Ecm Based Macroporous Microribbon Hydrogels With Tunable Compositions Induce Fast And Robust Bone Regeneration By Mscs In 3d
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Ecm Based Macroporous Microribbon Hydrogels With Tunable Compositions Induce Fast And Robust Bone Regeneration By Mscs In 3d
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Author :
language : en
Publisher:
Release Date : 2017
Ecm Based Macroporous Microribbon Hydrogels With Tunable Compositions Induce Fast And Robust Bone Regeneration By Mscs In 3d written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Hydrogels have been widely used as 3D niche for cell delivery and tissue engineering. However, most hydrogels are nanoporous, whereas macroporosity is desirable for efficient nutrient diffusion, cell proliferation and matrix deposition. Though porogens may be used to introduce macroporosity, they further decrease the already weak mechanical properties of the hydrogels. To overcome these limitations, we have recently reported a method to fabricate gelatin hydrogels into microribbon (u00b5RB)-like structures using wet-spinning, followed by further photocrosslinking to form a macroporous scaffold. We have demonstrated that such 2-step fabrication process allows homogeneous encapsulation of stem cells inside 3D macroporous scaffolds and the unique u00b5RB morphology confers markedly enhanced mechanical strength to the scaffolds. While our previous work demonstrates the advantage of macroporosity in hydrogels for enhancing stem cell-based tissue regeneration using gelatin u00b5RBs, previous method was not suitable for fabricating other ECM polymers into u00b5RB structures, and how tuning u00b5RB compositions impact MSC-based bone formation in 3D remains unknown. The goals of this study are to develop a method that enable fabricating various extracellular-matrix (ECM) compositions into u00b5RB-like structures, and assess the effect of ECM composition on osteogenesis of mesenchymal stem cells (MSCs) and bon matrix production for bone repair. We demonstrated successful syntheses of u00b5RBs from various ECM compositions for forming macroporous scaffolds. Gelatin u00b5RB alone lead to high collagen, low mineralization; while GAG u00b5RB alone lead to low collagen, high mineralization. Co-spun u00b5RBs, but not mixed gelatin and GAG u00b5RBs, led to synergized bone formation with robust mineralization and collagen deposition. In summary, u00b5RB-based scaffolds with tunable compositions provide novel injectable macroporous matrices to enhance stem cell based bone regeneration.
Basic Orthopaedic Biomechanics
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Author : Van C Mow
language : en
Publisher: Lippincott Raven
Release Date : 1997
Basic Orthopaedic Biomechanics written by Van C Mow and has been published by Lippincott Raven this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Biomechanics categories.
This classic text has been completely revised and updated to reflect the latest advances in orthopaedic biomechanics, and the successful application of mechanical laws to the locomotor system of the human body. The Second Edition features new chapters on cell-matrix interactions in articular cartilage and on the quantitative anatomy of diarthrodial joints, as well as expanded coverage of the biomechanics of artificial hip and knee joints.
Articular Cartilage Tissue Engineering
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Author : Kyriacos A. Athanasiou
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2010
Articular Cartilage Tissue Engineering written by Kyriacos A. Athanasiou and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions
Management Of Common Musculoskeletal Disorders
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Author : Darlene Hertling
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 1990
Management Of Common Musculoskeletal Disorders written by Darlene Hertling and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Medical categories.
Bone And Cartilage Regeneration
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Author : Phuc Van Pham
language : en
Publisher: Springer
Release Date : 2017-01-24
Bone And Cartilage Regeneration written by Phuc Van Pham and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-24 with Science categories.
This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.
Advances In Tissue Engineering
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Author : Julia Polak
language : en
Publisher: World Scientific
Release Date : 2008-08-20
Advances In Tissue Engineering written by Julia Polak and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-20 with Science categories.
Advances in Tissue Engineering is a unique volume and the first of its kind to bring together leading names in the field of tissue engineering and stem cell research. A relatively young science, tissue engineering can be seen in both scientific and sociological contexts and successes in the field are now leading to clinical reality. This book attempts to define the path from basic science to practical application. A contribution from the UK Stem Cell Bank and opinions of venture capitalists offer a variety of viewpoints, and exciting new areas of stem cell biology are highlighted. With over fifty stellar contributors, this book presents the most up-to-date information in this very topical and exciting field. Contents:Tissue Engineering: Past, Present and Future:An Introduction (R M Nerem)Cells for Tissue Engineering:A Brief Introduction to Different Cell Types (L Buttery & K M Shakesheff)Human Embryonic Stem Cells: International Policy and Regulation (M Allyse & S Minger)Human Embryonic Stem Cells: Derivation and Culture (E L Stephenson et al.)Stem Cells Differentiation (P V Guillot & W Cui)Marrow Stem Cells (D G Phinney)Cord Blood Stem Cells — Potentials and Realities (C P McGuckin & N Forraz)Fat Stem Cells (J M Gimble et al.)Control of Adult Stem Cell Function in Bioengineered Artificial Niches (M P Lutolf & H M Blau)Stem Cell Immunology (A P Hollander & D C Wraith)Development of a Design of Experiment Methodology: Applications to the Design and Analysis of Experiments (M Lim & A Mantalaris)Banking Stem Cell Lines for Future Therapies (G N Stacey & C J Hunt)Materials:Synthetic Biomaterials as Cell-Responsive Artificial Extracellular Matrices (M P Lutolf & J A Hubbell)Bioactive Composite Materials for Bone Tissue Engineering Scaffolds (S Verrier & A R Boccaccini)Aggregation of Cells Using Biomaterials and Bioreactors (Z Bayoussef & K M Shakesheff)Nanotechnology for Tissue Engineering (J S Stephens-Altus & J L West)Microscale Technologies for Tissue Engineering (A Khademhosseini et al.)Non-Invasive Methods to Monitor Tissue Re-Modelling: Biosensors(T Cass)Tissue-Engineering Monitoring Using Microdialysis (Z-H Li et al.)Characterisation of Tissue Engineering Constructs by Raman Spectroscopy and X-ray Micro-Computed Tomography (μCT) (I Notingher & J R Jones)Role of Stem Cell Imaging in Regenerative Medicine (G Passacquale & K Bhakoo)Biotechnology Sector:Lessons Learnt (N L Parenteau et al.)The Promise of Stem Cells: A Venture Capital Perspective (C Prescott)Tissue Engineering Products:Cell Expansion, Cell Encapsulation, 3D Cultures (J M Polak & A Mantalaris)Bioreactor Engineering: Regenerating the Dynamic Cell Microenvironment (T Dvir & S Cohen)UK Regulatory Issues: The View from the Researcher (C Munro & N Harris)Tissue Repair:Stem Cell Therapy: Past, Present, and Future (F Baron & R Storb)Tissue Engineered Skin Comes of Age? (S MacNeil)Liver Repair (N Levicar et al.)Tissue Engineering for Tooth Regeneration (I A Diakonov & P Sharpe)Urogenital Repair (A Atala)Cardiac Repair:Basic Science (S E Harding)Cardiac Repair Clinical Trials (A Green & E Alton)Myocardial Recovery Following LVAD Support (R S George & E J Birks)Osteoarticular Repair:Animal Models (E A Horner et al.)In Vitro 3D Human Tissue Models for Osteochondral Diseases (S Ghosh & D L Kaplan)Application of Tissue Engineering for Craniofacial Reconstruction (D M Gupta et al.)Clinical Trials (A K Haudenschild & M H Hedrick)Lung Repair:Tissue Engineering for the Respiratory Epithelium: Is There a Future for Stem Cell Therapy in the Lung? (V Besnard & J A Whitsett)The Artificial Lung (A N Maurer & G Matheis) Readership: Stem cell researchers, clinicians, surgeons and biotechnology companies. Keywords:Stem Cells;Tissue Engineering;Regenerative Medicine;BiomaterialsKey Features:Discusses in-depth a topical subject, treated with the very latest informationWritten by leading contributors in the field, with the world-renowned Professor Dame Julia Polak as the lead editorContains an array of color diagrams and illustrationsDiffers from competing titles in that its coverage ranges from the basic science of stem cells and biomaterials to clinical applications, policy issues, views from the commercial sector and many others
Reverse Shoulder Arthroplasty
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Author : David M. Dines
language : en
Publisher: Thieme
Release Date : 2017-10-08
Reverse Shoulder Arthroplasty written by David M. Dines and has been published by Thieme this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-08 with Medical categories.
The definitive book on reverse shoulder arthroplasty from leading orthopaedic shoulder surgeons This masterful book from top experts provides clinical insights on reverse shoulder arthroplasty gleaned from hands-on refinement of shoulder replacement techniques. Years of significant biomechanical and clinical research yielded invaluable knowledge that led to important improvements in functional outcome and implant durability. Among these refinements were stronger polyethylene derivatives, better ingrowth technology, and improved connection devices. As the durability and longevity of implant technology increased, younger active patients became suitable candidates for this procedure. In fact, RSA has played a pivotal role in making shoulder arthroplasty the fastest growing implant technology. In the first two sections, the authors take the reader through the history and evolution of RSA, followed by step-by-step surgical techniques for specific injuries and conditions. The next three sections discuss past and recent outcomes, complications, and rehabilitation. The last section covers special considerations including patient specific instrumentation, convertible humeral and glenoid components, and the future potential of stemless humeral technology. Key Features The latest trends in patient-specific components, guide systems, and instrument design The use of RSA for rotator cuff repair, shoulder arthritis, and acute and complex fractures In-depth discussion of techniques to improve deltoid function, avoid impingement, and increase implant longevity Clinical pearls on how to recognize and handle complications that occur: instability, infection, scapular notching, component loosening, glenoid and humeral bone loss, and RSA failure High quality videos and 300 superb illustrations further delineate techniques This book is a practical resource that enables learning complex procedures, putting them into practice, and handling complications should they arise. It is an essential tool for all orthopaedic surgeons who treat shoulder conditions.
Regenerative Medicine And Plastic Surgery
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Author : Dominik Duscher
language : en
Publisher: Springer Nature
Release Date : 2019-11-27
Regenerative Medicine And Plastic Surgery written by Dominik Duscher and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-27 with Science categories.
This book presents the latest advances in the field of regenerative medicine in plastic surgery. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner.The first part introduces readers to essential principles of skin and soft tissue regeneration, e.g. the possibility of using mesenchymal stem cells for wound healing. Since bone serves as a supportive tissue in most of the body, bone regeneration is an important aspect of regenerative medicine; accordingly, the second part discusses the novel bone implants, activated bone grafts and bone tissue engineering. The book’s third part, focusing on cartilage regeneration, includes chapters on e.g. stem cells and ear regeneration. In turn, part four addresses muscle and tendon regeneration: from tendon to bone and tendon to muscle, as well as aging in the realm of muscle regeneration. Lastly, part five highlights nerve regeneration, deepening surgeons’ knowledge to help them successfully treat injuries to the peripheral neural system. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "With beautiful clinical images and artwork, this book will be a central companion to both practicing plastic surgeons who wish to remain abreast of oncoming technologic advances and regenerative medicine researchers who wish to understand the current state of the art of surgical reconstruction." - Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine
Orthopaedic Basic Science Foundations Of Clinical Practice
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Author : Regis J. O'Keefe
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2018-05-16
Orthopaedic Basic Science Foundations Of Clinical Practice written by Regis J. O'Keefe and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-16 with Medical categories.
Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Build your Foundation of Basic Science – from Research to Clinical Application A great tool for MOC preparation! A 'must have' for residency! This fourth edition, developed in a partnership between the American Academy of Orthopaedic Surgeons (AAOS) and the Orthopaedic Research Society (ORS), is your concise and clinically relevant resource for the diagnosis and treatment of musculoskeletal diseases and conditions.
Beyond The Scalpel
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Author : Ralph Costanzo
language : en
Publisher: Dorrance Publishing Company
Release Date : 1991
Beyond The Scalpel written by Ralph Costanzo and has been published by Dorrance Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.