The Genetics Of Pain
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The Genetics Of Pain
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Author : Jeffrey Steven Mogil
language : en
Publisher: Progress in Pain Research and
Release Date : 2004
The Genetics Of Pain written by Jeffrey Steven Mogil and has been published by Progress in Pain Research and this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
Genetics more than any other biological approach can explain why some people experience more pain than others and receive less benefit from existing analgesics. Sixteen scholarly articles from international contributors describe the application of genetic techniques to the problem of pain and consider the knowledge that has so far resulted. Three themed sections review the techniques that are allowing the study of pain mechanisms at the genetic level; describe the progress being made in lab animals and humans in identifying the genes responsible for individual differences; and explore the practical and ethical issues that face pain researchers. The editor is associated with the Centre for Research on Pain, McGill U., Montreal. Annotation : 2004 Book News, Inc., Portland, OR (booknews.com).
Pain Genetics
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Author : Inna Belfer
language : en
Publisher: John Wiley & Sons
Release Date : 2013-11-15
Pain Genetics written by Inna Belfer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-15 with Science categories.
Pain Genetics: Basic to Translational Science is a timely synthesis of the key areas of research informing our understanding of the genetic basis of pain. The book opens with foundational information on basic genetic mechanisms underlying pain perception and progresses recently discovered complex concepts facing the field. The coverage is wide-ranging and will serves as an excellent entry point into understating the genetics of pain as well as providing a single resource for established researchers looking for a better understanding of the diverse strands of research going on in the area. With contributors painstakingly selected to provide a broad range of perspectives and research, Pain Genetics will be a valuable resource for geneticists, neuroscientists, and biomedical professionals alike.
Pain Genetics
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Author : Inna Belfer
language : en
Publisher: Wiley-Blackwell
Release Date : 2013-12-13
Pain Genetics written by Inna Belfer and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-13 with Science categories.
Effects Of Your Genetics On Pain
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Author : William Ackerman
language : en
Publisher: Createspace Independent Publishing Platform
Release Date : 2016-09-10
Effects Of Your Genetics On Pain written by William Ackerman and has been published by Createspace Independent Publishing Platform this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-10 with categories.
One's pain perception usually differs from others. This observation is why a "one size fits all" to pain treatment does not exist. This process slows down when one becomes an adult and gets progressively slower with age. Some cells like those in the brain and nerves do not continue to grow. Our bodies reflect our genetic capacity to adapt and repair, as well as tolerate the cumulative damage from disease processes. With advancing age, all of the body systems eventually demonstrate reduced efficiency, slowed building and replacement and actual loss of tissue. There is a gradual loss of bone tissue and the reduced tissue loss may be permanent. When a person is born, cells in the body duplicate rapidly which enables growth resiliency of blood vessels. A chromosome is a cell is a long strand of DNA in it. At the end of a chromosome is a telomere, which acts like a bookend. Telomeres keep chromosomes protected and prevent them from binding with other DNA. Many cells in the body need to replicate to keep the body healthy. When the telomeres fail one's health is affected and this failure is related to aging and chronic pain perception in some instances.
Pain Dynamics And Complexities
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Author : Daniel M. Doleys PhD
language : en
Publisher: Oxford University Press
Release Date : 2014-02-18
Pain Dynamics And Complexities written by Daniel M. Doleys PhD and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-18 with Medical categories.
Despite the proliferation of pain clinics and various pain-oriented therapies, there is an absence of data supporting any substantial change in the statistics regarding the incidence, development and persistence of pain. As renowned pain clinician and scientist Daniel M. Doleys argues, there may be a need for a fundamental shift in the way we view pain. In this thoughtful work, Doleys presents the evolving concept and complex nature of pain with the intention of promoting a broadening of the existing paradigm within which pain is viewed and understood. Combining neuroscience, psychology, and philosophy of science, this book reviews the history of pain and outlines the current concepts and theories regarding the mechanisms involved in the experience of pain. Experimental and clinical research in a broad array of areas including neonatal pain, empathy and pain, psychogenic pain, and genetics and pain is summarized. The notion of pain as a disease process rather than a symptom is highlighted. Although there is a continued interest in activation of the peripheral nociceptive system as a determining factor in the experience of pain, the growing appreciation for the brain as the intimate 'pain generator' is emphasized. The definition of consciousness and conscious awareness and a theory as to how it relates to nociceptive processing is discussed. Finally, the author describes the potential benefit of incorporating some of the concepts from systems and quantum theory into our thinking about pain. The area of pain research and treatment seems on the precipice of change. This work intends to provide a glimpse of what these changes might be in the context of where pain research and therapy has come from, where it currently is, and where it might be headed.
Pain Causes Concerns And Consequences
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Author : Puneetpal Singh
language : en
Publisher: Bentham Science Publishers
Release Date : 2016-11-01
Pain Causes Concerns And Consequences written by Puneetpal Singh and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-01 with Medical categories.
Pain is a significant medical problem, as it is a factor in many diseases and debilitating conditions. The processing of pain in the body is a complex process which involves nerve signaling in the milieu of biochemical, molecular and genetic interactions occurring in the brain and other parts of the body. Pain, as a spokesperson of real and impending injury, outlives its usefulness as a warning signal and instead becomes chronic and excruciating. The transition of the realization of pain up to the cortical processing as a persistent condition represents an intricate process governed by the interaction of various factors. Research on humans and animals has led to the advent of personalized medicine where every patient can be treated according to the set of genes they possess. However, the genetic basis for pain has largely been undefined so far. Research on epigenetic alterations and micro-RNA (miRNA) in relation to the assessment and prevention of pain is still in infancy. Pain: Causes, Concerns and Consequences focuses on pain in human diseases such as cardiac and non-cardiac disorders. This compendium on pain research offers basic information and useful updates on the pathology, genetics, and biomolecular pathways that cause pain. Additionally, readers will also learn about non-pharmacological therapies for pain. The monograph is a handy guide for medical students and doctors in different divisions such as oncology, surgery, neurology, psychiatry, psychology, physiotherapy and chiropractic care. The book also serves as a guide for life science researchers who are planning to develop methods to study pain in either a clinical or laboratory setting.
Epigenetics Of Chronic Pain
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-10-29
Epigenetics Of Chronic Pain written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-29 with Medical categories.
Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs. Compiles all known information on epigenetic regulation of chronic pain in one volume Covers the basic functionality of epigenetic mechanisms involved in pain management, applications of recent research in understanding different types of chronic pain, and pathways for developing therapeutics Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss epigenetics in inflammatory, neuropathic, visceral, and other pain models in-depth Enables clinicians, researchers, and pharmacologists to better understand and treat chronic pain
The Oxford Handbook Of The Neurobiology Of Pain
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Author : Professor John N. Wood
language : en
Publisher: Oxford University Press
Release Date : 2020-06-17
The Oxford Handbook Of The Neurobiology Of Pain written by Professor John N. Wood and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-17 with Science categories.
The Oxford Handbook of the Neurobiology of Pain represents a state of the art overview of the rapidly developing field of pain research. As populations age, the number of people in pain is growing dramatically, with half the population living with pain. The opioid crisis has highlighted this problem. The present volume is thus very timely, providing expert overviews of many complex topics in pain research that are likely to be of interest not just to pain researchers, but also to pain clinicians who are seeking new therapeutic opportunities to develop analgesics. Many of the topics covered are of interest to neuroscientists, as pain is one of the most amenable sensations for mechanistic dissection. The present volume covers all aspects of the topic, from a history of pain through invertebrate model systems to the human genetics of pain and functional imaging. Chapters include the role of ion channels, the opioid system, the immune and sympathetic systems, as well as the mechanisms that transform acute to chronic pain. Migraine and the interplay between sleep and pain are also discussed. New technology in the form of transgenic animals, chemogenetics, optogenetics, and proteomic analyses are providing significant advances in our research and are covered as well. Demystifying pain through an understanding of its fundamental biology, as outlined in this volume, is the most direct route to ameliorating this vast human problem.
Wall Melzack S Textbook Of Pain E Book
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Author : Stephen B. McMahon
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013-03-01
Wall Melzack S Textbook Of Pain E Book written by Stephen B. McMahon and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-01 with Medical categories.
Apply the latest scientific and clinical advances with Wall & Melzack's Textbook of Pain, 6th Edition. Drs. Stephen McMahon, Martin Koltzenburg, Irene Tracey, and Dennis C. Turk, along with more than 125 other leading authorities, present all of the latest knowledge about the genetics, neurophysiology, psychology, and assessment of every type of pain syndrome. They also provide practical guidance on the full range of today's pharmacologic, interventional, electrostimulative, physiotherapeutic, and psychological management options. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Benefit from the international, multidisciplinary knowledge and experience of a "who's who" of international authorities in pain medicine, neurology, neurosurgery, neuroscience, psychiatry, psychology, physical medicine and rehabilitation, palliative medicine, and other relevant fields. Translate scientific findings into clinical practice with updates on the genetics of pain, new pharmacologic and treatment information, and much more. Easily visualize important scientific concepts with a high-quality illustration program, now in full color throughout. Choose the safest and most effective management methods with expanded coverage of anesthetic techniques. Stay abreast of the latest global developments regarding opioid induced hyperalgesia, addiction and substance abuse, neuromodulation and pain management, identification of specific targets for molecular pain, and other hot topics.
The Genetic Characterization Of Chronic Pain Patients And Its Impact On Treatment Outcomes
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Author : Ramesh Singa
language : en
Publisher:
Release Date : 2017
The Genetic Characterization Of Chronic Pain Patients And Its Impact On Treatment Outcomes written by Ramesh Singa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Introduction: Recent literature has discussed how the employment of pharmacogenomics can be utilized in pain management. There is little in the literature, however, describing the classification of the genetic profiles of patients in pain practices and subsequently, if knowledge of those profiles have improved outcomes. We aimed to quantify the distribution of CYP2C19, CYP2C9, and CYP2D6 alleles, in a population of pain patients who underwent genetic testing, and to elaborate if those patients demonstrated a decrease in pain scores after identifying their altered medication metabolism.Methods: After obtaining approval from the Saint Barnabas Medical Center institutional review board, we obtained records of all patients from the pain center that underwent genetic testing. We noted their demographics and characterization of their metabolism for the CYP2C19, CYP2C9, and CYP2D6 alleles; medications identified by genetic testing as having effect changes due to altered metabolism; medications identified by genetic testing to have an interaction with patientsu2019 other medications; medication and dosages at each visit; and pain scores from initial presentation and last visit, as well as the lowest pain score expressed at any visit.Results: We identified 70 patients who underwent genetic testing with complete characterization of CYP2C19, CYP2C9, and CYP2D6 alleles. Average age = 54 years, females = 59%, males = 41%. For CYP2C19, variants = normal34.3%, intermediate 25.7%, rapid 32.9%, ultra-rapid 5.7%, and poor 1.4%. For CYP2C9 variants = normal 52.9%, intermediate 41.4%, and poor 5.7%. For CYP2D6 = normal 57.1%, intermediate 34.3%, and poor 2.9%. A total of 61 substantial known medication interactions existed amongst 25 patients, with 69% altered because of genetically identified altered metabolism with other medications (not pharmacologically identified prior), and 31% due to altered allele activity. The calculated average initial pain score on presentation = 8.6 points on a 10-point visual acuity scale. The calculated average greatest difference of pain scores on a 10-point scale was a decrease of 4.7 points from a patient's initial presentation to his lowest pain score identified on any one visit and the average difference of pain scores on the same pain scale from a patient's initial presentation to his last visit identified at the clinic was a decrease of 2.8 points; these decreases were observed after patientsu2019 pain medications were changed to reflect altered allele activity on genetic testing.Conclusion: For example, in the CYP2D6 allele, there was a 70% decrease of poor metabolizers and almost 20% increase of extensive metabolizers. In the CYP2C9 allele, there was a 300% increase of poor metabolizers. In the CYP2C19 allele, there was a 30% increase of ultra-rapid metabolizers and a 50% decrease of poor metabolizers. We also established patients who underwent genetic testing demonstrated an average 55% and 33% reduction in pain scores from initial presentation to greatest reduction at any visit and last visit, respectively, after appropriate pain medication changes were instituted to reflect altered allele activity. We also found that a majority of patients demonstrated drug-drug interactions only identified genetically that had substantial impacts on the prescribed effect, with a minority with substantial impacts on the prescribed effects of drugs secondary to alterations in CYP alleles.