Enfrentando O C Ncer Com Leveza
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Developmental Riding Therapy
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Author : Jan Spink
language : en
Publisher:
Release Date : 1993
Developmental Riding Therapy written by Jan Spink and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Horsemanship categories.
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Nursing Interventions Classification Nic
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Author : Gloria M. Bulechek, PhD, RN, FAAN
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-11-01
Nursing Interventions Classification Nic written by Gloria M. Bulechek, PhD, RN, FAAN and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-01 with Medical categories.
Covering the full range of nursing interventions, Nursing Interventions Classification (NIC), 6th Edition provides a research-based clinical tool to help in selecting appropriate interventions. It standardizes and defines the knowledge base for nursing practice while effectively communicating the nature of nursing. More than 550 nursing interventions are provided - including 23 NEW labels. As the only comprehensive taxonomy of nursing-sensitive interventions available, this book is ideal for practicing nurses, nursing students, nursing administrators, and faculty seeking to enhance nursing curricula and improve nursing care. More than 550 research-based nursing intervention labels with nearly 13,000 specific activities Definition, list of activities, publication facts line, and background readings provided for each intervention. NIC Interventions Linked to 2012-2014 NANDA-I Diagnoses promotes clinical decision-making. New! Two-color design provides easy readability. 554 research-based nursing intervention labels with nearly 13,000 specific activities. NEW! 23 additional interventions include: Central Venous Access Device Management, Commendation, Healing Touch, Dementia Management: Wandering, Life Skills Enhancement, Diet Staging: Weight Loss Surgery, Stem Cell Infusion and many more. NEW! 133 revised interventions are provided for 49 specialties, including five new specialty core interventions. NEW! Updated list of estimated time and educational level has been expanded to cover every intervention included in the text.
Critical Events
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Author : Veena Das
language : en
Publisher:
Release Date : 1995
Critical Events written by Veena Das and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Physical anthropology categories.
Fluxo Floema
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Author : Hilda Hilst
language : en
Publisher:
Release Date : 2018-06-12
Fluxo Floema written by Hilda Hilst and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-12 with Fiction categories.
Fluxo-Floema is a detective novel of sorts--pornographic, scatological, and spiritual--that ultimately references the failure and success of writing. It's about vocabulary, astrology, dramaturgy, science, a story within a story within a story. It's a celestial map to social interaction and the failure of connection, a crafted examination of the distortions of religion and piety. Here we, the reader, visit nonsense, pathos, violence, and the flights of fancy of human coexistence.
The Embodied Image
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Author : Juhani Pallasmaa
language : en
Publisher: John Wiley & Sons
Release Date : 2011-05-16
The Embodied Image written by Juhani Pallasmaa and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-16 with Architecture categories.
The Embodied Image The Embodied Image: Imagination and Imagery in Architecture Juhani Pallasmaa All artistic and architectural effects are evoked, mediated and experienced through poeticised images. These images are embodied and lived experiences that take place in ‘the flesh of the world’, becoming part of us, at the same time that we unconsciously project aspects of ourselves on to a conceived space, object or event. Artistic images have a life and reality of their own and they develop through unexpected associations rather than rational and causal logic. Images are usually thought of as retinal pictures but profound poetic images are multi-sensory and they address us in an embodied and emotive manner. Architecture is usually analysed and taught as a discipline that articulates space and geometry, but the mental impact of architecture arises significantly from its image quality that integrates the various aspects and dimensions of experience into a singular, internalised and remembered entity. The material reality is fused with our mental and imaginative realm. The book is organised into five main parts that look at in turn: the image in contemporary culture; language, thought and the image; the many faces of the image; the poetic image; and finally the architectural image. The Embodied Image is illustrated with over sixty images in pairs, which are diverse in subject. They range from scientific images to historic artistic and architectural masterpieces. Artworks span Michelangelo and Vermeer to Gordon Matta- Clark and architecture takes in Modern Masters such as Mies van der Rohe, Le Corbusier and Alvar Aalto, as well as significant contemporary works by Steven Holl and Daniel Libeskind.
Neuro Design
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Author : Darren Bridger
language : en
Publisher: Kogan Page Publishers
Release Date : 2017-02-03
Neuro Design written by Darren Bridger and has been published by Kogan Page Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-03 with Business & Economics categories.
COMMENDED: Business Book Awards 2018 - Thought Leader Category Today, businesses of all sizes generate a great deal of creative graphic media and content, including websites, presentations, videos and social media posts. Most big companies, including the likes of Procter & Gamble, Coca-Cola, Tesco and Google, now use neuroscience research and theories to optimize their digital content. Neuro Design opens up this new world of neuromarketing design theories and recommendations, and describes insights from the growing field of neuroaesthetics that will enable readers to enhance customer engagement through their website, and boost profitability. Neuro Design emphasizes the importance of understanding consumers' non-conscious reactions to design and how brands can use them to improve performance, and increase the credibility and persuasiveness of their content. Including practical methods such as neuro-research for testing websites, plus real world case studies from P&G, Coca-Cola, Google and neuroscientific advertising for Nielson, this is the essential handbook for any marketer looking to improve engagement with their creative graphic content. Also covering visuospatial resonance, banner blindness, visual saliency, the Gestalt Psychology Model, the halo effect and much more, Neuro Design will equip any marketer with the design techniques they need to engage with consumers. Online resources include web links to inspiring reading, and further website resources.
Fourth Generation Evaluation
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Author : Egon G. Guba
language : en
Publisher: SAGE
Release Date : 1989
Fourth Generation Evaluation written by Egon G. Guba and has been published by SAGE this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Social Science categories.
Publisher's description: Fourth Generation Evaluation represents a monumental shift in evaluation practice. Guba and Lincoln point to the inherent problems faced by previous generations of evaluators--politics, ethical dilemmas, imperfections and gaps, inconclusive deductions--and lay the blame for failure and nonutilization at the feet of the unquestioned reliance on the scientific/positivist paradigm of research. Fourth Generation Evaluation, a more informed and sophisticated approach, moves beyond science to include the myriad human, political, social, cultural, and contextual elements that are involved. Based upon relativism, a unity between knower and known, and a subjective epistemology, the authors show how fourth generation evaluation unites the evaluator and the stakeholders in an interaction that creates the product of the evaluation. Differing from previously existing generations, this new approach moves evaluation to a new level, whose key dynamic is negotiation. The constructivist paradigm is espoused by the authors and shown to offer multiple advantages, including empowerment and enfranchisement of stakeholders, as well as an action orientation that defines a course to be followed. Not merely a treatise on evaluation theory, Guba and Lincoln also comprehensively describe the differences between the positivist and constructivist paradigms of research, and provide a practical plan of the steps and processes in conducting a fourth generation evaluation.
Evaluation For The 21st Century
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Author : Eleanor Chelimsky
language : en
Publisher: SAGE
Release Date : 1997-01-28
Evaluation For The 21st Century written by Eleanor Chelimsky and has been published by SAGE this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-01-28 with Social Science categories.
Evaluation for the 21st Century features thoughtfully written introductions to each of the main sections that provide a context and synthesis of the various evaluators' chapters. After reading this groundbreaking book, researchers and practitioners will be able to recognize these new developments in evaluation as they encounter them, place them in context, and incorporate them into their own evaluation professions and practices.