Electrospun Multicomponent And Multifunctional Nanofibrous Tissue Engineering Scaffolds

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Electrospun Multicomponent And Multifunctional Nanofibrous Tissue Engineering Scaffolds

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Author : 王Chong (Researcher on mechanical engineering)
language : en
Publisher:
Release Date : 2013

Electrospun Multicomponent And Multifunctional Nanofibrous Tissue Engineering Scaffolds written by 王Chong (Researcher on mechanical engineering) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Biomedical materials categories.

Electrospun Multicomponent And Multifunctional Nanofibrous Tissue Engineering Scaffolds

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Author : Chong Wang
language : en
Publisher:
Release Date : 2017-01-27

Electrospun Multicomponent And Multifunctional Nanofibrous Tissue Engineering Scaffolds written by Chong Wang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-27 with categories.

This dissertation, "Electrospun Multicomponent and Multifunctional Nanofibrous Tissue Engineering Scaffolds: Fabrication, Characteristics and Biological Performance" by Chong, Wang, 王翀, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Electrospinning has attracted great attention in the fields of tissue engineering and controlled release of drugs/biomolecules. The aim of this project was to investigate electrospinning of nanofibers with core-shell structures using emulsion electrospinning, the formation of monolithic and core-shell structured nanofibrous drug/biomolecule delivery vehicles using polymers such as poly(D, L-lactic acid) (PDLLA) and poly(lactic-co-glycolic acid) (PLGA), and the formation of multicomponent bone tissue engineering scaffolds with angiogenic property, osteoinductivity and osteoconductivity. The foundation of this project was laid by investigating monocomponent scaffolds. First, effects of properties of polymer solutions and water-in-oil (w/o) emulsions and electrospinning parameters on the morphology, diameter and structure of fibers were systematically investigated. Second, drugs (vancomycin and rifamycin) and a model protein (bovine serum albumin) were incorporated in monolithic or core-shell nanofibers via blend electrospinning or emulsion electrospinning to form single or dual delivery systems, providing fundamental understandings. Growth factors such as recombinant human bone morphogenetic protein-2 (rhBMP-2) and basic-fibroblast growth factor (b-FGF) were then incorporated in PLGA or PDLLA nanofibrous delivery vehicles. The in vitro release behaviour of drugs and biomolecules was studied. Third, calcium phosphate (Ca-P) nanoparticles were synthesized and used for fabricating Ca-P/PLGA and Ca-P/PDLLA nanocomposite scaffolds. Homogeneous distribution of Ca-P in fibrous scaffolds could be achieved. With the assistance of emulsion electrospinning and nanocomposite electrospinning, bicomponent scaffolds containing rhBMP-2 and Ca-P nanoparticles were fabricated using dual-source dual-power electrospinning. The fibrous component ratio could be varied by using multiple syringes for electrospinning fibers. The structure and properties, including in vitro release behaviour, of mono- and bicomponent scaffolds were studied in detail. Tricomponent scaffolds incorporated with recombinant human vein endothelial growth factor (rhVEGF), rhBMP-2 and Ca-P nanoparticles were subsequently fabricated using multi-source dual-power electrospinning. To achieve a sequential release of firstly rhVEGF and then rhBMP-2, PLGA/polyethylene glycol (PEG) blends and PLGA were used for incorporating rhVEGF and rhBMP-2, respectively. For tricomponent scaffolds with different component ratios, different release amounts but similar release profiles could be achieved for the growth factors. In vitro biological investigations were conducted for mono-, bi- and tricomponent scaffolds. Pre-osteoblast cells (MC3T3-E1) were found to attach, spread, proliferate and express alkaline phosphatase (ALP) activity on rhBMP-2 and Ca-P nanoparticle incorporated bicomponent scaffolds. Calcium deposition was also observed in cells cultured with bicomponent scaffolds. Human umbilical vein endothelial cells (HUVECs) were found to attach, spread, proliferate on tricomponent scaffolds and rhVEGF released from mono-, bi- and tricomponent scaffolds could facilitate cell proliferation and migration, indicating released rhVEGF could promote angiogenesis. C3H10T1/2 cell line and human bone marrow derived mesenchymal stem cells (hBMSCs) were found to attach, spread and proliferate o

Electrospun Polymeric Nanofibers

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Author : R. Jayakumar
language : en
Publisher: Springer Nature
Release Date : 2023-04-27

Electrospun Polymeric Nanofibers written by R. Jayakumar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-27 with Technology & Engineering categories.

This volume deals with the various fabrication techniques, surface functionalization and biomedical applications of polymeric fibers possessing different scale and structure. It provides an overview of fabrication techniques such as Co-axial, Centrifugal, Melt and Yarning to procure multiscale, tubular and layered fibrous scaffold employed for biomedical applications. The chapters in this volume discusse the surface/chemical functionalization of fibers which enhance the biological properties of the fibrous scaffolds as well as the development of hybrid, layered and external stimuli-responsive fibrous scaffolds that hold potential application in biosensor and other biomedical fields. In addition, recent advances and applications of polymeric multiscale fibers in tissue engineering, regenerative medicine and drug delivery are presented. The potential use of fibrous scaffolds in bone, neural, tendon/ligament and cardiac tissue engineering, nanofibers as an antimicrobial wound dressing, employed in cancer theragnostics and in the treatment of skin/periodontal infections are discussed. The volume provides expert knowledge on the fabrication techniques, development of different scale and hybrid structure fibers, surface functionalization, layered and external stimuli responsive fibrous scaffolds. It will be beneficial to material/biomaterials scientists, bioengineering and biotechnologists by providing a better understanding on the subject of the innovative applications of fibrous scaffolds in drug delivery, tissue engineering, wound dressings and regenerative medicine.

Bioceramics

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Author : Akiyoshi Osaka
language : en
Publisher: Elsevier
Release Date : 2020-09-13

Bioceramics written by Akiyoshi Osaka and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-13 with Technology & Engineering categories.

Biologically functional ceramic materials have been known about for several decades, like phosphate cements and gypsum, and they are within the zeroth generation. Modern and artificially synthesized bioceramics include amorphous materials in the Bioglass® family that were developed in the early 1970’s and derivative glass ceramics such as Bioverit® and Cerabone A-W® that came in 1980’s. They are from the 2nd generation of materials, and mostly applicable to bone replacement or bone defect fillers. Since the late 1990’s, newer technologies have been introduced to the biologically functional material fields; they are the syntheses of organic-inorganic hybrids of micro- and macroscopic scales as well as nano-scales, organic fragment-covered ceramic particles of varied sizes, with light-controlling abilities to modify the frequency of light, in addition synthesis of high strength and high-tribological durability that had not been available before. With the advent of additive manufacturing technology employing lasers, electron beams, and printers, clinical materials of complicated porous structures are now easily prepared. These materials are of the 3rd generation. This book will cover almost all kinds of such 3rd generation ceramic and ceramic-related biomaterials. This book conveys the current state-of-the-art on the science and technology of bioceramics, from nano-size dots or particles to macro-scale architectures, of a wide range of constitutions including quantum dots with peptide fragments, meso-scale therapeutic particles designed to involve drugs or genes, mesoporous organic-inorganic hybrids, nano-structured oxide layers on metals and alloys. Comprehensively covers all aspects (research/experimental and commercial products) related to the latest progresses in bioceramic science, technology and applications, with emphasis on nanobioceramics Pulls together a broad range of materials, concepts, and technologies based on nanomaterials Features novel preparation procedures like additive manufacturing (3-D printing and related techniques) that have also been introduced and practiced for forming complicated architectures Features innovative 3rd generation ceramic and ceramic-related biomaterials

Electrospun Polymers And Composites

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Author : Yu Dong
language : en
Publisher: Woodhead Publishing
Release Date : 2020-10-24

Electrospun Polymers And Composites written by Yu Dong and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-24 with Technology & Engineering categories.

Electrospun Polymers and Composites: Ultrafine Materials, High Performance Fibres and Wearables reviews the latest technological developments and innovations in electrospun polymers and composites, highlighting the multifunctionality of these ultrafine materials as high performance fibers. The book's chapters investigate a wide range of different electrospinning applications, including drug delivery, tissue scaffolding, fiber reinforcement and nanofiltration, with a particular focus on shape memory effect and the wearable characteristics of electrospun polymers and composites. This will be a valuable reference resource for research and for industrial communities working in the field of electrospinning. Covers two important material systems in electrospun materials, including electrospun polymers and composites Emphasizes areas in shape memory effect and wearable features of electrospun polymers and composites Presents a multidisciplinary work that will attract a wide spectrum of readers in chemical engineering, biomedical engineering, chemistry, pharmacy, environmental science, materials science and engineering, as well as mechanical and electrical engineering

Fundamentals Of Bionanomaterials

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Author : Ahmed Barhoum
language : en
Publisher: Elsevier
Release Date : 2022-01-26

Fundamentals Of Bionanomaterials written by Ahmed Barhoum and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-26 with Technology & Engineering categories.

Bionanomaterials are molecular materials composed partially or completely of biological molecules, key biological structures, such as proteins, enzymes, viruses, DNA, biopolymers as well as metal, metal oxides, and carbon nanomaterials with characteristic bioactivity. Bionanomaterials have drawn much attention for their use in a wide range of industrial applications from scaffolds, dental implants, drug delivery, dialysis, biobatteries, biofuel cells, air purification, and water treatment. Therefore, the intensive current research in this area is driven towards the designing and functionalization of bionanomaterials for industrial applications. Fundamentals of Bionanomaterials covers the fundamental aspects, experimental setup, synthesis, properties, and characterization of the different types of bionanomaterial. It discusses the different structure and unique properties of bionanomaterials that can be obtained by modifying their morphology and composition, highlighting a wide range of fabrication techniques of bionanomaterials and critical processing parameters. This is an important reference source for all those seeking to gain a solid understanding of the characterization, properties and processing a variety of bionanomaterial classes. Explains the major properties and characterization techniques for a range of bionanomaterial classes Discusses the commercialization of different types of bionanomaterials for a variety of industry sectors Highlights the challenges and interdisciplinary perspective of bionanomaterials in science, biology, engineering, medicine, and technology, incorporating both fundamentals and applications

Polymeric Nanomaterials In Nanotherapeutics

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Author :
language : en
Publisher: Elsevier
Release Date : 2018-10-26

Polymeric Nanomaterials In Nanotherapeutics written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-26 with Science categories.

Polymeric Nanomaterials in Nanotherapeutics describes how polymeric nanosensors and nanorobotics are used for biomedical instrumentation, surgery, diagnosis and targeted drug delivery for cancer, pharmacokinetics, monitoring of diabetes and healthcare. Key areas of coverage include drug administration and formulations for targeted delivery and release of active agents (drug molecules) to non-healthy tissues and cells. The book demonstrates how these are applied to dental work, wound healing, cancer, cardiovascular diseases, neurodegenerative disorders, infectious diseases, chronic inflammatory diseases, metabolic diseases, and more. Methods of administration discussed include oral, dental, topical and transdermal, pulmonary and nasal, ocular, vaginal, and brain drug delivery and targeting. Drug delivery topics treated in several subchapters includes materials for active targeting and cases study of polymeric nanomaterials in clinical trials. The toxicity and regulatory status of therapeutic polymeric nanomaterials are also examined. The book gives a broad perspective on the topic for researchers, postgraduate students and professionals in the biomaterials, biotechnology, and biomedical fields. Shows how the properties of polymeric nanomaterials can be used to create more efficient medical treatments/therapies Demonstrates the potential and range of applications of polymeric nanomaterials in disease prevention, diagnosis, drug development, and for improving treatment outcomes Accurately explains how nanotherapeutics can help in solving problems in the field through the latest technologies and formulations

Application Of Electrospun Fibers In Tissue Engineering

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Author : Xiumei Mo
language : en
Publisher: Nova Science Publishers
Release Date : 2016

Application Of Electrospun Fibers In Tissue Engineering written by Xiumei Mo and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Biomedical materials categories.

The process of electrospinning has experienced decades of development for a variety of applications including air filtration and tissue engineering. However, it has not been until the past decade that this process has been a focus in the field of tissue engineering. The unique properties of electrospun fibers have drawn remarkable attention within the field of tissue engineering due to its capacity to mimic the native tissue structural element, the extracellular matrix, and its ability to promote cell proliferation and enhanced tissue regeneration. Herein, we have summarised some different applications of electrospun fibers in tissue engineering while demonstrating the cellular interactions between various cells and electrospun fiber scaffolds. The key aspect is a focus on the potential use of electrospinning in tissue regeneration. The hope is that this book will be beneficial to students and researchers in developing a general knowledge of the tissue engineering and regeneration application of electrospun fibers. We hope it will also inspire their curiosity and creativity to allow for the fabricating of advanced tissue engineering scaffolds for use in developing successful products that will allow for improving the quality of life.

Novel Biomaterials For Tissue Engineering 2018

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Author : Emmanuel Stratakis
language : en
Publisher: MDPI
Release Date : 2019-02-05

Novel Biomaterials For Tissue Engineering 2018 written by Emmanuel Stratakis and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-05 with Biomaterials categories.

This book is a printed edition of the Special Issue "Novel Biomaterials for Tissue Engineering 2018" that was published in IJMS

Electrospun Materials For Tissue Engineering And Biomedical Applications

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Author : Tamer Uyar
language : en
Publisher: Woodhead Publishing
Release Date : 2017-05-31

Electrospun Materials For Tissue Engineering And Biomedical Applications written by Tamer Uyar and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-31 with Technology & Engineering categories.

Electrospinning, an electro-hydrodynamic process, is a versatile and promising platform technology for the production of nanofibrous materials for tissue engineering and biomedical applications. Electrospun Materials for Tissue Engineering and Biomedical Applications, examines the rapid development of electrospun materials for use in tissue engineering and biomedical applications. With a strong focus on fundamental materials science and engineering, this book also looks at successful technology transfers to the biomedical industry, highlighting biomedical products already on the market as well as the requirements to successfully commercialize electrospun materials for potential use in tissue engineering and biomedical areas. This book is a valuable resource for materials and biomedical scientists and engineers wishing to broaden their knowledge on the tissue engineering and biomedical applications of electrospun fibrous materials. Provides all-encompassing coverage of fundamental science, technology and industrial case studies Presents guidance on industrial scalability of electrospun biomaterials Written by a multidisciplinary team or researchers from academia and industry, offering a balanced viewpoint on the subject