Endothelin In Renal Physiology And Disease
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Endothelin In Renal Physiology And Disease
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Author : M. Barton
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2011-09-01
Endothelin In Renal Physiology And Disease written by M. Barton and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-01 with Medical categories.
Endothelin is a 21-amino acid peptide that exerts uniquely potent and long-lasting effects on the kidney, including regulation of water and electrolyte excretion, blood pressure, cell growth, inflammation and fibrosis. During the past 10 years, the field has evolved rapidly; we are now uncovering the potential importance of endothelin receptor antagonists (ERAs) in the treatment of kidney disease.This book reviews experimental concepts, preclinical studies and clinical data which form the basis of our current understanding of the association between endothelin and kidney disease. Acclaimed experts in pharmacology, molecular biology, physiology, cardiovascular medicine, and nephrology have contributed timely reviews dealing with renal pharmacology and physiology of endothelin, the role of endothelin in renal disease development and ERAs in preclinical studies, and the current state of clinical development of ERA therapy in renal medicine.The publication at hand will be a valuable reference source for nephrologists, internists and other healthcare professionals, renal physiologists and molecular biologists, post-doctoral researchers and students in the life sciences, as well as for scientists and decision makers in drug research and development.
Endothelin In The Kidney
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Author : David Pollock
language : en
Publisher: Biota Publishing
Release Date : 2011-11-01
Endothelin In The Kidney written by David Pollock and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-01 with Medical categories.
The discovery of a potent vasoconstrictor, endothelin (ET)-1, derived from vascular endothelial cells was among a variety of key lines of investigation that helped to fuel a major explosion of studies related to endothelial cell biology. This was particularly evident within the pharmaceutical industry where receptor antagonists were quickly developed and are now on the market for treatment of pulmonary hypertension and in development for other diseases such as diabetic nephropathy and cancer. Importantly, we know that the kidney contains the highest level of ET-1 production and receptor expression in the body where it has been demonstrated to function as a pro-natriuretic autocrine and paracrine factor that is activated in conditions of high salt intake. This eBook provides a review of the various mechanisms whereby ET-1 has been shown to function within the kidney through a wide range of actions that include direct effects on tubular transport, intrarenal hemodynamics, as well as neural and endocrine functions. Much has yet to be discerned, but it is clear that the ET system is a major physiological regulator of fluid-electrolyte balance and blood pressure through these renal actions. Table of Contents: Discovery of Endothelin / Basic Biology of the Endothelin System / Renal Localization / Renal Hemodynamics / Renal Tubular Actions of Endothelin / Endothelin in Neural Modulation of Renal Function / Physiological Role of Endothelin / Endothelin in Renal Pathology / References / Author Biographies
Endothelin
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Author : Robert F. Highsmith
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Endothelin written by Robert F. Highsmith and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
A unique, integrated collection of original contributions on the molecular biology, physiology, and pathology of endothelin. Leading academic, clinical, and industrial researchers summarize the dramatic recent progress in endothelin research and indicate the optimal direction of future studies. The contributors produce a critical evaluation of endothelin chemistry and pharmacology, its mechanism of action, and its physiological functions. The book is certain to become the new standard reference source for both basic scientists and informed clinicians who want a clear idea of the roles endothelin may play in cardiovascular physiology and pathology.
Endothelin
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Author : Gabor M Rubanyi
language : en
Publisher: Springer
Release Date : 2013-05-27
Endothelin written by Gabor M Rubanyi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-27 with Medical categories.
Merely three years after the discovery of endothelin, a large amount of information has been generated about the molecular biology, biosynthesis, biological actions and potential physiological and pathological importance of this unique peptide and its isoforms. This first book on endothelins summarizes the early events which lead to the discovery of endothelin, the progress made in understanding the peptide's physiological role, and the current state-of-the-art in contemporary endothelin research. The book also discusses the potential significance of endothelins in health and disease, covers the potential role of the peptides in the integrated control of the cardiovascular system, and outlines future research directions. This comprehensive monograph is an indispensable reference for basic scientists and clinicians.
The Endothelins
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Author : Winifred G. Nayler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Endothelins written by Winifred G. Nayler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
"What we call the beginning is often the end, and to make an end is to make a beginning. The end is where we start from." T. S. ELIOT, "Geroniton" The discovery of endothelin-l was both an end and a beginning. It is an end because this discovery has started a plethora of investigations as to endothe1in's sites of production, mode of action, it's normal and abnormal physiological role and its involvement in a variety of pathological conditions ranging from renal failure to myocardial infarction, cardiac hypertrophy, hyperten sion, cyclosporine induced toxicity, mental depression, renal failure, stress related illness, and even stroke and sudden death. It is a beginning because no one can foresee where the investigations will ultimately lead, or how they will end. The discovery of the endothelins was a very recent event and soon specialist books will start to appear dealing in detail with different aspects of their chemistry, physiological role and pathological importance. The present book is intended to act as a guide and primer for those who are becoming intrigued by the many endothelin related articles which are now appearing in the journals but who as yet have not had the time or opportunity to be caught up in the web of enthusiasm and excitement which is motivating those more directly involved in the field of research.
Principles Of Renal Physiology
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Author : Christopher J. Lote
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Principles Of Renal Physiology written by Christopher J. Lote and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
/ 7 It is eleven years since the first edition of this book was published and six years since the second edition. There have been many advances in renal physiology over these years, a fact demonstrated by a comparison of the index of this new edition with that of 11 years ago. For example, words in the index of this edition which do not appear in the first edition include atrial natriuretic peptide, dopamine, erythropoietin, nitric oxide and prorenin. For this new edition, there are many completely new sections, includ ing a new chapter on tubular transport mechanisms, a section on the bladder and micturition and sections on the renal handling of magne sium, renal function in pregnancy and age-related changes in function. The accounts of renin synthesis, the actions of atrial natriuretic peptide and the mechanisms of ammonia secretion, have been rewritten and updated. The presentation of the book for this third edition is also new. The majority of the figures have been redrawn and 'boxes' have been included to present additional material (particularly information of clinical relevance), which can be read separately from the main text. The most popular features of the book - notably its cOllciseness and logical progression through renal physiology - have been retained.
Endothelin Receptors And Signaling Mechanisms
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Author : David M. Pollock
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Endothelin Receptors And Signaling Mechanisms written by David M. Pollock and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
This book focuses on the wide variety of intracellular events that occur as a result of endothelin receptor activation. This includes a discussion of the various pathways by which endothelin activates Ca2+ signals from several intra- and extracellular sources and the effects of endothelin on ion channels and membrane function. In addition, the mechanisms by which endothelin influences the ion transport within the renal epithelium are covered, as well as the signal transduction pathways activated by endothelin in both cardiac tissue and vascular smooth muscle.
The Endothelium In Cardiovascular Disease
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Author : Thomas Luescher
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Endothelium In Cardiovascular Disease written by Thomas Luescher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Since the endothelium plays such an important role in the pathophysiology of the circulatory system, the readers attention is directed here towards the possible involvement of these polypeptides in the aetiology of ischaemic heart disease, cerebrovascular accidents, hypertension, atherosclerosis and renal failure.
Renal Physiology In Health And Disease
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Author : Barry M. Brenner
language : en
Publisher: W.B. Saunders Company
Release Date : 1987
Renal Physiology In Health And Disease written by Barry M. Brenner and has been published by W.B. Saunders Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medical categories.
Vander S Renal Physiology
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Author : Douglas C. Eaton
language : en
Publisher: McGraw-Hill Scientific, Technical & Medical
Release Date : 2004
Vander S Renal Physiology written by Douglas C. Eaton and has been published by McGraw-Hill Scientific, Technical & Medical this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
Updated with pedagogical aids, this revision introduces the student to the basic principles and clinical applications of renal physiology. (Midwest).