Emulsions And Nanosuspensions For The Formulation Of Poorly Soluble Drugs
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Emulsions And Nanosuspensions For The Formulation Of Poorly Soluble Drugs
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Author : Rainer H. Müller
language : en
Publisher: CRC Press
Release Date : 1998
Emulsions And Nanosuspensions For The Formulation Of Poorly Soluble Drugs written by Rainer H. Müller and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Drug carriers (Pharmacy) categories.
Explore possible new approaches for overcoming poorly soluble drugs - a challenge to drug formulation work and an increasing problem. Many newly developed drugs are poorly soluble, very often simultaneously in aqueous and in organic media. Emulsions and Nanosuspensions for the Formulation of Poorly Soluble Drugs aims to: review the possibilities, limitations and future perspectives of emulsions as drug carriers considering technology from other than the phamaceutical industry (i.e food industry). show the production technology of nanosuspensions, explain the special dissolution properties (i.e. increased saturation solubility) and increased dissolution velocity (theory), and cover the possible applications. present the theory of high pressure homogenization and high pressure extrusion in dispersion techniques, including examples of applications and size measurements in concentrated dispersions.
Emulsions And Nanosuspensions For The Formulation Of Poorly Soluble Drugs
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Author : Rainer H. Müller
language : en
Publisher:
Release Date : 1998
Emulsions And Nanosuspensions For The Formulation Of Poorly Soluble Drugs written by Rainer H. Müller and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Submicron Emulsions In Drug Targeting And Delivery
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Author : S Benita
language : en
Publisher: CRC Press
Release Date : 2019-08-16
Submicron Emulsions In Drug Targeting And Delivery written by S Benita and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-16 with Medical categories.
It is anticipated that submicron emulsion and lipid suspension will find numerous and novel medical applications in the near future. The purpose of this multi-authore book is to provide the reader with an up-to-date general overview of submicron emulsions and lipid suspensions (solid lipid nanoparticles) as well as to emphasize the various methods of preparation, characerization, evaluation and potential applications in various therapeutic areas. Leading authors have contributed to this unique book which contains all state of the art and detailed knowledge related to the physico-chemical, pharmaceutical and medical aspects of these most interesting but complex dosage forms, thus making this information easily available to the reader. This book will be of interest to scientists working in the field of drug delivery and targeting in universities as well as in the pharmaceutical, food, cosmetic, veterinary and chemical industries.
Nanodispersions For Drug Delivery
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Author : Raj K. Keservani
language : en
Publisher: CRC Press
Release Date : 2018-09-24
Nanodispersions For Drug Delivery written by Raj K. Keservani and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-24 with Medical categories.
This volume addresses efforts to overcome the shortcomings of conventional dosage forms by exploiting the principles of nanoscience to deliver drugs for medical treatment. Nanodispersions are an important aspect because they possess globules/particles in sizes usually below 1000 nm in which the drug is dispersed in a continuous medium employing surface-active agents as stabilizers. With chapters written by experienced scientists and researchers in the field, this volume provides an abundance of information on various aspects of nanodispersions for drug delivery. The book is divided into several sections: nanoemulsions, nanosuspensions, and diverse dispersed systems. The chapters detail what nanodispersions have demonstrated in the past and what they are expoected to continue to do in the future as the technology further evolves. Key features: • Provides an overview of nanoemulsions for drug delivery • Introduces the general principles, classification, and methods of preparation of nanoemulsion-based drug delivery systems • Presents information relevant to specific routes of applications of nanoemulsions • Looks at the various aspects of nanosuspensions, including their formulation components, preparation methods, unique features, methods of characterization, and applications in various routes of administration • Explores nanomicellar approaches for drug delivery • Discusses the preparation, applications, and clinical considerations of nanogels for drug delivery
Insecticides Design Using Advanced Technologies
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Author : Isaac Ishaaya
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-02-15
Insecticides Design Using Advanced Technologies written by Isaac Ishaaya and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-15 with Technology & Engineering categories.
Among the highlights of this book are the use of nanotechnology to increase potency of available insecticides, the use of genetic engineering techniques for controlling insect pests, the development of novel insecticides that bind to unique biochemical receptors, the exploration of natural products as a source for environmentally acceptable insecticides, and the use of insect genomics and cell lines for determining biological and biochemical modes of action of new insecticides.
Drug Delivery Strategies For Poorly Water Soluble Drugs
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Author : Dionysios Douroumis
language : en
Publisher: John Wiley & Sons
Release Date : 2012-12-19
Drug Delivery Strategies For Poorly Water Soluble Drugs written by Dionysios Douroumis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-19 with Science categories.
Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self–microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on critical formulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug delivery, polymers and biomaterials.
Modified Release Drug Delivery Technology
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Author : Michael J. Rathbone
language : en
Publisher: CRC Press
Release Date : 2002-11-07
Modified Release Drug Delivery Technology written by Michael J. Rathbone and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-11-07 with Medical categories.
Describing formulation challenges and their solutions in the design, development, and commercialization of modified-release drugs delivery systems, this book contains eighty papers that review recent developments in design and manufacturing techniques. It includes detailed descriptions of extended release drug products for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal and transdermal pathways. With the exception of the final section addressing regulatory issues, each section covers a particular route for drug delivery and opens with an overview of the anatomical, physiological, and pharmaceutical basics of each route before moving on to cover specific technologies.
Pharmaceutical Emulsions And Suspensions
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Author : Françoise Nielloud
language : en
Publisher: CRC Press
Release Date : 2000-02-25
Pharmaceutical Emulsions And Suspensions written by Françoise Nielloud and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-02-25 with Medical categories.
Analyzes construction of experiments, focusing on variables, models, matrices, and reproducibility. This timely reference systematically examines the basic concepts and theoretical issues, methodologies for experiment and measurement, and practical health applications of emulsions and dispersions-describing formulation problems and identifying potential carriers for the delivery or targeting of new drugs. Evaluates anionic, cationic, and nonionic surfactants as dispersing, emulsifying, foaming, penetrating, and wetting agents. Written by more than 20 international researchers, Pharmaceutical Emulsions and Suspensions discusses uses of macroemulsions and (submicron) microemulsions illuminates delivery devices such as microparticles, nanospheres, liposomes, and mixed micelles investigates the application of self-emulsifying drug delivery systems (SEDDS) introduces techniques for increasing drug solubility with nanosuspensions addresses stabilization, flocculation, and coagulation problems in pharmaceutical and cosmetic suspensions surveys drug delivery by way of dermatological, follicular, and ocular routes explains the pharmacodynamics, bioavailability, and pharmacokinetics in the drug formulation development process compares and contrasts monomeric and micellar adsorption at oil-water interfaces and more! Containing over 1800 references, tables, equations, drawings, and micrographs, Pharmaceutical Emulsions and Suspensions is an ideal resource for pharmacists; physical, surface, colloid, cosmetic, food, and agricultural chemists; and upper-level undergraduate and graduate students in these disciplines.
Early Drug Development
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Author : Fabrizio Giordanetto
language : en
Publisher: John Wiley & Sons
Release Date : 2018-06-15
Early Drug Development written by Fabrizio Giordanetto and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-15 with Science categories.
This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources. Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.
Medicinal Chemistry With Pharmaceutical Product Development
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Author : Debarshi Kar Mahapatra
language : en
Publisher: CRC Press
Release Date : 2019-02-04
Medicinal Chemistry With Pharmaceutical Product Development written by Debarshi Kar Mahapatra and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-04 with Medical categories.
This volume focuses on novel therapeutics and strategies for the development of pharmaceutical products, keeping the drug molecule as the central component. It discusses current theoretical and practical aspects of pharmaceuticals for the discovery and development of novel therapeutics for health problems. Explaining the necessary features essential for pharmacological activity, it takes an interdisciplinary approach by including a unique combination of pharmacy, chemistry, and medicine along with clinical aspects. It takes into consideration the therapeutic regulations of the USP along with all the latest therapeutic guidelines put forward by WHO, and the US Food and Drug Administration.