Drug Resistance In Leishmania Parasites
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Drug Resistance In Leishmania Parasites
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Author : Alicia Ponte-Sucre
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-09-04
Drug Resistance In Leishmania Parasites written by Alicia Ponte-Sucre and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-04 with Medical categories.
One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.
Drug Discovery For Leishmaniasis
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Author : Luis Rivas
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-10-26
Drug Discovery For Leishmaniasis written by Luis Rivas and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-26 with Science categories.
For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the only treatment option for the bulk of patients. However, this is largely unaffordable for most. In the past three years numerous advances in drug discovery have been made for treating this disease by exploiting diverging metabolic pathways between the Leishmania enzymes and their hosts, using nanotechnology to target the immune cell phagolysosomes where Leishmania resides. Drug Discovery for Leishmaniasis aims to provide a perspective of the current treatments and their challenges, blended with the emerging strategies and methodologies that will drive new target appraisals and drug developments, as well as addressing the molecular basis of resistance in Leishmania. Recent studies have shown that leishmaniasis affects some of the poorest people in the world, with 95% of fatal cases occurring in only 6 countries. With the WHO goal of eliminating this public health problem in the South-east Asia Region by 2020, this book will be important for anyone who is interested in neglected tropical diseases.
Leishmania
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Author : Jay P. Farrell
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Leishmania written by Jay P. Farrell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Leishmania parasites cause a diverse group of diseases endemic to many tropical and subtropical regions of the world. This volume seeks to bring together recent research on cell and molecular biology of Leishmania with chapters on the host response to infection, the current epidemiology of leishmaniasis, explanations of the many different species, vector control, and strategies for vaccine development and drug treatment. Leishmania, volume four of World Class Parasites, is written for researchers, students and scholars who enjoy reading research that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. It is intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. It integrates vector, pathogen and host biology and celebrates the diversity of approach that comprises modern parasitological research.
Leishmania
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Author : Subrata Adak
language : en
Publisher:
Release Date : 2015
Leishmania written by Subrata Adak and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Medical categories.
Every year, with an estimated 1.3 million new cases and more than 20,000 deaths, Leishmaniasis continues to be a menace in countries across the globe. With the absence of an anti-Leishmania vaccine - along with the toxicity of current anti-parasite drugs and coupled with the rapid emergence of drug resistant Leishmania strains - there remains significant challenges for disease control. This has spurred a plethora of research initiatives into parasite biology, parasite-host interaction, mechanisms of disease pathogenesis, drug development, and the molecular mechanism of drug resistance. Insights obtained from various studies are essential for the development of novel anti-Leishmania treatment strategies. In this timely book, respected Leishmania experts distil important current research, highlighting the most insightful discoveries in the field. Topics covered include: modulation of host miRNA * heat shock proteins * iron in the Leishmania-macrophage interaction * oxidative and nitrosative stress response * cell death * strategies for immune evasion * STAT signaling * parasite modulation of toll-like receptors in macrophages * T cells in Leishmania infection * vaccine biology * inhibitors of Leishmania DNA topoisomerases * mechanism of drug resistance in visceral Leishmaniasis. The book is an essential text for everyone in the Leishmania community and is recommended for researchers working in related fields.
Drug Targets In Kinetoplastid Parasites
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Author : Hemanta K. Majumder
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-09-15
Drug Targets In Kinetoplastid Parasites written by Hemanta K. Majumder and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-15 with Medical categories.
The dreaded protozoal diseases caused by a number of Kinetoplastid parasites threaten mankind, as therapeutic tools for the treatment of most parasitic diseases are extremely limited. Development of commercially available vaccines is still far from reality, though research and trial programs continue. This book covers current research into drug therapeutics for the conditions caused by the parasites, which if viewed globally, pose an increasing threat to human health and welfare.
Leishmania And Leishmaniasis
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Author : Awanish Kumar
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-09-13
Leishmania And Leishmaniasis written by Awanish Kumar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-13 with Medical categories.
Leishmania-related illnesses remain among the world’s deadliest neglected tropical diseases, affecting approximately 12 million people in 88 countries. The mortality rate is substantial, contributing to nearly two million disability-adjusted life years. As more is understood about this parasite and its effects, work toward prevention, control, and treatment continues apace. Leishmania and Leishmaniasis will address the parasite and its attendant disease, which manifests in three syndromes: Visceral (VL), Cutaneous (CL) and Mucocutaneous Leishmaniasis (ML). The morphology and life cycles of the various species will be among the topics addressed in Part One. Part Two will focus on immunology, including host-immune response to Leishmania infection, cross-immunity between the different species and adoptive transfer of immunity. Parts Three and Four will address how Leishmania invade and survive, the clinical features of the disease, and its diagnosis. Drugs, vaccines and treatment will be thoroughly explored, including experimental models of therapeutics. Leishmania and Leishmaniasis will provide a thorough examination of a parasite, the illnesses it causes and the misery it continues to visit upon large segments of the population.
Challenges And Solutions Against Visceral Leishmaniasis
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Author : Angamuthu Selvapandiyan
language : en
Publisher: Springer
Release Date : 2024-01-28
Challenges And Solutions Against Visceral Leishmaniasis written by Angamuthu Selvapandiyan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-28 with Medical categories.
This book comprehensively reviews the epidemiology and surveillance strategies of Visceral Leishmaniasis, and the latest developments in disease diagnosis, drug discovery, and vaccine development. The initial chapters cover the epidemiology features and spatial distribution of Visceral Leishmaniasis. The book further discusses the manifestations of HIV-Visceral Leishmaniasis infection on the immunopathogenesis, diagnosis, and therapeutic response. It analyzes the role of different proteomic technologies in understanding the parasite development, survival, drug resistance mechanisms, host-pathogen interactions, and the development of new therapeutic approaches. The book concludes by discussing recent advancements in vaccine development for Visceral Leishmaniasis. It discusses the promising vaccine candidate, their developmental status, current challenges, and prospects for rational vaccine development against Leishmania. This book is an invaluable source of information for students, and researchers working to understand the Leishmania biology, and drug development.
Pathogenesis Treatment And Prevention Of Leishmaniasis
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Author : Mukesh Samant
language : en
Publisher: Academic Press
Release Date : 2021-08-18
Pathogenesis Treatment And Prevention Of Leishmaniasis written by Mukesh Samant and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-18 with Medical categories.
Leishmaniasis is a neglected tropical disease that is known to be transmitted by 90 different species of sandflies which carry 20 Leishmania species that cause human infection particularly in endemic countries. Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to provide information on this vector-borne disease and explore strategies for diagnosis and treatment. The book begins with an overview of leishmaniasis which includes historical and future perspectives of the disease. It also discusses the clinical manifestation of the disease, mechanisms of infection, therapeutic strategies, diagnostics, prevention, and cure of Leishmania parasite. The book goes on to explain new insights and challenges in the development of promising drug targets, biomarkers identification and advance vaccination strategies against leishmaniasis. Chapter contributions brings together diverse areas of expertise making Pathogenesis, Treatment, and Prevention of Leishmaniasis aims to bring together elements of leishmaniasis into one place and be a valuable resource for researchers, health care professionals, and graduate students, working in the field of leishmaniasis. Provides an overview Leishmania and leishmanisis which include its history, transmission, clinical picture, and treatment Discusses novel approaches to study parasite infection and treatment Explores recent advances in the development of diagnostic kits, drug development and various vaccination strategies
Frontiers In Anti Infective Drug Discovery
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Author : Atta-ur-Rahman
language : en
Publisher: Bentham Science Publishers
Release Date : 2013-09-15
Frontiers In Anti Infective Drug Discovery written by Atta-ur-Rahman and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-15 with Medical categories.
This ebook series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the ebook series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The third volume of this series features 6 chapters that cover a variety of topics including: - Drug Discovery for TB - Therapeutic Limitations due to Antibiotic Drug Resistance - Applications for Virus Vaccine Vectors in Infectious Disease Research - NewCastle Disease Virus - Anti-Infective Therapy Against Leishmaniasis - Anti-Viral Activity of Proanthocyanidins.
Leishmaniases As Re Emerging Diseases
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Author : Farhat Afrin
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-10-10
Leishmaniases As Re Emerging Diseases written by Farhat Afrin and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-10 with Medical categories.
Leishmania parasites plague the mammalian host causing high morbidity and mortality. The parasites persist in the hostile milieu, crippling its defensive arsenal. In the face of mounting resistance to an antiquated drug arsenal, new approaches are urgently desired to keep the infection at bay. Furthermore, to strengthen the leishmaniasis elimination drive, particular emphasis has to be laid on identification of new targets and vaccination strategies. This book gives a brief glimpse of the epidemiology of leishmaniasis, immune evasion, vaccination, and therapeutic modalities that may work by untangling the immunological cross-wires of pathogenic cross-talk. The Conventional treatment and its drawbacks, the prospects of phytotherapy and nanomedicines, are also discussed. The identification of drug targets with the aim of designing inhibitors is also exemplified.