Considered ""the Bible"" by medicinal chemists, the book emphasizes the methods that chemists use to conduct their research and design new drug entities. It serves as a practical handbook about the drug discovery process, from conception of the molecules to drug production. The first part of the book covers the background of the subject matter, which includes the definition and history of medicinal chemistry, the measurement of biological activities, and the main phases of drug activity. The second part of the book presents the road to discovering a new lead compound and creating a working hypothesis. The main parts of the book discuss the optimization of the lead compound in terms of potency, selectivity, and safety. The Practice of Medicinal Chemistry can be considered a ""first-read"" or ""bedside book"" for readers who are embarking on a career in medicinal chemistry.NEW TO THIS EDITION: * Focus on chemoinformatics and drug discovery * Enhanced pedagogical features* New chapters including: - Drug absorption and transport - Multi-target drugs* Updates on hot new areas: NEW! Drug discovery and the latest techniques NEW! How potential drugs can move through the drug discovery/ development phases more quickly NEW! Chemoinformatics
Structural Bioinformatics
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Author : Jenny Gu
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-20
Structural Bioinformatics written by Jenny Gu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-20 with Science categories.
Structural Bioinformatics was the first major effort to show the application of the principles and basic knowledge of the larger field of bioinformatics to questions focusing on macromolecular structure, such as the prediction of protein structure and how proteins carry out cellular functions, and how the application of bioinformatics to these life science issues can improve healthcare by accelerating drug discovery and development. Designed primarily as a reference, the first edition nevertheless saw widespread use as a textbook in graduate and undergraduate university courses dealing with the theories and associated algorithms, resources, and tools used in the analysis, prediction, and theoretical underpinnings of DNA, RNA, and proteins. This new edition contains not only thorough updates of the advances in structural bioinformatics since publication of the first edition, but also features eleven new chapters dealing with frontier areas of high scientific impact, including: sampling and search techniques; use of mass spectrometry; genome functional annotation; and much more. Offering detailed coverage for practitioners while remaining accessible to the novice, Structural Bioinformatics, Second Edition is a valuable resource and an excellent textbook for a range of readers in the bioinformatics and advanced biology fields. Praise for the previous edition: "This book is a gold mine of fundamental and practical information in an area not previously well represented in book form." —Biochemistry and Molecular Education "... destined to become a classic reference work for workers at all levels in structural bioinformatics...recommended with great enthusiasm for educators, researchers, and graduate students." —BAMBED "...a useful and timely summary of a rapidly expanding field." —Nature Structural Biology "...a terrific job in this timely creation of a compilation of articles that appropriately addresses this issue." —Briefings in Bioinformatics