Drugs And Aging
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Drugs And Aging
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Author : Dieter Platt
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Drugs And Aging written by Dieter Platt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Experimental gerontological research is necessary to obtain optimal information and thus ensure proper drug therapy for the elderly. Most older persons acquire multiple diseases, first of all chronic diseases. They involve complex problems of a physical, social, and psychological nature. The multimorbidity of the elderly raises many questions in drug therapy. By contrast with our extensive knowledge of pharmacokinetics and pharmacodynamics in younger age groups, few facts are available in respect of the elderly. A variety of factors may influence drug therapy. Physiological and pathological age-related changes of molecules, cells, organs, and the total organism may interact to enhance or inhibit drug therapy in higher age groups. It is well known that elderly patients are overmedicated and therefore the incidence of adverse drug reactions increases with age. Elderly patients with multimorbidity often have a diminished body clearance of drugs; age-related changes of the kidney seems to be one of the most important factors in this regard. Far less important than the elimination of drugs through the kidney is their excretion in the bile. So far results have disclosed that oxidative steps in drug clearance are more likely to be disturbed than phase II reactions. Furthermore; changes in distribution volume and age-related alterations in receptor sensitivity also influence the clearance of drugs in the elderly.
Food Drugs And Aging
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Author : Ruth E. Dunkle
language : en
Publisher: Churchill Livingstone
Release Date : 1986
Food Drugs And Aging written by Ruth E. Dunkle and has been published by Churchill Livingstone this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Medical categories.
Abstract: The interrelationship of food and drugs for the elderly within a biomedical and social perspective is discussed. This book consists of edited versions of papers presented at the Fall 1984 symposium, "Food, Drugs, and Aging" in Cleveland, Ohio, and sponsored by the University Center on Aging and Health at Case Western Reserve University. The monograph is comprised of the following parts: Part I: the biological and medical aspects of drug treatment in the elderly; part II focuses on the relationship of diseases and nutrition as affected by social, cultural, and economic concerns of older people; and part III concludes with therapeutic issues related to drugs and nutrition.
Anti Aging Drugs
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Author : Alexander M Vaiserman
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-02-01
Anti Aging Drugs written by Alexander M Vaiserman and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-01 with Aging categories.
Aging is a natural phenomenon that is peculiar to all living things. However, accumulating findings indicate that senescence could be postponed or prevented by certain approaches. Substantial evidence has emerged supporting the possibility of radical human health and lifespan extension, in particular through pharmacological modulation of aging. A number of natural dietary ingredients and synthetic drugs have been assumed to have geroprotective potential. In the development of anti-aging therapeutics, several cell, insect, and animal models may provide useful starting points prior to human studies. This book provides an overview of current research aimed to search for life-extending medications and describes pharmacological aspects of anti-aging medicine. Readers are introduced to the fascinating historical background of geroprotection in the first chapter. In-depth information on models for investigating geroprotective drugs precedes a section covering anti-aging properties of pharmaceutical compounds, such as calorie restriction mimetics, autophagy inducers, senolytics and mitochondrial antioxidants. Finally, strategies to translate discoveries from aging research into drugs and healthcare policy perspectives on anti-ageing medicine are provided to give a complete picture of the field. A timely and carefully edited collection of chapters by leading researchers in the field, this book will be a fascinating and useful resource for pharmacologists, gerontologists and any scientifically interested person wishing to know more about the current status of research into anti-aging remedies, challenges and opportunities.
Aging And Drug Therapy
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Author : G. Barbagallo-Sangiorgi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Aging And Drug Therapy written by G. Barbagallo-Sangiorgi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
One of the greatest advances in Geriatric Medicine during the last quarter of a century has been the increased realization of the possibilities of treatment for elderly patients. Neglect has been replaced by a more optimistic therapeutic endeavour and countless old people have benefitted from this approach. But there is also a drawback, and this is the risk of hazardous side effects of medication which are often directly proportional to the biological potency of the drug and may be unpredictably increased due to changes in the senile organism. In fact the anatomical and biological changes in old age alter both the kinetics of most drugs and the receptor response. On account of these changes the individual tolerance of aged patients to drug therapy may be quite different from that of younger subjects. Thus for a variety of reasons elderly patients receive more drugs, but they are at a higher risk of encountering adverse reactions, which often show atypical clinical features. We can therefore speak of "geriatric iatrogenic disorders" and point out that some of these side effects are determined by a complex pathogenesis due to the particular pathophysiological condition in the elderly. It is important to encourage the habit of individ ually evaluating potential risk versus expected advantages of drugs in keeping with the same principles adopted in the evaluation of cost/benefit ratio.
Drugs And The Elderly
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Author : Ronald C. Kayne
language : en
Publisher: Ethel Percy Andrus Gerontology California
Release Date : 1978
Drugs And The Elderly written by Ronald C. Kayne and has been published by Ethel Percy Andrus Gerontology California this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Medical categories.
Drug Related Problems In The Elderly
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Author : Patrik Midlöv
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-07-07
Drug Related Problems In The Elderly written by Patrik Midlöv and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-07 with Medical categories.
Drug-related problems in the elderly is intended to serve as a source of information and clinical support in geriatric pharmacotherapy for students as well as all health care professionals, e.g. physicians, nurses and pharmacists. Pharmacotherapy is of great importance to all mankind. Drugs are however powerful and must be handled appropriately. This is especially important for elderly patients. Drug-related problem is not a major subject in most university programmes in medicine or pharmacy. When there is no speci c course, there is often no book covering the topic. In our view, as teachers at various university courses, there has been a shortage of literature that re ects the most important aspects of drug-related problems in the elderly. Medical practitioners, nurses and pharmacists, need to have this knowledge to be able to serve their patients in the best way. This book covers most aspects of drug-related problems in the elderly. With b- ter knowledge of drug-related dif culties and risks we hope that elderly will have fewer drug-related problems and bene t more from their pharmacotherapy.
Aging And Drug Therapy
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Author : G. Barbagallo-Sangiorgi
language : en
Publisher: Springer
Release Date : 2011-11-04
Aging And Drug Therapy written by G. Barbagallo-Sangiorgi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-04 with Science categories.
One of the greatest advances in Geriatric Medicine during the last quarter of a century has been the increased realization of the possibilities of treatment for elderly patients. Neglect has been replaced by a more optimistic therapeutic endeavour and countless old people have benefitted from this approach. But there is also a drawback, and this is the risk of hazardous side effects of medication which are often directly proportional to the biological potency of the drug and may be unpredictably increased due to changes in the senile organism. In fact the anatomical and biological changes in old age alter both the kinetics of most drugs and the receptor response. On account of these changes the individual tolerance of aged patients to drug therapy may be quite different from that of younger subjects. Thus for a variety of reasons elderly patients receive more drugs, but they are at a higher risk of encountering adverse reactions, which often show atypical clinical features. We can therefore speak of "geriatric iatrogenic disorders" and point out that some of these side effects are determined by a complex pathogenesis due to the particular pathophysiological condition in the elderly. It is important to encourage the habit of individ ually evaluating potential risk versus expected advantages of drugs in keeping with the same principles adopted in the evaluation of cost/benefit ratio.
Drug Use And Misuse
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Author : United States. Congress. Senate. Special Committee on Aging
language : en
Publisher:
Release Date : 1983
Drug Use And Misuse written by United States. Congress. Senate. Special Committee on Aging and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Aged categories.
Anti Aging Pharmacology
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Author : Vitaly Koltover
language : en
Publisher: Academic Press
Release Date : 2022-12-07
Anti Aging Pharmacology written by Vitaly Koltover and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-07 with Medical categories.
Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm. This book contains the work of the world’s leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice. Includes updated information about current developments in anti-aging pharmacology Offers practical advice on the applicability of certain healthspan-promoting medications Discusses potential challenges related to the translation of anti-aging drugs in clinical practice
Drugs Ageing And Society
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Author : Bruce Burns
language : en
Publisher: Taylor & Francis
Release Date : 2024-05-10
Drugs Ageing And Society written by Bruce Burns and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-10 with Medical categories.
During the 1970s and 1980s prescription and over-the-counter drugs had come to play a major role in the health care of older people. Originally published in 1986, this book reviews the historical background to this development and explores its social and pharmacological implications. The main aim of the study was to provide a critical perspective on drug use together with a framework for developing effective prescribing policies. The authors do not, in developing their arguments, reject the enormous value of drugs in the treatment of many illnesses affecting older people; they do, however, criticise excessive as well as inappropriate prescribing. The intention was to provide some practical illustrations of how the harmful effects of drug use can be curtailed. This book was aimed, in particular, at workers in the health services, for example: doctors, health visitors, district nurses, pharmacists, the professions allied to medicine. However, it should also be of interest to other groups such as social workers, carers, support groups and older people themselves.
