Energetics Of Biological Macromolecules Part C
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Energetics Of Biological Macromolecules Part C
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Author :
language : en
Publisher: Elsevier
Release Date : 2000-08-09
Energetics Of Biological Macromolecules Part C written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-08-09 with Science categories.
Volume 323 of Methods in Enzymology is dedicated to the energetics of biological macromolecules. Understanding the molecular mechanisms underlying a biological process requires detailed knowledge of the structural relationships within the system and an equally detailed understanding of the energetic driving forces that control the structural interactions. This volume presents modern thermodynamic techniques currently being utilized to study the energetic driving forces in biological systems. It will be a useful reference source and textbook for scientists and students whose goal is to understand the energetic relationships between macromoleculer structures and biological functions. This volume supplements Volumes 259 and Volume 295 of Methods in Enzymology.Key Features* Probing Stability of Helical Transmembrane Proteins* Energetics of Vinca Alkaloid Interactions with Tubulin* Deriving Complex Ligand Binding Formulas* Mathematical Modeling of Cooperative Interactions in Hemoglobin* Analysis of Interactions of Regulatory Protein TyrR with DNA* Parsing Free Energy of Drug-DNA Interactions* Use of Fluorescence as Thermodynamics Tool
Fragment Based Drug Design
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Author :
language : en
Publisher: Academic Press
Release Date : 2011-02-28
Fragment Based Drug Design written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-28 with Medical categories.
There are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. Also elaborated by experienced researchers in FBDD are sample preparations of fragments, proteins, and GPCR as well as examples of how to generate leads from hits. - Offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens - The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD
Rna Helicases
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-11-13
Rna Helicases written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-13 with Science categories.
This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases. - This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases - The contributions in this volume cover the broad scope of methods in the research on these enzymes
Imaging And Spectroscopic Analysis Of Living Cells
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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2012-02-24
Imaging And Spectroscopic Analysis Of Living Cells written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-24 with Medical categories.
This volume of Methods in Enzymology is the third of 3 parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike. The third of 3 parts looking at current methodology for the imaging and spectroscopic analysis of live cells The chapters provide hints and tricks not available in primary research publications It is an invaluable resource for academics, researchers and students alike
The Unfolded Protein Response And Cellular Stress
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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2011
The Unfolded Protein Response And Cellular Stress written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Cell physiology categories.
This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights
Glycomics
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-10-25
Glycomics written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-25 with Science categories.
In this 3 volume collection focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers' own research efforts - Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves - Useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry
Glycobiology
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Author :
language : en
Publisher: Academic Press
Release Date : 2010-10-25
Glycobiology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-25 with Science categories.
In this 3 volume collection focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers' own research efforts - Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves - Useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry
Biothermodynamics
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Author : Michael L. Johnson
language : en
Publisher: Academic Press
Release Date : 2011
Biothermodynamics written by Michael L. Johnson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Carrier proteins categories.
In the last several years there has been an explosion in the ability of biologists, molecular biologists and biochemists to collect vast amounts of data on their systems. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.
Imaging And Spectroscopic Analysis Of Living Cells
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Author :
language : en
Publisher: Academic Press
Release Date : 2012-01-25
Imaging And Spectroscopic Analysis Of Living Cells written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-25 with Science categories.
This volume of Methods in Enzymology is the first of three parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike. - Expert authors who are leaders in the field - Extensively referenced and useful figures and tables - Provides hints and tricks to facilitate reproduction of methods
Gene Transfer Vectors For Clinical Application
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Author : Theodore Friedmann
language : en
Publisher: Academic Press
Release Date : 2012-03-06
Gene Transfer Vectors For Clinical Application written by Theodore Friedmann and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-06 with Medical categories.
This volume of Methods in Enzymology looks at Gene Transfer Vectors for Clinical Application. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume covers such topics as General principles of retrovirus vector design, Chronic granulomatous disease (CGD), Gene therapy for blindness, and Retrovirus genetic strategy and vector design. Chapters provide an invaluable resource for academics, researchers and students alike International board of authors This volume covers such topics as general principles of retrovirus vector design, chronic granulomatous disease (CGD), gene therapy for blindness, and retrovirus genetic strategy and vector design