Electrophysiology Measurements For Studying Neural Interfaces
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Electrophysiology Measurements For Studying Neural Interfaces
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Author : Mohammad M. Aria
language : en
Publisher: Academic Press
Release Date : 2020-05-15
Electrophysiology Measurements For Studying Neural Interfaces written by Mohammad M. Aria and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-15 with Medical categories.
Electrophysiology Measurements for Studying Neural Interfaces helps readers to choose a proper cell line and set-up for studying different bio-electronic interfaces before delving into the electrophysiology techniques available. Therefore, this book details the materials and devices needed for different types of neural stimulation such as photoelectrical and photothermal stimulations. Also, modern techniques like optical electrophysiology and calcium imaging in this book provides readers with more available approaches to monitor neural activities in addition to whole-cell patch-clamp technology. Details steps of an electrophysiology project from start to finish for graduate students employing the technique in their research Includes sample electrophysiological studies with multiple cell lines (PC12, N2a, NG108, SHSY, and embryonic stem cell lines) to facilitate research Features data analysis of electrophysiology results from various relevant experiments and cell culture tips
Neural Interface Engineering For Electrophysiology Application
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Author : Hyungsoo Kim
language : en
Publisher:
Release Date : 2018
Neural Interface Engineering For Electrophysiology Application written by Hyungsoo Kim and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
The brain is a wondrous and complex organ, a biological machine forged by the evolutionary forces of nature. The human brain contains 100 billion neurons and each neuron is connected by synapses to several thousand other neurons. Connected neurons work together to produce perceptions and sensations, memories and emotions, physical movements and abstract constructs. The neurons communicate by means of electricity that passes along and across their cellular membrane. Much of what is known about brain physiology is through the measurement of this electrical activity, either with relatively large electrodes placed on the scalp or tiny microelectrodes inserted into the brain tissue itself. At the finer end of this scale, scientists have discovered much about the way individual neurons extract sensory information, adapt their behavior to form a memory, and convey signals to other regions of the brain. However, it has long been recognized that the brain operates on a global scale, through the collective behavior and interaction of its neural units1. Information is processed in several regions of the brain simultaneously, and the activity of neighboring neurons can be quite different from one another. By one analogy, the attempt to assess brain function by observing a single neuron is like looking at the output of one transistor to learn how a computer works. Thus, the recording of many neurons simultaneously is necessary to truly reveal the mechanisms of the brain2. In recent decades, a variety of recording techniques have been developed for a neural interface such as electroencephalography (EEG), magneto-encephalography (MEG), electrocorticography (ECOG), local field potential (LFP) recordings, micro-electrode array (MEA) and peripheral nerve interfaces (PNIs) to the micron-level precision required for multi-neuron recording. Their small size allows many recording channels to be placed onto one device. One of the goals of neural interface research is to create a seamless connection between the nervous system and the neuroprostheses either by stimulating or by recording from neural tissue to restore or substitute function for individuals with neurological deficits or disabilities. Hence, significant amount of scientific and technological efforts have been devoted to develop neural interfaces that link the nervous system with robotic prosthetic devices. The creation of a novel neural interface is essential for developing the full potential of advanced prosthesis technology required to replace lost limbs. Additionally, meticulous studies of a single neuron and between neurons utilizing the neural interface technology should be made to elucidate fundamental biological phenomena such as cellular processes and heterogeneities. Particularly, an electrophysiological study of neural networks can provide knowledge to unravel the functions of brain. When fundamental research about molecular and cellular mechanisms of a single neuron and electrophysiological studies using neural interfaces on both the central and peripheral nervous systems are done together, it has a synergistic effect on neural interface technology. The research and methodologies described in this dissertation stem from our research group's efforts to optimize the design and expand the applications of neural interfaces. The dissertation is organized into four chapters. Chapter 1 is a review of neural interface technology and study of neural signal detection. This chapter provides a foundation for Chapter 2 and 3. Chapter 2 is a study of a neural interface as cellular level research. We present an advanced single-neuronal cell culture and monitoring platform using a fully transparent microfluidic dielectrophoresis (DEP) device for unabated monitoring of neuronal cell development and function. The device is mounted inside a sealed incubation chamber to ensure improved homeostatic conditions and reduced contamination risk. Consequently, we successfully trap and culture single neurons on a desired location and monitor their growth process over a week. Chapter 3 deals with the specific application of PNIs to the sciatic nerve of a rat as a nervous system-level research. We developed novel devices, "cuff and sieve electrodes" (CASE), that integrate microfabricated cuff and sieve electrodes capable of broad (via cuff) and precise (via sieve) selectivity to increase the strengths and simultaneously decrease the weaknesses of traditional electrode designs. We performed terminal device implantations in a rat sciatic transection and repair model to test the capacity of the CASE interface. The sciatic nerve was stimulated by the sieve portion of the CASE electrode and somatosensory evoked potentials were recorded from the somatosensory cortex via micro-eletrocorticography. The ability to elicit cortical responses from sciatic nerve stimulation demonstrates the proof of concept for both the implantation and chronic monitoring of CASE interfaces for innovative prosthetic control. Lastly, in Chapter 4, I will identify areas in which further investigation is needed and propose future directions of both cellular and system-level neural interface
Alzheimer S Disease From Molecular Mechanisms To Clinical Practices
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Author : Dildar Konukoğlu
language : en
Publisher: Nobel Tıp Kitabevi
Release Date :
Alzheimer S Disease From Molecular Mechanisms To Clinical Practices written by Dildar Konukoğlu and has been published by Nobel Tıp Kitabevi this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
“Alzheimer’s Disease: From Molecular Mechanisms to Clinical Practices” explores the extensive perspective from the molecular foundations to the clinical diagnosis and treatment of Alzheimer’s disease. The book serves as a fundamental resource for understanding the neurobiological basis and molecular pathogenesis of Alzheimer’s, while also discussing the challenges and opportunities of transitioning from the laboratory to clinical settings. The initial sections of the book comprehensively examine the fundamental molecular characteristics of Alzheimer’s disease; these include the accumulation of amyloid-beta peptide, hyperphosphorylation of tau protein, and how these processes lead to synaptic dysfunction and neuronal death. These chapters provide strategies on how to understand the pathology of the disease at a molecular level and how this knowledge can be translated into clinical practice. Subsequent parts focus on the development and use of biomarkers for the early diagnosis of Alzheimer’s disease. In addition to the role of genetic predispositions, the effects of environmental factors and lifestyle choices on Alzheimer’s disease are discussed, highlighting the multifactorial nature of the disease. In conclusion, this book is a valuable resource for clinicians, researchers, and medical students specializing in the field. It provides essential scientific and practical information necessary for a better understanding and management of Alzheimer’s disease, offering a comprehensive perspective on the integration of molecular mechanisms with clinical applications.
Advancement Of Neural Interfaces To Probe Network Electrophysiology
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Author : Greta Thompson-Steckel
language : en
Publisher:
Release Date : 2019
Advancement Of Neural Interfaces To Probe Network Electrophysiology written by Greta Thompson-Steckel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Transparent Neural Interfaces For Simultaneous Electrophysiology And Advanced Brain Imaging
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Author : Sagnik Middya
language : en
Publisher:
Release Date : 2023
Transparent Neural Interfaces For Simultaneous Electrophysiology And Advanced Brain Imaging written by Sagnik Middya and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
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Trials For Cerebellar Ataxias
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Author : Bing-wen Soong
language : en
Publisher: Springer Nature
Release Date : 2023-05-29
Trials For Cerebellar Ataxias written by Bing-wen Soong and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-29 with Medical categories.
Despite the critical importance of the cerebellum in brain function, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference, and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
Closing The Loop Around Neural Systems
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Author : Steve M Potter
language : en
Publisher: Frontiers Media SA
Release Date : 2014-12-03
Closing The Loop Around Neural Systems written by Steve M Potter and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-03 with Neurophysiology categories.
Closed-loop neurophysiology has been accelerated by recent software and hardware developments and by the emergence of novel tools to control neuronal activity with spatial and temporal precision, in which stimuli are delivered in real time based on recordings or behavior. Real-time stimulation feedback enables a wide range of innovative studies of information processing and plasticity in neuronal networks. This Research Topic e-Book comprises 16 Original Research Articles, seven Methods Articles, and seven Reviews, Mini- Reviews, and Perspectives, all peer-reviewed and published in Frontiers in Neural Circuits. The contributions deal with closed loop neurophysiology experiments at a variety of levels of neural circuit complexity. Some include modeling and theoretical analyses. New enabling technologies and techniques are described. Novel work is presented from experiments in vitro, in vivo, and in humans, along with their clinical and technological implications for improving the human condition.
Bridging The Gap In Neuroelectronic Interfaces
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Author : Jeffrey R. Capadona
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-09
Bridging The Gap In Neuroelectronic Interfaces written by Jeffrey R. Capadona and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-09 with categories.
Neural Interface Engineering
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Author : Liang Guo
language : en
Publisher: Springer Nature
Release Date : 2020-05-04
Neural Interface Engineering written by Liang Guo and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-04 with Technology & Engineering categories.
This book provides a comprehensive reference to major neural interfacing technologies used to transmit signals between the physical world and the nervous system for repairing, restoring and even augmenting body functions. The authors discuss the classic approaches for neural interfacing, the major challenges encountered, and recent, emerging techniques to mitigate these challenges for better chronic performances. Readers will benefit from this book’s unprecedented scope and depth of coverage on the technology of neural interfaces, the most critical component in any type of neural prostheses. Provides comprehensive coverage of major neural interfacing technologies; Reviews and discusses both classic and latest, emerging topics; Includes classification of technologies to provide an easy grasp of research and trends in the field.
Handbook Of Artificial Intelligence For Music
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Author : Eduardo Reck Miranda
language : en
Publisher: Springer Nature
Release Date : 2021-07-02
Handbook Of Artificial Intelligence For Music written by Eduardo Reck Miranda and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-02 with Computers categories.
This book presents comprehensive coverage of the latest advances in research into enabling machines to listen to and compose new music. It includes chapters introducing what we know about human musical intelligence and on how this knowledge can be simulated with AI. The development of interactive musical robots and emerging new approaches to AI-based musical creativity are also introduced, including brain–computer music interfaces, bio-processors and quantum computing. Artificial Intelligence (AI) technology permeates the music industry, from management systems for recording studios to recommendation systems for online commercialization of music through the Internet. Yet whereas AI for online music distribution is well advanced, this book focuses on a largely unexplored application: AI for creating the actual musical content.