Skeletal Muscle Ischemia And Heat Shock Proteins
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Skeletal Muscle Ischemia And Heat Shock Proteins
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Author :
language : en
Publisher:
Release Date : 1996
Skeletal Muscle Ischemia And Heat Shock Proteins written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Blood loss testing in decreased organ perfusion and subsequent ischemic injury of cardiac and skeletal muscle presents a significant problem for the soldier in combat. Recent findings indicate that different forms of noxious stress including exposure to increased temperature, noxious chemical agents, and schemia lead to increased expression of heat shock proteins (hsp) which have a protective effect against injury induced by noxious stimuli. We wanted to determine in this proposal if a muscle derived permanent cell line expressing increased amounts of hsp7O will show protection against damage induced by simulated ischemia. To generate cell lines which permanently overexpress the inducible hsp7O (hsp7Oi) proteins, cells will be transfected with a neomycin resistance gene and the hsp7Oi gene. Stable lines will be selected by growing L6 cells in the presence of neomycin. Cells which have the neomycin resistance gene and the hsp7O gene incorporated into their DNA will survive. Such stably transfected cell lines will then be exposed to simulated ischemia consisting of hypoxia, absence of glucose, low tonicity, and resultant schemic damage will be determined by quantitating cell viability measured in colony formation assays, the inhibition of protein synthesis, and the release of cytoplasmic enzymes like creatine kinase. These studies will determine if hsp7Oi exerts a protective effect against ischemia mediated muscle injury. Demonstrating a protective effect of hsp7O protein will make it a useful agent to reduce ischemic muscle damage in soldiers exposed to muscle injury in combat.
Effect Of Aerobic Exercise And The Induced Increase In Heat Shock Proteins On Recovery Of Skeletal Muscle Function After Ischemia Reperfusion Injury
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Author : Edward Kelly Merritt
language : en
Publisher:
Release Date : 2004
Effect Of Aerobic Exercise And The Induced Increase In Heat Shock Proteins On Recovery Of Skeletal Muscle Function After Ischemia Reperfusion Injury written by Edward Kelly Merritt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
The purpose of this study was to determine the effect of exercise training on the recovery of skeletal muscle function following ischemia reperfusion injury. Three groups of animals underwent 6 weeks of aerobic training to increase heat shock protein content of skeletal muscle. After training, 2 groups were subjected to a 2-hour ischemic bout induced by pneumatic tourniquet (TK). In one group 7 days following TK application in vivo force was measured in a method similar to Ashton-Miller (1992). Another group recovered 14 days before in vivo force was measured. Force of the TK leg vs. contralateral leg measured 7 and 14 days following TK application was 29.6 +/- 2.3% and 55.0 +/- 3.3% respectively. Non-exercised control rat’s TK leg force production was 22.0 +/- 2.9% and 53.1 +/-5.2% when compared to the contralateral leg. These data suggest that exercise training prior to I/R allows for greater maximal force production 7 days following TK application
Heat Shock Proteins And Whole Body Physiology
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Author : Alexzander A. A. Asea
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-10
Heat Shock Proteins And Whole Body Physiology written by Alexzander A. A. Asea and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-10 with Medical categories.
Heat Shock Proteins and Whole Body Physiology is an exciting new book in the Heat Shock Proteins series which provides the most up-to-date review on novel mechanisms insights into the important role played by heat shock proteins in human physiology. Written by leaders in the field of heat shock protein exercise physiology, neuroscience and aging, the chapters systematically and in a step wise fashion takes the reader through the fascinating mechanisms by which heat shock proteins modulate human disease and pathophysiology and provides answers as to its biological significance to the host. Section I, introduces the readers to the role played by heat shock proteins in various diseases and disorders (Heat Shock Proteins and Disease). Section II, addresses the role heat shock proteins play in psychological disorders including post traumatic stress disorders and learning (Heat Shock Proteins and Psychological Stress). Section III, present a detailed review of the role played by heat shock proteins in exercise physiology (Heat Shock Proteins and Exercise Physiology). This book is a must read for heat shock protein researchers, graduate and postgraduate fellows in the field of Medicine in general and specialities in Excersie Physiology, Neuroscience, Immunology, Aging and Pathology.
Role Of Heat Shock Proteins In Skeletal Muscle
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Author : Thiago Gomes Heck
language : en
Publisher:
Release Date : 2012
Role Of Heat Shock Proteins In Skeletal Muscle written by Thiago Gomes Heck and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medicine categories.
Role of Heat Shock Proteins in Skeletal Muscle.
Role Of Heat Shock Proteins In Skeletal Muscle
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Author : Thiago Gomes Heck
language : en
Publisher:
Release Date : 2012
Role Of Heat Shock Proteins In Skeletal Muscle written by Thiago Gomes Heck and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Time Course Of The Fall Of Heat Shock Protein 72 In Cardiac And Skeletal Muscle
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Author : Daniel Joseph Olson
language : en
Publisher:
Release Date : 2001
Time Course Of The Fall Of Heat Shock Protein 72 In Cardiac And Skeletal Muscle written by Daniel Joseph Olson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Biochemical Physiological Studies Of Heat Shock Proteins In Skeletal Muscle
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Author : Noni Tegan Larkins
language : en
Publisher:
Release Date : 2011
Biochemical Physiological Studies Of Heat Shock Proteins In Skeletal Muscle written by Noni Tegan Larkins and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Heat shock proteins categories.
A Comparison Of Heat Shock Protein Expression In Rat Skeletal Muscle After Lengthening Or Shortening Contractions
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Author : Andrew Holwerda
language : en
Publisher:
Release Date : 2013
A Comparison Of Heat Shock Protein Expression In Rat Skeletal Muscle After Lengthening Or Shortening Contractions written by Andrew Holwerda and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
The Chaperonopathies
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Author : Alberto J.L. Macario
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-10
The Chaperonopathies written by Alberto J.L. Macario and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-10 with Medical categories.
This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.
Heat Shock Protein 60 In Human Diseases And Disorders
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Author : Alexzander A. A. Asea
language : en
Publisher: Springer Nature
Release Date : 2019-10-31
Heat Shock Protein 60 In Human Diseases And Disorders written by Alexzander A. A. Asea and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-31 with Science categories.
The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.