Emerging Safety Science
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Emerging Safety Science
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2008-05-08
Emerging Safety Science written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-08 with Medical categories.
In recent years, the costs of new drug development have skyrocketed. The average cost of developing a new approved drug is now estimated to be $1.3 billion (DiMasi and Grabowski, 2007). At the same time, each year fewer new molecular entities (NMEs) are approved. DiMasi and Grabowski report that only 21.5 percent of the candidate drugs that enter phase I clinical testing actually make it to market. In 2007, just 17 novel drugs and 2 novel biologics were approved. In addition to the slowing rate of drug development and approval, recent years have seen a number of drugs withdrawn from the market for safety reasons. According to the Government Accountability Office (GAO), 10 drugs were withdrawn because of safety concerns between 2000 and March 2006 (GAO, 2006). Finding ways to select successful drug candidates earlier in development could save millions or even billions of dollars, reduce the costs of drugs on the market, and increase the number of new drugs with improved safety profiles that are available to patients. Emerging scientific knowledge and technologies hold the potential to enhance correct decision making for the advancement of candidate drugs. Identification of safety problems is a key reason that new drug development is stalled. Traditional methods for assessing a drug's safety prior to approval are limited in their ability to detect rare safety problems. Prior to receiving U.S. Food and Drug Administration (FDA) approval, a drug will have been tested in hundreds to thousands of patients. Generally, drugs cannot confidently be linked to safety problems until they have been tested in tens of thousands to hundreds of thousands of people. With current methods, it is unlikely that rare safety problems will be identified prior to approval. Emerging Safety Science: Workshop Summary summarizes the events and presentations of the workshop.
Safety Science Research
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Author : Jean-Christophe Le Coze
language : en
Publisher: CRC Press
Release Date : 2019-08-13
Safety Science Research written by Jean-Christophe Le Coze and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-13 with Technology & Engineering categories.
Safety Science Research: Evolution, Challenges and New Directions provides a unique perspective into the latest developments of safety science by putting together, for the first time, a new generation of authors with some of the pioneers of the field. Forty years ago, research traditions were developed, including, among others, high-reliability organisations, cognitive system engineering or safety regulations. In a fast-changing world, the new generation introduces, in this book, new disciplinary insights, addresses contemporary empirical issues, develops new concepts and models while remaining critical of safety research practical ambitions. Their ideas are then reflected and discussed by some of the pioneers of safety science. Features Allows the reader to discover how contemporary safety issues are currently framed by a new generation of researchers, brought together for the first time Includes an introduction and guide to the development of safety science over the last four decades Features an extraordinary collection of expert contributors, including pioneers of safety research, reflecting the evolution of the discipline and offering insightful commentary on the current and future state of the field Serves as an invaluable reference and guide for safety professionals and students from any established disciplines such as sociology, engineering, psychology, political science or management as well as dedicated safety programmes Some figures in the eBook are in colour
Introduction To Safety Science
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Author : Albert Kuhlmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Introduction To Safety Science written by Albert Kuhlmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Business & Economics categories.
For many years "safety technology" has constituted the essential instrument for the prevention of accidents as a direct result of handling new technology. Its awareness of the interactions prevalent in natural science causes safety technology to act on the basis of actual accidents, and it Ulilizes to their fullest extent any means provided by the engineering sciences. Man proceeds in a general direction towards preselVation and improvement, thus working towards the optimization of the technical design. However. a new set of basic problems presented itself the moment new large-scale technologies were introduced into the areas of processing, energy, and traffic, thereby creating a considerable amount of ad ditional danger potential. This also signified the end of an era when safety technology could be practiced chiefly on the basis of accident statistics. For ethical reasons it became necessary that a credible prognosis as to the type and effect of accidents took the place, or at least supplemented, the hitherto practiced purely reactive methods. The realization that the available means of safety technology were no longer sufficient in a highly technologized environment spurred the demand for entirely new concepts which would eventually lead to a higher degree of safety. A decisive step had to be taken away from a purely technical approach and fOwards and all-encompassing look at accident systems, because man had become aware of the fact that accidents will always be a part of the interaction between man, technology, and environment.
Introduction To Safety Science
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Author : Albert Kuhlmann
language : en
Publisher: Springer
Release Date : 2011-12-21
Introduction To Safety Science written by Albert Kuhlmann and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-21 with Business & Economics categories.
For many years "safety technology" has constituted the essential instrument for the prevention of accidents as a direct result of handling new technology. Its awareness of the interactions prevalent in natural science causes safety technology to act on the basis of actual accidents, and it Ulilizes to their fullest extent any means provided by the engineering sciences. Man proceeds in a general direction towards preselVation and improvement, thus working towards the optimization of the technical design. However. a new set of basic problems presented itself the moment new large-scale technologies were introduced into the areas of processing, energy, and traffic, thereby creating a considerable amount of ad ditional danger potential. This also signified the end of an era when safety technology could be practiced chiefly on the basis of accident statistics. For ethical reasons it became necessary that a credible prognosis as to the type and effect of accidents took the place, or at least supplemented, the hitherto practiced purely reactive methods. The realization that the available means of safety technology were no longer sufficient in a highly technologized environment spurred the demand for entirely new concepts which would eventually lead to a higher degree of safety. A decisive step had to be taken away from a purely technical approach and fOwards and all-encompassing look at accident systems, because man had become aware of the fact that accidents will always be a part of the interaction between man, technology, and environment.
From Safety To Safety Science
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Author : Paul Swuste
language : en
Publisher: Routledge
Release Date : 2021-11-29
From Safety To Safety Science written by Paul Swuste and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-29 with Technology & Engineering categories.
How do accidents and disasters occur? How has knowledge of accident processes evolved? A significant improvement in safety has occurred during the past century, with the number of accidents falling spectacularly within industry, aviation and road traffic. This progress has been gradual in the context of a changing society. The improvements are partly due to a better understanding of the accident processes that ultimately lead to damage. This book shows how contemporary crises instigated the development of safety knowledge and how the safety sciences pieced their theories together by research, by experience and by taking ideas from other domains. From Safety to Safety Science details 150 years of knowledge development in the safety sciences. The authors have rigorously extracted the essence of safety knowledge development from more than 2,500 articles to provide a unique overview and insight into the background and usability of safety theories, as well as modelling how they developed and how they are used today. Extensive appendices and references provide an additional dimension to support further scholarly work in this field. The book is divided into clear time periods to make it an accessible piece of science history that will be invaluable to both new and experienced safety researchers, to safety courses and education, and to learned practitioners.
Indo U S Workshop On Challenges Of Emerging Infections And Global Health Safety
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Author : Indian National Science Academy
language : en
Publisher: National Academies Press
Release Date : 2016-05-13
Indo U S Workshop On Challenges Of Emerging Infections And Global Health Safety written by Indian National Science Academy and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-13 with Medical categories.
The United States and India have pledged to deepen the linkages between their people, their businesses, and their governments for the mutual benefit of both countries and for the promotion of global peace, stability, economic growth and prosperity. Both nations are now inclined to improve relations and cooperation, but the nations need specific actions that will yield progress and build confidence and momentum for further cooperation. The Indo-U.S. Workshop on Challenges of Emerging Infections and Global Health Safety, held in November 2014, encouraged scientists from both countries to examine global issues related to emerging and existing infections and global health safety, to share experience and approaches, and to identify opportunities for cooperation to improve practice and research in these areas. This report summarizes the presentations and discussions from the workshop.
Patient Safety And Management
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Author : Eugene Williams (Editor at Nova Science Publishers)
language : en
Publisher:
Release Date : 2017
Patient Safety And Management written by Eugene Williams (Editor at Nova Science Publishers) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medical care categories.
New Opportunities And Challenges In Occupational Safety And Health Management
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Author : Daniel Podgórski
language : en
Publisher: CRC Press
Release Date : 2020-07-08
New Opportunities And Challenges In Occupational Safety And Health Management written by Daniel Podgórski and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-08 with Technology & Engineering categories.
Global economy and its business environment, and thus the world of work, have recently been influenced by demographic and social changes, globalisation, as well as rapid development and introduction of novel, sophisticated and previously unknown technologies and new business models, especially in the context of the so-called fourth industrial revolution. These changes pose a number of challenges in terms of maintaining and improving occupational safety and health (OSH) management performance, as traditional approaches to OSH management in new working environments may no longer be effective. In view of the above, the overall goal of this book is to present new approaches and methods for improving the effectiveness of OSH management. They are based on state-of-the-art research and are in line with the latest trends and concepts in the field. The book focuses on five thematic areas, which are discussed in respective chapters: 1) Implementing the process approach to OSH management; 2) Improving OSH management systems with fuzzy cognitive maps; 3) Implementing strategic thinking approaches in relation to OSH management; 4) Integrating OSH management within the framework of the CSR concept; 5) Enhancing OSH management processes through the use of smart digital technologies. The methods and solutions discussed may be considered as specific "opportunities" for the improvement to be taken into account in the processes of implementing and maintaining an OSH management system in light of the requirements of the new ISO 45001 standard.
Food Safety
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Author : Steven C Ricke
language : en
Publisher: Academic Press
Release Date : 2015-07-08
Food Safety written by Steven C Ricke and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-08 with Technology & Engineering categories.
Food Safety: Emerging Issues, Technologies and Systems offers a systems approach to learning how to understand and address some of the major complex issues that have emerged in the food industry. The book is broad in coverage and provides a foundation for a practical understanding in food safety initiatives and safety rules, how to deal with whole-chain traceability issues, handling complex computer systems and data, foodborne pathogen detection, production and processing compliance issues, safety education, and more. Recent scientific industry developments are written by experts in the field and explained in a manner to improve awareness, education and communication of these issues. Examines effective control measures and molecular techniques for understanding specific pathogens Presents GFSI implementation concepts and issues to aid in implementation Demonstrates how operation processes can achieve a specific level of microbial reduction in food Offers tools for validating microbial data collected during processing to reduce or eliminate microorganisms in foods
Quantum Safety
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Author : PAUL. STRETTON
language : en
Publisher: Productivity Press
Release Date : 2022-02-23
Quantum Safety written by PAUL. STRETTON and has been published by Productivity Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-23 with categories.
This book is the most comprehensive review of health and safety in half a century. Most organisational approaches to health and safety are based on the methodology developed during the 1970s, and despite the workplace changing beyond recognition since that time, these approaches have remained untouched. Quantum Safety will develop a new understanding fit for the modern workplace. Quantum Safety is an approach that is part of the new view debate. There have been a number of other new approaches to health and safety in recent years, and while they all have merit and improve understanding to help create the optimal, safe working environment, they have failed to significantly create the change desired. These approaches are often flawed at the philosophical or conceptual level or propose a solution without a pathway to implement the principles in safety-critical environments. Quantum Safety: The New Approach to Risk Management for the Complex Workplace is founded on a wholesale critical analysis of the conceptual foundations of health and safety before translating the revised principles into a tangible methodology. Central to the development of Quantum Safety is the application of Complexity Science. The traditional approach to health and safety is considered to be Newtonian - it uses linear models and deterministic analysis. Quantum Safety, due to the full consideration of Complexity Science, introduces multidimensional models and develops analysis based on probabilities. Crucially, this does not render Newtonian methodologies as worthless - in the same manner that Newtonian physics was able to take mankind to the moon, but required the quantum understanding within computers to make it possible - Quantum Safety provides the mechanisms to complete organisations' safety-based journeys. The new mechanisms are fully developed for the reader at both macro and micro levels. How an organisation measures safety and what it values are reset and re-examined. How we investigate adverse events and the consequential actions taken with employees to develop a true Just Culture within a high-performing culture are also completely revised. Essentially, Quantum Safety creates a pathway for understanding health and safety in the complex modern world. To achieve that, new models are introduced to replace the dated, simple tools and a new language is developed to communicate this powerful approach. It will help propel an organisation from considering safety within a concept of industrialised failure avoidance to valuing safety as an integrated aspect of high performance.