Drug Resistance And Selectivity Biochemical And Cellular Basis
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Drug Resistance And Selectivity Biochemical And Cellular Basis
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Author : Enrico Mihich
language : en
Publisher:
Release Date : 1973
Drug Resistance And Selectivity Biochemical And Cellular Basis written by Enrico Mihich and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Medical categories.
Anthracycline Antibiotics In Cancer Therapy
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Author : Franco M. Muggia
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Anthracycline Antibiotics In Cancer Therapy written by Franco M. Muggia and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
F. M. MUGGIA When faced with the inadequacies of current cancer treatment, we prefer to look at what the future may hold. Quite often, we take for granted the past, preferring research into totally new areas. However, the persistent development of fertile soil may yield surprising rewards for those who choose to build on the knowledge of the past--hence, this symposium on anthracycline antibiotics. Although the anthracycline antibiotics represent much of the present and future of cancer treatment, their actual use c stretches back barely two decades to the pioneering efforts of Aurelio Di Marco, who characterized the antitumor properties of daunomycin and adriamycin. * The clinical application of these two compounds heralded a decade of excitement among oncologists dealing with pediatric tumors, breast cancer, leukemias, and lymphomas, and opened new hope for patients afflicted with sar comas and a variety of other tumors that had been deemed - sistant to chemotherapy. These successes were tempered with the realization that the antitumor effect of anthracyclines could be achieved at times only at the very high price of risking cardiac decompensation and, almost invariably, with the occurrence of alopecia and other acute toxicities. This record of past achievements and problems has slowly given way to a present increasingly illuminated by our ability to modify the distressing toxicities of these agents. Detailed clinical studies supplemented by ingenious laboratory models have gradually elucidated mechanisms and risk factors im plicated in the cardiomyopathy.
Antitumor Drug Resistance
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Author : Brian W. Fox
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Antitumor Drug Resistance written by Brian W. Fox and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The study of tumour resistance to anticancer drugs has been the subject of many publications since the initial discovery of the phenomenon by J. H. Burchenal and colleagues in 1950. Many papers have been published since then reporting development of resistance to most of the well-known anticancer agents in many different animal tumour systems, both in vivo and in vitro. Many different mechanisms of resistance have been described, and it is clear that the tumour cell has a wide diversity of options in overcoming the cell-killing activity of these agents. Definition of the magnitude of the phenomenon in the clinic is, however, much more problematical, and it is with this in mind that the initial chapter, seeks to out line the problem as the clinicians see it. It appears that the phenomenon of true resistance to a drug, as the biochemist would recognise it, is an important cause of the failure which clinicians experience in treating the disease. The extent of the contribution of this phenomenon to the failure of treatment cannot easily be evaluated at the present time, but it is hoped that the development and application of new and more sophisticated techniques for the analysis of cellular sub populations may help to give a more exact estimate and to shed some light on the causes of failure of many of the present therapeutic techniques.
Drug Design
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Author : E. J. Ariëns
language : en
Publisher: Elsevier
Release Date : 2013-10-22
Drug Design written by E. J. Ariëns and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
Drug Design, Volume V covers the fundamental approaches to the development of bioactive compounds. The book discusses the utilization of operational schemes for analog synthesis in drug design; the design of enzyme inhibitors (transition state analogs); and the significance of structure-absorption-distribution relationships for drug design. The text describes the role of charge-transfer processes in the action of bioactive materials, as well as the approaches to the rational combination of antimetabolites for cancer chemotherapy. The physicochemical, quantum chemical, and other theoretical techniques for the understanding of the mechanism of action of central nervous system (CNS) agents, such as psychoactive drugs, narcotics, and narcotic antagonists and anesthetics, are also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design will find the book invaluable.
Cancer Treatment Reports
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Author :
language : en
Publisher:
Release Date : 1984
Cancer Treatment Reports written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Cancer categories.
Journal
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Author : National Cancer Institute (U.S.)
language : en
Publisher:
Release Date : 1977
Journal written by National Cancer Institute (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Cancer categories.
Journal Of The National Cancer Institute
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Author :
language : en
Publisher:
Release Date : 1997
Journal Of The National Cancer Institute written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Cancer categories.
Advances In Cancer Research
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Author :
language : en
Publisher: Academic Press
Release Date : 1981-02-23
Advances In Cancer Research written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981-02-23 with Medical categories.
Advances in Cancer Research
Biological Responses In Cancer
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Author : Enrico Mihich
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Biological Responses In Cancer written by Enrico Mihich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
The series of volumes entitled Biological Responses in Cancer provides information on approaches through which the interaction between neoplas tic and normal cells may be modified. Topics discussed in various volumes include immunological and host defense systems, control mechanisms of cell and population growth, cell differentiation, and cell transformation. This volume is specifically concerned with various aspects of cell interactions and regulation within heterogeneous tumor cell populations, and their role in tumor progression and metastasis. Knowledge in this area is likely to provide new leads toward the exploitation of novel cellular sites and mech anisms in the development of new types of therapies of cancer. Several topics are discussed within these general areas of consideration. The possibly unique characteristics and mechanisms of tumor vascularization and the potential sites of interference with angiogenesis that might have therapeutic impli cations are critically evaluated. Tumor cell-normal tissue interactions in volved in different phases of the growth and metastatic processes are dis cussed in two chapters dealing with mechanisms of tumor invasion and with the role of collagen in mammary tumor growth; here again potential leads are identified that may be exploited toward the development of new thera peutic approaches. The evolution of phenotypic diversity as a phenomenon complicating the biology of tumor metastasis and consequently affecting the opportunities offered by chemotherapy is also critically considered.
Drugs And Immune Responsiveness
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Author : J.L. Turk
language : en
Publisher: Springer
Release Date : 1979-06-17
Drugs And Immune Responsiveness written by J.L. Turk and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979-06-17 with Medical categories.