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Emerging Technology Platforms For Stem Cells

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Emerging Technology Platforms For Stem Cells

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Author : Uma Lakshmipathy
language : en
Publisher: John Wiley & Sons
Release Date : 2009-04-06

Emerging Technology Platforms For Stem Cells written by Uma Lakshmipathy and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-06 with Medical categories.

This book focuses on practical applications for using adult and embryonic stem cells in the pharmaceutical development process. It emphasizes new technologies to help overcome the bottlenecks in developing stem cells as therapeutic agents. A key reference for professionals working in stem cell science, it presents the general principles and methodologies in stem cell research and covers topics such as derivitization and characterization of stem cells, stem cell culture and maintenance, stem cell engineering, applications of high-throughput screening, and stem cell genetic modification with their use for drug delivery.

Emerging Technology Platforms For Stem Cells

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Author : Uma Lakshmipathy
language : en
Publisher: Wiley
Release Date : 2009-04-06

Emerging Technology Platforms For Stem Cells written by Uma Lakshmipathy and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-06 with Medical categories.

Stem Cells In Regenerative Medicine

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Author : Alain A. Vertes
language : en
Publisher: John Wiley & Sons
Release Date : 2015-12-02

Stem Cells In Regenerative Medicine written by Alain A. Vertes and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-02 with Science categories.

This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine. • Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics • Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline • Written by an expert team with extensive experience in the business, basic and applied science of stem cell research This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.

Potency Assays For Advanced Stem Cell Therapy Medicinal Products

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Author : Jorge S. Burns
language : en
Publisher: Springer Nature
Release Date : 2023-05-31

Potency Assays For Advanced Stem Cell Therapy Medicinal Products written by Jorge S. Burns and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-31 with Science categories.

This volume of the Springer book series Advances in Experimental Medicine and Biology covers potency assays, one of the most complex yet fundamental evaluations that critically influence stem cell regenerative medicine. Developing potency assays for cell-based medicinal products comes with numerous challenges due to the highly specialised nature of the application and purpose. This book provides the reader with the knowledge necessary to understand issues governing the successful development of potency assays, highlighting an international outlook of how the various challenges raised are being managed. Stakeholders concerned with potency assay development range from patient and clinician to contract research organisations, small and medium enterprise, regulatory authorities and even politicians. The value of potency assays is poised to increase given the inevitable watershed as early-stage clinical trials addressing safety progress to trials testing efficacy. Contributors from clinical, academic, industrial and regulatory sectors establish a broad point of view for guidance and timely debate. Potency assays require extensive collaboration across disciplines and sectors, as well as compromise and the authors aim to constructively address the many key aspects involved. Potency assays provide a quantitative measure of the biological activity of advanced therapy medicinal products (ATMPs) and thus are required for their market authorization. As the pace of ATMP development accelerates, the need to develop specific, accurate, and robust potency assays for each product is also accelerating. The volume Potency Assays for Stem Cell Advanced Therapy Medicinal Products presents a broad outlook on the development, quality attributes, and implementation of potency assays for ATMPs. The first few chapters introduce a nuanced historical perspective on the science of potency assay development, describe specific quality attributes of an idealized potency assay, indicate pitfalls associated with developing such assays for ATMPs, and review guidance recommended by regulatory authorities on assay suitability for product approval. Subsequent chapters highlight efforts to develop potency assays for specific ATMPs, including skeletal stem cells, mesenchymal stromal cells, extracellular vesicles, CAR T-cells, and discuss emerging technologies/platforms for potency assay design. The volume concludes with a chapter reviewing potency assays used for the release of commercial ATMP products, which amalgamates information contained in previous chapters. Overall, the knowledge contributed from leading authorities in both academia and industry is an ideal resource for technicians, scientists, clinicians, process engineers, and regulators working with ATMPs. —Donald G. Phinney, PhD Professor, Department of Molecular Medicine, Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

Plurixcel Emerging Technologies Of Regenerative Medicine

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Author : Xuejun H. Parsons
language : en
Publisher: Independently Published
Release Date : 2017-07-24

Plurixcel Emerging Technologies Of Regenerative Medicine written by Xuejun H. Parsons and has been published by Independently Published this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-24 with Education categories.

The limit capacity of heart muscle and brain cells for self-repair constitutes a significant challenge to traditional medicine for tissue and function restoration in seeking cures for a wide range of heart diseases and neurological disorders. Given their limited capacity for self-repair, cell-based therapy represents a promising therapeutic approach closest to provide a cure to restore normal tissue and function. However, the existing markets lack a scalable clinically-suitable human neuronal or heart cell source with adequate regenerative potential, which has been the major setback in developing safe and effective cell-based therapies. To date, the need to restore vital tissue and function for a wide range of neurological and heart diseases remains a daunting challenge to the conventional mode of drugs and treatments. The pluripotent human embryonic stem cells (hESC), the nature source of human pluripotent stem cells (hPSC), have unlimited expansion and differentiation capabilities, offering a practically inexhaustible source of replacement cells for tissue and function restoration. Therefore, they have been regarded as an ideal source to provide an unlimited supply of clinically-relevant functional human cells to heal the damaged or lost tissues that have naturally limited capacity for self-repair, such as the human brain and heart. As neurological and heart diseases incur exorbitant costs on the healthcare system worldwide, there is a strong focus on translating hPSC research to provide newer, more efficient solutions for these unmet therapeutic needs. However, a persistent challenge for clinical translation is to enable a well-controlled and efficient induction of non-functional hPSC exclusively and uniformly to a specific clinically relevant functional lineage. PluriXcel is a pioneer in stem cell therapeutics and remarkable advancement in stem cell research related to the differentiation of non-functional hPSC into specific functional lineages by small molecule induction. The PluriXcel technology platforms offer currently the only available human cell products with the pharmacological capacity to regenerate neurons and contractile heart muscles that allow restitution of function in the clinic. PluriXcel technological breakthroughs allow the achievement of a highly efficient direct conversion of clinical-grade hPSC into a large supply of high-purity human neuronal cells or heart muscle cells with adequate capacity to regenerate neurons or contractile heart muscles for cell regeneration or replacement therapies, as well as for tissue or organ biofabrication. The PluriXcel platforms not only constitute clinically representative progresses in both human neuronal and cardiac therapeutic products for treating a wide range of incurable or hitherto untreatable neurological and heart diseases, but also offer manufacturing innovations for production scale-up and creation of replacement human tissue and organ products. Medical innovations of PluriXcel technology provide scalable platforms to ensure a high degree of efficacy and safety of hPSC-derived cellular products, thus robust clinical benefits leading to therapies, for treating major human diseases challenging traditional medicine. Manufacturing innovations of PluriXcel technology provide scale-up cGMP manufacturing capability for production of large quantities of high quality clinical-grade hPSC-based cell therapy products to support clinical trials and tissue or organ engineering/biofabrication, improving the availability, reproducibility, accessibility, and standardization of manufacturing materials, technologies, and processes to create human repairing or replacing cell, tissue, and organ products. Medical and manufacturing innovations of PluriXcel technology provide life scientists and clinicians with novel, efficient, and powerful resources and tools to address major health concerns, which will shape the future of medicine and bring new therapeutics into the market.

Stem Cells

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Author : Michal K. Stachowiak
language : en
Publisher: World Scientific
Release Date : 2012

Stem Cells written by Michal K. Stachowiak and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Science categories.

Advances in stem cell biology and biotechnology have sparked hopes that therapies will soon be available for maladies which were considered incurable before. However, realization of the clinical potential of stem cells will require better understanding of stem cell physiology and the development of advanced technologies for their efficient differentiation in medically relevant quantities. Resolving these issues necessitates synergistic approaches from multiple fields. Systems biology can be employed to dissect the mechanisms regulating the genome and proteome of stem cells during self-renewal and commitment. Microfluidic platforms can be used to recreate aspects of the stem cell niche and obtain a better understanding of the interactions among stem cells and with their environment. The milieu of stem cells and their progeny can be shaped with appropriately designed biomaterials for the engineering of tissues to replace, reconstitute or regenerate damaged organs. To that end, enabling bioreactor technologies will be necessary for the generation of large quantities of stem cells and their derivatives in a robust and cost-efficient manner. This book invites world-renowned experts in the above fields to discuss the latest advances in their respective areas and to provide insights on the future challenges and achievements in the area of stem cells.

Stem Cell Technologies

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Author :
language : en
Publisher:
Release Date : 2010

Stem Cell Technologies written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Stem cells categories.

Cutting-edge coverage of stem cell biology and applications Featuring contributions from leading global experts, this authoritative volume addresses all major areas of stem cell biology and their potential therapeutic applications. The first part of the book covers embryonic stem cells and contains details on the emerging field of embryonic stem cell-based drug screening platforms. The second part deals with multipotent adult stem cells from different tissue types, and covers unique concepts such as cancer stem cells and tissue engineering-based approaches for designing microenvironments for tissue regeneration. Eighty pages of inserts with 113 color figures are included in this pioneering work. Coverage includes: Zebrafish, medaka, chicken embryonic, and mouse embryonic stem cells Derivation of human embryonic stem cells (hESCs) from blastocysts Treating diabetes with hESCs hESCs as a model system to study human genetics Application of hESCs in drug discovery Adult stem cells for regenerative medicine and cancer therapies Mesenchymal stem cells for neurodegenerative disease therapies Dental pulp, hematopoietic, and spermatogonial stem cells Epigenetic regulators of stem cell pluripotency Cancer stem cells.

The Sage Encyclopedia Of Stem Cell Research

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Author : Eric E. Bouhassira
language : en
Publisher: SAGE Publications
Release Date : 2015-06-15

The Sage Encyclopedia Of Stem Cell Research written by Eric E. Bouhassira and has been published by SAGE Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-15 with Medical categories.

The SAGE Encyclopedia of Stem Cell Research, Second Edition is filled with new procedures and exciting medical breakthroughs, including executive orders from the Obama administration reversing barriers to research imposed under the Bush administration, court rulings impacting NIH funding of research based on human embryonic stem cells, edicts by the Papacy and other religious leaders, and the first success in cloning human stem cells. Stem cell biology is clearly fueling excitement and potential in traditional areas of developmental biology and in the field of regenerative medicine, where they are believed to hold much promise in addressing any number of intractable medical conditions. This updated second edition encyclopedia will expand on information that was given in the first edition and present more than 270 new and updated articles that explore major topics in ways accessible to nonscientists, thus bringing readers up-to-date with where stem cell biology stands today, including new and evolving ethical, religious, legal, social, and political perspectives. This second edition reference work will serve as a universal resource for all public and academic libraries. It is an excellent foundation for anyone who is interested in the subject area of stem cell biology. Key Features: Reader’s Guide, Further Readings, Cross References, Chronology, Resource Guide, Index A Glossary will elucidate stem cell terminology for the nonscientist Statistics and selected reprints of major journal articles that pertain to milestones achieved in stem cell research Documents from Congressional Hearings on stem cells and cloning Reports to the President’s Council on Bioethics, and more

Stem Cell Therapy

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Author : Fouad Sabry
language : en
Publisher: One Billion Knowledgeable
Release Date : 2022-10-05

Stem Cell Therapy written by Fouad Sabry and has been published by One Billion Knowledgeable this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-05 with Medical categories.

What Is Stem Cell Therapy The use of a patient's own stem cells, either to cure or prevent a disease or condition, is the practice known as stem-cell therapy. As of the year 2016, hematopoietic stem cell transplantation is the only treatment that has been shown to be effective employing stem cells. The transplantation of bone marrow is the most common method used for this procedure; however, the cells may also be extracted from umbilical cord blood. Research is now being conducted to establish diverse sources for stem cells and to use stem-cell therapies for neurodegenerative disorders and ailments such as diabetes and heart disease. Additionally, research is being conducted to generate new stem cell sources. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Stem-cell therapy Chapter 2: Stem cell Chapter 3: Bone marrow Chapter 4: Hematopoietic stem cell transplantation Chapter 5: Embryonic stem cell Chapter 6: Regenerative medicine Chapter 7: Cell therapy Chapter 8: Cord blood Chapter 9: Adult stem cell Chapter 10: Stem-cell line Chapter 11: Knee cartilage replacement therapy Chapter 12: Cardiomyoplasty Chapter 13: Stem cell transplantation for articular cartilage repair Chapter 14: Mesenchymal stem cell Chapter 15: Clinical uses of mesenchymal stem cells Chapter 16: Muse cell Chapter 17: Guo Mei Chapter 18: Spinal cord injury research Chapter 19: Stem cell secretome Chapter 20: Shimon Slavin Chapter 21: Stem cell fat grafting (II) Answering the public top questions about stem cell therapy. (III) Real world examples for the usage of stem cell therapy in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of stem cell therapy' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of stem cell therapy.

Biology And Engineering Of Stem Cell Niches

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Author : Ajaykumar Vishwakarma
language : en
Publisher: Academic Press
Release Date : 2017-03-22

Biology And Engineering Of Stem Cell Niches written by Ajaykumar Vishwakarma and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-22 with Science categories.

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system Authored and edited by authorities in this emerging and multidisciplinary field Includes valuable links to 5-10 minute YouTube© author videos that describe main points

Emerging Technology Platforms For Stem Cells

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