Effect Of Aerobic Exercise And The Induced Increase In Heat Shock Proteins On Recovery Of Skeletal Muscle Function After Ischemia Reperfusion Injury
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Effect Of Aerobic Exercise And The Induced Increase In Heat Shock Proteins On Recovery Of Skeletal Muscle Function After Ischemia Reperfusion Injury
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Author : Edward Kelly Merritt
language : en
Publisher:
Release Date : 2004
Effect Of Aerobic Exercise And The Induced Increase In Heat Shock Proteins On Recovery Of Skeletal Muscle Function After Ischemia Reperfusion Injury written by Edward Kelly Merritt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
The purpose of this study was to determine the effect of exercise training on the recovery of skeletal muscle function following ischemia reperfusion injury. Three groups of animals underwent 6 weeks of aerobic training to increase heat shock protein content of skeletal muscle. After training, 2 groups were subjected to a 2-hour ischemic bout induced by pneumatic tourniquet (TK). In one group 7 days following TK application in vivo force was measured in a method similar to Ashton-Miller (1992). Another group recovered 14 days before in vivo force was measured. Force of the TK leg vs. contralateral leg measured 7 and 14 days following TK application was 29.6 +/- 2.3% and 55.0 +/- 3.3% respectively. Non-exercised control rat’s TK leg force production was 22.0 +/- 2.9% and 53.1 +/-5.2% when compared to the contralateral leg. These data suggest that exercise training prior to I/R allows for greater maximal force production 7 days following TK application
Skeletal Muscle Ischemia And Heat Shock Proteins
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Author :
language : en
Publisher:
Release Date : 1994
Skeletal Muscle Ischemia And Heat Shock Proteins written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with categories.
This research effort is directed at subobjective 2 as defined in the recent shock trauma mediators review memo from the U.S. Army Institute of Surgical Research. Specifically, we aimed at the prevention of secondary damage after hemorrhage by temporizing fundamental physiological or biochemical processes leading to cell death and organ failure. For this purpose, increased expression of the inducible heat shock 70 (hsp70I) will be employed. Hsp7OI works as a chaperone attaching to short hydrophobic peptide sequences as they are exposed in ischemic cells in which proteins undergo denaturation. By the association of hsp70 with such protein sequences further protein aggregation and cell damage is prevented. This leads to a faster recovery of cell function after the ischemic or hemorrhage episodes. Our results which are further summarized in the body indicate that overexpression of hsp70 in the heart of transgenic mice leads to marked protection against cardiac ischemic injury (1). In preliminary studies in collaboration with Dr. P. Lyden, UCSD and Dr. B. Nishimura, UCLA, we have found that the hsp70 transgene is also expressed in CNS-neurons and exerts a protective effect against ischemic damage in the brain as judged by behavioral scores in these transgenic mice.
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2003
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 2000
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medicine categories.
Chemical Abstracts
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Author :
language : en
Publisher:
Release Date : 2002
Chemical Abstracts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Chemistry categories.
Immune Function In Sport And Exercise
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Author : Michael Gleeson
language : en
Publisher: Elsevier Health Sciences
Release Date : 2006-01-01
Immune Function In Sport And Exercise written by Michael Gleeson and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-01 with Medical categories.
This title is directed primarily towards health care professionals outside of the United States. Designed to help readers understand and evaluate the relationship between exercise, immune function and infection risk, this book presents evidence for the "J-shaped" relationship between exercise load and infection risk. It also describes the components of the human immune system and key functions that protect the body from disease, the impact of acute and chronic psychological stress on immune function, and practical guidelines for minimizing the risk of immunodepression and infection in athletes. Further chapters explore different ways of measuring immune function, as well as the effects of heavy training on innate and specific (acquired) immunity, exercise in environmental extremes, and nutrition. Connections between exercise, infection risk, and immune function in special populations (elderly, obese, diabetic and HIV patients) are also addressed. Authored by a team of highly experienced experts. The "J-shaped" relationship between exercise load and infection risk is described, backed by current research and evidence. Components of the immune system and normal immune function are explained in detail, as well as methods for measuring immune function. The impact of acute and chronic psychological stress on immune function is presented, along with suggestions for minimizing the risk of immunodepression and infection in athletes. The effects of heavy training, exercise in environmental extremes, and nutrition are discussed with regard to their impact on innate and specific (acquired) immunity. Immune function in special populations (elderly, obese, diabetic and HIV patients) is also addressed, exploring links between exercise and infection risk in these groups. Evidence-based coverage includes a list of references in each chapter, as well as suggestions for further reading that direct readers to important texts and review articles. Information is presented in an easily accessible format, following a logical progression of material. LEach chapter begins with a list of learning objectives and ends with a list of key points to reinforce learning. A glossary at the end of the book defines all key terms and abbreviations.
Exercise And Stress Response
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Author : Marius Locke
language : en
Publisher: CRC Press
Release Date : 2002-03-28
Exercise And Stress Response written by Marius Locke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-28 with Medical categories.
Over the past 10 years, researchers have been investigating the expression, regulation, and protective nature of stress proteins (SPs) during and following exercise. Since the expression of SPs have been shown to provide protection to cells and tissues, the importance of understanding their role during exercise cannot be understated. However the terminology, the myriad of stress proteins, and their complex regulation creates a confusing arena in which to enter. Exercise and Stress Response: The Role of Stress Proteins provides an up-to-date review on topics related to exercise and health, giving investigators the necessary background to pursue stress proteins. ABOUT THE EDITORS: Marius Locke, Ph.D. is an Assistant Professor in the Faculty of Physical Education and Health at the University of Toronto in Ontario, Canada. Dr. Locke received a B.A. with honors in Physical Education (1984), a B.Sc. in Biology (1987), and a Ph.D. in Kinesiology from the University of Western Ontario (1992), where he also played varsity football. Dr. Locke was awarded a Natural Science and Engineering Research Council of Canada Post Doctoral Fellowship and studied at the Deborah Research Institute in Browns Mills, New Jersey from 1993-1996. In 1999, Dr. Locke received the American College of Sports Medicine's new investigator award. Dr. Locke is a member of American College of Sports Medicine, the Canadian Society for Exercise Physiology and the Cell Stress Society International. Earl G. Noble, Ph.D. is an Associate Professor in the School of Kinesiology at the University of Western Ontario in London, Ontario, Canada. He received his B.Sc. (1973) and M.Sc. (1975) in Kinesiology from the University of Waterloo and his Ph.D. from Washington State University (1980). Dr. Noble is a member of the Canadian Society for Exercise Physiology, the American College of Sports Medicine and the Cell Stress Society International and the Research Group on Biochemistry of Exercise of the International Council of Sport Science and Physical Education (UNESCO). The overriding theme of his research is to examine muscle plasticity and the manner in which muscle adapts to novel or stressful conditions, especially exercise.
Current Issues In Sports And Exercise Medicine
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Author : Michael Hamlin
language : en
Publisher: BoD – Books on Demand
Release Date : 2013-05-15
Current Issues In Sports And Exercise Medicine written by Michael Hamlin and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-15 with Health & Fitness categories.
This unique resource presents current issues in sports and exercise medicine which outlines new areas of knowledge and provides updates on current knowledge in the broad field of sports and exercise medicine. Written by experts in their own sub-disciplines, Current Issues in Sports and Exercise Medicine discusses the physiology behind sports injuries and presents new and exciting approaches to manage such injuries. In addition, the book explores the relationship between exercise, health and performance by providing new information in areas such as exercise and immunity, the use of iron supplementation for performance, how exercise affects reactive oxygen species, and the proposed benefits of real and simulated altitude training. This book is well referenced and illustrated and will be a valuable resource for sports medicine specialists, physiologists, coaches, physical conditioners, physiotherapists and graduate and medical school students.
Skeletal Muscle Circulation
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Author : Ronald J. Korthuis
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2011
Skeletal Muscle Circulation written by Ronald J. Korthuis and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
The aim of this treatise is to summarize the current understanding of the mechanisms for blood flow control to skeletal muscle under resting conditions, how perfusion is elevated (exercise hyperemia) to meet the increased demand for oxygen and other substrates during exercise, mechanisms underlying the beneficial effects of regular physical activity on cardiovascular health, the regulation of transcapillary fluid filtration and protein flux across the microvascular exchange vessels, and the role of changes in the skeletal muscle circulation in pathologic states. Skeletal muscle is unique among organs in that its blood flow can change over a remarkably large range. Compared to blood flow at rest, muscle blood flow can increase by more than 20-fold on average during intense exercise, while perfusion of certain individual white muscles or portions of those muscles can increase by as much as 80-fold. This is compared to maximal increases of 4- to 6-fold in the coronary circulation during exercise. These increases in muscle perfusion are required to meet the enormous demands for oxygen and nutrients by the active muscles. Because of its large mass and the fact that skeletal muscles receive 25% of the cardiac output at rest, sympathetically mediated vasoconstriction in vessels supplying this tissue allows central hemodynamic variables (e.g., blood pressure) to be spared during stresses such as hypovolemic shock. Sympathetic vasoconstriction in skeletal muscle in such pathologic conditions also effectively shunts blood flow away from muscles to tissues that are more sensitive to reductions in their blood supply that might otherwise occur. Again, because of its large mass and percentage of cardiac output directed to skeletal muscle, alterations in blood vessel structure and function with chronic disease (e.g., hypertension) contribute significantly to the pathology of such disorders. Alterations in skeletal muscle vascular resistance and/or in the exchange properties of this vascular bed also modify transcapillary fluid filtration and solute movement across the microvascular barrier to influence muscle function and contribute to disease pathology. Finally, it is clear that exercise training induces an adaptive transformation to a protected phenotype in the vasculature supplying skeletal muscle and other tissues to promote overall cardiovascular health. Table of Contents: Introduction / Anatomy of Skeletal Muscle and Its Vascular Supply / Regulation of Vascular Tone in Skeletal Muscle / Exercise Hyperemia and Regulation of Tissue Oxygenation During Muscular Activity / Microvascular Fluid and Solute Exchange in Skeletal Muscle / Skeletal Muscle Circulation in Aging and Disease States: Protective Effects of Exercise / References
Exercise Physiology
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Author : Thomas Fahey
language : en
Publisher: Independently Published
Release Date : 2019-09-03
Exercise Physiology written by Thomas Fahey and has been published by Independently Published this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-03 with categories.
Second of a two volume set.