Effects Of Your Genetics On Pain

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Effects Of Your Genetics On Pain

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Author : William Ackerman
language : en
Publisher: Createspace Independent Publishing Platform
Release Date : 2016-09-10

Effects Of Your Genetics On Pain written by William Ackerman and has been published by Createspace Independent Publishing Platform this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-10 with categories.

One's pain perception usually differs from others. This observation is why a "one size fits all" to pain treatment does not exist. This process slows down when one becomes an adult and gets progressively slower with age. Some cells like those in the brain and nerves do not continue to grow. Our bodies reflect our genetic capacity to adapt and repair, as well as tolerate the cumulative damage from disease processes. With advancing age, all of the body systems eventually demonstrate reduced efficiency, slowed building and replacement and actual loss of tissue. There is a gradual loss of bone tissue and the reduced tissue loss may be permanent. When a person is born, cells in the body duplicate rapidly which enables growth resiliency of blood vessels. A chromosome is a cell is a long strand of DNA in it. At the end of a chromosome is a telomere, which acts like a bookend. Telomeres keep chromosomes protected and prevent them from binding with other DNA. Many cells in the body need to replicate to keep the body healthy. When the telomeres fail one's health is affected and this failure is related to aging and chronic pain perception in some instances.

The Genetics Of Pain

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Author : Jeffrey Steven Mogil
language : en
Publisher: Progress in Pain Research and
Release Date : 2004

The Genetics Of Pain written by Jeffrey Steven Mogil and has been published by Progress in Pain Research and this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.

Genetics more than any other biological approach can explain why some people experience more pain than others and receive less benefit from existing analgesics. Sixteen scholarly articles from international contributors describe the application of genetic techniques to the problem of pain and consider the knowledge that has so far resulted. Three themed sections review the techniques that are allowing the study of pain mechanisms at the genetic level; describe the progress being made in lab animals and humans in identifying the genes responsible for individual differences; and explore the practical and ethical issues that face pain researchers. The editor is associated with the Centre for Research on Pain, McGill U., Montreal. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com).

Pain Genetics

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Author : Inna Belfer
language : en
Publisher: John Wiley & Sons
Release Date : 2013-11-15

Pain Genetics written by Inna Belfer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-15 with Science categories.

Pain Genetics: Basic to Translational Science is a timely synthesis of the key areas of research informing our understanding of the genetic basis of pain. The book opens with foundational information on basic genetic mechanisms underlying pain perception and progresses recently discovered complex concepts facing the field. The coverage is wide-ranging and will serves as an excellent entry point into understating the genetics of pain as well as providing a single resource for established researchers looking for a better understanding of the diverse strands of research going on in the area. With contributors painstakingly selected to provide a broad range of perspectives and research, Pain Genetics will be a valuable resource for geneticists, neuroscientists, and biomedical professionals alike.

The Impact Of Environmental And Genetic Factors On Pain Sensitivity And Chronic Pain Development

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Author : Kirsten Wilson
language : en
Publisher:
Release Date : 2022

The Impact Of Environmental And Genetic Factors On Pain Sensitivity And Chronic Pain Development written by Kirsten Wilson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.

The Genetic Characterization Of Chronic Pain Patients And Its Impact On Treatment Outcomes

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Author : Ramesh Singa
language : en
Publisher:
Release Date : 2017

The Genetic Characterization Of Chronic Pain Patients And Its Impact On Treatment Outcomes written by Ramesh Singa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.

Introduction: Recent literature has discussed how the employment of pharmacogenomics can be utilized in pain management. There is little in the literature, however, describing the classification of the genetic profiles of patients in pain practices and subsequently, if knowledge of those profiles have improved outcomes. We aimed to quantify the distribution of CYP2C19, CYP2C9, and CYP2D6 alleles, in a population of pain patients who underwent genetic testing, and to elaborate if those patients demonstrated a decrease in pain scores after identifying their altered medication metabolism.Methods: After obtaining approval from the Saint Barnabas Medical Center institutional review board, we obtained records of all patients from the pain center that underwent genetic testing. We noted their demographics and characterization of their metabolism for the CYP2C19, CYP2C9, and CYP2D6 alleles; medications identified by genetic testing as having effect changes due to altered metabolism; medications identified by genetic testing to have an interaction with patientsu2019 other medications; medication and dosages at each visit; and pain scores from initial presentation and last visit, as well as the lowest pain score expressed at any visit.Results: We identified 70 patients who underwent genetic testing with complete characterization of CYP2C19, CYP2C9, and CYP2D6 alleles. Average age = 54 years, females = 59%, males = 41%. For CYP2C19, variants = normal34.3%, intermediate 25.7%, rapid 32.9%, ultra-rapid 5.7%, and poor 1.4%. For CYP2C9 variants = normal 52.9%, intermediate 41.4%, and poor 5.7%. For CYP2D6 = normal 57.1%, intermediate 34.3%, and poor 2.9%. A total of 61 substantial known medication interactions existed amongst 25 patients, with 69% altered because of genetically identified altered metabolism with other medications (not pharmacologically identified prior), and 31% due to altered allele activity. The calculated average initial pain score on presentation = 8.6 points on a 10-point visual acuity scale. The calculated average greatest difference of pain scores on a 10-point scale was a decrease of 4.7 points from a patient's initial presentation to his lowest pain score identified on any one visit and the average difference of pain scores on the same pain scale from a patient's initial presentation to his last visit identified at the clinic was a decrease of 2.8 points; these decreases were observed after patientsu2019 pain medications were changed to reflect altered allele activity on genetic testing.Conclusion: For example, in the CYP2D6 allele, there was a 70% decrease of poor metabolizers and almost 20% increase of extensive metabolizers. In the CYP2C9 allele, there was a 300% increase of poor metabolizers. In the CYP2C19 allele, there was a 30% increase of ultra-rapid metabolizers and a 50% decrease of poor metabolizers. We also established patients who underwent genetic testing demonstrated an average 55% and 33% reduction in pain scores from initial presentation to greatest reduction at any visit and last visit, respectively, after appropriate pain medication changes were instituted to reflect altered allele activity. We also found that a majority of patients demonstrated drug-drug interactions only identified genetically that had substantial impacts on the prescribed effect, with a minority with substantial impacts on the prescribed effects of drugs secondary to alterations in CYP alleles.

Chronic Postsurgical Pain

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Author : Gérard Mick
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-02-20

Chronic Postsurgical Pain written by Gérard Mick and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-20 with Medical categories.

Primum non nocere... The fact that a surgical procedure can leave any kind of pain casts a shadow over this tenet, which is seen as the basis of medical practice and anchor of its principle ethic... It is all the more surprising in that medicine has only paid attention to this paradoxical chronic pain situation for the past few years. Clarifying the knowledge acquired in this field has become all the more urgent for any care-giver today confronted by a legitimate request from patients: Why and how can a surgical procedure, which is supposed to bring relief, leave behind an unacceptable sequela? This is the approach which the contributors to this new subject of major clinical interest invite you to follow as you work your way through this book.

Assessing Genetic Risks

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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 1994-01-01

Assessing Genetic Risks written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-01 with Medical categories.

Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.

Behavioural Phenotypes

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Author : Gregory O'Brien
language : en
Publisher: Cambridge University Press
Release Date : 1995

Behavioural Phenotypes written by Gregory O'Brien and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.

A timely distillation of current thinking on the presentation of behavioural disorders and their origins.

Genes

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Author : Jonathan Slack
language : en
Publisher: Oxford University Press, USA
Release Date : 2014

Genes written by Jonathan Slack and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Science categories.

Explores the discovery, nature, and role of genes in evolution and development.

Genes Behavior And The Social Environment

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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2006-12-07

Genes Behavior And The Social Environment written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-07 with Social Science categories.

Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.