Dynamics And The Problem Of Recognition In Biological Macromolecules
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Dynamics And The Problem Of Recognition In Biological Macromolecules
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Author : Oleg Jardetzky
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Dynamics And The Problem Of Recognition In Biological Macromolecules written by Oleg Jardetzky and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
From within complex structures of organisms and cells down to the molecular level, biological processes all involve movement. Muscular fibers slide on each other to activate the muscle, as polymerases do along nucleic acids for replicating and transcribing the genetic material. Cells move and organize themselves into organs by recognizing each other through macromolecular surface-specific interactions. These recognition processes involve the mu tual adaptation of structures that rely on their flexibility. All sorts of conformational changes occur in proteins involved in through-membrane signal transmission, showing another aspect of the flexibility of these macromolecules. The movement and flexibility are inscribed in the polymeric nature of essential biological macromolecules such as proteins and nucleic acids. For instance, the well-defined structures formed by the long protein chain are held together by weak noncovalent interac tions that design a complex potential well in which the protein floats, permanently fluctuating between several micro- or macroconformations in a wide range of frequencies and ampli tudes. The inherent mobility of biomolecular edifices may be crucial to the adaptation of their structures to particular functions. Progress in methods for investigating macromolecular structures and dynamics make this hypothesis not only attractive but more and more testable.
Essentials Of Chemical Biology
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Author : Andrew D. Miller
language : en
Publisher: John Wiley & Sons
Release Date : 2023-12-27
Essentials Of Chemical Biology written by Andrew D. Miller and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-27 with Science categories.
Essentials of Chemical Biology Discover a detailed knowledge of concepts and techniques that shape this unique multi-discipline Chemical Biology is devoted to understanding the way that Biology works at the molecular level. This is a problem-driven multi-discipline, incorporating as it does Organic, Physical, Inorganic, and Analytical Chemistry alongside newer emerging molecular disciplines. In recent years, Chemical Biology has emerged as a vibrant and growing multi-discipline distinct from Biochemistry that is focused on the quantitative analyses of the structures and functions of biological macromolecules and macromolecular lipid assemblies, at first in isolation, then in vitro and in vivo. The second edition of the Essentials of Chemical Biology begins with a thorough introduction to the structure of biological macromolecules and macromolecular lipid assemblies, before moving on to the principles of chemical and biological synthesis, followed by descriptions of a comprehensive variety of research techniques and experimental methods. In addition, the second edition now includes new sections on the behaviour of biological macromolecules and macromolecular lipid assemblies in cells in vitro and in organisms in vivo. Given this, the second edition of the Essentials of Chemical Biology promises to cement itself as the leading introduction to Chemical Biology, incorporating descriptions of cutting-edge research wherever appropriate. Hence, readers of the second edition of the Essentials of Chemical Biology will find: a general expansion in understanding of basic molecular mechanisms in Biology moving towards cellular and organismal mechanisms entirely new chapters covering miniaturization and array technologies, Chemical Cell Biology, and the interface between Chemical Biology and Nanotechnology updates to chapters reflecting recent research developments an increased engagement with medical applications Essentials of Chemical Biology is ideal for advanced undergraduates or (post) graduate students in Chemical Biology and adjacent fields.
Macromolecular Crystallography
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Author : Maria Armenia Carrondo
language : en
Publisher: Springer
Release Date : 2011-12-01
Macromolecular Crystallography written by Maria Armenia Carrondo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-01 with Science categories.
This volume is a collection of the contributions presented at the 42nd Erice Crystallographic Course whose main objective was to train the younger generation on advanced methods and techniques for examining structural and dynamic aspects of biological macromolecules. The papers review the techniques used to study protein assemblies and their dynamics, including X-ray diffraction and scattering, electron cryo-electron microscopy, electro nanospray mass spectrometry, NMR, protein docking and molecular dynamics. A key theme throughout the book is the dependence of modern structural science on multiple experimental and computational techniques, and it is the development of these techniques and their integration that will take us forward in the future.
Dynamics Structure And Function Of Biological Macromolecules
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Author : Oleg Jardetzky
language : en
Publisher: IOS Press
Release Date : 2001
Dynamics Structure And Function Of Biological Macromolecules written by Oleg Jardetzky and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Biomolecules categories.
A collection of articles looking at modern structural biology, summarizing the applications of physical methods - such as x-ray diffraction, high resolution nuclear magnetic resonance and molecular dynamics - to the study of protein structure and dynamics. There is a review of contemporary thoughts within the field, looking at the mechanisms of alloateric transitions and allosteric control, the transmission of information within protein structures and the role of dynamics in determining the specificity of protein - ligand interactions. There is also a look at future innovations.
Nmr Spectroscopy Of Biological Solids
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Author : A. Ramamoorthy
language : en
Publisher: CRC Press
Release Date : 2005-09-22
Nmr Spectroscopy Of Biological Solids written by A. Ramamoorthy and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-22 with Medical categories.
Over the past decade, a myriad of techniques have shown that solid-state nuclear magnetic resonance (NMR) can be used in a broad spectrum of applications with exceptionally impressive results. Solid-state NMR results can yield high-resolution details on the structure and function of many important biological solids, including viruses, fibril-formin
Protein Dynamics Function And Design
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Author : Robin Holbrook
language : en
Publisher: Springer Science & Business Media
Release Date : 1998
Protein Dynamics Function And Design written by Robin Holbrook and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Proteins categories.
This text offers a survey of the state of research worldwide on the interactions and dynamics of large biological molecules such as DNA and proteins and on the effects of dynamics upon structure determination. Authors from renowned laboratories and institutions discuss new findings and new directions for the greater understanding of the interactions of molecules to create life-processes. Although the topics covered in the book require a relatively advanced understanding of biomedical/biochemical and biophysical science, the overall range of expertise and focus provides a broad survey of experimental techniques and approaches to the problem of understanding molecular recognition and interaction and the potential for drug design and development.
Dynamics Of Biological Macromolecules By Neutron Scattering
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Author : Federica Migliardo
language : en
Publisher:
Release Date : 2011-09-09
Dynamics Of Biological Macromolecules By Neutron Scattering written by Federica Migliardo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-09 with Science categories.
Dynamics of Biological Macromolecules by Neutron Scattering provides insight into the study of the dynamics of biological macromolecules by neutron scattering techniques. The applicability of neutron scattering to expanding fields of biological studies is very extended and the neutron scattering community is interested in using these unique technologies to their best advantage. The book is focused on recent scientific results on biomolecular motions obtained by using neutron spectroscopy, and also discusses likely directions of future work on biological macromolecular systems while outlining some challenging, hitherto inaccessible problem areas. The Ebook should be very useful for biophysicists, biochemists, experts and non-experts in neutron scattering.
Protein Conformational Dynamics
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Author : Ke-li Han
language : en
Publisher: Springer
Release Date : 2016-08-27
Protein Conformational Dynamics written by Ke-li Han and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-27 with Medical categories.
This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.
The British National Bibliography
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Author : Arthur James Wells
language : en
Publisher:
Release Date : 2001
The British National Bibliography written by Arthur James Wells and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Bibliography, National categories.
Index Of Conference Proceedings
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Author : British Library. Document Supply Centre
language : en
Publisher:
Release Date : 1997
Index Of Conference Proceedings written by British Library. Document Supply Centre and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Conference proceedings categories.