Endotoxin Detection And Control In Pharma Limulus And Mammalian Systems
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Endotoxin Detection And Control In Pharma Limulus And Mammalian Systems
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Author : Kevin L. Williams
language : en
Publisher: Springer
Release Date : 2019-07-24
Endotoxin Detection And Control In Pharma Limulus And Mammalian Systems written by Kevin L. Williams and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-24 with Science categories.
Endotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects. The intersection of test activities includes the use of an ancient blood system from an odd “living fossil” (Limulus). It is used to detect remnants of the most primitive and destructive forms of life (prokaryotes) as contaminants of complex modern systems (mammalian and Pharma). Recent challenges in the field include those associated with the application of traditional methods to new types of molecules and manufacturing processes. The advent of “at will” production of biologics in lieu of harvesting animal proteins has revolutionized the treatment of disease. While the fruits of the biotechnology revolution are widely acknowledged, the realization of the differences in the means of production and changes in the manner of control of potential impurities and contaminants in regard to the new versus the old are less widely appreciated. Endotoxin as an ancient, dynamic interface between lifeforms, provides a singular perspective from which to view the parallel development of ancient and modern organisms as well as the progress of man in deciphering the complexity of their interactions in his efforts to overcome disease.
Advances In The Biology Aquaculture And Conservation Of Threatened Marine Species And Their Application In Human Health And Nutrition
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Author : Anthony Lee Dellinger
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-23
Advances In The Biology Aquaculture And Conservation Of Threatened Marine Species And Their Application In Human Health And Nutrition written by Anthony Lee Dellinger and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-23 with Science categories.
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 3 Environmental Toxicologic Pathology And Major Toxicant Classes
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Author : Wanda M. Haschek
language : en
Publisher: Elsevier
Release Date : 2023-02-24
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 3 Environmental Toxicologic Pathology And Major Toxicant Classes written by Wanda M. Haschek and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-24 with Medical categories.
Haschek and Rousseaux's Handbook of Toxicologic Pathology, Fourth Edition, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, this book covers the toxicologic pathology of major classes of environmental toxicants. Volumes emphasize the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. This series comprises the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately. - Provides updated and revised chapters for in-depth discussions of toxicologic pathology for the protection of the environment and food supplies - Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology - Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations
Microbiome Of Finfish And Shellfish
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Author : Arvind Diwan
language : en
Publisher: Springer Nature
Release Date : 2023-11-13
Microbiome Of Finfish And Shellfish written by Arvind Diwan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-13 with Medical categories.
This book helps us to understand the importance of the microbiome associated with finfish and shellfish inhabiting different locations and varied environmental and biological situations. It covers modern molecular tools for identifying microbiome composition and their precise identification at the species level. The book also covers the molecular structural composition of individual microbes, metabolite resources from microbiome species, their functional properties, and production aspects. Notable, the book covers the microbiome applications in the gut systems of finfish and shellfish to the digestion, nutrition, growth, reproduction, immune system, and vulnerability of the host to diseases. It also reviews diversity and functional properties, relationships with diseases, health status, data on species-specific metagenomics, and probiotic research. It highlights the relevance of microbial communities for the development of new and innovative bio-products to build bio and pharmaceuticalindustries, including aquaculture. This book is an invaluable source for researchers and professionals involved in fishery science, fisheries and aquaculture, fish biotechnology, and fish microbiology and pathology
Characterization Of Nanoparticles Intended For Drug Delivery
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Author : Jeffrey D. Clogston
language : en
Publisher: Springer Nature
Release Date : 2024-03-20
Characterization Of Nanoparticles Intended For Drug Delivery written by Jeffrey D. Clogston and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-20 with Medical categories.
This third edition volume expands on the previous editions with new and updated discussions on the latest developments in endotoxin contamination, complex physicochemical properties, in vitro immunotoxicity traits, and in vitro drug release properties. Eight chapters in this book are dedicated to physicochemical characterization techniques and cover newer methods such as asymmetric-flow field-flow fractionation, single particle inductively coupled plasma mass spectrometry, and resistive pulse sensing. The next eighteen chapters explore the immunotoxicity of nanomaterials, including microbial contaminants such as endotoxin and beta-glucans, anti-PEG antibodies, autoimmunity, and immunosuppressive properties. The last two chapters talk about new pharmacology protocols, including a new technique to assess drug release and a tissue distribution assay using PEG immunohistochemistry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step instructions to reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Characterization of Nanoparticles Intended for Drug Delivery, Third Edition is a valuable resource that will help both expert and novice researchers further enhance their understanding of this important and developing field.
Endotoxine Und Pyrogene
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Author : Michael Rieth
language : de
Publisher: John Wiley & Sons
Release Date : 2021-05-18
Endotoxine Und Pyrogene written by Michael Rieth and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-18 with Science categories.
Diese erste deutschsprachige Übersicht beschreibt praxisnah alle verfügbaren und in der europäischen Pharmakopöe aufgenommenen Nachweisverfahren für bakterielle Endotoxine und andere Pyrogene. Jede Methode wird ausführlich beschrieben und anhand von Praxisbeispielen einschließlich der produktbezogenen Methodenvalidierung präsentiert. Neueste Erkenntnisse zur Maskierung von Endotoxinen und dem LER (low endotoxin recovery)-Effekt sowie neuentwickelte Methoden zur Endotoxinbestimmung mittels rekombinanter Testsysteme werden vorgestellt. Eine Beschreibung der notwendigen Ausrüstung sowie der hauptsächlichen Einsatzgebiete runden dieses Buch ab.
Bacteriological Proceedings
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Author : American Society for Microbiology
language : en
Publisher:
Release Date : 1981
Bacteriological Proceedings written by American Society for Microbiology and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Bacteriology categories.
Abstracts of the annual meeting.
Index To Scientific Reviews
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Author :
language : en
Publisher:
Release Date : 1986
Index To Scientific Reviews written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Agriculture categories.
Science Citation Index
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Author :
language : en
Publisher:
Release Date : 1992
Science Citation Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Science categories.
Vols. for 1964- have guides and journal lists.
Endotoxins
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Author : Kevin L. Williams
language : en
Publisher: CRC Press
Release Date : 2007-02-23
Endotoxins written by Kevin L. Williams and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-23 with Medical categories.
This source expertly examines the discovery, biological structure, control, and continued clarification of endotoxin from a parenteral manufacturing perspective, with in-depth discussion of state-of-the-art technologies involving Limulus amebocyte lysate (LAL) such as assay development, automation, depyrogenation. Completely revised and exp